California is currently home to 5930 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Oxytocin to Treat PTSD
Recruiting
Posttraumatic stress disorder (PTSD) is a chronic, debilitating condition that disproportionately affects Veterans. Prolonged Exposure (PE) therapy is a "gold standard" treatment for PTSD. However, approximately one-third of Veterans fail to receive an adequate dose of treatment because they prematurely drop out of PE therapy. There is also room to improve PE treatment outcomes. Consistent with the VA Office of Research and Development initiative to develop effective treatments for PTSD, the pro... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
07/26/2023
Locations: San Francisco VA Medical Center, San Francisco, CA, San Francisco, California
Conditions: PTSD
Complex And Simple Appendicitis: REstrictive or Liberal Post-operative Antibiotic eXposure - UCSF
Recruiting
The purpose of this study is to demonstrate the safety, efficacy, and feasibility of short-course post-operative antibiotic treatment for simple and complicated appendicitis
Gender:
All
Ages:
18 years and above
Trial Updated:
07/25/2023
Locations: Zuckerberg San Francisco General Hospital, San Francisco, California
Conditions: Appendicitis
Continuous Monitoring and Management of Vaginal Health Via Multifunctional OCT/OCTA/OCE Endoscopy
Recruiting
We have recently developed and optimized a vaginal Optical Coherence tomography/angiography endoscopy imaging system. This technology is able to obtain a comprehensive image of the vaginal epithelium, blood vessels, and lamina propria. The primary focus of this study is establishing the Optical Coherence Tomography system's capability of capturing vaginal changes that occur before and after menopause, as well as before and after treatment with fractional-CO2 laser therapy. There are two aims of... Read More
Gender:
Female
Ages:
18 years and above
Trial Updated:
07/25/2023
Locations: UC Irvine, Costa Mesa, California
Conditions: Genitourinary Syndrome of Menopause
A Safety and Pharmacokinetics Study of IDP-122 Lotion in Pediatric Participants With Plaque Psoriasis
Recruiting
This study is to evaluate the safety, the systemic exposure of halobetasol propionate (HP), and the hypothalamic-pituitary-adrenal (HPA) axis suppression potential for topically applied IDP-122 lotion in pediatric participants with moderate to severe plaque psoriasis.
Gender:
All
Ages:
Between 6 years and 17 years
Trial Updated:
07/25/2023
Locations: Bausch Site 11, Fountain Valley, California
Conditions: Psoriasis
Responsive Neurostimulation For Loss Of Control Eating
Recruiting
The primary objective of this trial is to assess device function and safety, with secondary objectives including the feasibility.
Gender:
All
Ages:
Between 22 years and 65 years
Trial Updated:
07/25/2023
Locations: Stanford University, Stanford, California
Conditions: Loss of Control Eating, Obesity, Morbid
BGC101 (EnEPC) Autologous Cell Therapy From Patient's Own Blood for Treatment of Critical Limb Ischemia (CLI)
Recruiting
Evaluate the feasibility of an autologous cell preparation composed of a mixture of cells enriched for endothelial progenitor cells (EnEPCs) and multipotent adult hematopoietic stem/progenitor cells (HSPC) (BGC101), in the treatment of patients suffering from peripheral arterial disease (PAD) with critical limb ischemia (CLI) who have not responded to optimal pharmacological treatment or control of risk factors and/or had a revascularization failure, and do not have the option of further revascu... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
07/25/2023
Locations: University of San Francisco, San Francisco, California
Conditions: Critical Limb Ischemia, Peripheral Arterial Disease, Peripheral Vascular Disease
Oral Supplementation of Astaxanthin on Skin Photoaging, Hydration and Elasticity
Recruiting
This study is a double-blind placebo controlled study to assess whether oral astaxanthin can improve skin hydration, skin elasticity, improve skin pigmentation, and reduce facial redness.
Gender:
Female
Ages:
Between 30 years and 55 years
Trial Updated:
07/24/2023
Locations: Integrative Skin Science and Research, Sacramento, California
Conditions: Photoaging
Botensilimab, Balstilimab and Regorafenib for the Treatment of Patients With Microsatellite Stable Metastatic Colorectal Cancer Who Have Progressed on Prior Chemotherapy
Recruiting
This phase I/II trial tests how well botensilimab, balstilimab, and regorafenib works in treating patients with microsatellite stable colorectal cancer that has spread from where it first started (primary site) to other places in the body (metastatic) or that may have spread from where it first started to nearby tissue, lymph nodes, or distant parts of the body (advanced) and who have progressed on prior chemotherapy. Immunotherapy with monoclonal antibodies, such as botensilimab and balstilimab... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
07/24/2023
Locations: City of Hope Medical Center, Duarte, California
Conditions: Advanced Colorectal Adenocarcinoma, Advanced Microsatellite Stable Colorectal Carcinoma, Metastatic Colorectal Adenocarcinoma, Metastatic Microsatellite Stable Colorectal Carcinoma, Stage III Colorectal Cancer AJCC v8, Stage IV Colorectal Cancer AJCC v8
Dose Regimen Study of SLI-F06 in Healthy Volunteers
Recruiting
Multi-center, dose-regimen, double-blind study evaluating the safety and efficacy of 4 doses of SLI-F06 compared with vehicle for improvement in scar appearance
Gender:
All
Ages:
Between 18 years and 65 years
Trial Updated:
07/24/2023
Locations: California Dermatology & Clinical Research Institute, Encinitas, California
Conditions: Scar, Wound Healing
Safety and Efficacy of AM712 in Patients With nAMD
Recruiting
The purpose of this Phase 1 study is comprised of multiple ascending-dose component (Part 1) and high concentration component (Part 2) to evaluate the safety, tolerability, pharmacokinetics, and efficacy of AM712 in patients with neovascular age- related macular degeneration (nAMD).
Gender:
All
Ages:
50 years and above
Trial Updated:
07/24/2023
Locations: Retina Consultants San Diego, Poway, California
Conditions: Neovascular Age-related Macular Degeneration
The Association of Microbiome Patterns With Chronic Opioid Use
Recruiting
The United States is in the midst of an opioid epidemic, with the number of opioid-related deaths having risen six-fold since 1999. Chronic pain imposes a tremendous economic burden of up to US$635 billion per year in terms of direct costs (such as the costs of treatment) and indirect costs (such as lost productivity and time away from work). We need to better understand individual characteristics that may put patients at risk for chronic opioid use. Recently, the relationship between gut microb... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
07/24/2023
Locations: University of California San Diego, La Jolla, California
Conditions: Chronic Pain, Opioid Use
Predicting Chronic Opioid Use Following Lower Extremity Joint Arthroplasty
Recruiting
Personalized medicine is a concept in which medical care is individualized to a patient based on their unique characteristics, including comorbidities, demographics, genetics, and microbiome. After major surgery, some patients are at increased risk of opioid dependence. By identifying unique genetic and microbiome markers, clinicians may potentially identify individual risk factors for opioid dependence. By identifying these high risk patients early-on, personalized interventions may be applied... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
07/24/2023
Locations: University of California San Diego, La Jolla, California
Conditions: Joint Pain, Chronic Pain, Opioid Use