California is currently home to 5605 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
18F-FSPG PET/CT in Diagnosing Early Lung Cancer in Patients With Lung Nodules
Recruiting
This phase II trial studies how well 18F-FSPG positron emission tomography (PET)/computed tomography (CT) work in diagnosing early lung cancer in patients with lung nodules. PET imaging with an imaging agent called 18F-FDG is often used in combination with a PET/CT scanner to evaluate cancers. Giving 18F-FSPG before a PET/CT scan may work better in helping researchers diagnose early lung cancer in patients with lung nodules.
Gender:
ALL
Ages:
45 years and above
Trial Updated:
03/01/2024
Locations: Stanford Cancer Institute Palo Alto, Palo Alto, California
Conditions: Cigarette Smoker, Current Smoker, Former Smoker, Multiple Pulmonary Nodules, Pulmonary Nodule
Efficacy and Safety of REC-2282 in Patients With Progressive Neurofibromatosis Type 2 (NF2) Mutated Meningiomas
Recruiting
This is a two-staged, Phase 2/3, randomized, multi-center study to investigate the efficacy and safety of REC-2282 in patients with progressive NF2 mutated meningiomas.
Gender:
ALL
Ages:
12 years and above
Trial Updated:
02/29/2024
Locations: House Institute, Los Angeles, California
Conditions: Neurofibromatosis Type 2
Stool Sample Collection Study
Recruiting
The primary objective of this study is to obtain de-identified stool specimens from participants with colonoscopic biopsy-based histopathologic diagnosis of colorectal cancer (CRC) and/or a ≥1 cm colorectal polyp/adenoma/mass found during pre-enrollment colonoscopy that is of sufficient size to require surgical excision or complex colonoscopic polypectomy. The samples will be used for the purpose of research and development of a new molecular diagnostic test for the detection of neoplasms of th... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/28/2024
Locations: Associated Gastroenterology Medical Group, Anaheim, California
Conditions: Colorectal Cancer
Multi-center Trial to Improve Nocturia and Sleep in Older Adults
Recruiting
The Multi-center Trial to Improve Nocturia and Sleep in Older Adults (MINT) study is a randomized trial to determine and assess the efficacy of integrated treatment of coexisting nocturia and insomnia, as well as explore the effects of this treatment on quality of life.
Gender:
ALL
Ages:
60 years and above
Trial Updated:
02/28/2024
Locations: VA Greater Los Angeles Healthcare System, Los Angeles, California
Conditions: Nocturia, Insomnia
Frequency and E-field Enhancement of ITBS for Depression (FREED)
Recruiting
The investigators propose a randomized 3-arm double-blinded parallel experimental trial (20 sessions over 4 weeks) in 75 patients with TRD. The three arms include (1) the combination of a fully Individualized form of intermittent Theta Burst Stimulation (iTBS) (using BOTH the frequency and electric field (E-field) targeting approaches) (Ind-iTBS)), (2) iTBS individualized using E-field targeting only (targeted-iTBS) and (3) Standard iTBS treatment (i.e., typical iTBS localized to the dorsolatera... Read More
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
02/28/2024
Locations: University of California, San Diego, La Jolla, California
Conditions: Major Depressive Disorder
Pulse Oximeter Accuracy in Healthy Humans During Hypoxia
Recruiting
The aim of this project is to test the accuracy of pulse oximeters during mild, moderate and severe hypoxia. This is done by comparing the reading of the pulse oximeter during brief, steady state hypoxia with a gold-standard measurement of blood oxygen. This study will be done on healthy male or females between the age group of 18-50.
Gender:
ALL
Ages:
Between 21 years and 50 years
Trial Updated:
02/27/2024
Locations: Hypoxia Lab, UCSF Department of Anesthesia and Perioperative Care, San Francisco, California
Conditions: Hypoxia, Skin Pigmentation
NEPH-ROSIS (NEPHrology in CirRhOSIS) Pilot Trial: A Trial to Treat Acute Kidney Injury Among Hospitalized Cirrhosis Patients
Recruiting
The goal of this pilot, randomized, single-blind clinical trial is to estimate the effect size of a high and low mean arterial pressure (MAP)-target algorithm among cirrhosis patients hospitalized with acute kidney injury. The main aims to answer are: • Does an algorithm that has low (\<80 mmHg) and high (≥80) MAP-targets lead to significant differences in mean arterial pressure? • Are there any serious adverse events (e.g., ischemia) in a high blood pressure algorithm as compared to a low blood... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/27/2024
Locations: University of California San Francisco, San Francisco, California
Conditions: Acute Kidney Injury, Cirrhosis, Portal Hypertension, Hepatorenal Syndrome, Acute Tubule Necrosis, Prerenal Failure
Continuous Glucose Monitoring in Dialysis Patients to Overcome Dysglycemia Trial
Recruiting
This randomized controlled trial will investigate whether use of continuous glucose monitoring (CGM) vs. usual care with self-monitored blood glucose 1) enhances glycemic control, 2) reduces hypoglycemia risk, and 3) improves quality of life, diabetes distress, and fear of hypoglycemia in hemodialysis patients with diabetes mellitus.
Gender:
ALL
Ages:
Between 18 years and 99 years
Trial Updated:
02/27/2024
Locations: University of California, Irvine, Orange, California
Conditions: Hemodialysis, Diabete Mellitus, Continuous Glucose Monitoring
The Use of Venlafaxine in Reducing Pain in Primary Total Knee Replacement
Recruiting
Patients experience pain after their knee replacement surgery - and some may continue to experience persistent pain long after their knee replacement surgery. Traditional pain management strategies reply on pain medication such as opioids for pain control. However, these drugs do not work well for pain associated with movement or the the nerve pain (tingling, electrical sensations) after surgery. In addition, opioids are associated with significant side effects such as nausea, vomiting, respirat... Read More
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
02/27/2024
Locations: University of California San Francisco, San Francisco, California
Conditions: Acute Pain, Chronic Pain, Knee Pain Chronic, Neuropathic Pain
Evaluating the Efficacy of PECS II Block Versus Axillary Ring Block in Rotator Cuff Repair Patients
Recruiting
Our current standard of care is to perform an interscalene peripheral nerve block for patients receiving rotator cuff repair surgery as it is an effective opioid-free alternative for post-operative pain control. However, many of these repairs require a supplemental incision for an open biceps tenodesis, which is not covered by the interscalene block. The intercostobrachial nerve covers this incision and is targeted by an axillary ring block or a single shot nerve block in the fascial plane betwe... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/27/2024
Locations: Healthcare Center 3 - Keck Hospital of USC, Los Angeles, California
Conditions: Shoulder Pain
Dementia Family Caregiver Study
Recruiting
The proposed study will test a 3-month, community health worker (CHW) delivered home visit, culturally and language-appropriate intervention for ethnic and underserved dementia family caregivers of persons with dementia (PWD) using wearable technology for real time monitoring of caregivers' stress and sleep. The CHW delivered home visit intervention includes stress reduction techniques by mindful deep breathing and compassionate support/listening and caregiving education to improve caregiver's h... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/27/2024
Locations: University of California, Irvine, Irvine, California
Conditions: Dementia Caregiver
A Randomized Controlled Trial of Thyroid Hormone Supplementation in Hemodialysis Patients
Recruiting
Hypothyroidism, defined by elevated thyrotropin (TSH) levels, is a common endocrine complication in chronic kidney disease patients, and prior evidence shows that higher TSH levels, even within the normal laboratory range, are strongly associated with impaired quality of life and cardiovascular disease in this population. Levothyroxine is one of the most frequently prescribed medications in chronic kidney disease, yet its efficacy and safety in these patients have not been well-studied. Hence, t... Read More
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
02/27/2024
Locations: University of California Irvine, Orange, California
Conditions: Thyroid; Functional Disturbance, Hypothyroidism, Hemodialysis