California Paid Clinical Trials

A listing of 5599 clinical trials in California actively recruiting volunteers for paid trials and research studies in various therapeutic areas.

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California is currently home to 5599 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.

Featured Trial

Paid Clinical Studies Nationwide

Recruiting

Nationwide clinical trials offered in your area. Some trials offering up to several thousand dollars in compensation for participation.

Conditions:

Healthy

Healthy Volunteer Study

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* Compensation for time may be available

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Recruiting

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Conditions:

Overweight

Overweight and Obesity

Obesity

Weight Loss

Morbid Obesity

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Long COVID-19 Syndrome Lifestyle Intervention Study

NCT05836402

Recruiting

Rationale: Hyper-inflammatory responses seen in acute COVID-19 are also a feature of long covid, a condition of long-term consequences that are persisting or appearing after initial infection and recovery from acute COVID-19. Long-standing, often disabling symptoms are common in long covid and can be highly varied. Common symptoms include fatigue, brain fog, muscle and chest pain, migraines, shortness of breath, anosmia, muscle weakness, and cognitive dysfunction. 35% of post-COVID patients were found to have decreased kidney function at 6 months post-discharge. In this study, we will evaluate the effect of dietary interventions in long covid patients. The dietary interventions are aimed at lowering blood glucose levels, and raising blood BHB levels. The dietary plan will recommend a low-carbohydrate diet including the avoidance of foods containing sugars and starch, while simultaneously increasing the consumption of healthy fats and sources of protein. The dietary interventions are supported by the consumption of a medical food that delivers exogenous BHB in order to raise blood BHB levels without the necessity of adhering to a strict ketogenic diet which would be difficult to implement and typically requires strict medical supervision. Intervention: Dietary intervention with Ketocitra versus control arm (no intervention) in a 1:1 ratio Objectives: The hypothesis of this study is that low-carbohydrate dietary interventions leading to lowering of blood glucose and raising of blood BHB in addition to standard therapy will lead to faster recovery and amelioration of symptoms in long covid compared to those treated with standard therapy alone. Study population: Subjects with a history of COVID-19 at least 2 months ago and with at least 2 neurological and/or symptoms that are typical for long covid that either started at COVID-19 infection and are ongoing at time of study entry Study methodology: Prospective and interventional randomized controlled pilot study Study arms: Dietary intervention (including medical food) arm versus control arm Study endpoints: The primary endpoint is the feasibility, safety and tolerability of dietary intervention. Read Less

Gender:

ALL

Ages:

18 years and above

Trial Updated:

04/26/2024

Locations: Keck School of Medicine of USC, Los Angeles, California

Conditions: Long COVID-19 Syndrome

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[Lu-177]Ludotadipep in Castration-resistant Prostate Cancer(CRPC): Investigation of Drug and Application

NCT05458544

Recruiting

Phase 1: The objective of the Phase 1 part of the clinical trial is to verify safety and tolerability (dose-limiting toxicity \[DLT\], maximum tolerated dose \[MTD\]) of a single 3.7 Giga-Becquerel (GBq) dose with the potential for one dose level de-escalation to 2.775 GBq if necessary, to determine the recommended \[177Lu\]Ludotadipep dose for use in the Phase 2a part of the trial. Phase 2a: The objective of the Phase 2a part of the trial is to evaluate safety and efficacy for repeated adminis... Read More

Gender:

MALE

Ages:

18 years and above

Trial Updated:

04/25/2024

Locations: VA Greater Los Angeles Healthcare System,Cancer Center Research, Los Angeles, California

Conditions: Metastatic Castration-resistant Prostate Cancer

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Patient Decision Aid for Opioid Use Disorder

NCT03568552

Recruiting

The aim of the study is to test the effectiveness of the Patient Decision Aid for Opioid Use Disorder (PtDA-MAT) by conducting a stepped-wedge cluster-randomized trial in CA H\&SS (stratified by rural vs. non-rural areas) for adults with OUD. Patient outcomes will be tracked by (1) personal assessments (baseline, 3 months, and 6 months): drug use, overdose, healthcare utilization, and (2) clinical and administrative records (over approximately 24 months): drug treatment status and retention, phy... Read More

Gender:

ALL

Ages:

18 years and above

Trial Updated:

04/25/2024

Locations: UCLA Integrated Substance Abuse Programs, Los Angeles, California

Conditions: Opioid Use Disorder

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PREDICT Therapy Selection for JAK, T-cell, or IL-6 Inhibitor Therapies Using a Molecular Signature Response Classifier (PREDICT)

NCT06390709

Recruiting

Prospective, multi-center-observational study conducted within the US, collecting patient samples for research and development to train, test, and validate precision medicine classifiers. These molecular signature response classifiers (MSRC) aim to predict response status to JAK, T-cell, and IL-6 inhibitor therapies in patients with rheumatoid arthritis (RA).

Gender:

ALL

Ages:

Between 18 years and 100 years

Trial Updated:

04/24/2024

Locations: Medvin Clinical Research//Amicus Arthritis, Whittier, California

Conditions: Rheumatoid Arthritis

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Wound Irrigation Comparative Effectiveness Study

NCT06379919

Recruiting

The primary objective of this study is to compare the presence of C acnes in bacteriologic cultures taken from participant samples of subcutaneous and deep tissue prior to deep surgical irrigation using either Normal Saline Irrigation (Group 1) or Irrisept Irrigation (Group 2). Secondary objectives are evaluation of patient reported outcome measures and range of motion in relation to C acnes presence among subjects in the two groups.

Gender:

ALL

Ages:

18 years and above

Trial Updated:

04/24/2024

Locations: Hoag Orthopedics, Orange, California

Conditions: Cutibacterium Acnes Contamination

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Phase 2 Trial of HY209gel in Atopic Dermatitis Patients

NCT06024499

Recruiting

This is a randomized, double-blind, placebo-controlled, multi-center, phase 2 study in patients with mild to moderate Atopic Dermatitis(AD), which consists of 2 parts.

Gender:

ALL

Ages:

Between 18 years and 100 years

Trial Updated:

04/24/2024

Locations: RAOOF MD Dermatology, Encino, California

Conditions: Atopic Dermatitis, Atopic Dermatitis Eczema, Atopic Dermatitis of Scalp

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A Study of SNP-ACTH (1-39) Gel in Patients With Primary Membranous Nephropathy

NCT05696613

Recruiting

The goal of the Phase 3a part of this clinical trial is to determine the optimal dose that will be used in the Phase 3b part of this clinical trial. The goal of the Phase 3b part is to assess the efficacy of SNP-ACTH (1-39) Gel relative to rituximab in patients with primary membranous nephropathy (PMN) at month 24.

Gender:

ALL

Ages:

18 years and above

Trial Updated:

04/24/2024

Locations: Academic Medical Research Institute, Los Angeles, California

Conditions: Primary Membranous Nephropathy

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Study of Dextromethorphan in OCD and Related Disorders

NCT04899687

Recruiting

The purpose of the study is to assess the tolerability and efficacy of dextromethorphan in combination with fluoxetine for symptom relief in OCD and related disorders.

Gender:

ALL

Ages:

Between 18 years and 65 years

Trial Updated:

04/24/2024

Locations: Stanford University, Stanford, California

Conditions: Obsessive-Compulsive Disorder, Illness Anxiety Disorder, Body Dysmorphic Disorders, Somatic Symptom Disorder

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The Effect of Adipose-Derived Stem Cells for Knee Osteoarthritis

NCT03014401

Recruiting

The purpose of this study is to compare the clinical and functional outcomes of patients with mild to moderate arthroscopically confirmed osteoarthritis between the following two groups: 1. Partial fat pad harvest with Adipose-Derived Stem Cell (ADSC) transplantation with standard arthroscopic treatment consisting of: partial meniscectomy, cartilage stabilization, loose body removal and selective synovectomy. 2. Standard arthroscopic treatment (above) without cell transplant.

Gender:

ALL

Ages:

Between 35 years and 70 years

Trial Updated:

04/24/2024

Locations: Kerlan Jobe Orthopedic Institute, Santa Monica, California

Conditions: Knee Osteoarthritis

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Microfracture Versus Adipose Derived Stem Cells for the Treatment of Articular Cartilage Defects

NCT02090140

Recruiting

The purpose of this study is to compare two biologic methods for the treatment of articular cartilage defects in the knee. The first method, microfracture, is the standard of care and is routinely used to recruit cells from the subchondral bone marrow to the site of cartilage loss. The second method is the application of adipose-derived stem cells (ADSCs) to the defect site. In theory, ADSCs on a collagen scaffold should enable the delivery of more specific progenitor cells to the site of injury... Read More

Gender:

ALL

Ages:

Between 18 years and 50 years

Trial Updated:

04/24/2024

Locations: Stanford Medical Outpatient Center, Redwood City, California

Conditions: Degenerative Lesion of Articular Cartilage of Knee

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Treating Genital Herpes Infection to Reduce Racial Disparities in the Risk of Severe Maternal Morbidity

NCT05429346

Recruiting

Severe Maternal Morbidity (SMM) has been associated with maternal mortality, fetal risk, and long-term maternal risk. African American (AA) women are at consistently higher risk than White women. However, factors contributing to these racial disparities are largely unknown and commonly known factors have not been able to explain them, so strategies to reduce them are absent. CDC reports that the rate of GHSV infection is 4 times higher in AA than White women. Studies have shown that pregnant wom... Read More

Gender:

FEMALE

Ages:

Between 18 years and 55 years

Trial Updated:

04/23/2024

Locations: Division of Research, Kaiser Permanente Northern California, Oakland, California

Conditions: Genital Herpes Simplex, Maternal Morbidity, Racial Disparities

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Performance of SGM-101 for the Delineation of Primary and Recurrent Tumor and Metastases in Patients Undergoing Surgery for Colorectal Cancer

NCT03659448

Recruiting

The performance of SGM-101, an intraoperative imaging agent, will be compared to that of standard "white light" visualization during surgical resections of colorectal cancer.

Gender:

ALL

Ages:

18 years and above

Trial Updated:

04/23/2024

Locations: City of Hope National Medical Center, Duarte, California

Conditions: Colorectal Neoplasms

Learn More ›

Kaiser Permanente houses over 6,000 physicians in southern California and it is also one of the largest research centers on the state. On its clinical trial division, Kaiser Permanente conducts clinical trials of almost every specialty funded by pharmaceutical companies, government, and foundations.

The Cedars-Sinai Medical Center located in Los Angeles is one of the largest research centers owned and operated by a private hospital in the United States. Focusing on biomedical, cancer, and heart research among other specialties, you can find almost any type of clinical trials for both health and non-healthy volunteers at the research division of Cedar-Sinai Medical Center.

There are around 100,000 clinical trials happening every year across the United States about almost every condition out there. While most clinical trials are testing drugs or medical devices there are also many behavioral and observational trials going on at any point in time. Many paid research studies are held at these California locations.

Clinical trials are incredibly important for making new medical and scientific discoveries, finding new and better methods for diagnosing medical conditions early, testing new interventions, and even developing safer and more effective surgical procedures.

In order for all these discoveries to me made available to the general population they need to go through years of rigorous testing both in healthy and non-healthy volunteers. During those years, medical professionals follow a protocol that has been previously approved by the FDA or other regulatory agency to test the effectiveness and safety of their discovery.

Other people choose to participate in a clinical trial because they feel it is a good way to contribute to the advancement of medical knowledge and that their participation can help many people in the future. The following lists of trials are broken down by condition, and to find a specific clinical trial in your area click through to clinicaltrials.gov.