California is currently home to 5605 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
OSA PAP Treatment for Veterans With SUD and PTSD on Residential Treatment Unit
Recruiting
Substance use disorder (SUD) and posttraumatic stress disorder (PTSD) frequently co-occur and having both disorders is associated with greater psychological and functional impairment than having either disorder alone. This is especially true in residential settings where both disorders are more severe than outpatient settings. Obstructive sleep apnea (OSA) is highly comorbid with both disorders and untreated OSA is associated with worse functional impairment across multiple domains, worse qualit... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/18/2024
Locations: VA San Diego Healthcare System, San Diego, CA, San Diego, California
Conditions: Post Traumatic Stress Disorder, Obstructive Sleep Apnea, Substance Use Disorder, Residential Treatment Program
Trans-abdominal Fetal Pulse Oximetry; Tissue Light Scattering and Signal Integrity
Recruiting
The overall purpose of this study is to evaluate maternal-fetal tissue light scattering properties. The objectives of the study are: (i) integrate established mathematical principles of oxygen saturation to model with increasing accuracy the "body in a body" problem of fetus in mother; similar to existing pulse oximeters, the calculations will be integrated into software in the final commercial product; (ii) obtain human measurements against which both computational models and animal data can be... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
11/18/2024
Locations: Yaron Friedman, MD, Inc., Walnut Creek, California
Conditions: Fetal Hypoxia
Study of the Long-Term Safety and Outcomes of Treating Pulmonary Embolism With the Indigo Aspiration System
Recruiting
The objective of this study is to evaluate real world long-term functional outcomes, safety and performance of the Indigo Aspiration System for the treatment of pulmonary embolism (PE).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/18/2024
Locations: Long Beach Medical Center, Long Beach, California
Conditions: Pulmonary Embolism
Imaging of Solid Tumors Using FAP-2286
Recruiting
This is a multi-arm prospective trial that evaluates the ability of a novel imaging radiolabeled agents to detect metastatic cancer in participants with solid tumors using a gallium 68 (68Ga-) or copper 64 (64Cu-) FAP-2286 tracer. FAP-2286 is a peptidomimetic molecule that that binds to Fibroblast Activation Protein (FAP). FAP is a transmembrane protein expressed on cancer-associated fibroblasts, and has been shown to be present on a number of solid tumors.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/18/2024
Locations: University of California, San Francisco, San Francisco, California
Conditions: Solid Tumors, Adult, Metastatic Cancer
Phase III DAS181 Lower Tract PIV Infection in Immunocompromised Subjects (Substudy: DAS181 for COVID-19): RCT Study
Recruiting
This study will seek to enroll immunocompromised patients with Lower Tract parainfluenza infection. It also contains a sub-study to enroll patients with severe COVID-19.
Gender:
ALL
Ages:
All
Trial Updated:
11/18/2024
Locations: City of Hope cancer Center, Duarte, California
Conditions: Lower Respiratory Tract Infection, Parainfluenza, Immunocompromised, COVID-19
Pentoxifylline in Diabetic Kidney Disease
Recruiting
Pentoxifylline (PTX) is a medication that has been on the market since 1984 for use in disease in the blood vessels of the legs. There is some preliminary information that it may protect the kidneys from damage due to diabetes and other diseases. "Pentoxifylline in Diabetic Kidney Disease" is a study to bee conducted in 40 VA hospitals across the nation to determine definitively whether or not PTX can prevent worsening of kidney disease and delay death in patients with diabetic kidney disease.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/18/2024
Locations: VA Loma Linda Healthcare System, Loma Linda, CA, Loma Linda, California
Conditions: Diabetic Kidney Disease
Treatment of Radiation and Cisplatin Induced Toxicities with Tempol
Recruiting
A 10 week trial to assess the ability of Tempol to prevent and/or reduce toxicities associated with cisplatin and radiation treatment in head and neck cancer patients. Over the course of the 10 week trial, mucositis, nephrotoxicity, and ototoxicity will be monitored and assessed.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/18/2024
Locations: UCSD, La Jolla, California
Conditions: Mucositis, Nephrotoxicity, Ototoxicity
Alzheimer's Disease Neuroimaging Initiative 3 (ADNI3)
Recruiting
Since its launch in 2004, the overarching aim of the Alzheimer's Disease Neuroimaging Initiative (ADNI) has been realized in informing the design of therapeutic trials in AD. ADNI3 continues the previously funded ADNI-1, ADNI-GO, and ADNI-2 studies that have been combined public/private collaborations between academia and industry to determine the relationships between the clinical, cognitive, imaging, genetic and biochemical biomarker characteristics of the entire spectrum of Alzheimer's diseas... Read More
Gender:
ALL
Ages:
Between 55 years and 90 years
Trial Updated:
11/18/2024
Locations: University of California, Irvine, Irvine, California
Conditions: Mild Cognitive Impairment (MCI), Alzheimer's Disease (AD)
PET Imaging Study of 64Cu-GRIP B for Patients Receiving CD19-directed CAR-T Therapy
Recruiting
This is a phase I/Ib imaging study of granzyme B, 64-copper granzyme targeting restricted interaction peptide specific to family member B (64Cu-GRIP B) Positron Emission Tomography (PET) in patients with relapsed/refractory non-Hodgkin's lymphoma (NHL) receiving CD19-directed Chimeric antigen receptor T cells (CAR-T) therapy. The proposed study represents the first-ever lymphoma patient imaging studies with 64Cu-GRIP B PET. The tracer is designed to detect extracellular granzyme B as it is secre... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/15/2024
Locations: University of California, San Francisco, San Francisco, California
Conditions: Non Hodgkin Lymphoma
Coenzyme Q10 for Gulf War Illness: A Replication Study
Recruiting
The purpose of this study is to assess whether a high quality preparation of ubiquinone (coenzyme Q10) benefits symptoms, function, and quality of life in veterans with Gulf War illness.
Gender:
ALL
Ages:
50 years and above
Trial Updated:
11/15/2024
Locations: UC San Diego, La Jolla, California
Conditions: Gulf War Syndrome, Persian Gulf Syndrome, Mitochondrial Disorder, Respiratory Chain
PRCT001 Aquablation theraPy Outcomes in pRostate Cancer patienTs
Recruiting
The goal of this clinical trial is to assess the performance and safety of the AQUABEAM Robotic System for the resection and removal of prostate tissue in patients experiencing lower urinary tract symptoms (LUTS) and are diagnosed with localized prostate cancer. Participants will go through baseline and follow up assessments up to 12 months.
Gender:
MALE
Ages:
80 years and below
Trial Updated:
11/15/2024
Locations: San Diego Clinical Trials, La Mesa, California
Conditions: Benign Prostatic Hyperplasia, Localized Prostate Cancer
Effects of Acupuncture on Perceived Stress and Health in Military Service Members
Recruiting
The goal of this is to investigate the effect of a Manual Standardized Stress Acupuncture (MSSA) protocol as an adjunct treatment to a short-term mindfulness therapy for perceived stress and general health in service members (i.e., active duty military personnel and veterans). The specific aims of this study are Aim 1) To evaluate the effectiveness of a brief MSSA as an adjunct treatment with a short-term Mindfulness-Based Stress Reduction (MBSR) compared with MBSR alone for perceived stress an... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
11/15/2024
Locations: Naval Medical Center, San Diego, San Diego, California
Conditions: Perceived Stress