California is currently home to 5605 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Better Sleep Study
Recruiting
The overall aim of this proposal is a confirmatory efficacy trial sufficiently powered and designed to test the hypothesis that improving the relationship between biological circadian timing and waketime, a novel modifiable target, improves depression outcomes in a subgroup of adolescents with depression and a misaligned relationship between biological circadian timing and waketime utilizing a cognitive-behavioral sleep intervention.
Gender:
ALL
Ages:
Between 12 years and 18 years
Trial Updated:
02/26/2024
Locations: UCSF Nancy Friend Pritzker Psychiatry Building, San Francisco, California
Conditions: Depression in Adolescence, Delayed Sleep Phase
BullyDown, a Text Messaging-based Bullying Prevention Program for Middle School-aged Youth
Recruiting
Given the limited impact of existing school-based interventions and the time associated with implementing them during school time, more efficient and effective intervention methods are needed. Programs that can be delivered to middle school youth irrespective of whether they are attending school physically or virtually may be especially relevant as school boundaries become more fluid. BullyDown addresses this critical need by providing a scalable program that could be quickly and cost-effectivel... Read More
Gender:
ALL
Ages:
All
Trial Updated:
02/26/2024
Locations: Center for Innovative Public Health Research, San Clemente, California
Conditions: Bullying
Trial to Evaluate Safety and Tolerability of GP-2250 in Combination With Gemcitabine
Recruiting
This is a phase 1 first in human, dose escalation trial of GP-2250 administered in combination with gemcitabine in subjects with advanced pancreatic cancer previously treated with 5-fluorouracil-based chemotherapy. Prior radiosensitization with gemcitabine, the use of 5-fluorouracil, FOLFIRINOX or Nab-paclitaxel/gemcitabine in the neoadjuvant setting, and prior pancreaticoduodenectomy (Whipple procedure) is allowed. If prior treatment with gemcitabine was at therapeutic doses, a minimum of 3 mo... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/26/2024
Locations: Hoag Family Cancer Institute, Newport Beach, California
Conditions: Pancreatic Cancer, Adult
Enroll -HD: A Prospective Registry Study in a Global Huntington's Disease Cohort
Recruiting
Enroll-HD is a longitudinal, observational, multinational study that integrates two former Huntington's disease (HD) registries-REGISTRY in Europe, and COHORT in North America and Australasia-while also expanding to include sites in Latin America. More than 30,000 participants have now enrolled into the study. With annual assessments and no end date, Enroll-HD has built a large and rich database of longitudinal clinical data and biospecimens that form the basis for studies developing tools and b... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/26/2024
Locations: University of California - Irvine Medical Center, Irvine, California
Conditions: Huntington's Disease
Gravitas Feeding Tube System Placement Validation in Neonates
Recruiting
The purpose of this study is to validate the Gravitas Feeding Tube System Placement Algorithm for NICU patients and to evaluate the safety and effectiveness of the Gravitas Feeding Tube in the neonate population for the administration of nutrition, fluids and medications.
Gender:
ALL
Ages:
Between 0 weeks and 18 weeks
Trial Updated:
02/23/2024
Locations: Lucile Packard (Stanford) Children's Hospital, Stanford, California
Conditions: Nasogastric Tube
Feasibility of an In-home Standing and Walking Intervention for Infants With and at High Risk of Cerebral Palsy
Recruiting
The purpose of this study is to evaluate the feasibility and begin to evaluate the effect of an intensive in-home standing and walking intervention for infants with or at high risk of cerebral palsy.
Gender:
ALL
Ages:
Between 5 months and 2 years
Trial Updated:
02/23/2024
Locations: University of Southern California, Los Angeles, California
Conditions: Cerebral Palsy
SOUND Pivotal Trial - (Sonomotion stOne comminUtion resoNance ultrasounD)
Recruiting
The goal of this clinical trial is to test the Break Wave™ system in patients with upper urinary tract stones. The main question it aims to answer is whether the device is safe and effective in fragmenting (breaking) stones. Participants will a) undergo the Break Wave™ procedure, b) have a telehealth visit at 2 weeks, and c) return for an imaging study at approximately 10 weeks post-procedure.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/23/2024
Locations: University of California- San Diego, San Diego, California
Conditions: Kidney Stone, Urolithiasis, Nephrolithiasis, Renal Calculi, Kidney Calculi, Nephrolith, Urinary Calculi
ADG126 in Combination With Pembrolizumab in Patients With Advanced/Metastatic Solid Tumors
Recruiting
This is a Phase 1b/2, open-label, dose escalation study to evaluate the safety, tolerability, PK, and immunogenicity of ADG126-pembrolizumab combination regimens in patients with advanced/metastatic solid tumors.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/23/2024
Locations: City of Hope National Medical Center, Duarte, California
Conditions: Advanced/Metastatic Solid Tumors
Focal Therapy for Localized Prostate Cancer
Recruiting
This prospective registry and longitudinal study that is designed to carefully measure details of prostate cancer patients' outcomes with focal therapy. The goal of which is to improve patient care.
Gender:
MALE
Ages:
18 years and above
Trial Updated:
02/22/2024
Locations: University of California, San Diego, La Jolla, California
Conditions: Prostate Cancer
A Study to Investigate the Safety, Tolerability, Drug Levels and Drug Effects of BMS-986326 in Adult Participants With Different Forms of Lupus
Recruiting
The purpose of this study is to evaluate safety, drug levels and drug effects on cells and organs of the body, after receiving multiple increasing doses of BMS-986326 via intravenous (IV) infusion or subcutaneous (SC) injection, in participants with different forms of lupus.
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
02/22/2024
Locations: TriWest Research Associates - La Mesa, San Diego, California
Conditions: Lupus
Feasibility and Efficacy Study of the CardioPulmonary Management (CPM) System in Patients With Chronic Heart Failure
Recruiting
The primary purpose for this study is to support the hypothesis (pilot data) that the use of the CPM system reduces the rate of HF related events and the related healthcare cost. The study will also measure the impact on quality of care and patient satisfaction. In order to support the primary objective, the study will compare the outcomes and costs for patients using the CPM system against those who are not. This can either be done using institutions averages, if available, or through a control... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/22/2024
Locations: Desert Oasis Healthcare, Palm Springs, California
Conditions: Heart Failure
Retro-active Immunological Tolerance in Patients With Well-functioning Pre-existing HLA-identical Kidney Transplants
Recruiting
The study seeks to determine if patients with a pre-existing, well-functioning kidney transplant from a HLA-identical living donor can be withdrawn from immunosuppressive medications without compromising allograft function through hematopoietic stem cell (HPSC) infusion from the same donor. HPSC infusion will be preceded by a conditioning regimen of total lymphoid irradiation (TLI) and rabbit anti-thymocyte globulin (rATG).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/22/2024
Locations: UCLA, Los Angeles, California
Conditions: End Stage Kidney Disease, Immunological Tolerance, Kidney Transplant Failure and Rejection, Chronic Kidney Diseases