There are currently 253 active clinical trials seeking participants for Depression research studies. The states with the highest number of trials for Depression participants are California, New York, Florida and Texas.
Incorporating Positive Affect Promoting Activities Into Cognitive Behavioral Therapies
NCT06432959
Recruiting
In this study, the investigators will test whether the incorporation of positive affect promoting activities in treatment sessions improves outcomes in the context of CBT for depression and DBT for problems of emotion dysregulation. In clinics focused on each of these treatments, the investigators will evaluate these treatments with and without the addition of positive affect promoting activities.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/24/2024
Locations: Department of Psychology, The Ohio State University, Columbus, Ohio
Conditions: Depression, Borderline Personality Disorder, Emotion Regulation
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Ketogenic Intervention in Depression
NCT06080932
Recruiting
The goal of this study is to examine whether a well-formulated ketogenic diet (KD) can be implemented into a university counseling treatment program for major depression and to test whether such a program has any benefit on mental and metabolic health.
Gender:
ALL
Ages:
Between 18 years and 30 years
Trial Updated:
04/01/2024
Locations: The Ohio State University, Columbus, Ohio
Conditions: Depression, Ketosis
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Positive Processes and Transition to Health - Single-Session (PATH-SS)
NCT06900712
Recruiting
The goal of this clinical trial is to test a brief, new psychotherapy (called Positive Processes and Transition to Health - Single Session, or PATH-SS) that aims to provide relief for people who are suffering after experiencing a sexual assault. This research will explore whether this new psychotherapy reduces sexual assault related distress, including posttraumatic stress and depression symptoms. The main questions it aims to answer are: Does PATH-SS leads to improvements in PTSD and depressio... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
03/22/2025
Locations: Case Western Reserve University, Cleveland, Ohio
Conditions: PTSD, Depression
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TEAM-Red, a Remotely Delivered Self-management Program for Depressed Black Women at Risk for Hypertension
NCT05488782
Recruiting
The proposed project is a 24-week prospective randomized controlled trial (RCT) evaluating the effects of TargEted MAnageMent Intervention (TEAM, N=41) vs. enhanced waitlist (eWL, N=41) control in young (\<50 years) African American women who are depressed or suffering from stress, and at risk for hypertension.
Gender:
FEMALE
Ages:
Between 18 years and 49 years
Trial Updated:
10/04/2024
Locations: University Hospitals Cleveland Medical Center, Cleveland, Ohio
Conditions: Depression
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Determining Optimal Treatment Sequences in Anxious Depression (DOTS-AD)
NCT04245748
Recruiting
Acute, double-blind, adaptively randomized treatment with duloxetine or escitalopram, followed by double-blind, randomized adjunctive treatment with clonazepam or pregabalin for persistent symptoms.
Gender:
ALL
Ages:
Between 18 years and 50 years
Trial Updated:
08/28/2024
Locations: University of Cincinnati, Department of Psychiatry & Behavioral Neuroscience, Cincinnati, Ohio
Conditions: Anxious Depression, Depression
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Lithium Effects on the Brain's Functional and Structural Connectome in the Treatment of Bipolar Disorder
NCT03336918
Recruiting
Lithium is highly effective in the treatment of bipolar disorder. This study aims to investigate, for the first time, the impact of lithium monotherapy on the structural and functional connectivity of the brain using MRI imaging.
Gender:
ALL
Ages:
Between 18 years and 60 years
Trial Updated:
04/05/2024
Locations: Cleveland Clinic Foundation Center for Behavioral Health, Cleveland, Ohio
Conditions: Bipolar Disorder, Bipolar I Depression, Bipolar II Depression, Bipolar Depression, Depression, Major Depressive Episode
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CAMPUS Expanded "Classification and Assessment of Mental Health Performance Using Semantics Expanded"
NCT04493736
Recruiting
Open enrollment study to collect data for the optimization of machine learning models for use in an app for the early detection of mental health and suicidal risk.
Gender:
ALL
Ages:
Between 8 years and 75 years
Trial Updated:
02/05/2024
Locations: Clarigent Health, Mason, Ohio
Conditions: Suicide, Suicidal, Suicide, Attempted, Suicidal Ideation, Depression, Anxiety, Aggression, Trauma, Psychological
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Probiotic Administration for Adolescent Depression
NCT06898788
Recruiting
This double-blind, placebo-controlled clinical trial will examine the effect of probiotic Visbiome on the brain and gut microbiome of individuals 15 to 24 years of age.
Gender:
ALL
Ages:
Between 15 years and 24 years
Trial Updated:
05/05/2025
Locations: UCSF, San Francisco, California
Conditions: Depression
Register for Updates
RXWell to Decrease Post-Operative Opioid Use in Total Knee or Hip Arthroplasty
NCT05658796
Recruiting
It is envisioned that multipronged benefits from this pilot work for the UPMC ISD and its members. It is expected the RxWell platform to provide the following benefits: expansion of the use of RxWell to all UPMC ISD members providing peri-operative mood management with advantage of improved peri-operative outcomes, improving saving for the UPMC ISD by hastening the recovery and decreased resource utilization, and addition to the high-value care of UPMC with this holistic approach to patient peri... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/05/2025
Locations: UPMC East, Monroeville, Pennsylvania +2 locations
Conditions: Mood Disorders, Anxiety, Depressive Symptoms, Depression, Anxiety Disorders, Anxiety Depression
Register for Updates
Self-Compassion for Children and Caregivers
NCT05818397
Recruiting
The Self-Compassion for Children and Caregivers Study aims to understand if an online course designed to help kids and their caregivers learn self-compassion is feasible, enjoyable, and helpful for well-being and relationships in families from diverse backgrounds. Children ages 8-11 who have a caregiver willing to participate with them will: * Attend 2 in-person study visits (about 1-1.5 hour each) that includes * A survey for caregiver and child * A brief computer puzzle challengetask whi... Read More
Gender:
ALL
Ages:
Between 8 years and 11 years
Trial Updated:
05/05/2025
Locations: University of Wisconsin, Madison, Wisconsin
Conditions: Anxiety, Depression
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Expanding First-line Options for Depression and Matching Treatments to Patients: Hatha Yoga vs. Behavioral Therapy
NCT05546697
Recruiting
This is a parallel group study design. The investigators propose to compare an online, synchronous group-based yoga intervention developed for individuals with depression to an online, synchronous individualized, evidence-based behavioral therapy for depression, or Brief Behavioral Activation Treatment for Depression (BA). This study is a multi-site randomized trial of adults with clinically significant depressive symptoms. Participants (N=518) will be randomized in an equal allocation ratio (i.... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/05/2025
Locations: Giuliana Chau, Boston, Massachusetts
Conditions: Depression
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Resilience in Adolescent Development
NCT03458936
Recruiting
RAD is a 10-year natural history, longitudinal, prospective assessment study of a cohort of 2,500 participants (ages 10-24 years) that will help uncover the socio-demographic, lifestyle, clinical, psychological, and neurobiological factors that contribute to resilience among children, adolescents, and young adults at-risk for mood and anxiety disorders. As this is an exploratory study, we will assess a comprehensive panel of carefully selected participant specific parameters, including socio-dem... Read More
Gender:
ALL
Ages:
Between 10 years and 24 years
Trial Updated:
05/04/2025
Locations: UT Southwestern Medical Center, Dallas, Texas
Conditions: Risk Assessment, Resilience, Psychological, Depression, Mood Disorders, Anxiety Disorders, Mental Health
Register for Updates