California is currently home to 5602 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Use of Acthar in Rheumatoid Arthritis (RA) Related Flares
NCT02541955
Recruiting
This is a Rheumatoid Arthritis (RA) study. The purpose of this research study is to determine in RA flare, whether musculoskeletal ultrasound (MSUS) inflammatory scores and/or disease activity scores improve with Acthar treatment.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/28/2025
Locations: UCLA David Geffen School of Medicine, Division of Rheumatology, Los Angeles, California
Conditions: Rheumatoid Arthritis (RA)
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Better Breaks: Strength Breaks vs Walk Breaks for Sedentary Behavior Breaks
NCT06909097
Recruiting
This study investigates the benefits of two different types of 2 minute activity breaks during sedentary workdays for people who sit for long periods of time in sedentary jobs.
Gender:
ALL
Ages:
30 years and above
Trial Updated:
03/27/2025
Locations: Stanford Prevention Research Center, Palo Alto, California
Conditions: Sedentary Employees
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North American Comfilcon A Clinical Study
NCT06902584
Recruiting
The main objective of this study is to demonstrate acceptable safety and effectiveness (performance) of comfilcon A Sphere, Toric, Multifocal, Toric Multifocal and Energys lenses, when used in the general population.
Gender:
ALL
Ages:
Between 8 years and 75 years
Trial Updated:
03/27/2025
Locations: University of Berkeley, Berkeley, California
Conditions: Astigmatism, Presbyopia, Ametropia
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TTVR STRONG Under Coverage With Evidence Development (CED) Study
NCT06833476
Recruiting
This Coverage with Evidence Development (CED) study measures the long-term health outcomes of patients with severe, symptomatic Tricuspid Regurgitation who received a Transcatheter Tricuspid Valve Replacement procedure using the EVOQUE system.
Gender:
ALL
Ages:
65 years and above
Trial Updated:
03/27/2025
Locations: Edwards Lifesciences, Irvine, California
Conditions: Tricuspid Regurgitation
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Pilot Feasibility Trial of HEALthy Beginnings for Middle-Aged, and Older Homeless Women
NCT06743685
Recruiting
This is a mixed methods pilot feasibility trial of HEALthy Beginnings, an innovative, nurse-driven intervention. Middle-aged and older, homeless women (MAO-HW) will participate in the HEALthy Beginnings intervention and select MAO-HW will be invited to participate in post-intervention qualitative focus groups to evaluate the program.
Gender:
FEMALE
Ages:
40 years and above
Trial Updated:
03/27/2025
Locations: Downtown Women's Center, Los Angeles, California
Conditions: Homelessness, Health Promotion, Chronic Disease Self-care, Multimorbidity, Unhoused
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Chronobiological Basis of Menopausal Depression: Correcting Misaligned Circadian Rhythms With Sleep and Light Interventions
NCT06678880
Recruiting
The goal of this clinical trial is to learn more about mood, sleep, and activity during menopause. The main question it aims to answer is: can mood and sleep dysfunction in menopause be improved by resetting misaligned circadian rhythm through one night of strategic sleep timing adjustment and two weeks of exposure to bright light at a certain time of day? Researchers will compare sleep timing (earlier vs. later) and bright white light exposure (morning or evening) to investigate the effect of m... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
03/27/2025
Locations: University of California San Diego Hillcrest Medical Center, San Diego, California
Conditions: Depression, Depression During the Menopausal Transition, Menopausal Depression
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Targeting Minority Stressors to Improve Eating Disorder Symptoms in Sexual Minority Individuals With Eating Disorders
NCT06565637
Recruiting
The goal of this clinical trial is to learn if a new intervention (Promoting Resilience to Improve Disordered Eating; PRIDE) can decrease internalized stigma and increase the ability to cope effectively with stressors in sexual minority populations diagnosed with eating disorders. The main question it aims to answer is: Will an eating disorders treatment focused on decreasing internalized stigma and increasing sexual minority stress coping self efficacy in sexual minority populations? Participa... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
03/27/2025
Locations: San Diego State University, San Diego, California
Conditions: Eating Disorders, Sexual Minorities
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Massive Transfusion in Children-2: A Trial Examining Life Threatening Hemorrhage in Children
NCT06070350
Recruiting
The MATIC-2 is a multicenter clinical trial enrolling children who are less than 18 years of age with hemorrhagic shock potentially needing significant blood transfusion. The primary objective of the clinical trial is to determine the effectiveness of Low Titer Group O Whole Blood (LTOWB) compared to component therapy (CT), and Tranexamic Acid (TXA) compared to placebo in decreasing 24-hour all-cause mortality in children with traumatic life threatening hemorrhage.
Gender:
ALL
Ages:
17 years and below
Trial Updated:
03/27/2025
Locations: University of California Davis, Sacramento, California
Conditions: Hemorrhagic Shock, Trauma Injury
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CANF-Comb-II PET-MR in Atherosclerosis Multisite
NCT05838547
Recruiting
The goal of this observational study is to learn more about plaque biology in asymptomatic carotid artery stenosis (ACAS) patients through imaging. The main questions it aims to answer are: * To determine the ability of 64Cu-CANF-Comb positron emission tomography (PET) to risk stratify ACAS patients for stroke event, to include transient ischemic attack or remote ipsilateral intervention. * To further understand the role of Natriuretic Peptide Receptor C (NPRC) in the evolution of carotid ather... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/27/2025
Locations: Cedars Sinai Medical Center, Los Angeles, California
Conditions: Carotid Atherosclerosis, Asymptomatic Carotid Artery Stenosis, Carotid Artery Atheroma
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Trial to Evaluate the Safety and Effectiveness of Treatment With COMS One Device in Subjects With Diabetic Foot Ulcers
NCT05758545
Recruiting
The purpose of this clinical trial is to evaluate the safety and effectiveness of the treatment with the COMS One device in subjects with refractory diabetic foot ulcers (DFUs). The prospective randomized, double-blinded, sham-controlled trial is designed to demonstrate superiority of wound closure of the COMS One device to a sham-control device through 24 weeks post-application, when each is administered in conjunction with standard of care (SOC) in the treatment of DFUs.
Gender:
ALL
Ages:
Between 22 years and 90 years
Trial Updated:
03/27/2025
Locations: Center for Clinical Research Inc., Castro Valley, California
Conditions: Diabetic Foot Ulcer
Register for Updates
Aesthetic Outcome of Tie-over Bolster Application in Surgical Wounds
NCT05758168
Recruiting
When patients have surgery on the head and face, stitches are the standard way to close the wound. Wounds always result in a scar, but doctors are always looking for ways to reduce scarring. Several studies have been done to test ways to close wounds that reduce scarring. One idea is to reduce the tension around the cut. One way to reduce tension is to stitch a small piece of a special gauze over the top of the regular stitches. This procedure is called a "tie-over bolster dressing." As the name... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/27/2025
Locations: University of California, Davis - Dermatology Department, Sacramento, California
Conditions: Scarring
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Family, Responsibility, Education, Support, and Health for Families With a Child With Autism
NCT05741840
Recruiting
The objective of this proposed study is to collect initial efficacy data on a telehealth parent-based behavioral program for children with autism and overweight or obesity (PBT-A), compared with health education (HE).
Gender:
ALL
Ages:
Between 6 years and 12 years
Trial Updated:
03/27/2025
Locations: UC San Diego Center for Healthy Eating and Activity Research (CHEAR), La Jolla, California
Conditions: Autism Spectrum Disorder, Obesity, Childhood, Autism
Register for Updates