Massachusetts is currently home to 3367 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Boston, Worcester, Springfield and Burlington. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Resiliency Training in Adolescents With NF1 and NF2
Recruiting
This randomized controlled trial for resiliency training in adolescents with Neurofibromatosis 1 and Neurofibromatosis 2 via secure live video to determine the efficacy two stress and symptom management programs. Both programs are 8 week group programs.
Gender:
All
Ages:
Between 12 years and 17 years
Trial Updated:
09/07/2021
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Neurofibromatoses
Management of Esophagitis Following Repair of Esophageal Atresia
Recruiting
The goal of this study is to prospectively evaluate the impact of antacid therapy on esophagitis in children with repaired esophageal atresia. Recent clinical guidelines have attempted to define a systematic approach to the management of these patients with regards to minimizing and treating esophagitis (Krishnan et al 2016), however the quality of evidence supporting many of the recommendations are based on expert opinion or on limited, retrospective studies. Risk factors for esophagitis and op... Read More
Gender:
All
Ages:
Between 30 days and 17 years
Trial Updated:
09/02/2021
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Esophageal Atresia, Esophagitis
GARNET™ Filter (GARNET Device) IDE Used in Chronic Hemodialysis Patients With a Bloodstream Infection
Recruiting
To evaluate the feasibility of performing combined hemodialysis with the GARNET device in chronic hemodialysis patients with a blood stream infection (BSI), and measure clinical performance and safety endpoints.
Gender:
All
Ages:
Between 18 years and 90 years
Trial Updated:
09/01/2021
Locations: Beth Israel Deaconess Medical Center, Boston, Massachusetts
Conditions: Bloodstream Infection
Identification/Characterization of Changes in Microscopic Colitis
Recruiting
The goal of this study is to establish a prospective observational cohort of adult patients with microscopic colitis and collect clinical information and specimens over the course of their treatment. This information will be used in order to establish a patient registry with detailed clinical data and a specimen repository for future research as well as to specifically identify genetic and molecular characteristics associated with microscopic colitis.
Gender:
All
Ages:
18 years and above
Trial Updated:
08/31/2021
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Colitis, Microscopic
taVNS Treatment for Fibromyalgia
Recruiting
In this research study we want to learn more about if transcutaneous electrical nerve stimulation (TENS), a safe electrical stimulation tool, can relieve Fibromyalgia pain. A total of 60 subjects with Fibromyalgia will be enrolled in this study at Massachusetts General Hospital, Charlestown Navy Yard campus.
Gender:
All
Ages:
Between 18 years and 65 years
Trial Updated:
08/30/2021
Locations: Massachusetts General Hospital, Charlestown, Massachusetts
Conditions: Fibromyalgia
Blood Transfusion by Boston MedFlight Registry
Recruiting
The primary aim of this observational registry is to study the outcomes of patients with hemorrhagic shock transported by Boston MedFlight receiving blood products during transport.
Gender:
All
Ages:
18 years and above
Trial Updated:
08/30/2021
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Hemorrhagic Shock
The EndRAD Trial: Eliminating Total Body Irradiation (TBI) for NGS-MRD Negative Children, Adolescents, and Young Adults With B-ALL
Recruiting
This study will evaluate the use of non- TBI (total body irradiation) conditioning for B-ALL patients with low risk of relapse as defined by absence of NGS-MRD (next generation sequencing minimal residual disease) before receiving a hematopoietic cell transplant (HCT). Patients diagnosed with B-ALL who are candidates for HCT will be screened by NGS-MRD on a test of bone marrow done before the HCT. Subjects who are pre-HCT NGS-MRD negative will be eligible to receive a non-TBI conditioning regime... Read More
Gender:
All
Ages:
Between 1 year and 25 years
Trial Updated:
08/20/2021
Locations: Floating Hospital for Children at Tufts Medical Center, Boston, Massachusetts
Conditions: B-cell Acute Lymphoblastic Leukemia
Optimization of Diet Before Surgery (OptiSurg)
Recruiting
The overarching goal of this project is to assess whether a controlled short-term Time restricted feeding (TRF) intervention leads to metabolic benefits, improves recovery after vascular surgery and that TRF is safe. Participants suffering from intermittent claudication (Fontaine stage II peripheral artery disease, PAD) will be randomly assigned to a 2-week TRF or active control dietary advices before open surgical revascularization. Prior to the surgery, the investigators will assess the eating... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
08/02/2021
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Surgery, Time Restricted Feeding
Novel Assessment of Synaptic Density in Progressive MS
Recruiting
The investigators propose to use the novel SV2a-PET ligand, [F-18]SDM-8 to assess synaptic density in progressive MS (including primary progressive multiple sclerosis (PPMS) and secondary progressive multiple sclerosis (SPMS)) as compared to relapsing-remitting multiple sclerosis (RRMS) patients and healthy controls, given its improved imaging characteristics and potential for large scale applicability. The specific aims of the study are: Aim 1: To compare the cortical and subcortical grey mat... Read More
Gender:
All
Ages:
Between 18 years and 60 years
Trial Updated:
07/20/2021
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Primary Progressive Multiple Sclerosis, Secondary Progressive Multiple Sclerosis, Relapsing Multiple Sclerosis, Multiple Sclerosis
Phytochemicals on "Metabolic Aging" in Older Overweight Adults
Recruiting
Aging is a complex and inevitable biological process that is associated with numerous chronic health conditions and the development and progression of diseases. It is manifested partly by a progressive decline in fitness and an increase in death. The key to healthy aging is a healthy lifestyle, including eating a variety of healthy foods and frequently participating in physical activities. Supplements made from widely consumed plant products have the potential for promoting healthy aging. Howeve... Read More
Gender:
All
Ages:
55 years and above
Trial Updated:
07/19/2021
Locations: Jean Mayer USDA Human Nutrition Research Center on Aging, Boston, Massachusetts
Conditions: Mitochondrial Functions
Apple Heart & Movement Study
Recruiting
This study will look for factors that affect heart health and potentially cause deterioration in mobility or heart function. Participant's Apple Watch and iPhone can help researchers gain a better understanding of potential early warning signs. This can lead to new interventions and products that will help millions lead longer, healthier, and more active lives.
Gender:
All
Ages:
18 years and above
Trial Updated:
07/19/2021
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Prevention
iConquerMS™ - A Patient-Powered Research Network for Multiple Sclerosis
Recruiting
iConquerMS™ is a research initiative developed by and for people with multiple sclerosis (MS) to contribute their health data and ideas to advance and accelerate research into MS.
Gender:
All
Ages:
21 years and above
Trial Updated:
07/19/2021
Locations: Accelerated Cure Project, Waltham, Massachusetts
Conditions: Multiple Sclerosis