Massachusetts is currently home to 3368 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Boston, Worcester, Springfield and Burlington. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Transcranial Magnetic Stimulation to Measure Cortical Excitability in Dravet Syndrome
NCT04614506
Recruiting
Dravet syndrome (DS) is an epileptic encephalopathy caused by pathogenic variants in the SCN1A gene resulting in medically refractory epilepsy and psychomotor delays. As a pilot study assessing for feasibility, the investigators aim to test whether alterations in cortical excitatory:inhibitory ratio can be reliably recorded. The investigators will utilize transcranial magnetic stimulation (TMS) metrics of cortical excitatory and inhibitory tone as an initial step towards translating findings fr... Read More
Gender:
All
Ages:
Between 6 months and 30 years
Trial Updated:
03/08/2022
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Dravet Syndrome
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Non Exudative AMD Imaged With SS-OCT- Extension
NCT04469140
Recruiting
The investigators wish to better understand the role of the choriocapillaris (CC) in the formation and progression of non-exudative in age related macular degeneration (armd) by imaging the retinal pigment epithelium (rpe) and the choroidal microvasculature and by studying their inter-dependence to determine if the loss of the CC could prove useful as an anatomic clinical trial endpoint in future drug trials.
Gender:
All
Ages:
All
Trial Updated:
03/08/2022
Locations: New England Eye Center/Tufts Medical Center, Boston, Massachusetts
Conditions: Dry Macular Degeneration
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Effects of Green Light Exposure on Epileptic Spikes in Patients With Refractory Epilepsy
NCT03857074
Recruiting
The purpose of this study is to obtain preliminary data in advance of a larger clinical trial aimed to test whether a single session of green light exposure can lead to a clinically significant reduction in epileptic spikes in patients with medically-refractory epilepsy. As this is a potentially fragile patient population, the study will test safety and tolerability as well as efficacy.
Gender:
All
Ages:
Between 6 months and 30 years
Trial Updated:
03/08/2022
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Epilepsy, Epilepsy Intractable
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Prospective Global Registry for the Study of Chronic Total Occlusion Intervention
NCT02061436
Recruiting
Percutaneous coronary intervention (PCI) of chronic total occlusions (CTOs) is increasingly being performed in patients with advanced coronary artery disease, but there is limited information on the techniques utilized and the procedural outcomes. The goal of this multicenter, investigator initiated registry is to collect information on treatment strategies and outcomes of consecutive patients undergoing CTO PCI among various participating centers. The information collected will be used to deter... Read More
Gender:
All
Ages:
All
Trial Updated:
03/08/2022
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Coronary Artery Disease
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Imaging Histone Deacetylase in the Heart
NCT03549559
Recruiting
The overall goal of this PET-MR imaging trial is to evaluate 11C-Martinostat, a histone deacetylase targeted radioligand, in patients with aortic stenosis, individuals with diabetes, and healthy volunteers.
Gender:
All
Ages:
Between 18 years and 85 years
Trial Updated:
03/01/2022
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Heart Failure With Normal Ejection Fraction, Left Ventricular Hypertrophy, Aortic Valve Stenosis, Diabetes
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Diffusion MRI in Heart Failure
NCT02973633
Recruiting
The development of symptomatic heart failure is frequently preceded by a pre-clinical period of structural remodeling in the heart. The remodeling process driving this transition, however, remains poorly understood. The investigators hypothesize that imaging the diffusion of water in the heart with MRI will allow its microstructure to be resolved. The investigators further hypothesize that the characterization of microstructural changes in the heart will help elucidate the pathogenesis of heart... Read More
Gender:
All
Ages:
Between 18 years and 85 years
Trial Updated:
03/01/2022
Locations: Massachusetts General Hospital, Charlestown, Massachusetts
Conditions: Heart Failure, Myocardial Infarction, Left Ventricular Hypertrophy
Register for Updates
Photobiomodulation to Improve Cognition in TBI, With fMRI
NCT04230577
Recruiting
The purpose of this small, research study is to examine effectiveness of an at-home application of an experimental intervention, on thinking and memory in mild-moderate, closed-head, traumatic brain injury cases. The experimental intervention is light-emitting diode (LED) therapy, which is applied to the scalp and through the nose using a head frame device. Participants are expected to complete two, 5-week series of LED treatments, at home, 3 times a week. There will be a 1-month period between... Read More
Gender:
All
Ages:
Between 18 years and 65 years
Trial Updated:
02/24/2022
Locations: VA Boston Healthcare System, Boston, Massachusetts
Conditions: Traumatic Brain Injury, Closed Head Injury, Cognitive Dysfunction
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Home Hospital for Bariatric Sleeve Gastrectomy
NCT05259111
Recruiting
Providing acute care at home for medicine patients is a well-studied care model. Providing acute care at home immediately following major surgery is less well understood. The investigators seek to demonstrate the noninferiority of care at home versus the hospital for patients undergoing bariatric sleeve gastrectomy.
Gender:
All
Ages:
Between 21 years and 55 years
Trial Updated:
02/18/2022
Locations: Brigham and Women's Faulkner Hospital, Boston, Massachusetts
Conditions: Bariatric Surgery Candidate, Bariatric Sleeve Gastrectomy, Home Hospital
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Osseointegrated Transtibial Prosthesis With Neural Interface
NCT05249049
Recruiting
The e-OPRA Implant System, is a further development of the OPRA (Osseointegrated Prostheses for the Rehabilitation of Amputees) Implant System. The e-OPRA Implant system is an implant system for direct skeletal anchorage of amputation prostheses. The added feature in the e-OPRA Implant system, is a bidirectional interface into the human body that allows permanent and reliable communication using implanted electrodes. These electrodes will provide long-term stable bioelectric signals for an impro... Read More
Gender:
All
Ages:
Between 22 years and 65 years
Trial Updated:
02/18/2022
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Amputation
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Performance of the Dexcom Continuous Glucose Monitoring (CGM) System in Pregnant Women With Diabetes Mellitus
NCT04905628
Recruiting
Performance of the Dexcom Continuous Glucose Monitoring (CGM) System in Pregnant Women With Diabetes Mellitus
Gender:
Female
Ages:
18 years and above
Trial Updated:
02/17/2022
Locations: Joslin Diabetes Center, Boston, Massachusetts
Conditions: Diabetes Mellitus
Register for Updates
Care Transition Intervention for Hospitalized Patients With Advanced Cancer
NCT05142345
Recruiting
This study is examining whether a care transition intervention, CONTINUUM (CONTINUity of care Under Management by video visits), consisting of a supportive care-focused video visit with an oncology nurse practitioner (NP) within three business days of hospital discharge, may improve post-discharge transitions of care for recently hospitalized patients with advanced cancer.
Gender:
All
Ages:
18 years and above
Trial Updated:
02/10/2022
Locations: Massachusetts General Hospital Cancer Center, Boston, Massachusetts
Conditions: Cancer, Follow-Up Care, Consultation, Remote, Advanced Cancer
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Shared-Decision Making for Hydroxyurea
NCT03442114
Recruiting
The goal of the study is to understand how best to help parents of young children with sickle cell disease and their clinicians have a shared discussion about hydroxyurea (one that takes into account medical evidence and parent values and preferences). The study will compare two methods to help clinicians facilitate this-a clinician pocket guide and a clinician hydroxyurea shared decision making toolkit-in a group of parents of children ages 0-5 with sickle cell disease. The investigators hope t... Read More
Gender:
All
Ages:
Between 1 month and 5 years
Trial Updated:
02/09/2022
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Sickle Cell Anemia, Children, Only
Register for Updates