California is currently home to 5600 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
CAR-T Cells for HIV Infection
Recruiting
This is a limited-center, open-label dose escalating phase I/IIa study of autologous T cells expressing LVgp120duoCAR molecules in people with HIV infection. It will follow a 3+3 design. Dose escalation decisions will be made when a minimum of three participants have completed the safety-evaluation period (45 days) at a given dose level. Cohort 1 will undergo infusion of a single low-dose regimen of LVgp120duoCAR-T cells. Cohort 2 will undergo non-ablative conditioning with cyclophosphamide, fol... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
06/17/2024
Locations: University of California, Davis, Sacramento, California
Conditions: HIV Infections
SCOPE Analytic Treatment Interruption Protocol
Recruiting
The goal of this study is to understand the interaction between HIV and the host at the earliest stages when HIV medications are paused. Volunteers with HIV will interrupt antiretroviral therapy (ART) and then have intensive studies preformed two to three times per week. Most will resume therapy within three weeks, even if the virus does not rebound during this time.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/17/2024
Locations: University of California San Francisco, San Francisco, California
Conditions: HIV/AIDS
Closed-Loop Deep Brain Stimulation for Refractory Chronic Pain
Recruiting
Chronic pain affects 1 in 4 US adults, and many cases are resistant to almost any treatment. Deep brain stimulation (DBS) holds promise as a new option for patients suffering from treatment-resistant chronic pain, but traditional approaches target only brain regions involved in one aspect of the pain experience and provide continuous 24/7 brain stimulation which may lose effect over time. By developing new technology that targets multiple, complimentary brain regions in an adaptive fashion, the... Read More
Gender:
ALL
Ages:
Between 22 years and 80 years
Trial Updated:
06/17/2024
Locations: University of California, San Francisco, San Francisco, California
Conditions: Spinal Cord Injuries, Nerve Injury, Pain, Postoperative, Post Herpetic Neuralgia, Complex Regional Pain Syndromes, Post-Stroke Pain, Post Radiation Brain Injury, Post Radiation Plexopathy, Nerve Root Avulsion
The Use of Lymph Node Biopsies to Support HIV Pathogenesis Studies
Recruiting
HIV medicines have led to dramatic improvements in health. However, there remains a concern for potential drug toxicities, cost of drugs, and need for life-long treatment. In addition, research has found that health is not completely restored in HIV-infected patients, even if they have been taking effective HIV medicines for a long time. This may be due to direct drug-toxicity, continued replication of the virus, and/or inflammation of the body in response to the virus. Therefore, a more complet... Read More
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
06/17/2024
Locations: San Francisco General Hospital, San Francisco, California
Conditions: HIV
SCOPE: Observational Study of the Consequences of the Protease Inhibitor Era
Recruiting
SCOPE is an observational, prospective study of HIV-1 infected volunteers designed to provide a specimen bank of samples with carefully characterized clinical data. SCOPE specimens will be used to examine multiple questions involving virologic, immunologic, and host factors involved in HIV-1 infection, progression, non-progression, response to treatment, control of HIV-1 virus, and evolution of drug resistance.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/17/2024
Locations: San Francisco General Hospital, San Francisco, California
Conditions: HIV Infections
Comparing Supplemental Topical Agents for the Treatment of Acute Radiation Dermatitis in Patients With Breast Cancer
Recruiting
This clinical trial compares two supplemental topical agents (Aquaphor and Miaderm) for the treatment of acute radiation dermatitis in patients with breast cancer undergoing radiation therapy. Radiation dermatitis is a radiation-induced skin reaction which can cause itching, swelling, pain, and general discomfort. Aquaphor is a commonly available, inexpensive, petrolatum-based multi-purpose ointment designed to protect and sooth extremely dry skin, chapped lips, cracked hands and feet, minor cut... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
06/16/2024
Locations: City of Hope Medical Center, Duarte, California
Conditions: Breast Ductal Carcinoma In Situ, Invasive Breast Carcinoma
The Effects of Almond on Facial Skin Collagen and Wrinkles
Recruiting
Investigate the effects of almond consumption on collagen production, elastin levels, wrinkles, and pigmentation among premenopausal women and postmenopausal women belonging to all Fitzpatrick skin types.
Gender:
FEMALE
Ages:
Between 35 years and 70 years
Trial Updated:
06/15/2024
Locations: Integrative Skin Science and Research, Sacramento, California
Conditions: Collagen Degeneration, Wrinkle, Pigmentation, Elastic Skin
Using a Novel Skin Tag Removal Device
Recruiting
The aim of this study is to investigate the use of a mechanical device to remove skin tags in adults. The device ("Skin Tag Removal", or STR) utilizes the ligation method by applying a silicone band around the base of a skin tag, therefore restricting the blood supply, which is vital to its growth and survival. Because this method does not include freezing or burning of tissue in or around the skin tag, it could be considered less invasive and less risky than other options.
Gender:
ALL
Ages:
22 years and above
Trial Updated:
06/14/2024
Locations: Center for Dermatology Clinical Research, Inc., Fremont, California
Conditions: Achrochordon
Longitudinal Prospective Study of Neurocognition & Neuroimaging in Primary BT Patients
Recruiting
In this proposal, the investigators introduce a novel, translational study to prospectively examine primary brain tumor patients undergoing fractionated radiation therapy to the brain. Quantitative neuroimaging, radiation dose information, and directed neurocognitive testing will be acquired through this study to improve understanding of cognitive changes associated with radiation dosage to non-targeted tissue, and will provide the basis for evidence-based cognitive- sparing brain radiotherapy.
Gender:
ALL
Ages:
Between 18 years and 99 years
Trial Updated:
06/14/2024
Locations: Moores Cancer Center, San Diego, California
Conditions: Primary Brain Tumor, Glioma, Meningioma, Schwannoma
Single Arm Trial of Tumor-Treating Fields in Combination With Nivolumab and Ipilimumab in Metastatic Uveal Melanoma
Recruiting
Tumor Treating Fields targeted to liver metastases may improve outcomes for patients with metastatic uveal melanoma treated with immune checkpoint inhibitors.
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
06/14/2024
Locations: The Angeles Clinic and Research Insititute, Los Angeles, California
Conditions: Uveal Melanoma
Abbott Vascular Medical Device Registry
Recruiting
The AV-MDR is a prospective, non-randomized, open-label, multi-center registry. The purpose of the AV-MDR study is to proactively collect and evaluate clinical data on the usage of the devices in scope within their intended use with the aim of confirming safety and performance throughout their expected lifetime, ensuring the continued acceptability of identified risks, detecting emerging risks on the basis of factual evidence, ensuring the continued acceptability of the benefit-risk ratio, and i... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/14/2024
Locations: Kaiser Permanente Los Angeles Medical Center, Los Angeles, California
Conditions: Acute Myocardial Infarction, Restenoses, Coronary, Coronary Artery Lesions, Venous Embolism, Arterial Embolism
UCSD Image-Guided Cognitive-Sparing Radiosurgery for Brain Metastases
Recruiting
In this proposal, the investigators introduce advanced diffusion and volumetric imaging techniques along with innovative, automated image parcellation methods to identify critical brain regions, incorporate into cognitive-sparing SRS, and analyze biomarkers of radiation response. This work will advance the investigators' understanding of neurocognitive changes after brain SRS and help create interventions that preserve cognitive-function in brain metastases patients.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/14/2024
Locations: Moores Cancer Center, San Diego, California
Conditions: Brain Metastases, Adult, Neurocognitive Function, Cancer