California is currently home to 5588 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Phenotyping Response to Spinal Cord Stimulation in Chronic Low Back Pain
Recruiting
Chronic low back pain (CLBP) is a debilitating condition and costly to treat. Long-term drug treatment often fails due to habituation, breakthrough of pain, or adverse effects of drug treatment. Opioid use to manage this pain has contributed to the opioid epidemic. Spinal cord stimulators have emerged as a promising treatment and reduces reliance on drugs. However, response to spinal cord stimulation (SCS) is unpredictable. It is difficult to predict which patients will respond positively to SCS... Read More
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
06/03/2024
Locations: University of California, Los Angeles, Los Angeles, California
Conditions: Chronic Low Back Pain
Clinical Trial to Compare the Efficacy of Celiprolol to Placebo in Patients With Vascular Ehlers-Danlos Syndrome
Recruiting
This is a prospective, Phase 3, randomized, double-blind, placebo-controlled efficacy study to evaluate celiprolol in patients genetically confirmed as COL3A1-positive vEDS using a decentralized clinical trial design.
Gender:
ALL
Ages:
Between 15 years and 64 years
Trial Updated:
06/03/2024
Locations: Science 37, Culver City, California
Conditions: Vascular Ehlers-Danlos Syndrome
Evaluating the Feasibility of VR for Pediatric Renal Biopsies
Recruiting
The purpose of this study is to assess the use of virtual reality (VR) as an adjunct or alternative to pharmacologic sedation in pediatric patients undergoing renal biopsy.
Gender:
ALL
Ages:
Between 5 years and 17 years
Trial Updated:
06/03/2024
Locations: UCSF Benioff Children's Hospital, San Francisco, California
Conditions: Pain, Procedural, Procedural Anxiety, Sedation Complication
Eliminating Monitor Overuse Trial (EMO Trial)
Recruiting
The purpose of this study is to identify the optimal deimplementation strategies for an overused practice: continuous pulse oximetry monitoring of children hospitalized with bronchiolitis who are not receiving supplemental oxygen.
Gender:
ALL
Ages:
2 months and above
Trial Updated:
06/03/2024
Locations: University of California Davis, Davis, California
Conditions: Bronchiolitis Acute Viral
Mitral Valve Screening Survey
Recruiting
This study aims to examine the clinical profile/anatomical characteristics and natural history of patients who subsequently fail screening for transcatheter mitral valve intervention (TMVI).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/03/2024
Locations: Keck Hospital of USC, Los Angeles, California
Conditions: Mitral Valve Disease
A Double Blind, Randomized Controlled Study, Evaluating the Safety and Efficacy of RD2 Ver.02 For the Management of Anal Fistulas
Recruiting
The goal of this clinical trial is to assesses the safety of autologous RD2 Ver.02 as compared to a control for managing transsphincteric and intersphinsteric anal fistulas. The main questions it aims to answer are: Assess the safety and efficacy of RD2 Ver.02 in anal fistula application, compared to control. Complication rate by 6 months of anal fistula treatment with RD2 Ver.02 compared to control. Recurrence of anal fistula at 12 months post-treatment Incidence of perirectal infection by... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/02/2024
Locations: Karen Zaghiyan, M.D, Los Angeles, California
Conditions: Anal Fistula
PROMISE III: Percutaneous Deep Vein Arterialization for the Treatment of Late-Stage Chronic Limb-Threatening Ischemia
Recruiting
A prospective, single-arm, multi-center study designed to gather additional information on the LimFlow System.
Gender:
ALL
Ages:
Between 18 years and 95 years
Trial Updated:
05/31/2024
Locations: University of California, San Diego Health, La Jolla, California
Conditions: Critical Limb Ischemia, Peripheral Arterial Disease, Chronic Limb-Threatening Ischemia
Treatment of Refractory BK Infections With Related Donor BK Specific Cytotoxic T-cells (CTLs)
Recruiting
BK cytotoxic T cells (CTLs) manufactured with the Miltenyi CliniMACS Prodigy Cytokine Capture System will be safe and effective in decreasing specific viral load in children, adolescents and young adults (CAYA) with refractory BK infection post Allogeneic Hematopoietic Stem Cell Transplantation (AlloHSCT) or with primary immunodeficiencies (PID).
Gender:
ALL
Ages:
Between 1 month and 79 years
Trial Updated:
05/30/2024
Locations: University of California San Francisco, San Francisco, California
Conditions: Viral Infection, Primary Immune Deficiency Disorder
Phase II Protocol of Proton Therapy for Partial Breast Irradiation in Early Stage Breast Cancer
Recruiting
The purpose of this research study is to compare the effects (good and bad) on women and their cancer using proton radiation therapy. This study is being done to see if proton radiation therapy will prove to be beneficial for women with early stage breast cancer. A clinical study is necessary to compare the results (good or bad) of proton radiation therapy.
Gender:
FEMALE
Ages:
50 years and above
Trial Updated:
05/30/2024
Locations: California Protons Cancer Therapy Center, San Diego, California
Conditions: Breast Cancer, Breast Neoplasm, Breast Tumor, Cancer of the Breast
Registry Study for Radiation Therapy Outcomes
Recruiting
The purpose of this research study is to collect and analyze information from patients being treated with various forms of radiation therapy.
Gender:
ALL
Ages:
All
Trial Updated:
05/30/2024
Locations: California Protons Cancer Therapy Center, San Diego, California
Conditions: Neoplasms
Safety and Preliminary Efficacy of MT-601 in Patients With Relapsed/Refractory Lymphoma
Recruiting
This study is a Phase 1 multicenter study with a Dose Escalation and Dose Expansion evaluating safety and efficacy of MT-601 administration to patients with Relapsed or Refractory Lymphoma. The starting dose administered is 200 x 10\^6 cells (flat dosing).
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
05/29/2024
Locations: City of Hope, Duarte, California
Conditions: Non-Hodgkin Lymphoma, Adult, Non-Hodgkin Lymphoma, Refractory, Non-Hodgkin Lymphoma, Relapsed, Non Hodgkin Lymphoma, Hodgkin Lymphoma, Hodgkin Lymphoma, Adult, Hodgkin's Lymphoma, Relapsed, Adult
CBM588 Capsules in Combination With Nivolumab and Ipilimumab for the Treatment of Advanced Stage Kidney Cancer
Recruiting
This phase I trial tests the safety, side effects, best dose, and effectiveness of CBM588 in combination with nivolumab and ipilimumab in treating patients with kidney cancer that may have spread from where it first started to nearby tissue, lymph nodes, or distant parts of the body (advanced). CBM588 is a live biotherapeutic that may help improve the effects of immunotherapy. Nivolumab and ipilimumab are monoclonal antibodies that may interfere with the ability of tumor cells to grow and spread... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/28/2024
Locations: City of Hope Medical Center, Duarte, California
Conditions: Advanced Clear Cell Renal Cell Carcinoma, Advanced Renal Cell Carcinoma, Advanced Sarcomatoid Renal Cell Carcinoma, Metastatic Clear Cell Renal Cell Carcinoma, Metastatic Renal Cell Carcinoma, Metastatic Sarcomatoid Renal Cell Carcinoma, Stage III Renal Cell Cancer AJCC v8, Stage IV Renal Cell Cancer AJCC v8