California is currently home to 5602 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
A Prospective, US-based Study Assessing Mogamulizumab-associated Rash in Patients Diagnosed With Mycosis Fungoides or Sezary Syndrome and Treated With Standard of Care Mogamulizumab
Recruiting
This study is being done to assess mogamulizumab-associated rash in patients diagnosed with mycosis fungoides or sezary syndrome and treated with standard of care mogamulizumab. One of the most common side effects of mogamulizumab is a rash, currently named mogamulizumab-associated rash (MAR) which can look like MF or SS. However, mogamulizumab-associated rash (MAR) does not indicate failure of mogamulizumab, and may be a sign that the drug is working. If not properly evaluated, mogamulizumab-as... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/02/2025
Locations: City of Hope Medical Center, Duarte, California
Conditions: Recurrent Mycosis Fungoides, Recurrent Sezary Syndrome, Refractory Mycosis Fungoides, Refractory Sezary Syndrome, Stage IB Mycosis Fungoides and Sezary Syndrome AJCC v8, Stage IIA Mycosis Fungoides and Sezary Syndrome AJCC v8, Stage IIB Mycosis Fungoides and Sezary Syndrome AJCC v8, Stage III Mycosis Fungoides and Sezary Syndrome AJCC v8, Stage IV Mycosis Fungoides and Sezary Syndrome AJCC v8
A Study of ZL-1310 in Participants With Selected Solid Tumors
Recruiting
A Phase Ib/II, Open-label, Multi-center Study of ZL-1310 in Participants With Selected Solid Tumors
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/02/2025
Locations: Zai Lab Site 2001, San Francisco, California
Conditions: Solid Tumors
Motor Outcomes to Validate Evaluations in Pediatric FSHD (MOVE Peds)
Recruiting
The primary goal of this study is to validate motor and functional outcomes and refine clinical trial strategies for pediatric-onset FSHD
Gender:
ALL
Ages:
Between 5 years and 17 years
Trial Updated:
06/02/2025
Locations: Stanford University, Palo Alto, California
Conditions: Muscular Dystrophy, Facioscapulohumeral
Effectiveness of Brief Intervention in Primary Care for Diverse Young People (Chat)
Recruiting
Brief motivational interviewing intervention to address alcohol use among diverse teens 12-17.
Gender:
ALL
Ages:
Between 12 years and 17 years
Trial Updated:
06/02/2025
Locations: AltaMed Health Services, Commerce, California
Conditions: Adolescent Drinking, Cannabis Use
Assessing Improvements in Mood and Sleep Trial
Recruiting
This is a multi-site randomized control trial involving people age 55+ years who have current depression symptoms plus another suicide risk indicator (either current suicidal ideation or a past history of attempt). Our goal is evaluate which of two different approaches works best to improve things like trouble sleeping, bad moods, and any suicidality. Participants will complete diagnostic interviews, self-report scales, and wear an actigraphy device for the 8 weeks starting at the baseline visi... Read More
Gender:
ALL
Ages:
55 years and above
Trial Updated:
06/02/2025
Locations: The Regents of the University of California, Los Angeles, Los Angeles, California
Conditions: Depression, Suicidality, Sleep
Study to Assess the Efficacy of Rina-S Compared to Treatment of Investigator's Choice in Participants With Platinum Resistant Ovarian Cancer
Recruiting
This phase 3 study will be conducted in different countries all over the world. The purpose of this study is to compare how well Rina-S works against platinum-resistant ovarian cancer compared to chemotherapy drugs that are already approved and used for platinum-resistant ovarian cancer. Treatment in this study could be Rina-S or it could be 1 of 4 indicated chemotherapy agents that are considered standard medical care. There is an equal (50:50) chance of getting Rina-S or an approved chemothe... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
06/02/2025
Locations: Providence Saint Joseph Medical Center - Roy and Patricia Disney Family Cancer Center, Burbank, California
Conditions: Platinum-resistant Ovarian Cancer
Study to Evaluate the Safety and Efficacy of CSB-001 Ophthalmic Solution 0.1% in Subjects With Limbal Stem Cell Deficiency
Recruiting
This study will enroll subjects with qualifying limbal stem cell deficiency (LSCD). All subjects will receive CSB-001 investigational drug in either one or both study eyes. The study is comprised of two identical phases (Dosing Phase I and II) of test article dosing separated by a 31- to 40-day period, the Dosing Holiday, where no test article is administered. Dosing Phase II is followed by an observational, noninterventional phase (Observation Phase).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/02/2025
Locations: Loma Linda University Eye Institute, Loma Linda, California
Conditions: Limbal Stem Cell Deficiency
Integrating CHWs Into Prenatal Care for Maternal Smoking Cessation
Recruiting
This develops a novel behavioral tobacco cessation program for pregnant smokers in San Bernardino County.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
06/02/2025
Locations: Loma Linda University Medical Center, Loma Linda, California
Conditions: Tobacco Use, Tobacco Use Cessation, Tobacco Use in Childbirth
The Effects of Fresh Mango Consumption on Cardiometabolic Outcomes in Free-living Individuals With Prediabetes
Recruiting
The goal of this clinical trial is to test the effect of 12 weeks of 1.5 cups per day of fresh mango on glucose control, insulin resistance, lipids, inflammation, oxidation and body composition in individuals with prediabetes. The main questions it aims to answer are: * What is the effect of 1.5 cups per day of fresh mango over 12 weeks on indicators of glycemic control including fasting glucose and HgbA1c? * What is the effect of 1.5 cups per day of fresh mango over 12 weeks on fasting blood i... Read More
Gender:
ALL
Ages:
Between 40 years and 60 years
Trial Updated:
06/02/2025
Locations: Nutrition Research Center, School of Public Health, Loma Linda University, Loma Linda, California
Conditions: Hyperglycemia, Dyslipidemias, Insulin Resistance, Inflammation, Oxidative Stress
Pasireotide s.c. in Patients With Post-Bariatric Hypoglycaemia
Recruiting
The Total duration of trial participation for each participant with post-bariatric hypoglycemia will be a maximum of 59 weeks, with the following duration of trial periods * 19 weeks for the Core Phase. It is composed of: * a Screening period: a maximum of 3 weeks * a Run-in period (no treatment): 4 weeks * a Blinded Treatment Phase: 12 weeks * 36 weeks Extension Phase = an open-label Treatment period * 4 weeks for the safety follow-up period (without any treatment).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/02/2025
Locations: Stanford University School of Medicine, Endocrinology, 800 Welch Road,, Palo Alto, California
Conditions: Post-Bariatric Hypoglycemia
Study of Apalutamide With Carotuximab in Metastatic, Castration-Resistant Prostate Cancer
Recruiting
This is an open-label, multi-site study of apalutamide with carotuximab in patients who have progressed on androgen receptor signaling inhibitor (ARSI) therapy. This study will begin with a safety assessment in the first 10 subjects (part 1: Safety Lead-in). If the combination is deemed safe, the trial will proceed to the Phase II stage. The purpose of this study is to compare progression free survival (PFS) between patients receiving apalutamide and apalutamide + carotuximab using Response Eval... Read More
Gender:
MALE
Ages:
18 years and above
Trial Updated:
06/02/2025
Locations: City of Hope, Duarte, California
Conditions: Castration-resistant Prostate Cancer
Study of Vorasidenib and Pembrolizumab Combination in Recurrent or Progressive IDH-1 Mutant Glioma
Recruiting
Vorasidenib in combination with pembrolizumab in participants with recurrent or progressive isocitrate dehydrogenase-1 (IDH-1) mutant Glioma.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/02/2025
Locations: University of California, Los Angeles (Site: 840113), Los Angeles, California
Conditions: Astrocytoma, Oligodendroglioma