California is currently home to 5602 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Novel α2-Antiplasmin Inactivation for Lysis of Intravascular Thrombi (NAIL-IT) Trial
Recruiting
Phase II trial of TS23
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/08/2023
Locations: Cedars Sinai Medical Center, Los Angeles, California
Conditions: Pulmonary Embolism
Cognition and Motor Learning Post-stroke
Recruiting
This project seeks to determine how post-stroke cognitive impairment moderates motor learning during walking in older adults with chronic stroke and identify brain structural markers that mediate this relationship. The chosen experimental design integrates biomechanical analyses, neuropsychological assessments, and brain imaging techniques to determine the impact of post-stroke cognitive impairment severity on two forms of motor learning (explicit and implicit) and examine the role of the dorsol... Read More
Gender:
ALL
Ages:
Between 45 years and 85 years
Trial Updated:
07/08/2023
Locations: Center for Health Professions, Los Angeles, California
Conditions: CVA (Cerebrovascular Accident), Stroke
Selinexor and Pembrolizumab for the Treatment of Cisplatin-Ineligible or Cisplatin-Refractory Locally Advanced or Metastatic Urothelial Carcinoma
Recruiting
This phase Ib/II trial finds the best dose of selinexor and its effect with pembrolizumab in treating patients with urothelial carcinoma that are not eligible to receive the chemotherapy drug cisplatin, or have been given cisplatin and the cancer has gotten worse. Patients must also have urothelial carcinoma that has spread locally, near where it started (locally advanced), or has spread to other parts of the body (metastatic). Selinexor may stop the growth of tumor cells by blocking a protein,... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/30/2023
Locations: University of California Davis Comprehensive Cancer Center, Sacramento, California
Conditions: Advanced Urothelial Carcinoma, Locally Advanced Urothelial Carcinoma, Metastatic Urothelial Carcinoma, Refractory Urothelial Carcinoma
Canadian-American Spinal Cord Perfusion Pressure and Biomarker Study
Recruiting
This multicenter study will enroll 100 patients with acute traumatic cervical and thoracic SCI who have a lumbar intrathecal catheter inserted within 24 hours of their injury. The lumbar intrathecal catheter will be inserted pre-operatively for the measurement of ITP and the collection of cerebrospinal fluid (CSF) samples. SCPP will be calculated as the difference between MAP and the ITP. There are two important distinct yet related objectives in this prospective interventional study. 1. Deter... Read More
Gender:
ALL
Ages:
17 years and above
Trial Updated:
06/30/2023
Locations: Zuckerberg San Francisco General Hospital and Trauma Center, San Francisco, California
Conditions: Acute Spinal Cord Injury, Acute Spinal Paralysis, Spinal Cord Injuries, SPINAL Fracture
Cellular Aging and Neurobiology of Depression Study
Recruiting
We are conducting an eight week longitudinal study to learn if blood levels of certain naturally occurring compounds and genetic markers differ between patients with depression and healthy adults who are not depressed, and if any such differences relate to memory performance, mood, and neurobiology. We are also interested in how the gut microbiome is affected by antidepressant treatment. We will do this by comparing the unmedicated depressed patients with matched healthy controls at baseline an... Read More
Gender:
ALL
Ages:
Between 21 years and 60 years
Trial Updated:
06/30/2023
Locations: University of California San Francisco, San Francisco, California
Conditions: Major Depressive Disorder
Packing Versus no Packing for Cutaneous Abscess
Recruiting
The goal of this study is to examine patients undergoing incision and drainage of cutaneous abscesses to determine if routine packing of the abscess cavity affects the need for further interventions such as repeat incision and drainage, antibiotic administration or hospital admission.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/26/2023
Locations: Community Regional Medical Center, Fresno, California
Conditions: Cutaneous Abscess
A Diagnostic Study of CD38-Targeted ImmunoPET of Myeloma
Recruiting
Evaluation of myeloma disease burden is currently suboptimal. This limits treatment planning and evaluation of residual disease following treatment. 89Zr-DFO-daratumumab is a novel immunoPET tracer, designed to detect CD38 on myeloma cells and allow visualization of myeloma in a PET scanner. A phase I study of 89Zr-DFO-daratumumab demonstrated safety and successful visualization of myeloma with 89Zr-DFO-daratumumab. This will be a phase II study of 89Zr-DFO-daratumumab to evaluate potential clin... Read More
Gender:
ALL
Ages:
21 years and above
Trial Updated:
06/23/2023
Locations: Hoag Memorial Hospital Presbyterian, Irvine, California
Conditions: Multiple Myeloma
Autologous huMNC2-CAR44 or huMNC2-CAR22 T Cells for Breast Cancer Targeting Cleaved Form of MUC1 (MUC1*)
Recruiting
Phase I/II study of adoptive immunotherapy for advanced MUC1\* positive breast cancer with autologous T cells engineered to express either a chimeric antigen receptor, huMNC2-CAR44 or huMNC2-CAR22, which are specific for a cleaved form of MUC1 (MUC1\*).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/15/2023
Locations: City of Hope Medical Center, Duarte, California
Conditions: Metastatic Breast Cancer
TRIAD Appendicitis Decision-making Surveys
Recruiting
While appendectomy has been the main treatment of appendicitis for over 100 years, recent European studies found that, at least among highly selected patients, antibiotics alone can be an effective alternative. Surgeons and patients alike have a difficult time deciding if surgery or antibiotics are the best choice to treat appendicitis. The goal of the TRIAD is to evaluate the patients who are a part of the TRIAD implementation program and assess satisfaction and decisional regret for patients w... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/13/2023
Locations: Kaiser Permanente Baldwin Park, Baldwin Park, California
Conditions: Appendicitis
Ashwagandha for Cognitive Dysfunction
Recruiting
This is a 1:1 randomized double blinded placebo controlled trial. • To determine if ashwagandha can improve cognitive dysfunction when compared with placebo in patients undergoing chemotherapy for cancer.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/13/2023
Locations: Sutter Cancer Center, Sacramento, California
Conditions: Chemo Fog
Trametinib in the Treatment of Complicated Extracranial Arterial Venous Malformation
Recruiting
Arteriovenous malformation (AVM) is a congenital vascular anomaly that progresses throughout life and causes complications including tissue destruction due to rapid overgrowth, bleeding, functional deficits, severe deformity and cardiac failure. Unfortunately, traditional managements have transient benefits with more than 90 recurrence rate within a year. Therefore, there is a significant unmet medical need. The purpose of this study is to assess the safety and efficacy of Trametinib in children... Read More
Gender:
ALL
Ages:
Between 12 years and 60 years
Trial Updated:
06/09/2023
Locations: Pediatric Dermatology Clinic at Stanford Children's Hospital, Palo Alto, California
Conditions: Venous Malformation, Arterial Disease
AMP SCZ® Observational Study: PREDICT-DPACC
Recruiting
The Accelerating Medicines Partnership® Schizophrenia (AMP® SCZ) is a large international collaboration to develop algorithms using a set of clinical and cognitive assessments, multi-modal biomarkers, and clinical endpoints that can be used to predict the trajectories and outcomes of individuals at clinical high risk (CHR) for psychosis and to advance the testing of pharmacological interventions for CHR individuals in need. The goal is to accurately predict which individuals are likely to remit,... Read More
Gender:
ALL
Ages:
Between 12 years and 30 years
Trial Updated:
06/06/2023
Locations: University of California Irvine, Irvine, California
Conditions: Clinical High Risk, Psychosis, Remission, Conversion