California is currently home to 5930 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Perioperative Mindfulness Proposal
Recruiting
The purpose of this study is to determine if a regular meditation and breath work practice started before surgery and continued through post-surgical recovery can improve anxiety and pain related to breast cancer and its treatment.
Gender:
Female
Ages:
18 years and above
Trial Updated:
02/27/2023
Locations: Hoag Memorial Hospital Presbyterian, Newport Beach, California
Conditions: Breast Cancer, DCIS
U01-Biomarkers for Noninvasive and Early Detection of Pancreatic Cancer
Recruiting
This is an observational, biospecimen collection protocol to develop a bank of pancreatic cancer tissue and normal tissue.
Gender:
All
Ages:
18 years and above
Trial Updated:
02/27/2023
Locations: Hoag Memorial Hospital Presbyterian, Newport Beach, California
Conditions: Pancreatic Cancer
Implementation of Adverse Childhood Experiences (ACEs) Policy
Recruiting
Adverse Childhood Experiences (ACEs) are pervasive among children with 45% experiencing at least one ACE and 10% experiencing three or more, placing them at high risk for toxic stress and symptomatology. Yet, ACEs often go undetected in primary care settings during well-child visits due to unclear policies and tested implementation strategies. This pilot study will use mapping methodology, guided by the Exploration, Preparation, Implementation and Sustainment (EPIS) framework, to refine a multi-... Read More
Gender:
All
Ages:
Between 0 years and 5 years
Trial Updated:
02/24/2023
Locations: Borrego Health, Desert Hot Springs, California
Conditions: Adverse Childhood Experiences
Assessing the Clinical Benefit of Molecular Profiling in Patients With Solid Tumors
Recruiting
Many patients are treated for advanced cancer without knowledge of underlying molecular features that might indicate FDA approved therapies or potential eligibility for biomarker-selected clinical trials. The Strata Trial (STR-001-001) has been initiated by Strata Oncology to evaluate the clinical benefit of systematic comprehensive genomic profiling for participants with advanced cancer using real-world data and endpoints, while assessing the proportion of participants available for clinical t... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
02/23/2023
Locations: Kaiser Permanente - Southern California, Pasadena, California
Conditions: Cancer, Adult Solid Tumor, Lymphoma, Multiple Myeloma
The Effect of Zolpidem on Outcomes Following Lumbar Spine Fusion
Recruiting
The purpose of this study is to evaluate if peri-operative zolpidem for posterior lumbar spinal fusion improves patient reported outcomes following surgery.
Gender:
All
Ages:
Between 18 years and 75 years
Trial Updated:
02/22/2023
Locations: Keck Medical Center of USC, Los Angeles, California
Conditions: Spine Fusion, Lumbar Spine Degeneration, Pain, Postoperative, Lumbar Spine Spondylosis
ADG126, ADG126 in Combination With Anti PD1 Antibody, and ADG126 in Combination With ADG106 in Advanced/Metastatic Solid Tumors
Recruiting
ADG126, ADG126 in Combination with anti-PD1 antibody, and ADG126 in Combination with ADG106 in Patients with Advanced/Metastatic Solid Tumors .
Gender:
All
Ages:
18 years and above
Trial Updated:
02/22/2023
Locations: University of California Los Angeles, Los Angeles, California
Conditions: Advanced/Metastatic Solid Tumors
The Gastric Cancer Foundation: A Gastric Cancer Registry
Recruiting
The Gastric Cancer Registry will combine data acquired directly from patients with gastric cancer; with a family history of gastric cancer in a first or second degree relative; or persons with a known germline mutation in their CDH1 (E-Cadherin) gene via an online questionnaire with genomic data obtained from saliva, blood and tissue samples. The purpose of this registry is to gain better understanding of the causes of gastric cancer, both environmental and genetic; whether certain genomic data... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
02/22/2023
Locations: Stanford University, School of Medicine, Stanford, California
Conditions: Gastric Cancer
Randomized Feasibility Trial for Mesh in Pre-Pectoral Reconstruction
Recruiting
Surgical mesh products, particularly acellular dermal matrices (ADM), are now used by the majority of plastic surgeons to assist with the nearly 100,000 prosthetic breast reconstruction procedures in the United States, despite never being approved by Food and Drug Administration (FDA) for this indication. As surgeons transition to placing breast implants above the chest muscle (pre-pectoral), there has been an increasing reliance on these often expensive mesh products without robust evidence to... Read More
Gender:
Female
Ages:
Between 22 years and 75 years
Trial Updated:
02/21/2023
Locations: University of California Los Angeles, Los Angeles, California
Conditions: Breast Cancer, Breast Implant; Complications, Infection or Inflammation
A Study of Combination of Selinexor, Pomalidomide, and Dexamethasone (SPd) Versus Elotuzumab, Pomalidomide, and Dexamethasone (EloPd) in Subject With Previously Treated Multiple Myeloma
Recruiting
This phase 3 randomized, open-label multicenter trial will compare the efficacy, safety and the impact on health-related quality of life (HR-QoL) of SPd versus EloPd in pomalidomide-naïve patients with MM who have received 1 to 4 prior anti-MM regimens and been treated with an immunomodulatory imide drug (IMiD), proteasome inhibitor (PI) and an anti-CD38 monoclonal antibody (mAb).
Gender:
All
Ages:
18 years and above
Trial Updated:
02/20/2023
Locations: University of California, San Francisco, Fresno, California
Conditions: Multiple Myeloma
Lung Function Outcomes Following Removal of Airway Mucus Plugs in Patients With Asthma (FOCUS)
Recruiting
This is a single-center study that will evaluate the safety and tolerability of removal of mucus plugs by bronchoscopy in patients with asthma. This protocol will also plan for the analysis of the features of the mucus plugs removed.
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
02/17/2023
Locations: UCSF Airway Clinical Research Center, San Francisco, California
Conditions: Asthma
NEURESCUE Device as an Adjunct to In-Hospital Cardiac Arrest (ARISE)
Recruiting
The NEURESCUE device is the first intelligent catheter for aortic balloon occlusion, an emergency technique that supercharges blood flow to the heart and brain within one minute from deployment. The catheter-based device is delivered via the femoral artery, temporarily inflating a soft balloon in the descending aorta to redirect blood flow towards the upper body. The objective of this study is to investigate the feasibility of the NEURESCUE device as an adjunct to Advanced Cardiac Life Support... Read More
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
02/16/2023
Locations: Long Beach Medical Center, Long Beach, California
Conditions: Cardiac Arrest, Cardiopulmonary Arrest, Cardiovascular Diseases
Prospective Research Assessment in Multiple Myeloma: An Observational Evaluation (PREAMBLE)
Recruiting
The purpose of this study is to assess the clinical effectiveness of all approved multiple myeloma (MM) therapies in the newly-diagnosed (NDMM) and the relapsed/refractory MM (RRMM) settings in real-world clinical practice.
Gender:
All
Ages:
18 years and above
Trial Updated:
02/16/2023
Locations: Local Institution, Anaheim, California
Conditions: Multiple Myeloma