California is currently home to 5602 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
One Up, One Down: Analyzing Patient Preference on Cryotherapy Machine Tubing Placement
Recruiting
The purpose of this research study is to better understand patient preference and their satisfaction rates with cryotherapy machines based on the direction of the tubing. This study will evaluate both satisfaction and pain of patients who use the cryotherapy machines in the two groups: tubing facing towards the head, and the other with tubing facing toward the feet.
Gender:
ALL
Ages:
Between 10 years and 18 years
Trial Updated:
03/11/2025
Locations: Children's Hospital of Orange County, Orange, California
Conditions: Cryotherapy Tubing Placement
Fiber and Calcium Absorption in Older Men
Recruiting
Osteoporotic fractures are a major but underrecognized problem in men. There is growing evidence that low dietary fiber intake is a modifiable risk factor for age-related bone loss in men. Preclinical and human studies in adolescents and postmenopausal women suggest that dietary fiber intake influences bone metabolism by modulating the gut microbiome to augment intestinal calcium absorption, but it is unclear through what molecular mechanism and whether dietary fiber has the same effects in olde... Read More
Gender:
MALE
Ages:
60 years and above
Trial Updated:
03/11/2025
Locations: San Francisco VA Medical Center, San Francisco, CA, San Francisco, California
Conditions: Aging
A Study of CBX 12 in Subjects With Platinum Resistant or Refractory Ovarian Cancer
Recruiting
The purpose of this study is to assess the safety, tolerability, and efficacy of CBX-12 in female subjects with platinum resistant or refractory ovarian cancer at 2 doses; 125 mg/m2 every 21 days or 100 mg/m2 every 21 days.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
03/11/2025
Locations: Usc Norris Comprehensive Cancer Center, Los Angeles, California
Conditions: Platinum-resistant Ovarian Cancer, Refractory Ovarian Carcinoma
Photobiomodulation for Lower Back Pain Post Spinal Fusion and Decompression Surgery
Recruiting
After spinal fusion and decompression surgery there is a possible risk of developing chronic back pain. After surgery there is typically inflammation around the operation site and this inflammation can be painful and debilitating to patients. Many possible treatment plans have been incorporated to assist the patient with recovery - notably medications, physical therapy, and braces. However, few studies have looked at laser diodes that utilize high-power laser lights that are aimed at decreasing... Read More
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
03/11/2025
Locations: Semel Institute of Neuroscience at UCLA, Los Angeles, California
Conditions: Spinal Fusion, Chronic Lower Back Pain
A Phase II Trial of Sacituzumab Govitecan in Patients With Advanced Thymic Epithelial Tumors
Recruiting
The goal of this clinical trial is to study the effect of sacituzumab govitecan-hziy in adult patients with advanced thymoma and thymic carcinoma after progressing on at least one prior line of therapy. The main question it aims to answer is: • What is the overall response rate (ORR) in patients with advanced thymoma and thymic carcinoma? Participants will: * receive a fixed dose of 10 mg/kg given intravenously, once weekly on Days 1 and 8 of continuous 21-day treatment cycles until disease... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/11/2025
Locations: Stanford Cancer Institute, Palo Alto, California
Conditions: Thymoma, Thymic Carcinoma
Partner Navigation Intervention for Hepatitis C Treatment Among Young People Who Inject Drugs
Recruiting
The Partner Navigation Intervention Study is a randomized controlled study (RCT) to assess the efficacy and mechanism of action of the first behavioral intervention to increase hepatitis C (HCV) treatment initiation among adult people who inject drugs (PWID).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/11/2025
Locations: University of California, San Francisco, San Francisco, California
Conditions: Hepatitis C
VIrtual STudy in Achondroplasia for the US (VISTA)
Recruiting
This is an observational study of individuals with achondroplasia in the United States. The primary study population consists of pediatric individuals treated and untreated with VOXZOGO™. Study enrollment started in February 2023. The projected total duration of the study is approximately 5 years at minimum from start of study recruitment in February 2023, with the duration of individual prospective follow-up differing depending on the time of enrollment. The study duration may be extended based... Read More
Gender:
ALL
Ages:
Between 0 months and 18 years
Trial Updated:
03/11/2025
Locations: UCSF, Oakland, California
Conditions: Achondroplasia
MCNAIR Study: coMparative effeCtiveness of iN-person and teleheAlth cardIac Rehabilitation
Recruiting
Cardiac rehabilitation is a medically recommended program for patients with certain heart conditions. It includes exercise training, health education, and counseling. Unfortunately, many patients do not participate in cardiac rehabilitation. Some find it challenging to attend the in-person sessions. This study aims to compare two methods of delivering cardiac rehabilitation: in-person and through telehealth. The investigators want to know if the effects of these two programs are alike and if cer... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/11/2025
Locations: University of California, San Francisco, San Francisco, California
Conditions: Myocardial Infarction, Heart Failure, Systolic, Heart Valve Diseases, Angina, Stable, Coronary Artery Disease, Heart Transplant
Ventilation and Esophageal Pressure Changes
Recruiting
A study to observe the effect of variations in ventilator settings including tidal volume and PEEP on transpulmonary pressure monitored with an esophageal balloon catheter and to correlate intraoperative transpulmonary pressure variations and intraoperative stroke volume variation changes.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/11/2025
Locations: UC Davis Medical Center, Sacramento, California
Conditions: Mechanical Ventilation
Gender Disparities in Voice Outcomes After Tracheoesophageal Puncture in Total Laryngectomy Patients (UC Davis)
Recruiting
To perform a multi-site prospective study assessing, both subjectively and objectively, the gender disparities in speech outcomes of patients using TEP after total laryngectomy. The investigators hypothesize that speech outcomes, both subjective and objective measures, will be significantly poorer for female patients compared to male patients. The outcome of the study is to prospectively assess both subjective and objective gender disparities in voice and speech outcomes of patients using TEP a... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/11/2025
Locations: University of California San Diego, La Jolla, California
Conditions: Speech Disorders, Speech Dysfunction, Laryngectomy; Status, Tracheoesophageal Prosthesis, Total Laryngectomy
BAFFR-targeting CAR T Cells for Patients with Relapsed or Refractory B-NHL
Recruiting
A Phase 1 Study Evaluating BAFFR-targeting CAR T Cells for Patients with Relapsed or Refractory B-cell Non-Hodgkin's Lymphoma (B-NHL)
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/11/2025
Locations: City of Hope Medical Center, Duarte, California
Conditions: Relapsed or Refractory B-cell Non-Hodgkin's Lymphoma
Proof of Concept Trial of Cannabis Derivatives in Neuropathic Pain
Recruiting
Chronic neuropathic pain (CNP) is disabling. Research on frontline treatments for CNP, shows inconsistent outcomes and dissatisfaction among Veterans. Veterans and clinicians have shown significant interest in cannabis derivatives (THC, CBD) for neuropathic pain control, but there are no well-controlled trials guiding expectations for benefit and adverse outcomes associated with cannabis for CNP. Because Veterans are likely to present with pain and pain-related polymorbidity significantly differ... Read More
Gender:
ALL
Ages:
21 years and above
Trial Updated:
03/11/2025
Locations: VA San Diego Healthcare System, San Diego, CA, San Diego, California
Conditions: Diabetic Neuropathic Pain, Peripheral Neuropathic Pain