There are currently 251 active clinical trials seeking participants for Depression research studies. The states with the highest number of trials for Depression participants are California, New York, Florida and Pennsylvania.
Home-Based Transcranial Direct Current Stimulation (tDCS) for Depression in Multiple Sclerosis (MS)
NCT06901687
Recruiting
This project is a double-blind, sham-controlled, parallel-arm, randomized controlled trial. We will recruit n=170 people living with MS, who are experiencing an episode of depression in the context of a major depressive episode (MDE). Using our remotely supervised (RS) tDCS protocol, enrolled participants will complete 30 days of 30-minute tDCS (2.0, DLPFC left anodal) while listening to mindfulness meditation. Over the course of the study, participants will complete assessments of depression an... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
07/21/2025
Locations: NYU Langone Health, New York, New York
Conditions: Multiple Sclerosis, Depression
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Individualized (fMRI-guided) TMS Treatment for Depression
NCT06266390
Recruiting
The purpose of this study is to investigate the responses of the brain region known as the subgenual anterior cingulate cortex (sgACC) during transcranial magnetic stimulation (TMS) in individuals with depression. Specifically, investigators aim to determine whether the sgACC is engaged when TMS is delivered to specific targets and if the engagement of sgACC changes throughout a full TMS treatment intervention. To achieve this goal, the investigators will employ a combination of TMS and Magnetic... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
07/21/2025
Locations: University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Depression, Major Depressive Disorder, Persistent Depressive Disorder
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Well-being Training for Adolescent Depressive Symptoms (TeenWell Study)
NCT06626425
Recruiting
This study is being done to see if the Healthy Minds Program app helps adolescents with elevated depressive symptoms. Up to 200 participants will be on study for 20 weeks.
Gender:
ALL
Ages:
Between 14 years and 19 years
Trial Updated:
07/21/2025
Locations: Center for Healthy Minds, University of Wisconsin Madison, Madison, Wisconsin
Conditions: Depression
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Telehealth Behavioral Activation for Teens
NCT06273995
Recruiting
Behavioral activation is one such empirically supported intervention. Derived from cognitive-behavioral therapy, a well-established treatment for depression, behavioral activation uses psychoeducation and skill-building to increase an individual's engagement in valued and enjoyable activities (e.g., socializing with family and friends, exercising, participating in a hobby) in order to improve depressive symptoms. Research has shown that behavioral activation is an effective intervention for depr... Read More
Gender:
ALL
Ages:
Between 12 years and 18 years
Trial Updated:
07/18/2025
Locations: Baylor College of Medicine, Houston, Texas
Conditions: Depression, Suicide and Self-harm, Depression in Adolescence, Depression Mild, Depression Moderate, Depression Severe
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A Study to Explore the Effect of SP-624 on Brain Network Analytics in Healthy Adults and Adults With Major Depression
NCT06570369
Recruiting
The main goal of this clinical trial is to learn if the active study drug (code name: SP-624) has any effect on the electrical activity of the brain in adult healthy volunteers and in adults with major depression. Another goal of the study is to learn if SP-624 improves memory and learning in adults with major depression. The study will also provide additional information on the safety of SP-624 and how well it is tolerated in adult healthy volunteers and adults with major depression. Researche... Read More
Gender:
ALL
Ages:
Between 18 years and 60 years
Trial Updated:
07/18/2025
Locations: CenExel CNS, Garden Grove, California +1 locations
Conditions: Major Depressive Disorder, Depression, Healthy
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Equity Using Interventions for Pain and Depression
NCT06500780
Recruiting
This project is part of the NIH Helping to End Addiction Long-term (HEAL) initiative (https://heal.nih.gov/). This randomized controlled trial (RCT) is phase 2 of a two-phase, 5-year project with the overarching goal of testing a decision aid (DA)/coaching intervention, tailored to Black patients with comorbid chronic pain and depression, to encourage use of and adherence to nonpharmacological pain treatments (NPTs). This 2-arm trial will randomize 304 patients with comorbid chronic musculoskel... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/17/2025
Locations: Eskenazi Health Primary Care, Indianapolis, Indiana
Conditions: Chronic Pain, Musculoskeletal Pain, Depression, Health Equity
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The Neural Underpinnings of Depression and Cannabis Use in Young People Living With HIV
NCT05453513
Recruiting
To elucidate mechanisms of substance use disorders (SUD) and comorbid mental illnesses in people living with HIV (PLWH), the study team seeks to investigate reward and pain circuitry in cannabis use and depression comorbidity, two highly prevalent conditions in PLWH. The study team proposes a tightly integrative study to test the overall hypothesis that cannabis use and depression in young PLWH have an additive effect, inducing both reward deficits and pain hypersensitivity, and that this patter... Read More
Gender:
ALL
Ages:
Between 18 years and 59 years
Trial Updated:
07/17/2025
Locations: University of Miami, Miami, Florida
Conditions: Hiv, Depression, Cannabis Use Disorder
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Treatment Research Investigating Depression Effects on Neuroimmune Targets (TRIDENT)
NCT05136703
Recruiting
The purpose of this randomized controlled trial is to understand how a cognitive-behavioral treatment (a form of psychological treatment) for depression changes the gut microbiome (micro-organisms that regulate the health of the gut), immune system, and the brain functioning in people living with HIV.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/16/2025
Locations: University of Miami Neuroimaging Facility, Coral Gables, Florida +1 locations
Conditions: Depression, HIV-1-infection, Inflammation
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Characterization and Treatment of Adolescent Depression
NCT03388606
Recruiting
This research study seeks to find causes and treatments of depression in teenagers. The study goals are to increase our knowledge of treatments for depression and understand how the brain changes when teenagers have depression. The study will also compare teenagers with depression to those without mental health diagnoses. This outpatient study is recruiting participants ages 11-17 who are depressed. They must have a pediatrician or other medical provider, be medically healthy, and able to perfo... Read More
Gender:
ALL
Ages:
Between 11 years and 25 years
Trial Updated:
07/16/2025
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Depression
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Developing Resilience and Anxiety Management Through the Arts
NCT07033052
Recruiting
The Developing Resilience and Anxiety Management Through the Arts (DRAMA) Study examines the degree to which the arts can help to address stress, anxiety, and sad mood in children and adolescents. The researchers will pair theatrical improvisation exercises with cognitive-behavioral therapy (CBT) techniques versus improvisation exercises alone versus a social craft group on reducing elevated levels of anxiety and depression.
Gender:
ALL
Ages:
Between 8 years and 17 years
Trial Updated:
07/16/2025
Locations: Case Western Reserve University, Cleveland, Ohio
Conditions: Anxiety, Depression, Mood
Register for Updates
Amplification of Positivity for Alcohol Use
NCT06030154
Recruiting
The proposed study consists of two phases. During Phase 1, the investigators will recruit a small sample of participants to complete a psychosocial intervention termed Amplification of Positivity (AMP) for individuals experiencing comorbid depression or anxiety disorders and alcohol use disorder (AMP-A). These participants will be asked to provide both qualitative and quantitative input about the AMP-A intervention. Based on their input and clinician input, the AMP-A manual will be modified for... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
07/15/2025
Locations: Laureate Institute for Brain Research, Tulsa, Oklahoma
Conditions: Alcohol Use Disorder, Anxiety, Depression
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A Study to Assess Change in Disease Activity and Adverse Events (AEs) With Cariprazine in the Treatment of Depressive Episodes in Pediatric Participants Participants (10 to 17 Years of Age) With Bipolar I Disorder.
NCT04777357
Recruiting
Bipolar disorder is a severe chronic mood disorder that affects up to 4% of the adult population and 1.8% of the pediatric population in the United States. The treatment of the depressive episodes of bipolar disorder in the pediatric population has not been as widely studied as the treatment of depressive episodes in bipolar disorder in adults, therefore pharmacotherapeutic options are limited. Given the change in disease state and safety demonstrated in adults with depressive episodes associate... Read More
Gender:
ALL
Ages:
Between 10 years and 17 years
Trial Updated:
07/14/2025
Locations: Pillar Clinical Research /ID# 226504, Bentonville, Arkansas +70 locations
Conditions: Depression, Bipolar I Disorder
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