California is currently home to 5617 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Gene Modified Immune Cells (IL13Ralpha2 CAR T Cells) After Conditioning Regimen for the Treatment of Stage IIIC or IV Melanoma or Metastatic Solid Tumors
Recruiting
This phase I trial studies the side effects and best dose of modified immune cells (IL13Ralpha2 CAR T cells) after a chemotherapy conditioning regimen for the treatment of patients with stage IIIC or IV melanoma or solid tumors that have spread to other places in the body (metastatic). The study agent is called IL13Ralpha2 CAR T cells. T cells are a special type of white blood cell (immune cells) that have the ability to kill tumor cells. The T cells are obtained from the patient's own blood, gr... Read More
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
03/26/2025
Locations: UCLA / Jonsson Comprehensive Cancer Center, Los Angeles, California
Conditions: Metastatic Melanoma, Metastatic Malignant Solid Neoplasm, Pathologic Stage IIIC Cutaneous Melanoma AJCC v8, Pathologic Stage IV Cutaneous Melanoma AJCC v8, Recurrent Malignant Solid Neoplasm, Refractory Malignant Solid Neoplasm, Uveal Melanoma, Acral Melanoma, Neuroendocrine Tumors, Paraganglioma, Pheochromocytoma, Adrenocortical Carcinoma, Pancreatic Neuroendocrine Tumor, Thyroid Cancer, Breast Cancer, Lung Adenocarcinoma, Head and Neck Squamous Cell Carcinoma
Effects of Watermelon Consumption on Satiety and Digestive Health
Recruiting
The objective of the proposed research is to determine the effects of watermelon (fruit and rind blenderized) on satiety, metabolic markers, bowel habits, microbiome and weight management in children and adults
Gender:
ALL
Ages:
Between 10 years and 55 years
Trial Updated:
03/26/2025
Locations: School of Exercise and Nutritional Sciences, SDSU, San Diego, California
Conditions: Satiety
Effects of Fresh Mango Pulp Consumption on Satiety and Cardiometabolic Health
Recruiting
The objective of the study is to determine the effects of fresh mango pulp consumption on satiety and metabolic parameters in overweight/obese adults.
Gender:
ALL
Ages:
Between 18 years and 55 years
Trial Updated:
03/26/2025
Locations: School of Exercise and Nutritional Sciences, SDSU, San Diego, California
Conditions: Satiety
Effects of Snack Types on Acute Glucose and Insulin Response
Recruiting
The purpose of the present study was to determine the effects of different type of snack consumption on postprandial satiety, glucose, insulin, antioxidant capacity and anxiety in healthy subjects.
Gender:
ALL
Ages:
Between 18 years and 55 years
Trial Updated:
03/26/2025
Locations: School of Exercise and Nutritional Sciences, SDSU, San Diego, California
Conditions: Satiety
Regional Blocks for Lateral Condyle Fractures
Recruiting
The purpose of this study is to investigate the post-operative pain control in pediatric patients with closed lateral condyle fractures who undergo open reduction and percutaneous pinning. Patients will be randomized into one of two groups. Group 1 will receive an infraclavicular nerve block to the affected extremity by a fellowship trained pediatric anesthesiologist prior to surgery. Group 2 will undergo the Orthopaedic Institute of Children's (OIC) standard preoperative protocol. Post-operativ... Read More
Gender:
ALL
Ages:
Between 4 years and 12 years
Trial Updated:
03/26/2025
Locations: Orthopaedic Institute for Children, Los Angeles, California
Conditions: Fractures, Closed, Humeral Fractures, Pain
Supracondylar Post-Operative Pain Study
Recruiting
The purpose of this study to investigate post-operative pain control in pediatric patients with closed supracondylar humerus fracture who undergo closed reduction and percutaneous pinning. Currently, it is standard of care that patients receive a narcotic prescription for post-operative pain control. All patients will initially be seen in our pediatric urgent care and recruited at the time of surgery. Patients will be randomized to receiving acetaminophen and ibuprofen or acetaminophen and oxyco... Read More
Gender:
ALL
Ages:
Between 5 years and 12 years
Trial Updated:
03/26/2025
Locations: Orthopaedic Institute for Children, Los Angeles, California
Conditions: Supracondylar Humerus Fracture
TAP Blocks With Ropivacaine Continuous Infusion Catheters vs Single Dose Liposomal Bupivicaine After Kidney Transplant
Recruiting
This study is a comparison of the analgesic efficacy of transversus abdominis plane (TAP) blocks with ropivacaine bolus plus continuous ropivacaine infusion via catheters versus single shot TAP blocks with liposomal bupivacaine.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/26/2025
Locations: University of California Davis, Sacramento, California
Conditions: Transplant;Failure,Kidney, Pain, Postoperative
Effects of Fresh Watermelon Consumption on Satiety and Cardiometabolic Health
Recruiting
The goal of the proposed study is to determine the effects of fresh watermelon fruit consumption on satiety, metabolic parameters and weight management.
Gender:
ALL
Ages:
Between 18 years and 55 years
Trial Updated:
03/26/2025
Locations: Exercise and Nutritional Sciences, SDSU, San Diego, California
Conditions: Satiety
Effects of Watermelon Juice on Heart Rate Recovery and Post-exercise Muscle Soreness
Recruiting
The purpose of this study was to determine the effects of a pre-exercise, single practical dose of watermelon juice, Gatorade, sugar water or water on heart rate recovery, blood lactate levels, and 24-hour post exercise muscle soreness.
Gender:
ALL
Ages:
Between 21 years and 50 years
Trial Updated:
03/26/2025
Locations: Exercise and Nutritional Sciences, SDSU, San Diego, California
Conditions: Heart Rate Recovery
Effects of Mixed Nut Consumption on Satiety and Weight Management
Recruiting
The first goal of the proposed study is to determine acute and long-term effects of mixed nuts (almonds, hazelnuts, pecans, pistachios, walnuts, and peanuts) on metabolic parameters and weight management. While numerous studies have shown the beneficial effects of nuts on promoting negative energy balance and weight loss, mechanistic studies exploring how the inclusion of nuts in the diet promotes a negative energy balance and weight loss have not been conducted. The second goal is to determine... Read More
Gender:
ALL
Ages:
Between 18 years and 55 years
Trial Updated:
03/26/2025
Locations: School of Exercise and Nutritional Sciences, SDSU, San Diego, California
Conditions: Satiety
Bio-Repository of High Risk Cohorts for the Early Detection of Pancreas Cancer
Recruiting
Bio-repository to collect bio-specimens from patients with 1) pancreatic cysts and 2) patients at high risk, defined by family history and/or genetic mutations, for pancreatic cancer.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/26/2025
Locations: Stanford University, Stanford, California
Conditions: Pancreatic Cyst, Pancreas Disease
Microbiome Sampling During Endurance Exercise
Recruiting
The small intestine and feces of subjects undergoing endurance exercise will be sampled to examine their microbiome composition
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
03/25/2025
Locations: Stanford University, Stanford, California
Conditions: Healthy, Exercise-Induced Lactic Acidemia