California is currently home to 5592 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
A Study of Selinexor Monotherapy in Subjects with JAK Inhibitor-naïve Myelofibrosis and Moderate Thrombocytopenia
Recruiting
The main purpose of this study with corresponding optional expansion is to evaluate the efficacy of selinexor in JAKi-naïve participants with myelofibrosis (MF) and moderate thrombocytopenia based on spleen volume reduction (SVR). Additional efficacy and safety parameters will also be assessed during the study.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/03/2025
Locations: City of Hope - Duarte Main Site, Duarte, California
Conditions: Myelofibrosis, Moderate Thrombocytopenia
Resilience Programming for Occupational Therapy Students
Recruiting
The purpose of this study is to explore the effectiveness of integrated health and resiliency programs into the Entry-Level Doctor of Occupational therapy curriculum. The objectives are to: 1. Determine if students perceive health and resiliency programming as beneficial for their health and well-being 2. Determine if students' lifestyle behaviors, self-esteem, attachment security, and mindfulness improve with health and resiliency programming 3. Determine if students' symptoms of depression a... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
02/03/2025
Locations: Loma Linda Universtiy, Loma Linda, California
Conditions: Health and Wellbeing of Occupational Therapy Students
SELUTION 4 De Novo Small Vessel IDE Trial
Recruiting
Prospective, randomized controlled, single-blind, multicenter, clinical trial to demonstrate the safety and efficacy of the SELUTION SLR 014 PTCA DEB for treatment of de novo lesions in small coronary vessels, defined as reference vessel diameter (RVD) of 2.00 mm to 2.75 mm, in support of a pre-market approval (PMA) application to the United States (US) FDA. The Study will enroll up to 910 randomized subjects, up to 30 subjects in a parallel angiographic substudy, and up to 20 subjects in a par... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/03/2025
Locations: HCA Los Robles, Thousand Oaks, California
Conditions: Coronary Artery Disease
Incomplete Cervical SCI Without Instability
Recruiting
A multicenter, international, prospective, observational case series patient cohort with incomplete cervical SCI without instability will be enrolled to obtain information and data that could inform the feasibility of administering a set of additional core and optional outcome assessments in cervical SCI patients to capture the aspects of neurologic impairment. Baseline, intraoperative, and postoperative characteristics, including demographics, injury details, treatment details, neurological ass... Read More
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
02/03/2025
Locations: San Francisco General Hospital, San Francisco, California
Conditions: Cervical Spinal Cord Injury
Interleukin-6 Receptor Inhibitor Sarilumab in Combination With Ipilimumab, Nivolumab and Relatlimab in Patients With Unresectable Stage III or Stage IV Melanoma
Recruiting
The study will evaluate how safe the study drug is, how well you tolerate it, and how it works in the body and the disease's response to the drug. The study drug being tested is sarilumab, when given with the combination of ipilimumab, nivolumab, and relatlimab in patients with stage III or stage IV melanoma that cannot be removed by surgery. Previous studies have provided a strong rationale for combining sarilumab, with ipilimumab, nivolumab and relatlimab in metastatic melanoma to reduce side... Read More
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
02/03/2025
Locations: The Angeles Clinic at Cedars Sinai, Los Angeles, California
Conditions: Melanoma, Unresectable Melanoma
Limited Ankle Dorsiflexion and Effect on Single Limb Squats in Individuals With Patellofemoral Pain
Recruiting
The purpose of this graduate student research study is to investigate the relationship between limited ankle dorsiflexion and the potential effects on a single limb squat task in the Patellofemoral/Knee Pain population.
Gender:
FEMALE
Ages:
Between 18 years and 59 years
Trial Updated:
02/03/2025
Locations: Loma Linda University, Loma Linda, California
Conditions: Patellofemoral Pain
Prostate Assessment with Restriction Spectrum Imaging (RSI) MRI
Recruiting
This single-center study will enroll 40 male participants to complete 2 diffusion magnetic resonance images within 30 days of each other.
Gender:
MALE
Ages:
18 years and above
Trial Updated:
02/03/2025
Locations: UCSD Moores Cancer Center, La Jolla, California
Conditions: Prostate Cancer
A Study to Evaluate the Benefits and Risks of Conversion of Existing Adolescent Kidney Transplant Recipients Aged 12 to <18 Years to a Belatacept-based Immunosuppressive Regimen as Compared to Continuation of a Calcineurin Inhibitor-based Regimen, and Their Adherence to Immunosuppressive Medications
Recruiting
The purpose of this study is to evaluate the benefits and risks of conversion of existing adolescent kidney allograft recipients aged 12 to less than 18 years of age to a belatacept-based immunosuppressive regimen as compared to continuation of a calcineurin inhibitor-based regimen and their adherence to immunosuppressive medications.
Gender:
ALL
Ages:
Between 12 years and 17 years
Trial Updated:
02/03/2025
Locations: Local Institution - 0041, Los Angeles, California
Conditions: Renal Allograft Recipients
BI-1808 As a Single Agent and with Pembrolizumab (KEYTRUDA® ) in Treatment of Advanced Malignancies(Keynote-D20)
Recruiting
The goal of this first in human clinical trial is to test BI-1808 administered as single agent and in combination with pembrolizumab in subjects with advanced malignancies whose disease has progressed after standard therapy. The main questions it aims to answer are: * how safe and tolerable is BI-1808 * what is maximum tolerated or administrated dose * to determine recommended dose for further clinical trials. Participants will receive infusions of BI-1808 alone or combination with pembrolizum... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/03/2025
Locations: City of Hope National Medical Center, Duarte, California
Conditions: Advanced Malignancies, Ovarian Cancer, T-cell Lymphoma, Melanoma
Study of Selinexor in Combination with Ruxolitinib in Myelofibrosis
Recruiting
This is a global, multicenter, 2-part study to evaluate the efficacy and safety of selinexor plus ruxolitinib in JAK inhibitor (JAKi) treatment-naïve myelofibrosis (MF) participants. The study will be conducted in two phases: Phase 1 (open-label) and Phase 3 (double-blind). Phase 1 (enrollment completed) was an open-label evaluation of the safety and recommended Phase 2 dose (RP2D) of selinexor in combination with ruxolitinib and included a dose escalation using a standard 3+3 design (Phase 1a)... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/03/2025
Locations: UCLA - Satellite Site, Beverly Hills, California
Conditions: Myelofibrosis
Fluoroscopy Radiation Reduction During Sacral Neuromodulation Lead Placement
Recruiting
Fluoroscopy is performed when placing a lead during a sacral neuromodulation procedure. During lead placement, subjects will receive either conventional or experimental fluoroscopic settings. The radiation exposure will be compared between the two groups.
Gender:
ALL
Ages:
Between 18 years and 89 years
Trial Updated:
02/03/2025
Locations: Loma Linda University Health, Loma Linda, California
Conditions: Radiation Exposure, Overactive Bladder, Urge Incontinence, Urgency-frequency Syndrome
Reaching for Equity in Sleep Apnea Treatment (REST) Study
Recruiting
This study will test a brief telephonic health coaching intervention to improve adherence to positive airway pressure therapy for treatment of obstructive sleep apnea.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/03/2025
Locations: Zuckerberg San Francisco General Hospital Sleep Clinic, San Francisco, California
Conditions: Sleep Apnea