California is currently home to 5615 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Remimazolam for Cataract Surgery
Recruiting
The goal of this study is to assess any post operative cognitive changes following benzodiazepine administration during cataract surgery. The investigators will compare effects of Midazolam vs. Remimazolam on cognition at the time of discharge from the post operative care unit and the next day following surgery. Cognitive changes will be assessed by administration of Montreal Cognitive Assessment (MoCA). Participants will: 1. Complete MoCA testing prior to surgery 2. Randomize in either Midaz... Read More
Gender:
ALL
Ages:
65 years and above
Trial Updated:
03/17/2025
Locations: Ronald Reagan UCLA Medical Center, Department of Anesthesiology & Perioperative Medicine, Los Angeles, California
Conditions: Cataract Surgery, Cognitive Impairment
Lupus Landmark Study: A Prospective Registry and Biorepository
Recruiting
The purpose of the registry and biorepository is to provide a mechanism to store clinical data, linked biospecimens and molecular data to support the conduct of future research on Systemic Lupus Erythematosus (SLE), including Lupus Nephritis (LN).
Gender:
ALL
Ages:
Between 18 years and 110 years
Trial Updated:
03/17/2025
Locations: Wallace Rheumatic Studies Center, Beverly Hills, California
Conditions: Systemic Lupus Erythematosus (SLE), Lupus Nephritis, Neuropsychiatric Systemic Lupus Erythematosus
Assessment of Biomarker-Guided CNI Substitution In Kidney Transplantation
Recruiting
800 adult first time kidney transplant recipients will be enrolled in the Observational Study and followed to evaluate their Human Leukocyte Antigen (HLA)-DR/DQ molecular mismatch (mMM) score as a risk-stratifying prognostic biomarker. Six months after transplant the study will identify those who meet the eligibility criteria for the Nested Randomized Control Trial (RCT). 300 eligible subjects will be randomized 2:1 to abatacept or Standard of care (SOC) in the randomization and followed for 18... Read More
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
03/17/2025
Locations: Cedars Sinai Medical Center: Transplantation, Los Angeles, California
Conditions: Kidney Transplant
Glofitamab With Obinutuzumab, Venetoclax, and Lenalidomide for the Treatment of Patients With Newly Diagnosed High Risk Mantle Cell Lymphoma
Recruiting
This phase I/II trial tests the safety and effectiveness of glofitamab (with obinutuzumab pretreatment), venetoclax, and lenalidomide in treating patients with newly diagnosed, high risk mantle cell lymphoma. Glofitamab and obinutuzumab are monoclonal antibodies that may interfere with the ability of cancer cells to grow and spread. Venetoclax is in a class of medications called B-cell lymphoma-2 (BCL-2) inhibitors. It may stop the growth of cancer cells by blocking Bcl-2, a protein needed for c... Read More
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
03/17/2025
Locations: City of Hope Medical Center, Duarte, California
Conditions: Blastoid Variant Mantle Cell Lymphoma, Mantle Cell Lymphoma, Pleomorphic Variant Mantle Cell Lymphoma
A Clinical Study to Assess the Efficacy and Safety of Leriglitazone in Adult Male Subjects With Cerebral Adrenoleukodystrophy
Recruiting
A Clinical Study to Assess the Efficacy and Safety of Leriglitazone in Adults Male Subjects with Cerebral Adrenoleukodystrophy.
Gender:
MALE
Ages:
18 years and above
Trial Updated:
03/17/2025
Locations: Stanford University Medical Center, Palo Alto, California
Conditions: Cerebral Adrenoleukodystrophy (cALD)
Metabolic Mechanisms Induced by Enteral DHA and ARA Supplementation in Preterm Infants
Recruiting
A comprehensive analysis of the impact of exogenous enteral DHA and ARA supplementation on lipid metabolism including the production of downstream derived mediators and how this impacts important biological pathways such as metabolism, inflammation, and organogenic factors.
Gender:
ALL
Ages:
36 weeks and below
Trial Updated:
03/17/2025
Locations: University of California, Los Angeles (UCLA), Los Angeles, California
Conditions: Premature
Psilocybin Therapy for Chronic Low Back Pain
Recruiting
This study evaluates whether psilocybin therapy helps patients cope with chronic low back pain more effectively. Patients may be recruited at Stanford and University of California San Francisco (UCSF), study procedures will occur at UCSF. Each participant will receive a dose of psilocybin with possibly one or more other drugs. Participants will undergo two preparation sessions, a dosing session, three integration sessions to discuss their psilocybin experience, and several follow up sessions.
Gender:
ALL
Ages:
Between 25 years and 70 years
Trial Updated:
03/17/2025
Locations: University of California San Francisco, San Francisco, California
Conditions: Chronic Low-back Pain
Biomarker-guided rTMS for Treatment Resistant Depression
Recruiting
Repetitive transcranial magnetic stimulation (rTMS) is a treatment for depression. The investigators are continuing to learn how to optimize outcomes from rTMS treatment. The purpose of this research project is to use brain network connectivity patterns as measured by resting state functional magnetic resonance imaging (fMRI) to confirm a way to optimize the use of rTMS to treat depression. In addition, the study aims to gain a better understanding of how rTMS influences brain networks.
Gender:
ALL
Ages:
Between 22 years and 65 years
Trial Updated:
03/17/2025
Locations: Stanford University, Stanford, California
Conditions: Treatment Resistant Depression, Major Depressive Disorder
Medtronic Deep Brain Stimulation (DBS) Therapy for Epilepsy Post-Approval Study (EPAS)
Recruiting
The purpose of this post-approval study is to further evaluate the long-term safety and effectiveness of Medtronic DBS therapy for epilepsy on seizure reduction in newly implanted participants through 3 years of follow-up.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/17/2025
Locations: University of California Los Angeles (UCLA), Los Angeles, California
Conditions: Epilepsy
International Pediatric Adrenocortical Tumor Registry
Recruiting
This study aims to collect demographic and medical information including detailed family history of cancer of children and adolescents with adrenocortical tumors in order to learn more about the clinical and epidemiological aspects, treatment modalities, and outcome of patients with this rare disease, worldwide. In addition, investigators at St. Jude Children's Research Hospital (SJCRH) plan to perform molecular studies of tumor cells aimed to clarify the role of the TP53 gene and other genetic... Read More
Gender:
ALL
Ages:
21 years and below
Trial Updated:
03/17/2025
Locations: Stanford University, Stanford, California
Conditions: Adrenocortical Tumor
Comparative Effectiveness Trial of Two Supportive Cancer Care Delivery Models for Adults With Cancer
Recruiting
This cluster-randomized comparative effectiveness trial compares a technology-based supportive cancer care (SCC) approach with a redesigned team-based supportive cancer care (SCC) approach.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/15/2025
Locations: Beckman Research Institute of City of Hope, Duarte, California
Conditions: End of Life, Cancer
Observe Change in Nasal Swab DRD2 Gene Expression in Restless Legs Syndrome (RLS) Patients on Prolonged Dopamine Agonist Treatment
Recruiting
The study aims to observe changes in dopaminergic genes expression in peripheral tissue upon prolonged dopamine agonist treatment on patients with Restless Legs Syndrome (RLS). Similar studies in Parkinson's disease have shown changes in alpha-synuclein expression, which might offer insights into the dopaminergic gene regulation seen in RLS. The dopamine agonist drugs to be included in this study are: Pramipexole (Mirapex), Ropinirole (Requip), Rotigotine (Neupro), Apomorphine (Apokyn), Bromocri... Read More
Gender:
ALL
Ages:
Between 18 years and 60 years
Trial Updated:
03/14/2025
Locations: Alethios Inc, San Francisco, California
Conditions: Restless Leg Syndrome (RLS)