California is currently home to 5600 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Opioid Rapid Response System: Naloxone Training in Communities
Recruiting
The pervasive impact of the opioid epidemic has touched all layers of society for the past two decades, resulting in over 115 deaths daily and imposing annual costs of $78.5 billion. Responding swiftly to overdoses, akin to various medical emergencies, poses a significant challenge, particularly in geographically dispersed rural areas and densely populated urban settings. Effectively delivering the life-saving drug naloxone, which counteracts the effects of overdoses, necessitates a well-coordin... Read More
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
11/20/2024
Locations: Ewald & Wasserman Research Consultants, LLC, San Francisco, California
Conditions: Opioid Overdose
A Study of HC-7366 in Combination With Belzutifan (WELIREG™) in Patients With Renal Cell Carcinoma
Recruiting
This is a Phase 1b, open-label, multicenter, safety, tolerability and efficacy study of HC-7366 in combination with belzutifan (WELIREG™). This is a multipart study that consists of a HC-7366 monotherapy cohort, a combination dose escalation, and a combination dose expansion. Approximately 80 patients will be enrolled in this study (up to 20 patients will be enrolled into the HC-7366 monotherapy cohort, up to 30 patients into the combination dose escalation, and up to 30 patients into the combin... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/20/2024
Locations: University of California San Diego Moores Cancer Center, La Jolla, California
Conditions: Renal Cell Carcinoma
SLC13A5 Deficiency Natural History Study - United States Only
Recruiting
SLC13A5 deficiency (Citrate Transporter Disorder, EIEE 25) is a rare genetic disorder with neurodevelopmental delays and seizure onset in the first few days of life. This natural history study is designed to address the lack of understanding of disease progression. Additionally it will identify clinical and biomarker endpoints for use in future clinical trials.
Gender:
ALL
Ages:
All
Trial Updated:
11/20/2024
Locations: Lucille Packard Children's Hospital, Stanford University, Palo Alto, California
Conditions: Citrate Transporter Deficiency, Epilepsy, Rare Diseases, Movement Disorders, Genetic Disorder, SLC13A5 Deficiency, EIEE25, Kohlschutter-Tonz Syndrome (Non-ROGDI), Citrate Transporter Disorder, DEE25
Improving Overactive Bladder Treatment Access and Adherence
Recruiting
Overactive bladder (OAB) and urinary incontinence (UI) are chronic debilitating and embarrassing conditions that affect 33 million Americans. Yet, both are underdiagnosed and undertreated with significant financial and health-related consequences. OAB syndrome is characterized by urinary urgency, with and without urinary incontinence, urinary frequency, and nocturia. Evidence-based treatments are available, including behavioral therapy, pharmacotherapy, and minimally invasive procedures. Diagnos... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
11/20/2024
Locations: Stanford Pelvic Health Center, Redwood City, California
Conditions: Overactive Bladder Syndrome, Urinary Incontinence
Efficacy of Ra-223 in PSMA PET Optimally Selected Patients
Recruiting
This phase II trial studies how well prostate-specific membrane antigen (PSMA) positron emission tomography (PET) scans (in combination with bone scans) work in selecting patients for Ra-223 radiation therapy that have castration-resistant prostate cancer that has spread from where it first started (primary site) to the bones (bone metastasis). Ra-223 is a type of therapy that emits radiation. Radiation gives off energy which can kill tumor cells and other cells that may support the tumor cells.... Read More
Gender:
MALE
Ages:
18 years and above
Trial Updated:
11/20/2024
Locations: University of California, San Francisco, San Francisco, California
Conditions: Castration-Resistant Prostate Carcinoma, Metastatic Malignant Neoplasm in the Bone, Stage IVB Prostate Cancer AJCC v8
Randomized Trial for cLBP (Gokhale Project)
Recruiting
The study aims to compare the effectiveness of the Gokhale Method posture therapy for low back pain (LBP) management to standard physical therapy (PT) with posture training. The second aim of this study is to evaluate usability and user adherence of the online/digital intervention through the Gokhale Method Foundation Class (online delivery with smartphone App). The investigator hopes to learn: The effectiveness of the Gokhale Method posture therapy for low back pain management, in comparison... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
11/20/2024
Locations: Outpatient Surgery Center/Stanford Spine Clinic, Redwood City, California
Conditions: Lower Back Pain Chronic
Comparing Operative vs Non Operative Treatment for Pilonidal Disease
Recruiting
The goal is to evaluate whether surgical excision of the pilonidal disease is needed after resolution of the initial symptoms when the patient follows regular hair removal regimen such as laser epilation.
Gender:
ALL
Ages:
8 years and above
Trial Updated:
11/20/2024
Locations: Stanford University School of Medicine, Palo Alto, California
Conditions: Pilonidal Disease
Treatment of Adult Traumatic Rib Fractures With Percutaneous Cryoneurolysis
Recruiting
The purpose of this research study is to examine the effectiveness of using the Iovera Smart Time 190, for ultrasound-guided cryoneurolysis, in trauma patients 18-64 years old with rib fractures that are not candidates for surgical stabilization. This will offer patients the benefits of cryoneurolysis of the intercostal nerves, thereby providing short and long term pain control while their ribs heal. The Iovera Smart Tip 190 is FDA approved for cryoneurolysis.
Gender:
ALL
Ages:
Between 18 years and 64 years
Trial Updated:
11/20/2024
Locations: Stanford Hospital and Clinics, Palo Alto, California
Conditions: Rib Fractures
A Study of Amivantamab in People with Esophagogastric Cancer
Recruiting
The purpose of this study is to see whether the study drug, amivantamab, is an effective treatment for people with EGFR- or MET-amplified esophagogastric cancer. The researchers will also look at whether amivantamab is a safe treatment that causes few or mild side effects in participants.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/20/2024
Locations: University of California, Irvine, Irvine, California
Conditions: Esophagogastric Cancer
Decreasing Emergence Agitation With Personalized Music
Recruiting
The purpose of the study is to assess the impact of personalized music on emergence agitation (EA), as measured by Pediatric Anesthesia Emergence Delirium scores in pediatric patients recovering from elective procedures under general anesthesia. Personalized music may help to decrease EA in children undergoing elective surgeries under general anesthesia by decreasing perioperative anxiety and minimizing perceived pain. The study has the potential to improve perioperative care by improving safet... Read More
Gender:
ALL
Ages:
Between 3 years and 9 years
Trial Updated:
11/20/2024
Locations: Stanford University, Stanford, California
Conditions: Surgical Procedure, Unspecified
Diagnostic and Prognostic Biomarkers for High-impact Chronic Pain: Development and Validation
Recruiting
To identify diagnostic and prognostic biomarker signatures of recovery versus having persisting high-impact chronic pain and functional disability in adults with Chronic Musculoskeletal Pain.
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
11/20/2024
Locations: Stanford University, Palo Alto, California
Conditions: Chronic Musculoskeletal Pain, Pain, Pain, Chronic, Joint Pain
tDCS and Cognitive Training in Active Duty Service Members With Mild TBI: A Pilot Study
Recruiting
The proposed study will evaluate a new approach to cognitive rehabilitation of mild traumatic brain injury (mTBI) using a brain stimulation technique called transcranial direct current stimulation (tDCS). Specifically, we will investigate how tDCS combined with cognitive training improves deficits to attention and working memory in Active Duty Service Members with a history of mild traumatic brain injury (TBI). Measures of attention-related brain activity, neurocognitive assessments, and self-re... Read More
Gender:
ALL
Ages:
Between 18 years and 55 years
Trial Updated:
11/20/2024
Locations: Naval Medical Center San Diego, San Diego, California
Conditions: Brain Concussion, Brain Trauma, Attention Concentration Difficulty, Brain Injuries, Brain Injuries, Traumatic, Neurocognitive Dysfunction, Attention Impaired, Memory Impairment, Mild Traumatic Brain Injury, Mild Cognitive Impairment