California is currently home to 5602 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Veri-T: A Trial of Verdiperstat in Patients With svPPA Due to TDP-43 Pathology
Recruiting
The purpose of the study is to test the safety and tolerability of twice daily Verdiperstat in patients with semantic variant primary progressive aphasia (svPPA) due to frontotemporal lobar degeneration with TDP-43 pathology (FTLD-TDP). Three-fourths of the participants will receive Verdiperstat and one-fourth will receive Placebo during the 24-week treatment duration.
Gender:
ALL
Ages:
Between 18 years and 85 years
Trial Updated:
10/28/2024
Locations: UCSF Memory and Aging Center, San Francisco, California
Conditions: Semantic Dementia
SPL Insufficiency Syndrome (SPLIS)/NPHS14: a SPLIS Observational Study and Patient Registry (International)
Recruiting
This protocol aims to gather information about sphingosine phosphate lyase insufficiency syndrome (SPLIS), also known as NPHS14, and to create a SPLIS patient registry. Medical records, radiological and pathology results, blood test results, and genetic information will be collected. Samples of blood, cheek cells, urine and stool may be collected for analysis. If a skin biopsy has been performed for medical care, cells from the biopsy may be analyzed. No treatment or other intervention is involv... Read More
Gender:
ALL
Ages:
All
Trial Updated:
10/28/2024
Locations: University of California San Francisco, San Francisco, California
Conditions: Sphingolipidoses, Enzyme Deficiency
A Study of Bevonescein in Patients Undergoing Abdominopelvic Surgery
Recruiting
Feasibility study of Bevonescein to highlight Nerves and Ureter in patients undergoing Minimally Invasive Surgery
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/25/2024
Locations: University of California San Diego, San Diego, California
Conditions: Surgery, Nerve Injury, Imaging
Quasi-Randomized Evaluation of the UCLA Next Day Clinic (NDC)
Recruiting
The Next Day Clinic (NDC) is a quality improvement initiative that will be launched and operated by UCLA Health starting July 22, 2024. Its goals are to improve patient care and safety and to maximize cost effectiveness. The way it does this is by identifying patients in the ED who would normally be admitted for low-acuity conditions, and diverting them to a high-acuity clinic the following day called the NDC. This will help decompress the ED and the hospital, and allow for overall higher qualit... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/25/2024
Locations: Ronald Reagan UCLA Medical Center, Los Angeles, California
Conditions: Pneumonia, Syncope, Congestive Heart Failure, Cellulitis, Pyelonephritis, AKI - Acute Kidney Injury, Diabetic Foot Infection, Osteomyelitis
Autologous Hair Follicle Derived Secretome as Adjunct to Aesthetic Procedures
Recruiting
Non-interventional, multi-site, prospective, open-label, observational, real-world study of autologous hair follicle secretome use.
Gender:
ALL
Ages:
Between 18 years and 60 years
Trial Updated:
10/25/2024
Locations: Glenn Vallecillos MD Inc, Beverly Hills, California
Conditions: Post Procedural Erythema
Sexual Health Advocacy for Guys - a Text Messaging-based HIV Prevention Program for Guys Who Are Into Guys
Recruiting
SHAG is a text messaging-based HIV prevention program designed for cisgender sexual minority boys and men 13-20 years of age across the United States. Investigators will test it against a control group that receives messages about healthy lifestyle.
Gender:
MALE
Ages:
Between 13 years and 22 years
Trial Updated:
10/25/2024
Locations: Center for Innovative Public Health Research, San Clemente, California
Conditions: HIV Infections
Feasibility and Colorectal Benefits of Pulses Supplementation
Recruiting
Beans are a forgotten staple food that shows promise in improving health. The goal of this study is to look at how bean supplementation affects metabolic and bowel health. In the long-term, the investigators believe this research will lead to a better understanding of the impact of beans on bowel health. The investigators also hope that this research study will help us understand ways to improve human diet and prevent colon cancer in the future.
Gender:
ALL
Ages:
Between 30 years and 80 years
Trial Updated:
10/25/2024
Locations: University of California Davis, Sacramento, California
Conditions: Colorectal Polyp, Obesity
Open-label Study to Evaluate the Safety of Various Dosing Regimens of MuSK-CAART for MuSK Myasthenia Gravis
Recruiting
Muscle-specific tyrosine kinase (MuSK) myasthenia gravis (MG) is a rare but potentially severe disease, in which patients develop pathogenic autoantibodies that specifically target the MuSK protein in the neuromuscular junction. This phase 1 study is being conducted to evaluate the safety of various dosing regimens of an investigational cell therapy, MuSK-CAART, that can be given to patients with anti-MuSK antibody positive Myasthenia Gravis (MuSK MG), who have active disease. Various dosing reg... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/25/2024
Locations: UC Irvine, Department of Neurology, Orange, California
Conditions: MuSK Myasthenia Gravis
Trial of Latex Vs Non-latex Hemorrhoid Banding
Recruiting
This study will involve the recruitment of adult patients with hemorrhoids for whom rubber band ligation is the recommended treatment. Patients will be randomized to receive banding with a latex band or non-latex band. Our goal will be to measure the performance of latex bands vs non-latex bands.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/24/2024
Locations: Huntington Memorial Hospital, Pasadena, California
Conditions: Hemorrhoid, Hemorrhoid Bleeding
The Effects of Dietary Erythritol on Platelet Reactivity and Vascular Inflammation
Recruiting
The purpose is to conduct a dietary intervention study in which human participants will consume beverages sweetened with erythritol or aspartame, each for 2 weeks, in a randomized crossover design
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
10/24/2024
Locations: Ragle Human Nutrition Research Center, University of California, Davis, Davis, California
Conditions: Platelet Aggregation, Spontaneous, Vascular Thrombosis
Preventing Liver Cancer Mortality Through Imaging With Ultrasound vs. MRI
Recruiting
The study is a randomized trial of two different screening methods for early detection of liver cancer in patients with cirrhosis of the liver. The goal of PREMIUM is to compare an abbreviated version of the diagnostic gold standard for HCC (aMRI) +AFP to the standard-of-care screening (US+AFP) in patients at high risk of developing HCC. The investigators hypothesize that HCC will be detected at earlier stages, allowing for more curative treatments and resulting in a reduction in HCC-related mor... Read More
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
10/24/2024
Locations: VA Long Beach Healthcare System, Long Beach, CA, Long Beach, California
Conditions: Carcinoma, Hepatocellular, Cirrhosis
A Study of Combination of Selinexor, Pomalidomide, and Dexamethasone (SPd) Versus Elotuzumab, Pomalidomide, and Dexamethasone (EloPd) in Subject With Previously Treated Multiple Myeloma
Recruiting
This phase 3 randomized, open-label multicenter trial will compare the efficacy, safety and the impact on health-related quality of life (HR-QoL) of SPd versus EloPd in pomalidomide-naïve patients with MM who have received 1 to 4 prior anti-MM regimens and been treated with an immunomodulatory imide drug (IMiD), proteasome inhibitor (PI) and an anti-CD38 monoclonal antibody (mAb).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/24/2024
Locations: California Cancer Associates for Research and Excellence, Encinitas, California
Conditions: Multiple Myeloma