California is currently home to 5592 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Study Assessing CLENPIQ As Bowel Preparation for Pediatric Colonoscopy
Recruiting
Bowel preparation for pediatric colonoscopy.
Gender:
ALL
Ages:
Between 2 years and 8 years
Trial Updated:
02/03/2025
Locations: Ferring Investigational Site, San Diego, California
Conditions: Bowel Preparation
Assessing Neurocognition After Cerebrovascular Intervention
Recruiting
Decreased blood flow to the brain can cause decreased cognitive function. Carotid disease can result in decreased blood flow to the brain. The investigators seek to assess this relationship prospectively through performing a battery of neurocognitive assessments, collection of serum markers of inflammation, and through neuroimaging at two points before intervention (2 months and 1 month before stenting) and at two points after intervention (1 month and 2 months after intervention). The goal is t... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/03/2025
Locations: UCSD Medical Center, San Diego, California
Conditions: Carotid Artery Diseases, Neurocognitive Dysfunction
Safety and Feasibility Study of Autologous Engineered Urethral Constructs for the Treatment of Strictures
Recruiting
This is a Phase I clinical study to determine the safety and efficacy of using autologous, engineered urethral constructs for the treatment of urethral strictures in adult males. The proposed study design is a prospective non-randomized and uncontrolled single-center investigation. Autologous urothelial cells (UCs) and smooth muscle cells (SMCs), obtained from enrolled male subjects' bladder tissue samples, will be culture expanded in vitro and used to seed tubular PGA scaffolds to create autol... Read More
Gender:
MALE
Ages:
Between 21 years and 75 years
Trial Updated:
02/03/2025
Locations: University of California San Francisco, San Francisco, California
Conditions: Urologic Diseases, Male Urogenital Diseases, Urethral Stricture, Urethral Injury
Study for Participants Continuing From Pfizer-sponsored Palbociclib (a Study Medicine) Studies
Recruiting
The purpose of this clinical trial is to provide study medicine(s) and learn about their safety. This study is seeking participants who: * Have benefited from ongoing study treatment as determined by the study doctor in a Pfizer-sponsored palbociclib Parent Study * Must agree to follow the reproductive criteria * Are willing and able to comply with all scheduled visits, treatment plans, and other study procedures * Can give signed informed consent documents Participants in this study will cont... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/02/2025
Locations: UCSF Medical Center at Mission Bay, San Francisco, California
Conditions: Breast Cancer, Head and Neck Cancer
Study to Test the Safety and Tolerability of PF-07220060 in Participants With Advance Solid Tumors
Recruiting
This is a Phase 1/2A, open label, multicenter, nonrandomized, multiple dose, safety, tolerability, pharmacokinetic and pharmacodynamic study of PF-07220060 administered as a single agent and then in combination with endocrine therapy. The study consists of two parts and a China and Japan monotherapy cohort. Part 1 includes dose escalation cohorts evaluating PF-07220060 as single agent or in combination with endocrine therapy or enzalutamide, as well as a food effect cohort and a DDI cohort Part... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/02/2025
Locations: Ellison Institute, Los Angeles, California
Conditions: Liposarcoma, Prostate Cancer, Breast Neoplasms, Adenocarcinoma of Lung
Shorter Versus Extended Course of Antibiotic Therapy for Necrotizing Soft Tissue Infections
Recruiting
Necrotizing soft tissue infection (NSTI) is a devastating disease that results in a high rate of in-hospital complications and despite advances in critical care, wound care, and early intervention, NSTI continues to be associated with a mortality rate of nearly 30%. The antibiotics used in this treatment are Clindamycin, Vancomycin, Piperacillin Tazobactam; these antibiotics may be administered combined or individually, based on individualized patient treatment. Although one of the tenets of man... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/01/2025
Locations: University of California Irvine Medical Center, Orange, California
Conditions: Necrotizing Soft Tissue Infection
Mediators and Moderators of Auditory Training
Recruiting
The goal of this clinical trial is to learn how Auditory Training (AT) may help people better understand speech in noisy environments. As people get older, it becomes harder for them to hear speech clearly when there is background noise. This can be frustrating, and it can affect their independence and quality of life. AT is often used to support people with and without hearing loss, especially when a person is not a good candidate for a hearing aid or when amplification from a hearing aid does... Read More
Gender:
ALL
Ages:
Between 18 years and 85 years
Trial Updated:
01/31/2025
Locations: University of California, Riverside, Riverside, California
Conditions: Hearing Handicap
Augmented Reality BCI Longitudinal Study for Persons with Late Stage ALS
Recruiting
The goal of this study is refine the usability of a BCI based communication platform. The study will take place in the greater Los Angeles area and will enroll up to 10 participants with late stage ALS. Each subject will receive a Cognixion Axon-R augmented reality brain computer interface and associated communication software. The study duration is 3 months for each participant. The key questions that will be addressed in this study are: 1. How quickly can participants learn and gain confide... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/31/2025
Locations: Cognixion, Santa Barbara, California
Conditions: ALS (Amyotrophic Lateral Sclerosis)
PS230005 Control-IQ 1.5 Post-Approval Study
Recruiting
This 522 post-market surveillance study is a single-arm, decentralized prospective observational cohort study designed to collect safety data on Control-IQ technology v1.5 in children with type 1 diabetes ages 2 to \<6 years old. Participants will use Control-IQ technology v1.5 for 12 months in the real-world setting.
Gender:
ALL
Ages:
Between 2 years and 5 years
Trial Updated:
01/31/2025
Locations: Tandem Diabetes Care, San Diego, California
Conditions: Type 1 Diabetes
Median Versus Ulnar Nerve Quantitative Electromyography Neuromuscular Blockade Monitoring Comparison
Recruiting
Medications used to relax the muscles are used during surgery. The amount of muscle relaxation can monitored with devices that stimulate a specific nerve and evaluate the muscle response. The response to, and recovery from, medications that relax the muscles are best described for a nerve in the arm called the ulnar nerve. The investigators believe that other nerves in the arm, such as the median nerve, could be used to monitor the amount of muscle relaxation. The purpose of this study is to com... Read More
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
01/31/2025
Locations: Loma Linda University Troesch Medical Center, Loma Linda, California
Conditions: Neuromuscular Blockade
Immersive Mixed Reality Simulation to Evoke Empathy
Recruiting
This is a quantifiable study evaluating the ability of a mixed reality (MR), immersive simulation experience to evoke empathy in anesthesiology trainees. Quantitative methodologies will be employed using standardized questionnaires including the The Jefferson Scale of Physician Empathy for Health Professions Students, (HP-version). Trainees will assess their preliminary, baseline empathy using the Jefferson Scale and after the simulation and debrief, will reassess empathy scores, once again usin... Read More
Gender:
ALL
Ages:
Between 18 years and 99 years
Trial Updated:
01/31/2025
Locations: Lucile Packard Children's Hospital Stanford, Palo Alto, California
Conditions: Educational Problems
Dose Escalation Trial of Safety, Pharmacokinetic/Pharmacodynamic and Preliminary Clinical Activity of Briquilimab in Adult Patients with Chronic Spontaneous Urticaria (CSU)
Recruiting
This trial will be performed as a three-part dose escalating clinical trial where Parts 1 is open label and Parts 2 and 3 are randomized, double-blinded, and placebo-controlled. The trial is intended to determine the safety and tolerability and assess the preliminary efficacy of briquilimab in adult participants with chronic spontaneous urticaria (CSU), who remain symptomatic despite treatment with H1 antihistamines and omalizumab. Additionally, pharmacokinetic (PK) properties of briquilimab, a... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/31/2025
Locations: Site 117, Fremont, California
Conditions: Chronic Spontaneous Urticaria