California is currently home to 5619 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Groningen International Study on Sentinel Nodes in Vulvar Cancer-III
Recruiting
Vulvar cancer patients with SN-metastasis \> 2mm will receive chemoradiation instead of an inguinofemoral lymphadenectomy.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
07/27/2023
Locations: UC Irvine Health/Chao Family Comprehensive Cancer Center, Orange, California
Conditions: Vulvar Cancer, Sentinel Lymph Node, Lymph Node Metastases
A Safety and Pharmacokinetics Study of IDP-122 Lotion in Pediatric Participants With Plaque Psoriasis
Recruiting
This study is to evaluate the safety, the systemic exposure of halobetasol propionate (HP), and the hypothalamic-pituitary-adrenal (HPA) axis suppression potential for topically applied IDP-122 lotion in pediatric participants with moderate to severe plaque psoriasis.
Gender:
ALL
Ages:
Between 6 years and 17 years
Trial Updated:
07/25/2023
Locations: Bausch Site 11, Fountain Valley, California
Conditions: Psoriasis
Oral Supplementation of Astaxanthin on Skin Photoaging, Hydration and Elasticity
Recruiting
This study is a double-blind placebo controlled study to assess whether oral astaxanthin can improve skin hydration, skin elasticity, improve skin pigmentation, and reduce facial redness.
Gender:
FEMALE
Ages:
Between 30 years and 55 years
Trial Updated:
07/24/2023
Locations: Integrative Skin Science and Research, Sacramento, California
Conditions: Photoaging
Dose Regimen Study of SLI-F06 in Healthy Volunteers
Recruiting
Multi-center, dose-regimen, double-blind study evaluating the safety and efficacy of 4 doses of SLI-F06 compared with vehicle for improvement in scar appearance
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
07/24/2023
Locations: California Dermatology & Clinical Research Institute, Encinitas, California
Conditions: Scar, Wound Healing
The Association of Microbiome Patterns With Chronic Opioid Use
Recruiting
The United States is in the midst of an opioid epidemic, with the number of opioid-related deaths having risen six-fold since 1999. Chronic pain imposes a tremendous economic burden of up to US$635 billion per year in terms of direct costs (such as the costs of treatment) and indirect costs (such as lost productivity and time away from work). We need to better understand individual characteristics that may put patients at risk for chronic opioid use. Recently, the relationship between gut microb... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/24/2023
Locations: University of California San Diego, La Jolla, California
Conditions: Chronic Pain, Opioid Use
Predicting Chronic Opioid Use Following Lower Extremity Joint Arthroplasty
Recruiting
Personalized medicine is a concept in which medical care is individualized to a patient based on their unique characteristics, including comorbidities, demographics, genetics, and microbiome. After major surgery, some patients are at increased risk of opioid dependence. By identifying unique genetic and microbiome markers, clinicians may potentially identify individual risk factors for opioid dependence. By identifying these high risk patients early-on, personalized interventions may be applied... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/24/2023
Locations: University of California San Diego, La Jolla, California
Conditions: Joint Pain, Chronic Pain, Opioid Use
Predicting Chronic Pain Following Breast Surgery
Recruiting
Breast surgery, which includes mastectomy, breast reconstructive surgery, or lumpectomies with sentinel node biopsies, may lead to the development of chronic pain and long-term opioid use. In the era of an opioid crisis, it is important to risk-stratify this surgical population for risk of these outcomes in an effort to personalize pain management. The opioid epidemic in the United States resulted in more than 40,000 deaths in 2016, 40% of which involved prescription opioids. Furthermore, it is... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/24/2023
Locations: University of California San Diego, La Jolla, California
Conditions: Chronic Pain, Opioid Use, Breast Pain, Breast Cancer
Lucid Registry Study
Recruiting
This is a multicenter, prospective, observational study designed to capture a limited set of data consisting of diagnostic test results and clinical management information on subjects who undergo EC/EG to assess for the presence of BE/EAC. Once sufficient time has elapsed for EsoGuard results to be available, as well as for any subsequent clinical evaluation to have been performed (e.g., upper endoscopy and any initial therapeutic management), study staff will obtain the desired information and... Read More
Gender:
ALL
Ages:
12 years and above
Trial Updated:
07/20/2023
Locations: LUCID DX, Lake Forest, California
Conditions: Barrett Esophagus, Esophageal Adenocarcinoma, Barretts Esophagus With Dysplasia, Barrett's Esophagus Without Dysplasia
Personalized Need-focused Single Session Intervention
Recruiting
This is a two-site randomized controlled trial, with two goals. First, the investigators aim to demonstrate that single-session interventions for mild-to-moderate anxiety and depression can generate statistically significant symptom change as a main effect across control and experimental (i.e. personalized) conditions. Second, the investigators hope to establish the additional incremental efficacy of personalization via person-specific intensive longitudinal data collection and analysis.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/18/2023
Locations: University of California, Berkeley, Berkeley, California
Conditions: Depression and/or Anxiety in the Mild-to-moderate Range
Anti-Inflammatory Dietary Intervention for Rheumatoid Arthritis
Recruiting
The primary objective of this study is to assess if there is a significant difference in the mean disease activity score in individuals with RA participating in a dietary intervention compared to those in the control group measured by DAS-28. Other measures to track disease activity will include monitoring number and severity of disease flares and any changes in medications. This will be done by completing a single-blinded randomized controlled trial, parallel in design. The study population wil... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/18/2023
Locations: Attune Health Research Inc, Beverly Hills, California
Conditions: Rheumatoid Arthritis
PET/MRI in the Diagnosis of Chronic Pain
Recruiting
Several studies have implicated involvement of sigma-1 receptors (SR1s) in the generation of chronic pain, while others are investigating anti SR1 drugs for treatment of chronic pain. Using \[18F\]-FTC-146 and positron emission tomography/magnetic resonance imaging (PET/MRI), the investigators hope to identify the source of pain generation in patients with chronic pain. The purpose of this study is to compare the uptake of \[18F\]FTC-146 in healthy volunteers to that of individuals suffering fro... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/18/2023
Locations: Stanford University, Stanford, California
Conditions: Neuropathic Pain, Nociceptive Pain, MIxed Pain (Nociceptive and Neuropathic), Spinal Pain, Radiculopathy, Myelopathy, Neurogenic Claudication
The Effect of Beetroot Juice Supplementation Dose on Neuromuscular Performance During Resistance Exercise
Recruiting
Dietary nitrate supplementation, administered in the form of nitrate-rich beetroot juice, has been shown to improve exercise performance and may have more pronounced effects on exercise that requires high-power and high-velocity muscle contraction such as weightlifting and body-mass resisted exercise (i.e, resistance exercise). However, limited data are available that have examined the potential performance enhancing effect of beetroot juice in resistance exercise. Moreover, there is no informat... Read More
Gender:
MALE
Ages:
Between 18 years and 45 years
Trial Updated:
07/16/2023
Locations: Pepperdine University, Malibu, California
Conditions: High Nitrate Dose, Moderate Nitrate Dose, Low Nitrate Dose, Nitrate-depleted Dose