There are currently 249 active clinical trials seeking participants for Depression research studies. The states with the highest number of trials for Depression participants are California, New York, Florida and Pennsylvania.
E-Mindfulness Approaches for Living After Breast Cancer
NCT06748222
Recruiting
NRG-CC015 is a prospective, randomized phase III clinical trial to evaluate the efficacy of two distinct digital approaches for delivering a mindfulness-based intervention: a live, instructor-led version delivered over Zoom (MAPs LO), and an app-based, self-paced version (MAPs App). Participants will include younger breast cancer survivors (BCS) who were diagnosed with breast cancer at or before age 50 years, have completed their primary cancer treatment (i.e., surgery, radiation, and/or chemoth... Read More
Gender:
ALL
Ages:
Between 18 years and 50 years
Trial Updated:
08/01/2025
Locations: Salinas Valley Memorial, Salinas, California +32 locations
Conditions: Breast Cancer, Depression
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Pilot Effectiveness Trial of an ACT Self-help Workbook Tailored Specifically for Prisons
NCT06162624
Recruiting
The goal of this research study is to adapt an ACT-self-help workbook to the prison setting and determine the feasibility acceptability, and effectiveness of this workbook. Participants can expect to be in the study for 13 weeks.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/01/2025
Locations: University of Wisconsin, Madison, Wisconsin
Conditions: Anxiety, Depression, Depression, Anxiety, Anxiety Disorders
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Mindfulness Engaged Neurostimulation for Depression
NCT06399406
Recruiting
Repetitive Transcranial Magnetic stimulation (rTMS) is an FDA-approved therapy for treatment resistant depression (TRD) that involves brief magnetic stimulation pulses on the dorsolateral prefrontal cortex (DLPFC) brain region. But studies of rTMS alone show remission rates of \~30%. Additionally, rTMS has not been shown to improve cognitive functioning that may be an independent factor predicting treatment success. This study will develop a novel multimodal treatment, which combines intermitten... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
08/01/2025
Locations: University of California San Diego, La Jolla, California
Conditions: Depression, Treatment Resistant Depression, Major Depressive Disorder, Depressive Disorder
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Characterization and Treatment of Adolescent Depression
NCT03388606
Recruiting
This research study seeks to find causes and treatments of depression in teenagers. The study goals are to increase our knowledge of treatments for depression and understand how the brain changes when teenagers have depression. The study will also compare teenagers with depression to those without mental health diagnoses. This outpatient study is recruiting participants ages 11-17 who are depressed. They must have a pediatrician or other medical provider, be medically healthy, and able to perfo... Read More
Gender:
ALL
Ages:
Between 11 years and 25 years
Trial Updated:
07/31/2025
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Depression
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taVNS or TMS or Both for Depression
NCT05725239
Recruiting
The purpose of the research is to test out a combined treatment for depression where the investigators stimulate a nerve in the ear while at the same time stimulate the brain with magnets. These treatments are called transcutaneous (through the skin) auricular (ear) vagus nerve stimulation (taVNS) and transcranial (through the skull) magnetic stimulation (TMS). For participants who already have a cervical VNS device, the investigators will not change their treatment and will use this in place of... Read More
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
07/31/2025
Locations: Medical University of South Carolina Institute of Psychiatry, Charleston, South Carolina
Conditions: Depression
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Evaluation of Patients With Mood and Anxiety Disorders and Healthy Volunteers
NCT00024635
Recruiting
The purpose of this protocol is to allow for the careful screening of patients and healthy volunteers for participation in research protocols in the Experimental Therapeutics and Pathophysiology Lab (ETPB) at the National Institute of Mental Health (NIMH) and for the collection of natural history data. In addition the protocol will allow clinicians to gain more experience in the use of a variety of polysomnographic and high-density EEG recordings. Subjects in this protocol will undergo an evalua... Read More
Gender:
ALL
Ages:
Between 3 years and 99 years
Trial Updated:
07/31/2025
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Depression, Mood Disorders, Anxiety Disorders, Healthy Volunteers, Bipolar Disorder
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Enhancing Transdiagnostic Mechanisms of Cognitive Dyscontrol (R33)
NCT06273527
Recruiting
The proposed project aims to test the cognitive and neural effects of a cognitive training in a sample of individuals seeking treatment for anxiety, depression, or traumatic stress symptoms. Participants will be randomly assigned to one of two groups. Group 1 will receive a computer-based program that is designed as a cognitive training intervention and Group 2 will receive a similar computer-based exercise that researchers think will be less effective in training thinking skills (also known as... Read More
Gender:
ALL
Ages:
Between 21 years and 55 years
Trial Updated:
07/31/2025
Locations: UC San Diego, San Diego, California
Conditions: Anxiety Disorders, Depression, Post Traumatic Stress Disorder
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Neurobiology of Suicide
NCT02543983
Recruiting
Background: There are no good treatments for people considering suicide. Researchers want to study suicide with questions, blood tests, brain imaging, and sleep studies. They hope to better understand suicide, so they can help suicidal people. Objective: To understand what happens in the brain when someone has thought about or attempted suicide. Eligibility: Group 1: Adults ages 18 70 who have thought about or attempted suicide recently Group 2: Adults ages 18 70 who have thought about or... Read More
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
07/31/2025
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Healthy Volunteers, Depression
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Suicide Specific Rumination in Veterans
NCT06481033
Recruiting
Few treatments target core features of suicidal thoughts and behaviors in Veterans. Real-time functional magnetic resonance imaging neurofeedback can provide information regarding brain activation associated with suicide-specific rumination, defined as a "repetitive mental fixation on one's suicidal thoughts and intentions." The goal of this feasibility study is for Veterans to learn strategies for modulating activity within brain regions that have been demonstrated to contribute to the maintena... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
07/30/2025
Locations: James J. Peters VA Medical Center, Bronx, NY, Bronx, New York
Conditions: Depression, Suicide, Mood Disorders
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Type I Hybrid Effectiveness-Implementation Trial of Primary Care Brief Mindfulness Training for Veterans
NCT06162741
Recruiting
The VA wants to understand what type of integrative and whole health approaches are helpful for Veterans. The study is comparing two primary care based mental health treatments, a mindfulness class that teaches mindfulness meditation and a problem-solving class that teaches problem-solving skills and how to build resilience, for Veterans who are experiencing symptoms of anxiety, depression, and/or PTSD. The goal of the study is to understand if the classes reduce symptoms of anxiety, depression,... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/29/2025
Locations: Phoenix VA Health Care System, Phoenix, AZ, Phoenix, Arizona +3 locations
Conditions: Post Traumatic Stress Disorder (PTSD), Depression, Anxiety
Register for Updates
S.T.A.N.D. Alacrity Center Signature Project
NCT05591937
Recruiting
The purpose of this study is to evaluate clinical decision-making algorithms for (a) triaging to level of care and (b) adapting level of care in a low income, highly diverse sample of community college students at East Los Angeles College (ELAC). The target enrollment is 200 participants per year, for five years (N=1000). Participants are between the ages of 18 and 40 years and will be randomized into either symptom severity decision-making (SSD) or data-driven decision-making (DDD). Participan... Read More
Gender:
ALL
Ages:
Between 18 years and 40 years
Trial Updated:
07/29/2025
Locations: East Los Angeles College, Los Angeles, California
Conditions: Depression, Anxiety
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Project 2: Optimizing Engagement and Outcomes in STAND Digital Therapy
NCT05908565
Recruiting
The goal is to optimize peer coaching in order to optimize engagement and outcomes in digital therapy. The unmet mental health needs of community college students are staggering and a growing body of research demonstrates that therapy provided digitally with the assistance of trained community members without advanced degrees in mental health is an effective and scalable way to address these needs. Despite being effective for improving symptoms and functioning in those who engage in it, uptake a... Read More
Gender:
ALL
Ages:
Between 18 years and 40 years
Trial Updated:
07/29/2025
Locations: East Los Angeles College, Los Angeles, California
Conditions: Depression, Anxiety
Register for Updates