Massachusetts is currently home to 3366 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Boston, Worcester, Springfield and Burlington. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Slow Heart Registry of Fetal Immune-mediated High Degree Heart Block
Recruiting
Few studies are specifically designed to address health concerns that are already relevant during pregnancy. The consequence is a lack of evidence on best clinical practice. This includes mothers and their babies when pregnancy is complicated by an abnormally slow heart rate due to maternal antibody-mediated heart disease in the unborn baby (fetus). Since the late seventies, it has been possible to detect and monitor fetal disease by ultrasound images and to treat selected conditions with pharma... Read More
Gender:
Female
Ages:
Between 16 years and 50 years
Trial Updated:
06/10/2021
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Heart Block Complete, Heart Block Second Degree
Determinants of Incident Stroke Cognitive Outcomes and Vascular Effects on RecoverY
Recruiting
The overall goal of the DISCOVERY study is to better understand what factors contribute to changes in cognitive (i.e., thinking and memory) abilities in patients who experienced a stroke. The purpose of the study is to help doctors identify patients at risk for dementia (decline in memory, thinking and other mental abilities that significantly affects daily functioning) after their stroke so that future treatments may be developed to improve outcomes in stroke patients. For this study, a "stroke... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
06/03/2021
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Ischemic Stroke, Intracerebral Hemorrhage, Subarachnoid Hemorrhage, Dementia, Vascular, Mild Cognitive Impairment, Vascular Cognitive Impairment
Pilot Study of a Multimodal Prehabilitation Pancreatic Cancer Program
Recruiting
The purpose of this research is to explore the benefits of an exercise and nutrition program during total neoadjuvant therapy (TNT) in preparation for surgery for participants that have pancreatic ductal adenocarcinoma (PDAC)
Gender:
All
Ages:
18 years and above
Trial Updated:
05/13/2021
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Pancreatic Ductal Adenocarcinoma
Sleep Profiles in REM Sleep Behavior Disorder
Recruiting
Rapid eye movement (REM) sleep behavior disorder (RBD) is a sleep disorder in which you act out dreams during REM sleep. Sleep disturbances are very common in RBD, where they negatively impact patients' quality of life and safety. One of the known causes of sleep disturbance is the impairment of the "circadian rhythm", or the human sleep/wake cycle. The purpose of this study is to examine the role of disruption of the circadian rhythm in the development of RBD.
Gender:
All
Ages:
40 years and above
Trial Updated:
05/12/2021
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Rapid Eye Movement Sleep Behavior Disorder
The Role of Naps and Overnight Sleep on Cognitive Learning in Preschoolers
Recruiting
The goal of this research is to understand the role of sleep on memory function in early childhood. Specifically, we seek to examine how promoted naps vs. promoted waking in habitual and non-habitual napping children may impact overnight sleep physiology and subsequent memory consolidation.
Gender:
All
Ages:
Between 33 months and 71 months
Trial Updated:
05/12/2021
Locations: University of Massachusetts, Amherst, Massachusetts
Conditions: Sleep
Physical Rehabilitation of COVID-19 Survivors by Heat Therapy
Recruiting
Older adults and people with underlying medical conditions are at higher risk for developing serious complications related to SARS-CoV-2 resulting in prolonged sequelae. The goal of this proposal is to compare the benefits of home-based lower limb heat therapy to exercise training on cardio-metabolic function and mobility in older adults during their convalescence from hospitalization due to SARS-CoV-2.
Gender:
All
Ages:
Between 55 years and 85 years
Trial Updated:
04/27/2021
Locations: Institute of Applied Life Sciences, Amherst, Massachusetts
Conditions: Covid19, Physical Disability
Alcohol and Sex Risk mHealth-Enhanced Brief Intervention for BLMSM
Recruiting
Randomized controlled pilot trial to test the feasibility and efficacy of a brief intervention with app-based messaging to reduce sexual risk behavior and heavy drinking among Black/African American and Hispanic/Latino MSM.
Gender:
Male
Ages:
Between 21 years and 50 years
Trial Updated:
04/03/2021
Locations: Boston University, Boston, Massachusetts
Conditions: Heavy Drinking and Sexual Risk Behavior
Impact of 'Recovery' Footwear on Lower Extremity Comfort and Biomechanics
Recruiting
The goal of this study is to understand the impact of wearing shoes with a compliant, energy absorbing midsole material, outside of athletic training sessions on the mechanics of movement, performance, and perceived joint pain and stiffness. Advances in material science have led to a wider range of cushioning system material properties and mid and outsole geometries in footwear. While there are many marketing claims about the potential health benefits of this new class of footwear these have not... Read More
Gender:
All
Ages:
Between 18 years and 30 years
Trial Updated:
04/01/2021
Locations: Musculoskeletal & Orthopedic Biomechanics Laboratory/ University of Massachusetts Amherst, Amherst, Massachusetts
Conditions: Arthralgia, Joint Stiffness, Gait Mechanics
Comparison of Quadratus Lumborum Block Types
Recruiting
This study will compare the quality of analgesia and reduction of opioid use, between standard of care and two groups of local anesthetic blocks in different location in the quadratus lumborum plane, for postoperative pain control after lumbar spinal fusion and if it reduces opioid consumption.
Gender:
All
Ages:
Between 40 years and 80 years
Trial Updated:
03/18/2021
Locations: UMASS Memorial Medical Center, Worcester, Massachusetts
Conditions: Pain, Opioid Use, Lumbar Disc Herniation
Cognition and the Immunology of Postoperative Outcomes
Recruiting
This research will test the hypothesis that immune system disequilibrium / dysfunction explains why preoperative cognitive impairment is a strong predictor of postoperative morbidity in older surgical patients. The investigators propose that cognitive impairment influences surgical morbidity because of underlying immune disequilibrium / dysfunction (risk marker) and that this shapes the immune response to surgery and defines immunological hallmarks of postoperative morbidity (disease marker). Th... Read More
Gender:
All
Ages:
65 years and above
Trial Updated:
03/08/2021
Locations: Brigham & Women's Hospital, Boston, Massachusetts
Conditions: Cognitive Impairment, Frail Elderly Syndrome, Delirium, Surgery
Clinical Performance Evaluation of Veye Lung Nodules
Recruiting
Veye Lung Nodules (Aidence B.V., Amsterdam, the Netherlands) is a medical software device that is intended to assist radiologists with pulmonary nodule management on CT chest scans. This clinical trial aims to assess the clinical performance of Veye Lung nodules via a standalone performance evaluation and a reader study.
Gender:
All
Ages:
18 years and above
Trial Updated:
03/08/2021
Locations: Intrinsic Imaging, Boston, Massachusetts
Conditions: Lung; Node
A Phase IB/II Study of Alectinib Combined With Cobimetinib in Advanced ALK-Rearranged (ALK+) NSCLC
Recruiting
This research study is studying a drug combination as a possible treatment for anaplastic lymphoma kinase-positive (ALK+) non-small cell lung cancer. The drugs involved in this study are: Alectinib Cobimetinib
Gender:
All
Ages:
18 years and above
Trial Updated:
03/07/2021
Locations: Massachusetts general Hospital, Boston, Massachusetts
Conditions: Non-small Cell Lung Cancer