California is currently home to 5600 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Integrating Quantitative MRI and Artificial Intelligence to Improve Prostate Cancer Classification
Recruiting
This study evaluates how new magnetic resonance imaging (MRI) and artificial intelligence techniques improve the image quality and quantitative information for future prostate MRI exams in patients with suspicious of confirmed prostate cancer. The MRI and artificial intelligence techniques developed in this study may improve the accuracy in diagnosing prostate cancer in the future using less invasive techniques than what is currently used.
Gender:
MALE
Ages:
18 years and above
Trial Updated:
04/12/2024
Locations: UCLA / Jonsson Comprehensive Cancer Center, Los Angeles, California
Conditions: Prostate Carcinoma
Brain Health in Breast Cancer Survivors
Recruiting
Endocrine therapy (ET) is widely used to treat hormone receptor positive breast cancer and prevent recurrence by downregulating estrogen function. However, ETs readily cross the blood brain barrier and interfere with the action of estrogen in the brain. Estrogen supports cognition and menopausal status is closely linked to cognitive health in women. This has raised concern that anti-estrogen ETs may affect cognition and brain health in breast cancer survivors. However, evidence across existing s... Read More
Gender:
FEMALE
Ages:
Between 35 years and 65 years
Trial Updated:
04/12/2024
Locations: University of California at Los Angeles, Los Angeles, California
Conditions: Cognitive Impairment, Cognitive Function
Quality of Pediatric Resuscitation in a Multicenter Collaborative
Recruiting
This is a prospective, observational, multi-center cohort study of pediatric cardiac arrests. The purpose of the study is to determine the association between chest compression mechanics (rate, depth, flow fraction, compression release) and patient outcomes. In addition, the investigators will determine the association of post cardiac arrest care with patient outcomes.
Gender:
ALL
Ages:
Between 0 years and 17 years
Trial Updated:
04/12/2024
Locations: Kaiser Permanente, Los Angeles, California
Conditions: Cardiac Arrest, Cardiopulmonary Arrest
Assessment of TRanscathetEr and Surgical Aortic BiOprosthetic Valve Thrombosis and Its TrEatment With Anticoagulation
Recruiting
This is a prospective study designed to evaluate the structural and functional integrity of transcatheter or surgical bioprosthetic valves with multimodality imaging. The study further aims to confirm resolution of the early bioprosthetic valve thrombotic changes with anticoagulation.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/12/2024
Locations: Cedars-Sinai Medical Center, Los Angeles, California
Conditions: Prosthetic Valve Thrombosis
Enhancing Team Effectiveness for a Collaborative School-based Intervention for ADHD
Recruiting
The proposed project aims to integrate team-based implementation strategies with an established school-based intervention for children with ADHD, the Collaborative Life Skills Program (CLS), to enhance its implementation and optimize its effectiveness. The investigators will tailor three empirically-supported team development interventions, Team Charters, Team Communication Training (Student Handoff Protocols), and Team Performance Monitoring, and integrate them into a team-enhanced CLS implemen... Read More
Gender:
ALL
Ages:
Between 7 years and 11 years
Trial Updated:
04/11/2024
Locations: IN STEP Children's Mental Health Center, San Diego, California
Conditions: Team-effectiveness Research, School-based Interventions, Attention Deficit/ Hyperactivity Disorder, Implementation Science
Phase 1 Study of SON-1010 in Adult Patients With Advanced Solid Tumors
Recruiting
This is a Phase 1, first-in-human, open-label, adaptive-design outpatient study to assess the safety, tolerability, and PK/PD of SON-1010 administered to patients with advanced solid tumors.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/11/2024
Locations: Sarcoma Oncology Center, Santa Monica, California
Conditions: Advanced Solid Tumor
A Multi-Center Post-Market Data Collection Protocol to Evaluate the Performance of Orthofix Spine Devices
Recruiting
This protocol is designed to study Orthofix regulatory approved and commercially available spine devices to generate Real World Evidence (RWE) of device safety and performance in the treatment of patients with spine injuries and/or disorders following the local medical standard of care. The clinical data generated from this study will support compliance to global regulatory requirements including but not limited to the European Medical Device Regulation (EU MDR) for the applicable devices.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/11/2024
Locations: Lanman Spinal Neurosurgery, Beverly Hills, California
Conditions: Spinal Disorders/Injuries
Effects of Nicotine and Attention on Frequency Tuning in Auditory Cortex
Recruiting
Nicotine enhances auditory-cognitive function because it mimics the brain's system for "paying attention" to important sounds amid distractions (for example, understanding speech in a noisy environment). In part, nicotine does this by activating inhibitory neurons in the auditory cortex. Since age-related hearing deficits result, in part, from the loss of inhibitory neurons in auditory cortex, this project will determine whether nicotine's effects can compensate for reduced inhibition in the agi... Read More
Gender:
ALL
Ages:
Between 18 years and 85 years
Trial Updated:
04/11/2024
Locations: University of California, Berkeley, Berkeley, California
Conditions: Aging
Eversense® Non-adjunctive Use Post Approval Study
Recruiting
This is a non-blinded, prospective, multi-center, single arm longitudinal cohort study (patient serving as their own control), to evaluate the effectiveness of diabetes with the Eversense CGM System non-adjunctively compared to self-monitoring of blood glucose (SMBG) using a blood glucose (BG) meter in participants with either Type 1 or Type 2 diabetes. Subjects will serve as their own control, with their baseline based on using SMBG to manage their diabetes for the first 6 months followed by us... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/11/2024
Locations: LA Universal Research Center, Inc., Los Angeles, California
Conditions: Diabetes
Interstitial Brachytherapy for the Treatment of Unresectable/Unablatable Kidney Cancer
Recruiting
This phase I/II trial investigates the side effects of interstitial brachytherapy and to see how well it works in limiting the growth of large kidney cancer masses in patients with kidney cancer that have refused or are unable to undergo surgery or ablation (unresectable/unablatable). Brachytherapy, also known as internal radiation therapy, temporarily introduces a radiation source into or near the tumor to eradicate the tumor cells. Giving brachytherapy may potentially reduce the size of the ki... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/11/2024
Locations: UCLA / Jonsson Comprehensive Cancer Center, Los Angeles, California
Conditions: Stage I Renal Cell Cancer, Stage II Renal Cell Cancer
Experimental PET Imaging Scans Before Cancer Surgery to Study the Amount of PET Tracer Accumulated in Normal and Cancer Tissues
Recruiting
This phase I trial studies a new imaging technique called FAPi PET/CT to determine where and to which degree the FAPI tracer (68Ga-FAPi-46) accumulate in normal and cancer tissues in patients with non-prostate cancer. The research team also want to know whether what they see on PET/CT images represents the tumor tissue being excised from the patient's body. The research team is also interested to investigate another new imaging technique called PSMA PET/CT. Participants will be invited to underg... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/11/2024
Locations: Ethan Lam, Los Angeles, California
Conditions: Breast Carcinoma, Colon Carcinoma, Esophageal Carcinoma, Gastric Carcinoma, Head and Neck Carcinoma, Kidney Carcinoma, Lung Carcinoma, Ovarian Carcinoma, Pancreatic Carcinoma, Solid Neoplasm, Uterine Corpus Cancer
S1501 Carvedilol in Preventing Cardiac Toxicity in Patients With Metastatic HER-2-Positive Breast Cancer
Recruiting
This phase III trial studies how well carvedilol works in preventing cardiac toxicity in patients with human epidermal growth factor receptor (HER)-2-positive breast cancer that has spread to other places in the body. A beta-blocker, such as carvedilol, is used to treat heart failure and high blood pressure, and it may prevent the heart from side effects of chemotherapy.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/11/2024
Locations: Kaiser Permanente-Deer Valley Medical Center, Antioch, California
Conditions: Cardiotoxicity, HER2/Neu Positive, Metastatic Malignant Neoplasm in the Brain, Recurrent Breast Carcinoma, Stage IV Breast Cancer AJCC v6 and v7