California is currently home to 5602 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Pediatric Pulmonary Hypertension Network (PPHNet) Informatics Registry
Recruiting
Patients are being asked to be in this research study because medical researchers hope that by gathering information about a large number of children with pulmonary hypertension over time, their understanding of the disease process will increase and lead to better treatment. Investigators believe that pulmonary hypertension in children is different than pulmonary hypertension in adults and this study will help us understand those differences.
Gender:
ALL
Ages:
Between 1 day and 21 years
Trial Updated:
03/10/2025
Locations: Stanford University Medical Center, Palo Alto, California
Conditions: Pulmonary Vascular Disease, Pulmonary Arterial Hypertension
A Study of LM-24C5 For Advanced Solid Tumors
Recruiting
To assess the safety and tolerability, obtain the recommended phase 2 dose (RP2D)/optimal biologic dose (OBD) and/or Maximum Tolerated Dose (MTD) for LM-24C5 in subjects with advanced solid tumors.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/08/2025
Locations: University of Southern California (USC) - Norris Comprehensive Cancer Center, Los Angeles, California
Conditions: Advanced Solid Tumor
Research on Equity in Abortion Care by TeleHealth
Recruiting
This study will examine the ways in which telehealth for reproductive healthcare affects timing, costs, and follow-up care; whether telehealth reaches people in areas with greater health inequities; and the attributes of telehealth that patients want. Study surveys will be administered to interested, eligible participants: 2,000 patients seeking abortion care will complete the study, comprising of 2 groups: patients seeking medication abortion care either (1) in-person or (2) via telehealth. Thi... Read More
Gender:
ALL
Ages:
Between 14 years and 64 years
Trial Updated:
03/07/2025
Locations: Advancing New Standards in Reproductive Health (ANSIRH), Oakland, California
Conditions: Abortion in First Trimester, Abortion Early, Abortion; Attempted
Allogeneic CMV-Specific CD19-CAR T Cells Plus CMV-MVA Triplex Vaccine After Matched Related Donor Hematopoietic Cell Transplant for the Treatment of Patients With High-Risk Acute Lymphoblastic Leukemia
Recruiting
This early phase I trial tests the safety and side effects of allogeneic CMV-specific CD19-CAR T cells plus CMV-MVA vaccine and how well it works in treating patients with high-risk acute lymphoblastic leukemia after a matched related donor (allogeneic) hematopoietic stem cell transplant (alloHSCT). Chimeric antigen receptor (CAR) T-cell therapy is a type of treatment in which T cells (a type of immune system cell) are changed in the laboratory so they will attack cancer cells. T cells are taken... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/07/2025
Locations: City of Hope Medical Center, Duarte, California
Conditions: Acute Lymphoblastic Leukemia
Reliability of the Samsung Galaxy for the Detection of Moderate to Severe Obstructive Sleep Apnea
Recruiting
The study will test the reliability of the Samsung Galaxy for the Detection of Moderate to Severe Obstructive Sleep Apnea (OSA)
Gender:
ALL
Ages:
22 years and above
Trial Updated:
03/07/2025
Locations: Stanford University, Palo Alto, California
Conditions: Obstructive Sleep Apnea of Adult
OPtilume™ BPH Catheter SystEm for Treatment of Men eXperiencing Symptomatic BPH
Recruiting
APEX is a prospective multi-site registry of real-world experience with the Optilume™ BPH Catheter System for treatment of men experiencing symptomatic BPH.
Gender:
MALE
Ages:
All
Trial Updated:
03/07/2025
Locations: Golden State Urology, Sacramento, California
Conditions: Benign Prostatic Hyperplasia
PTT-936 Alone or in Combination in Patients With Locally Advanced or Metastatic Solid Tumors
Recruiting
This Phase 1/2a study will explore the safety and efficacy of PTT-936, an Alpha Kinase 1 (ALPK1) activator, used alone or in combination with anti-PD-1/L1 therapy in patients with locally advanced or metastatic solid tumors. The study is divided into two parts: Phase 1 (Part A) focuses on determining the pharmaceutically active dosage range and evaluating the safety profile of PTT-936 when administered as a monotherapy. Phase 2a (Part B) will assess the safety and efficacy of PTT-936 combined wi... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/07/2025
Locations: Precision NextGen Oncology and Research Center, Beverly Hills, California
Conditions: Locally Advanced or Metastatic Solid Tumors
Study to Evaluate NRCT-101SR in Pediatric Subjects with ADHD
Recruiting
To evaluate the efficacy and safety of NRCT-101SR compared to placebo in subjects 13-17 years of age with ADHD
Gender:
ALL
Ages:
Between 13 years and 17 years
Trial Updated:
03/07/2025
Locations: Advanced Research Center, Inc, Anaheim, California
Conditions: Attention-Deficit/Hyperactivity Disorder (ADHD)
CirrhosisRx CDS System
Recruiting
The aim of the study is to compare the effect of CirrhosisRx, a novel clinical decision support (CDS) system for inpatient cirrhosis care, versus "usual care" on adherence to national quality measures and clinical outcomes for hospitalized patients with cirrhosis.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/07/2025
Locations: University of California San Francisco Medical Center, San Francisco, California
Conditions: Cirrhosis, Decision Support Systems, Clinical
Spinal Cord Stimulation to Shorten Ventilator Dependence in ARDS Patients
Recruiting
This is an early phase, proof-of-concept clinical trial assessing the safety and feasibility of non-invasive spinal cord stimulation to prevent respiratory muscle atrophy in mechanically ventilated ARDS patients. The investigators will recruit 10 elective surgery patients (surgery cohort) and 10 ARDS patients (ARDS cohort) for this study. A non-invasive, alpha-prototype Restore Technology stimulator using hydrogel surface electrodes will be used to stimulate the spinal cord at the cervical or th... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/07/2025
Locations: University of California, Los Angeles, Los Angeles, California
Conditions: Respiratory Distress Syndrome
Comparison of Artificial Disc Implants in Cervical Disc Arthroplasty
Recruiting
This study will comprehensively evaluate the outcomes and endpoints of these two different FDA-approved artificial disc implants used to treat cervical spondylotic myelopathy and/or radiculopathy today: Biomet Zimmer Mobi-C and Nuvasive Simplify. Both implants are structurally different with the Nuvasive Simplify implementing a three-piece design with two endplates and a semi-constrained mobile core while the Biomet Zimmer Mobi-C implements an unconstrained three piece design. Subjects will be a... Read More
Gender:
ALL
Ages:
Between 18 years and 60 years
Trial Updated:
03/07/2025
Locations: UCLA, Los Angeles, California
Conditions: Cervical Spondylosis With Myelopathy, Cervical Radiculopathy, Cervical Disc Herniation, Degenerative Disc Disease
Family Intervention to Prevent Childhood Obesity
Recruiting
Consumption of sweetened beverages, media-viewing, and physical activity patterns are often established during early childhood, and family-based obesity interventions show effectiveness in shaping healthy behaviors and weight outcomes for young children, including Latino children. Missing from these interventions, however, are methods to increase accessibility and dissemination to multiple family caregivers. The proposed work will use a randomized study design to evaluate the impact a family-bas... Read More
Gender:
ALL
Ages:
2 years and above
Trial Updated:
03/07/2025
Locations: Head Start, Los Angeles, California
Conditions: Childhood Obesity