Massachusetts is currently home to 3359 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Boston, Worcester, Springfield and Burlington. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Niraparib in Combination With Osimertinib in EGFR-Mutated Advanced Lung Cancer
Recruiting
This research study is studying a combination of drugs as a possible treatment for EGFR-Mutated Advanced Lung Cancer. The names of the study drugs involved in this study are Niraparib and Osimertinib.
Gender:
All
Ages:
18 years and above
Trial Updated:
12/14/2020
Locations: Dana Farber Cancer Institute, Boston, Massachusetts
Conditions: Lung Cancer
Developing a Down Syndrome Health Instrument
Recruiting
Although over 200,000 individuals with DS live in the United States, studies to date have focused on outcomes apart from health. The foundation for this proposal is based on the need to accurately measure health of all individuals - specifically, with DS - and the dearth of available tools for this population. Creating such an instrument will provide a barometer of the current state of health for DS and hold use in future research. In this project, I propose to create an instrument that directly... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
11/10/2020
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Down Syndrome, Health, Subjective
Bone Health in Youth With Type 1 Diabetes
Recruiting
This is an observational study of children and young adults ages 6-20 years with type 1 diabetes and age- and race-matched controls. The investigators will be examining blood and urine hormone levels as well as measures of bone density including DXA and high-resolution peripheral quantitiative computed tomography. The investigators will also be collecting data regarding physical activity via use of wearable accelerometers. The investigators hypothesize that youth with type 1 diabetes will have s... Read More
Gender:
All
Ages:
Between 6 years and 20 years
Trial Updated:
10/07/2020
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Type 1 Diabetes, Osteoporosis
ASTX727 in Recurrent/Progressive Non-enhancing IDH Mutant Gliomas
Recruiting
this research study is evaluating the highest dose of ASTX727 that can be administered safely to recurrent/progressive non-enhancing IDH mutant gliomas patients.
Gender:
All
Ages:
18 years and above
Trial Updated:
09/05/2020
Locations: Massachusetts General Hospital Cancer Center, Boston, Massachusetts
Conditions: Neurological Cancer
Proton or Photon RT for Retroperitoneal Sarcomas
Recruiting
This research study is a Phase I clinical trial. Phase I clinical trials test the safety of an investigational intervention. Phase I studies also try to define the appropriate dose of the investigational therapy to use for further studies. "Investigational" means that the intervention is still being studied and that research doctors are trying to find out more about it. Retroperitoneal sarcomas are soft tissue tumors located at the far back of the abdomen. Typically, patients with retroperitone... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
09/01/2020
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Retroperitoneal Sarcoma
Study on the Compensatory Mechanism of Iodine Nutrition and the Optimal Intake Level of Lactating Women
Recruiting
Due to the lack of direct evidence of optimal iodine intake of Chinese children, pregnant and lactating women and infants were found during the recent revision of Chinese dietary reference intakes (DRIs) of iodine in 2013 by the applicant Pro. Zhang, and no systematical research about compensatory mechanism of iodine nutrition in lactating women was found yet. Previous study funded by United Nations International Children's Emergency Fund (UNICEF) cooperated with the international experts on iod... Read More
Gender:
All
Ages:
Between 1 day and 40 years
Trial Updated:
08/09/2020
Locations: Boston University School of Medicine; Iodine Global Network (IGN), Boston, Massachusetts
Conditions: Nutritional Requirements
Study of Crenolanib vs Midostaurin Following Induction Chemotherapy and Consolidation Therapy in Newly Diagnosed FLT3 Mutated AML
Recruiting
A phase III randomized multi-center study designed to compare the efficacy of crenolanib with that of midostaurin when administered following induction chemotherapy, consolidation chemotherapy and bone marrow transplantation in newly diagnosed AML subjects with FLT3 mutation. About 510 subjects will be randomized in a 1:1 ratio to receive either crenolanib in addition to standard first line treatment of AML (chemotherapy and if eligible, transplantation) (arm A) or midostaurin and standard treat... Read More
Gender:
All
Ages:
Between 18 years and 60 years
Trial Updated:
05/21/2020
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Newly Diagnosed FLT3 Mutated AML
Biocellular-Cellular Regenerative Treatment Scaring Alopecia and Alopecia Areata
Recruiting
The primary objective of this study is to evaluate the safety and efficacy of the use of a biocellular mixture of emulsified adipose-derived tissue stromal vascular fraction (AD-tSVF) and high density platelet-rich plasma concentrate (HD- PRP). Additionally, comparison with clinical outcomes of adipose-derived cellular Stromal Vascular Fraction (AD-cSVF) + AD-tSVF + HD PRP; AD-cSVF + emulsified AD-tSVF + HD- PRP; emulsified AD-tSVF + HD PRP + AD-cSVF; AD-cSVF via intravenous infusion in treatmen... Read More
Gender:
All
Ages:
Between 18 years and 75 years
Trial Updated:
04/15/2020
Locations: Regeneris Medical, North Attleboro, Massachusetts
Conditions: Alopecia Areata, Scarring Alopecia
TMS in Preclinical and Prodromal AD: Modulation of Brain Networks and Memory
Recruiting
The purpose of this study is to assess the effects of non-invasive brain stimulation on memory in cognitively unimpaired older adults and in patients amnestic mild cognitive impairment (aMCI) due to Alzheimer's disease (AD). This study will use repetitive Transcranial Magnetic Stimulation (rTMS) to stimulate nodes of the Default Mode Network (DMN)- which is thought to support episodic memory and to be affected by Alzheimer's pathology. We will use functional connectivity MRI (fcMRI) to assess c... Read More
Gender:
All
Ages:
Between 60 years and 85 years
Trial Updated:
03/11/2020
Locations: Massachuetts General Hospital, Charlestown, Massachusetts
Conditions: Alzheimer Disease, Mild Cognitive Impairment, Aging
Sleep-dependent Learning in Aging
Recruiting
The specific objective of this proposed research is to understand whether deficits in sleep-dependent memory changes reflect age-related changes in sleep, memory, or both. The central hypothesis is that changes in both memory and sleep contribute to age-related changes in sleep-dependent memory processing. To this end, the investigators will investigate changes in learning following intervals of sleep (overnight and nap) and wake in young and older adults.
Gender:
All
Ages:
Between 18 years and 75 years
Trial Updated:
03/11/2019
Locations: University of Massachusetts, Amherst, Massachusetts
Conditions: Sleep
REtroperitoneal SArcoma Registry: an International Prospective Initiative
Recruiting
Surgery is currently the only potentially curative treatment modality for localized retroperitoneal sarcoma (RPS). Available studies regarding oncologic outcomes are mainly retrospective in nature, and RPS are recognized as a rare disease. Therefore, prospective analysis of high quality data is a top priority. Primary Objectives of this study are: to prospectively collect standardized clinical data and radiological and pathological material from primary RPS patients treated with surgery at ref... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
02/11/2019
Locations: Brigham and Women's Hospital/Dana-Farber Cancer Institute, Boston, Massachusetts
Conditions: Retroperitoneal Sarcoma