Massachusetts is currently home to 3310 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Boston, Worcester, Springfield and Burlington. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Physical Rehabilitation of COVID-19 Survivors by Heat Therapy
NCT04673318
Recruiting
Older adults and people with underlying medical conditions are at higher risk for developing serious complications related to SARS-CoV-2 resulting in prolonged sequelae. The goal of this proposal is to compare the benefits of home-based lower limb heat therapy to exercise training on cardio-metabolic function and mobility in older adults during their convalescence from hospitalization due to SARS-CoV-2.
Gender:
All
Ages:
Between 55 years and 85 years
Trial Updated:
04/27/2021
Locations: Institute of Applied Life Sciences, Amherst, Massachusetts
Conditions: Covid19, Physical Disability
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Alcohol and Sex Risk mHealth-Enhanced Brief Intervention for BLMSM
NCT04821427
Recruiting
Randomized controlled pilot trial to test the feasibility and efficacy of a brief intervention with app-based messaging to reduce sexual risk behavior and heavy drinking among Black/African American and Hispanic/Latino MSM.
Gender:
Male
Ages:
Between 21 years and 50 years
Trial Updated:
04/03/2021
Locations: Boston University, Boston, Massachusetts
Conditions: Heavy Drinking and Sexual Risk Behavior
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Impact of 'Recovery' Footwear on Lower Extremity Comfort and Biomechanics
NCT04830540
Recruiting
The goal of this study is to understand the impact of wearing shoes with a compliant, energy absorbing midsole material, outside of athletic training sessions on the mechanics of movement, performance, and perceived joint pain and stiffness. Advances in material science have led to a wider range of cushioning system material properties and mid and outsole geometries in footwear. While there are many marketing claims about the potential health benefits of this new class of footwear these have not... Read More
Gender:
All
Ages:
Between 18 years and 30 years
Trial Updated:
04/01/2021
Locations: Musculoskeletal & Orthopedic Biomechanics Laboratory/ University of Massachusetts Amherst, Amherst, Massachusetts
Conditions: Arthralgia, Joint Stiffness, Gait Mechanics
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Comparison of Quadratus Lumborum Block Types
NCT04588389
Recruiting
This study will compare the quality of analgesia and reduction of opioid use, between standard of care and two groups of local anesthetic blocks in different location in the quadratus lumborum plane, for postoperative pain control after lumbar spinal fusion and if it reduces opioid consumption.
Gender:
All
Ages:
Between 40 years and 80 years
Trial Updated:
03/18/2021
Locations: UMASS Memorial Medical Center, Worcester, Massachusetts
Conditions: Pain, Opioid Use, Lumbar Disc Herniation
Register for Updates
Cognition and the Immunology of Postoperative Outcomes
NCT04792983
Recruiting
This research will test the hypothesis that immune system disequilibrium / dysfunction explains why preoperative cognitive impairment is a strong predictor of postoperative morbidity in older surgical patients. The investigators propose that cognitive impairment influences surgical morbidity because of underlying immune disequilibrium / dysfunction (risk marker) and that this shapes the immune response to surgery and defines immunological hallmarks of postoperative morbidity (disease marker). Th... Read More
Gender:
All
Ages:
65 years and above
Trial Updated:
03/08/2021
Locations: Brigham & Women's Hospital, Boston, Massachusetts
Conditions: Cognitive Impairment, Frail Elderly Syndrome, Delirium, Surgery
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Clinical Performance Evaluation of Veye Lung Nodules
NCT04792632
Recruiting
Veye Lung Nodules (Aidence B.V., Amsterdam, the Netherlands) is a medical software device that is intended to assist radiologists with pulmonary nodule management on CT chest scans. This clinical trial aims to assess the clinical performance of Veye Lung nodules via a standalone performance evaluation and a reader study.
Gender:
All
Ages:
18 years and above
Trial Updated:
03/08/2021
Locations: Intrinsic Imaging, Boston, Massachusetts
Conditions: Lung; Node
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Multimodal, Task-Aware Movement Assessment and Control: Clinic to the Home
NCT04675307
Recruiting
The investigators seek to construct a novel, multimodal, distributed system that facilitates a new paradigm of home-based medical surveillance and treatment for frail older adults centered on timely diagnosis of movement system impairments and personalized intervention. Measurements from a heterogeneous set of complementary sensors will be combined with clinically-informed and data-learned dynamic models of human motion to enable real-time activity recognition (e.g., sitting, standing, walking)... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
03/02/2021
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Frailty
Register for Updates
Best Practices to Prevent COVID-19 Illness in Staff and People With Serious Mental Illness and Developmental Disabilities in Congregate Living Settings
NCT04726371
Recruiting
Best Practices to Prevent COVID-19 Illness in Staff and People With Serious Mental Illness and Developmental Disabilities in Congregate Living Settings is a research study aimed at developing, implementing, and evaluating a package of interventions specifically designed to reduce COVID-19 and other infectious-disease incidence, hospitalizations, and mortality among staff and adults with Serious Mental Illness and Intellectual and Developmental Disabilities in congregate-living settings.
Gender:
All
Ages:
18 years and above
Trial Updated:
01/26/2021
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Intellectual Disability, Developmental Disability, Axis I Diagnosis, Mental Illness, Covid19, Coronavirus
Register for Updates
Translational Research Center for TBI and Stress Disorders: Virtual Assessment of Deployment Trauma and Rehabilitation
NCT04723745
Recruiting
For this clinical demonstration study, Veterans will be assessed with a battery of questionnaires/surveys and a 1:1 clinical interview with a V-TRACTS psychologist to target domains of head injury, psychological trauma, depression, suicidality, anxiety, chronic pain and sleep, substance use and activity level. V-TRACTS will convene a weekly consensus meeting to evaluate all the data, and develop a recommendation plan. After the consensus meeting, a V-TRACTS psychologist will provide comprehensiv... Read More
Gender:
All
Ages:
Between 18 years and 70 years
Trial Updated:
01/20/2021
Locations: VA Boston Healthcare System, Boston, Massachusetts
Conditions: TBI (Traumatic Brain Injury), PTSD
Register for Updates
Proton Craniospinal Irradiation With Bone Sparing to Decrease Growth Decrement From Radiation
NCT03281889
Recruiting
This research study is studying proton radiation as a possible treatment for brain tumor that requires radiation. The radiation involved in this study is: -Proton Radiation
Gender:
All
Ages:
Between 3 years and 18 years
Trial Updated:
01/03/2021
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Brain Tumor
Register for Updates
Phase II Study of Proton Radiation Therapy for Neuroblastoma
NCT02112617
Recruiting
This research study is evaluating a therapy called proton beam radiation therapy (PBRT) as a possible treatment for neuroblastoma. Neuroblastoma most commonly occurs in and around the adrenal glands, which are located at the top of the kidneys. However, it can also occur in other areas where groups of nerve cells exist, such as other areas of the abdomen, neck and near the spine. Conventional radiation therapy with photons is used as standard treatment for many patients with neuroblastic tumor... Read More
Gender:
All
Ages:
Between 6 months and 25 years
Trial Updated:
01/03/2021
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Neuroblastoma, Ganglioneuroblastoma
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A Pilot Study Examining Diet in Primary Sclerosing Cholangitis
NCT04678219
Recruiting
This research study is exploring the effects of dietary intervention in PSC. Study participants will be randomly assigned to either the Specific Carbohydrate Diet (SCD) or a vegan/low-sulfur diet for 8 weeks; the entire study will last approximately 14 weeks. Participants will work with BWH Registered Dieticians and receive dietary educational materials, recipes, and a food procurement stipend to support the new diet. Subjects will attend 7 video visits and have regular lab tests performed, requ... Read More
Gender:
All
Ages:
Between 18 years and 70 years
Trial Updated:
12/16/2020
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Primary Sclerosing Cholangitis
Register for Updates