California is currently home to 5602 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Genetics of Charcot Marie Tooth (CMT) - Modifiers of CMT1A, New Causes of CMT2
Recruiting
This project includes two projects. One is looking for new genes that cause Charcot Marie Tooth disease (CMT). The other is looking for genes that do not cause CMT, but may modify the symptoms a person has.
Gender:
ALL
Ages:
All
Trial Updated:
05/09/2024
Locations: Cedars-Sinai Medical Center, Los Angeles, California
Conditions: Charcot-Marie-Tooth Disease, Type Ia (Disorder), HMSN
Natural History Evaluation of Charcot Marie Tooth Disease (CMT) Types CMT1B, CMT2A, CMT4A, CMT4C, and Others
Recruiting
This is an observational longitudinal study to determine the natural history and genotype-phenotype correlations of disease causing mutations in Charcot Marie Tooth disease (CMT) type 1B (CMT1B), 2A (CMT2A), 4A (CMT4A), and 4C (CMT4C). The investigators will also be determine the capability of the newly developed CMT Pediatric Scale (CMT Peds scale) and the Minimal Dataset to measure impairment and perform longitudinal measurements in patients with multiple forms of CMT over a five year window
Gender:
ALL
Ages:
All
Trial Updated:
05/09/2024
Locations: Cedars-Sinai Medical Center, Los Angeles, California
Conditions: Charcot Marie Tooth Disease
Short Title: Standard vs. Lower Pressure Pneumoperitoneum
Recruiting
This study aims to investigate the effect of varying insufflation pressures on post-operative pain and adequacy of surgical field visualization among patients undergoing laparoscopic surgery with a minimally invasive gynecologic surgeon.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
05/08/2024
Locations: Cedars-Sinai Medical Center, Los Angeles, California
Conditions: Laparoscopic Surgery
PARTNER 3 Trial - Aortic Valve-in-Valve
Recruiting
This study will assess the safety and effectiveness of the SAPIEN 3/SAPIEN 3 Ultra transcatheter heart valve (THV) in patients with a failing aortic bioprosthetic valve.
Gender:
ALL
Ages:
All
Trial Updated:
05/08/2024
Locations: University of California Los Angeles, Los Angeles, California
Conditions: Aortic Stenosis, Aortic Stenosis, Severe
Blunt Fascial vs. Veress Needle Peritoneal Entry in Laparoscopic Gynecologic Surgery
Recruiting
This study aims to investigate the effect of two peritoneal entry techniques on intraoperative and post-operative outcomes among patients undergoing laparoscopic surgery with a minimally invasive gynecologic surgeon. Patients will be randomized to either blunt fascial or veress needle peritoneal entry. Insufflation times, failed entries, complications and post-operative pain scores will be collected. The investigators hypothesize that the blunt entry technique will be associated with shorter in... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
05/07/2024
Locations: Cedars Sinai Medical Center, Los Angeles, California
Conditions: Laparoscopic Surgery
Optimizing Treatment of Adhesive Small Bowel Obstruction
Recruiting
Small bowel obstruction (SBO) is one of the most common causes of serious gastrointestinal disease in the US. Adhesion-related SBO (aSBO) is usually treated by the placement of a nasogastric tube (NGT) to decompress the stomach, administration of intravenous (IV) fluids and observation by a surgical team. The purpose of this feasibility study is to determine the potential for implementation of treatment protocols for aSBO and determine the feasibility of randomizing patients with aSBO to receiv... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/07/2024
Locations: University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, California
Conditions: Adhesive Small Bowel Obstruction
Engaging Diverse and Underserved Communities in Cancer Awareness Training and Education
Recruiting
The University of California Davis, Comprehensive Cancer Center's (UCDCCC) Office of Community Outreach and Engagement (OCOE) serves the 19 catchment counties which approximately consists of 5 million residents. Currently, the overall catchment population cancer screening rates fall below 80%. The aim of OCOE is to increase cancer education (prevention, screening, and vaccination) and training. Through education, and encouraging participation in routine screening for early detection, this can he... Read More
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
05/07/2024
Locations: University of California, Davis Comprehensive Cancer Center, Sacramento, California
Conditions: Cancer Awareness and Prevention Education
Effect of Anti-inflammatory (ITIS) Diet in Knee Osteoarthritis
Recruiting
To study the effect of anti-inflammatory diet on clinical and biological outcomes in patients with knee osteoarthritis
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/07/2024
Locations: UCSD, La Jolla, California
Conditions: Osteoarthritis, Knee
Micro/Nanobubbles (MNBs) for Treatment of Acute and Chronic Wounds
Recruiting
The purpose of this study is to assess the safety and efficacy of Micro/nanobubbles (MNB's) for the healing of acute and chronic wounds.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/07/2024
Locations: UCI Medical Center, Orange, California
Conditions: Open Wound, Wound Heal
Medial-prefrontal Enhancement During Schizophrenia Systems Imaging
Recruiting
This randomized controlled trial in healthy controls (HC) and patients with schizophrenia (SZ) aims to examine 1) the underlying cognitive and neural cause of self-agency deficits in SZ; 2) the responsiveness to a novel navigated repetitive transcranial magnetic stimulation (nrTMS) target in the medial/superior prefrontal cortex (mPFC); and 3) how modulation of mPFC activity impacts the larger self-agency network to mediate changes in self-agency judgments. Our overall hypothesis is that increas... Read More
Gender:
ALL
Ages:
Between 18 years and 64 years
Trial Updated:
05/07/2024
Locations: UCSF, San Francisco, California
Conditions: Schizophrenia
Effect of Anti-inflammatory Diet in Rheumatoid Arthritis
Recruiting
In a previous exploratory study, the investigators observed an effect on disease activity outcomes of anti-inflammatory diet. The investigators also observed change in microbiome and circulating metabolites. The current study will determine whether or not the addition of anti-inflammatory diet improves the clinical outcomes in participants with rheumatoid arthritis, and the role of microbiome and circulating metabolites.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/07/2024
Locations: UCSD, La Jolla, California
Conditions: Rheumatoid Arthritis
AETOS Shoulder System
Recruiting
The goal of this study is to confirm the safety and performance of the AETOS Shoulder System for USA adoption. This is a prospective, open, adaptive, non-comparative, multi-centre investigation enrolling a maximum of 220 subjects in 2 cohorts (anatomic and reverse) at up to 15 sites. No intra-study comparator group will be included, and there will be no randomization
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/06/2024
Locations: California Pacific Orthopedics, San Francisco, California
Conditions: Shoulder Osteoarthritis, Shoulder Arthritis