California is currently home to 5930 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Investigator Initiated Trial to Further Evaluate the Safety and Efficacy of Trans-perineal Focal Laser Ablation of Localized Prostate Cancer Using High Frequency Micro-ultrasound Imaging
Recruiting
Trans-perineal focal laser ablation represents a promising alternative focal therapy option for patients with low-risk or favorable intermediate risk prostate cancer. FLA has been extensively utilized for over a decade in the treatment of PCa using different anatomical approaches. The proposed study differs from past ones in that a trans-perineal approach with reduced risk of infection will be used in contrast to the current trans-rectal approach. In addition, high frequency micro-ultrasound ima... Read More
Gender:
Male
Ages:
Between 40 years and 85 years
Trial Updated:
05/31/2023
Locations: Genesis Research LLC., San Diego, California
Conditions: Prostate Cancer, Low-risk or Favorable Intermediate Risk Prostate Cancer Who Are on an Active Surveillance Regimen
S.T.A.N.D. Alacrity Center Signature Project
Recruiting
The purpose of this study is to evaluate clinical decision-making algorithms for (a) triaging to level of care and (b) adapting level of care in a low income, highly diverse sample of community college students at East Los Angeles College (ELAC). The target enrollment is 200 participants per year, for five years (N=1000). Participants are between the ages of 18 and 40 years and will be randomized into either symptom severity decision-making (SSD) or data-driven decision-making (DDD). Participan... Read More
Gender:
All
Ages:
Between 18 years and 40 years
Trial Updated:
05/31/2023
Locations: East Los Angeles College, Los Angeles, California
Conditions: Depression, Anxiety
Investigation of DEXA-C Anterior Cervical Interbody System
Recruiting
FDA Cleared interbody product for the cervical spine, designed to match a patients DEXA scan for increase in fusion rate.
Gender:
All
Ages:
18 years and above
Trial Updated:
05/30/2023
Locations: UCI Center for Clinical Research, Orange, California
Conditions: Degenerative Disc Disease
Natural History Study of and Genetic Modifiers in Spinocerebellar Ataxias
Recruiting
Spinocerebellar ataxias (SCA) are genetic neurological diseases that cause imbalance, poor coordination, and speech difficulties. There are different kinds of SCA and this study will focus on types 1, 2,3, and 6 (SCA 1, SCA 2, SCA 3 , also known as Machado-Joseph disease and SCA 6). The diseases are rare, slowly progressive, cause increasingly severe neurological difficulties and are variable across and within genotypes. The purpose of this research study is to bring together a group of experts... Read More
Gender:
All
Ages:
6 years and above
Trial Updated:
05/30/2023
Locations: University of California Los Angeles, Los Angeles, California
Conditions: Spinocerebellar Ataxia Type 1, Spinocerebellar Ataxia Type 2, Spinocerebellar Ataxia Type 3, Spinocerebellar Ataxia Type 6
Detection of Integrin avb6 in IPF, PSC, and COVID19 Using PET/CT
Recruiting
Detection of Integrin avb6 in Idiopathic Pulmonary Fibrosis, Primary Sclerosing Cholangitis, and Coronavirus Disease 2019 with [18F]FP-R01-MG-F2 with PET/CT
Gender:
All
Ages:
18 years and above
Trial Updated:
05/27/2023
Locations: Stanford University, Stanford, California
Conditions: Idiopathic Pulmonary Fibrosis, Primary Sclerosing Cholangitis, Covid19 Pneumonia
The Resilience Clinic Evaluation
Recruiting
Early life adversity can affect children's physical and mental health. The Resilience Clinic is a support program for young children and their caregivers who have been exposed to significant adversity, aiming to prevent the harmful effects of stress and improve child health, behavior, and development while also reducing caregiver stress. This study seeks to evaluate the Resilience Clinic, assessing the intervention's impact on child health, behavior, and development and caregiver stress and ment... Read More
Gender:
All
Ages:
Between 2 years and 5 years
Trial Updated:
05/26/2023
Locations: La Clinica de la Raza, Oakland, California
Conditions: Early Life Adversity, Caregiver Stress
Collection of Blood for Multiple Collaborative Studies
Recruiting
This study seeks to confidentially collect blood from HIV-positive individuals and HIV-negative controls to provide basic scientists with specimens for collaborative studies.
Gender:
All
Ages:
18 years and above
Trial Updated:
05/26/2023
Locations: San Francisco General Hospital, San Francisco, California
Conditions: HIV
The Use of Leukapheresis to Support HIV Pathogenesis Studies
Recruiting
Despite the dramatic improvements that have resulted from combination antiretroviral treatment, long-term efficacy, toxicity, cost, and the requirements for life-long adherence remain as formidable challenges. Also, there is emerging consensus that persistent HIV-associated disease occurs during long-term highly active antiretroviral therapy (HAART). This disease may be due to either direct drug-toxicity and/or persistent viral replication/production and/or persistent HIV-associated inflammation... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
05/26/2023
Locations: San Francisco General Hospital, San Francisco, California
Conditions: HIV
Improving Cognition Through Telehealth Aerobic Exercise and Cognitive Training After a First Schizophrenia Episode
Recruiting
The participants in the study will receive psychiatric treatment at the UCLA Aftercare Research Program. All participants in this 12-month RCT will receive cognitive training. Half of the patients will also be randomly assigned to the aerobic exercise and strength training condition, and the other half will be randomly assigned to the Healthy Living Group condition. The primary outcome measures are improvement in cognition and level of engagement in the in-group and at-home exercise sessions. In... Read More
Gender:
All
Ages:
Between 18 years and 45 years
Trial Updated:
05/25/2023
Locations: UCLA Aftercare Research Program, Los Angeles, California
Conditions: Schizophrenia, Schizophreniform Disorder, Schizoaffective Disorder
Feasibility Study to Evaluate Therapeutic Ultrasound (TUS) to Acutely Increase the Perfusion in Peripheral Arterial Disease (PAD)
Recruiting
This study is evaluating whether a therapeutic ultrasound device can improve symptoms in the leg of peripheral arterial disease (PAD) patients 65 years of age and over.
Gender:
All
Ages:
65 years and above
Trial Updated:
05/24/2023
Locations: Vascular & Interventional Specialists of Orange County, Orange, California
Conditions: Peripheral Arterial Disease
Clinical Study of a Micro-Implantable Pulse Generator for the Treatment of Peripheral Neuropathic Pain (COMFORT 2)
Recruiting
This post market study is being conducted to document the comparative effectiveness and safety of peripheral nerve stimulation plus conventional medical management versus conventional medical management alone in the treatment of chronic, intractable peripheral neuralgia of post-traumatic or postsurgical origin. This is a prospective, minimal risk, multi-center, randomized control trial.
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
05/24/2023
Locations: Comprehensive Spine & Pain Physicians, Burbank, California
Conditions: Peripheral Neuralgia, Peripheral Neuropathy, Chronic Pain
A PD-1 Checkpoint Inhibitor (Cemiplimab) for High-Risk Localized, Locally Recurrent, or Regionally Advanced Skin Cancer
Recruiting
This phase II trial studies how well cemiplimab before surgery works in treating patients with skin cancer that is high-risk and has not spread to other parts of the body (localized), has come back locally (locally recurrent), or has spread regionally (regionally advanced), and can be removed by surgery (resectable). Immunotherapy with monoclonal antibodies, such as cemiplimab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spre... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
05/24/2023
Locations: Los Angeles County-USC Medical Center, Los Angeles, California
Conditions: Recurrent Skin Squamous Cell Carcinoma, Resectable Skin Squamous Cell Carcinoma, Stage I Skin Cancer, Stage II Skin Cancer, Stage III Skin Cancer