California is currently home to 5595 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
A Study of TSR-022 in Participants With Advanced Solid Tumors (AMBER)
Recruiting
This is a first-in-human study evaluating the anti-T cell immunoglobulin and mucin containing protein-3 (TIM-3) antibody TSR-022. The study will be conducted in 2 parts with Part 1 consisting of dose escalation and Part 2 dose expansion. Part 1 will determine the recommended Phase 2 dose (RP2D) of TSR-022 and Part 2 will evaluate the antitumor activity of TSR-022 in combination with TSR-042 or docetaxel and as monotherapy.
Gender:
All
Ages:
18 years and above
Trial Updated:
03/14/2024
Locations: GSK Investigational Site, Encinitas, California
Conditions: Neoplasms
Motivational Wellness Coaching to Reduce Childhood Obesity in Families and Kids
Recruiting
Primary care settings lack interventions to address the childhood obesity epidemic that are feasible and sustainable without requiring significant resources. The investigators propose to modify and test an intervention shown to lower children's body mass index(BMI) so that it is feasible, sustainable, and easily disseminated in a real-world clinical setting. If successful, the investigators will be able to provide recommendations to providers and health care systems that help prioritize future i... Read More
Gender:
ALL
Ages:
Between 2 years and 8 years
Trial Updated:
03/14/2024
Locations: Kaiser Permanente Pasadena, Pasadena, California
Conditions: Obesity
KIDney Injury in Times of COVID-19 (KIDCOV)
Recruiting
There is an unmet need to evaluate the impact of sub-clinical/mild COVID19 disease in the outpatient setting on prevalent and incident renal injury, as this data is currently unavailable. To capture the diversity of race/ethnic risk and COVID19 related municipal shelter-in-place guidance, the investigators will enroll COVID19-negative and COVID19-positive samples balanced by race/ethnicity from 3 different states, California, Michigan, and Illinois. Study endpoints will be assayed from urine sam... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/14/2024
Locations: UCSF, San Francisco, California
Conditions: SARS-CoV Infection, Covid19, Corona Virus Infection, Acute Kidney Injury, Kidney Injury
Characterization of T-cell Repertoire in Patients With Acute Myeloid Leukemia Undergoing Donor Stem Cell Transplant
Recruiting
This research trial studies characterization of T-cell repertoire through next-generation sequencing in patients with acute myeloid leukemia undergoing stem cell transplant. Characterizing T-cell repertoire may help to understand if immune system plays a significant role in high risk patients with acute myeloid leukemia.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/14/2024
Locations: USC / Norris Comprehensive Cancer Center, Los Angeles, California
Conditions: Acute Myeloid Leukemia
Pharmacogenomics of Asparaginase Induced Hepatotoxicity
Recruiting
This pilot trial studies the impact of genetic information on developing liver damage caused by asparaginase in participants with newly diagnosed acute lymphoblastic leukemia. Testing saliva samples may help doctors find certain genetic markers that may predict whether participants will tolerate asparaginase, which is given as part of clinical care for acute lymphoblastic leukemia.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/14/2024
Locations: USC / Norris Comprehensive Cancer Center, Los Angeles, California
Conditions: Acute Lymphoblastic Leukemia
FID-007 in Treating Participants With Advanced Solid Tumors
Recruiting
This phase I trial studies the side effects and best dose of PEOX-based polymer encapsulated paclitaxel FID-007 (FID-007) in treating participants with malignant neoplasms that have spread to other places in the body and do not respond to treatment. FID-007 is a packaged form of the chemotherapy drug paclitaxel, and uses a polyethylozaxoline (PEOX) polymer which may allow the drug to reach deeper into tumors and less into normal cells by being smaller.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/14/2024
Locations: Los Angeles General Medical Center, Los Angeles, California
Conditions: Advanced Malignant Solid Neoplasm, Refractory Malignant Solid Neoplasm
Collection of Blood in Studying Metabolites in Patients With Prostate Cancer
Recruiting
This pilot research trial utilizes the collection of blood in studying metabolites in patients with prostate cancer. Metabolites are the small molecule products of cellular metabolism that are produced naturally in all living cells. Collecting blood in order to study metabolites may help doctors monitor and treat prostate cancer more effectively.
Gender:
MALE
Ages:
18 years and above
Trial Updated:
03/14/2024
Locations: USC / Norris Comprehensive Cancer Center, Los Angeles, California
Conditions: Prostate Carcinoma
Coronary Atherosclerosis T1-Weighted Characterization (CATCH)
Recruiting
This study proposes to develop an MRI technique named Coronary Atherosclerosis T1-weighed Characterization (CATCH) that will improve the quality and reliability of coronary atherosclerosis evaluation, as well as simplify the scanning process and significantly shorten imaging time compared with conventional imaging methods.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/13/2024
Locations: Cedars-Sinai Medical Center, Los Angeles, California
Conditions: Coronary Atherosclerosis
Ambrosia: Evaluating the Effects of a Food-As-Medicine Platform on Gut Microbiome Composition and Metabolism
Recruiting
The objective of this study is to test whether dietary behavior modification impacts diet quality and stool microbiome composition and metabolism using microbial whole genome sequencing, targeted metabolomics, and immune profiling. 400 adults 18-64 years old at high risk for CRC (based on past colonoscopy findings or lifestyle risk factors) will be assigned to one of two cohorts, with approximately 200 participants in each. * Cohort 1 will serve as the control group without any directed dietar... Read More
Gender:
ALL
Ages:
Between 18 years and 64 years
Trial Updated:
03/12/2024
Locations: Persephone Biosciences, Inc., San Diego, California
Conditions: Impact of Dietary Chages Directed by Medical Nutrition Therapy on Gut Microbiome Composition
Risk-ADAPTed Conditioning Regimen for Allogeneic Hematopoietic Stem Cell Transplantation
Recruiting
This is a prospective, single-arm, phase II study. Patients will be treated with an allogeneic stem cell transplantation (AHSCT) using fludarabine, melphalan and total body irradiation (TBI) conditioning with different melphalan and TBI doses based on patient- and disease-related risk.
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
03/12/2024
Locations: Chao Family Comprehensive Cancer Center, University of California Irvine, Orange, California
Conditions: Allogeneic Hematopoietic Stem Cell Transplantation, Allogeneic Stem Cell Transplantation, Hematologic Malignancies
Specialty Compared to Oncology Delivered Palliative Care for Patients With Acute Myeloid Leukemia
Recruiting
This research study is evaluating whether primary palliative care is an alternative strategy to specialty palliative care for improving quality of life, symptoms, mood, coping, and end of life outcomes in patients with acute myeloid leukemia (AML).
Gender:
ALL
Ages:
Between 18 years and 120 years
Trial Updated:
03/12/2024
Locations: Stanford University, Stanford, California
Conditions: Relapsed Adult AML, Primary Refractory Acute Myeloid Leukemia, High Risk Acute Myeloid Leukemia
The Role of Virtual Reality During Regional Anesthesia
Recruiting
In this study, we will analyze the role of virtual reality in acute pain and anxiety management for regional anesthesia in pre-operative patients at Cedars-Sinai Medical Center.
Gender:
ALL
Ages:
Between 18 years and 64 years
Trial Updated:
03/12/2024
Locations: Cedars Sinai Medical Center, Los Angeles, California
Conditions: Anxiety, Pain