California is currently home to 5955 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
A 48 Week Observational Study of the Frequency of Symptomatic Herpes Virus I and II in HIV Infected Subjects
Recruiting
This study is an observational, cohort, prospective study looking at the frequency of Herpes Simplex Virus (HSV) 1 and or 2 outbreaks in HIV positive patients who's HIV virus is controlled on highly active anti-retroviral therapy. We will be enrolling fifty (50) patients.
Gender:
All
Ages:
18 years and above
Trial Updated:
04/09/2023
Locations: Global Research Institute, Los Angeles, California
Conditions: HIV Disease, Herpes Simplex 1, Herpes Simplex 2
FreeStyle Libre 2 Discharge Trial
Recruiting
The goal of this clinical trial is to learn about the benefits of using aa Continuous Glucose Monitoring (CGM) system in patients with diabetes following discharge from the hospital. The main question it aims to answer is: • If the use of CGM with alarms is safe and effective for managing low and/or high blood sugars when compared with performing finger sticks several times per day Participants will wear one or two FreeStyle Libre CGM sensors for 12-14 days three times over a 12-week (3 month)... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
04/07/2023
Locations: Palo Alto Medical Foundation Research Institute, Palo Alto, California
Conditions: Diabetes Mellitus, Type 2, Hypoglycemia
Safety of AV-MEL-1 With Anti-PD-1 Therapy in Metastatic Melanoma
Recruiting
This is an open label, single-arm, phase IB treatment study to determine the safety of administering anti-PD1 monoclonal antibodies with AV-MEL-1 and to get some suggestion of efficacy, in patients with measurable metastatic melanoma. The study is open to patients who have either never received treatment for metastatic melanoma or were previously treated with anti-PD-1 with or without anti-CTLA-4 or with enzymatic inhibitors of the BRAF/MEK pathway because of BRAF600E/K mutations, and are about... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
04/07/2023
Locations: Jericho Rabago, Irvine, California
Conditions: Metastatic Melanoma
Use of T-allo10 in Hematopoietic Stem Cell Transplantation (HSCT) for Blood Disorders
Recruiting
A significant number of patients with hematologic malignancies need a hematopoietic stem cell transplant (HSCT) to be cured. Only about 50% of these patients have a fully matched donor, the remaining patients will require an HSCT from a mismatched related or unrelated donor. Almost 60% of these mismatched donor HSCTs will result in graft-versus-host disease (GvHD), which can cause significant morbidity and increased non-relapse mortality. GvHD is caused by the donor effector T cells present in t... Read More
Gender:
All
Ages:
Between 3 years and 45 years
Trial Updated:
04/07/2023
Locations: Lucile Packard Children's Hospital, Palo Alto, California
Conditions: AML - Acute Myeloid Leukemia, MDS (Myelodysplastic Syndrome), Mixed Phenotype Acute Leukemia, NHL - Non-Hodgkin's Lymphoma, Hodgkin's Lymphoma, ALL
Silicone Gel vs. Estrogen Vaginal Cream for the Management of Genitourinary Syndrome of Menopause
Recruiting
The goal of this randomized controlled trial is to test the efficacy of StrataMGT in the management of Genitourinary Syndrome of Menopause (GSM) compared to estrogen therapy. The main question it aims to answer is: - Will StrataMGT be non-inferior regarding patient quality of life compared to standard of care? Participants will use either StrataMGT or estrogen vaginal cream to treat GSM for 3 consecutive months. After the baseline assessment, participants will be assessed monthly for quality o... Read More
Gender:
Female
Ages:
18 years and above
Trial Updated:
04/06/2023
Locations: Orange Coast Women's Medical Group, Laguna Hills, California
Conditions: Genitourinary Syndrome of Menopause
A Phase 2a Study of IV BCV in Subjects With Adenovirus Infection (ATHENA)
Recruiting
The purpose of this study is to determine the Dose from the safety and tolerability of intravenous Brincidofovir (BCV, SyB V-1901) using multiple ascending doses in subjects with Adenovirus infection.
Gender:
All
Ages:
2 months and above
Trial Updated:
04/06/2023
Locations: Research Site, Los Angeles, California
Conditions: Adenovirus Infection
Improving Survivorship Care for Older Adults After Chemotherapy
Recruiting
The researchers want to find out if older adults receiving a survivorship care plan followed by a geriatric assessment visit improves quality of life and satisfaction with care compared to receiving only a survivorship care plan for older adults who have completed chemotherapy for cancer treatment.
Gender:
All
Ages:
65 years and above
Trial Updated:
04/06/2023
Locations: Community Cancer Institute, Clovis, California
Conditions: Survivorship
UCDCC#272: IL-2, Radiotherapy, and Pembrolizumab in Patients Refractory to Checkpoint Blockade
Recruiting
This is a phase I/II study that will evaluate the safety and toxicity of this combinatorial approach. Eligible patients >18 years of age with histologically proven metastatic NSCLC, melanoma, RCC, or HNSCC who have failed PD-1 / PD-L1 checkpoint blockade therapy will be enrolled. Patients must have a candidate treatment lesion (subcutaneous, nodal, or visceral) accessible and safe for radiotherapy and serial intralesional injections as specified by the protocol. They must also have at least one... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
04/06/2023
Locations: UC Davis Medical Center, Sacramento, California
Conditions: Non Small Cell Lung Cancer, Metastatic Melanoma, Metastatic Renal Cell Carcinoma, Head and Neck Squamous Cell Carcinoma
Studying Tumor Tissue Samples and Blood Samples to Learn More About DNA Changes in Patients With Lung Cancer
Recruiting
RATIONALE: Studying samples of tumor tissue and blood from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. PURPOSE: This laboratory study is looking at tumor tissue samples and blood samples to learn more about DNA changes in patients with lung cancer.
Gender:
All
Ages:
18 years and above
Trial Updated:
04/06/2023
Locations: University of California Davis Cancer Center, Sacramento, California
Conditions: Lung Cancer
Exercise Intolerance in Non-obstructive Hypertrophic Cardiomyopathy
Recruiting
The EXCITE-HCM study is a randomized, controlled, blinded clinical trial designed to evaluate the effect of moderate intensity exercise training versus usual physicial activity on the improvement of HCM-related symptoms and cardiac function. About 70 participants will be recruited and randomized on a 1:1 ratio to either moderate intensity training or usual physicial activity interventions. Patients will be followed during a period of 24 weeks and assesesments as physical examination, questionnai... Read More
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
04/05/2023
Locations: University of California - San Francisco, San Francisco, California
Conditions: Hypertrophic Cardiomyopathy
Phenotyping Mitochondrial and Immune Dysfunction in POTS With Targeted Clinical Intervention.
Recruiting
The mechanisms underlying POTS are not well understood. Though heterogeneous in nature, patients often present with symptoms that include fatigue, orthostatic lightheadedness and tachycardia, "brain fog", shortness of breath, and sleep disruption. The central mediator that links observations in disease entities similar to POTS is energy use and balance driven by mitochondrial health. Mitochondrial dysfunction (i.e. respiration defects, reactive oxygen species (ROS) generation, and structural abn... Read More
Gender:
All
Ages:
Between 18 years and 70 years
Trial Updated:
04/05/2023
Locations: Altman Clinical and Translational Research Institute, La Jolla, California
Conditions: Postural Tachycardia Syndrome
BXQ-350 in Newly Diagnosed Metastatic Colorectal Carcinoma
Recruiting
The study will assess the safety and efficacy of BXQ-350 plus modified FOLFOX7 (mFOLFOX7) and bevacizumab in participants who have newly diagnosed metastatic adenocarcinoma of the colon/rectum. The study will also evaluate if the administration of BXQ-350 with mFOLFOX7 and bevacizumab may diminish oxaliplatin induced sensory neurotoxicity, enabling participants to receive the total and planned doses of mFOLFOX7. All participants will receive BXQ-350 by intravenous (IV) infusion along with stand... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
04/05/2023
Locations: UC Irvine Health, Orange, California
Conditions: Metastatic Colorectal Carcinoma, Neuropathy