California is currently home to 5605 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Post-authorization Safety Study in North America to Monitor Pregnancy and Infant Outcomes Following Administration of Dupilumab During Planned or Unexpected Pregnancy
Recruiting
The objective is to evaluate the potential effect of exposure to dupilumab in pregnancy compared to the primary comparison group of disease-matched pregnant women who are not exposed to dupilumab, and the secondary comparison group of healthy pregnant women. The primary outcome of the study is major structural defects, and the secondary outcomes of the study are spontaneous abortion/miscarriage, stillbirth, elective termination/abortion, premature delivery, small for gestational age, pattern of... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
11/17/2023
Locations: Regeneron Research Site, La Jolla, California
Conditions: Atopic Dermatitis (AD), Asthma
Effect of Rapid Rollover on Pneumothorax After CT-Guided Lung Biopsy
Recruiting
Pneumothorax is the most common complication after CT-guided lung biopsy, and several techniques have been proposed to reduce the risk. Among them, rapid rollover is the maneuver to immediately reposition the patient, with biopsy-side down after removal of biopsy needle. It has been theorized that the technique reduces the size of alveoli surrounding the needle tract, leading to airway closure and reduction in the alveolar-to-pleural pressure gradient, thereby preventing pneumothorax. The aim of... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/16/2023
Locations: Zuckerberg San Francisco General Hospital and Trauma Center, San Francisco, California
Conditions: Lung Cancer, Pneumothorax
Efficacy of the Nanodropper Device on Intraocular Pressure in Patients With Glaucoma
Recruiting
Glaucoma is the leading cause of irreversible blindness worldwide. Previous studies demonstrate that smaller eye drops used in the treatment of glaucoma are just as efficacious as their larger counterparts. The proposed study hopes to demonstrate the non-inferiority of using Nanodropper to lower intraoccular pressure (IOP) in glaucoma patients compared to standard of care eye drops.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/16/2023
Locations: University of California, San Francisco, San Francisco, California
Conditions: Glaucoma, Ocular Hypertension, Open Angle Glaucoma
Still Climbin': An Intervention to Improve Coping Among Black Sexual Minority Men
Recruiting
This study consists of a randomized controlled trial of a multi-session cognitive behavior therapy (CBT) group intervention that addresses coping with discrimination and medical mistrust among Black sexual minority men (SMM). Primary intervention objectives include increasing health care engagement and receipt of evidence-based preventive care, as well as better coping and reduced anticipated and internalized stigma, and medical mistrust among intervention participants.
Gender:
MALE
Ages:
18 years and above
Trial Updated:
11/16/2023
Locations: APLA Health, Los Angeles, California
Conditions: Discrimination, Social, Health Care Utilization
Biomarkers of Depression and Treatment Response
Recruiting
This study is a stratified, parallel-group, single-center study utilizing multimodal imaging techniques to identify biomarkers for Major Depressive Disorder (MDD). The study goal is to identify biomarkers for MDD and treatment response that can be implemented in clinical diagnosis and care as valid and reliable measures, through monitoring neurophysiological and electrophysiological changes across the course of transcranial magnetic stimulation (TMS) treatment.
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
11/16/2023
Locations: University of California, San Francisco, San Francisco, California
Conditions: Depressive Disorder, Major
A Cognitive Behavioral Therapy Group Intervention to Increase HIV Testing and PrEP Use Among Latinx Sexual Minority Men
Recruiting
This study consists of a randomized controlled trial (RCT) of a multi-session cognitive behavior therapy (CBT) group intervention that aims to improve HIV outcomes by increasing adaptive, effective coping responses to stigma from intersectional identities related to ethnicity, immigration status, sexual minority identity, HIV status, and PrEP use among Latinx sexual minority men (SMM).
Gender:
MALE
Ages:
18 years and above
Trial Updated:
11/16/2023
Locations: Bienestar Human Services, Inc, Los Angeles, California
Conditions: HIV
The Reducing Risk Study
Recruiting
The present study will test an innovative mobile health adaptation of a behavioral intervention that improves sleep and mental health concerns among adolescents.
Gender:
ALL
Ages:
Between 12 years and 18 years
Trial Updated:
11/16/2023
Locations: University of California, San Francisco, San Francisco, California
Conditions: Insomnia, Delayed Sleep Phase
Glucose Evaluation Through Continuous Glucose Monitors in Polycystic Ovary Syndrome
Recruiting
PCOS is the most common endocrine disorder of reproductive aged women. In addition to menstrual and endocrine abnormalities, PCOS is characterized by insulin resistance and glycemic dysregulation. The pattern of glycemic abnormalities among patients with PCOS may be different than the general population, as evidenced by invasive, time consuming, and costly procedures such as the euglycemic clamp or oral glucose tolerance test. Continuous glucose monitoring (CGM) offers an opportunity to evaluate... Read More
Gender:
FEMALE
Ages:
Between 18 years and 45 years
Trial Updated:
11/15/2023
Locations: UCSF Center for Reproductive Health, San Francisco, California
Conditions: PCOS (Polycystic Ovary Syndrome) of Bilateral Ovaries, Dysglycemia, Insulin Resistance
Bortezomib and Pembrolizumab With or Without Pelareorep for the Treatment of Relapsed or Refractory Multiple Myeloma, AMBUSH Trial
Recruiting
This phase I/II trial studies the safety of the combination of bortezomib, dexamethasone, and pembrolizumab with or without pelareorep in treating patients with multiple myeloma that has come back (relapsed) or does not response to treatment (refractory). Chemotherapy drugs, such as bortezomib and dexamethasone, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Immunotherapy with monoclonal... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/15/2023
Locations: Los Angeles County-USC Medical Center, Los Angeles, California
Conditions: Recurrent Plasma Cell Myeloma, Refractory Plasma Cell Myeloma
Core Biopsies for Establishing a Breast Tumor Tissue Repository
Recruiting
This research trial establishes a breast tumor tissue repository from core biopsies. Collecting breast tissue from core biopsies may allow doctors to learn more about the biology of breast cancer and to analyze proteins, genes, and other components of tumor cells. It may also allow doctors to conduct future studies to help understand how breast cancer grows and how it responds to different types of therapy. This will help doctors develop better breast cancer therapies and better tests to help ma... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/15/2023
Locations: USC Norris Comprehensive Cancer Center, Los Angeles, California
Conditions: Breast Cancer
Retinal Imaging in Patients With Inherited Retinal Degenerations
Recruiting
The purpose of this study is to determine whether the structure and function of the human retina can be studied with high resolution in patients with inherited retinal degenerations using the Adaptive Optics Scanning Laser Ophthalmoscope (AOSLO).
Gender:
ALL
Ages:
13 years and above
Trial Updated:
11/15/2023
Locations: Department of Ophthalmology Retinal Degenerations Clinic, UCSF, San Francisco, California
Conditions: Retinitis Pigmentosa
Fatigue in Short-Haul Operations
Recruiting
The purpose of the present study is to assess fatigue levels of short-haul pilots during normal operations. The investigators will collect objective and subjective sleep, sleepiness, workload, and performance data from on-duty pilots during short-haul flight operations. Data will be collected during days off prior to the trip start, during flights, and during days off following the flight operations.
Gender:
ALL
Ages:
Between 18 years and 60 years
Trial Updated:
11/14/2023
Locations: NASA Ames Research Center, Mountain View, California
Conditions: Fatigue