California is currently home to 5602 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
A Study of EP0031 in Patients With Advanced RET-altered Malignancies
Recruiting
The aim of this study is to assess the safety, side effects and effectiveness of EP0031 in patients with advanced RET-altered malignancies
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/17/2024
Locations: David Geffen School of Medicine at UCLA, Los Angeles, California
Conditions: Advanced Solid Tumor
Evaluating and Establishing the Relationship in the Five Critical X-ray Time Points in Spinal Deformity Realignment
Recruiting
To establish the relationship in the five critical X-ray time points during multilevel posterior column osteotomies (MPCO) spinal deformity realignment in patients with adult spinal deformity and to follow the participants longitudinally to examine any follow-up X-rays and clinical data to compare to the post-operative standing scan and pre-operative data.
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
12/17/2024
Locations: University of California, San Diego, San Diego, California
Conditions: Spine, Spine Deformity
OurRelationship for Veteran Couples
Recruiting
Access to a flexible spectrum of family-based VA mental health care for Veterans is mandated by law. Research shows that relationship distress harms Veterans' mental health, physical health, and mortality, while healthy relationships provide resilience and facilitate recovery from illness. However, there are many barriers to accessing couple and family care within VA, including system-level barriers such as insufficient access to specialty providers and couple-level barriers such as difficulty c... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/17/2024
Locations: VA San Diego Healthcare System, San Diego, CA, San Diego, California
Conditions: Relationship Distress
Phase II Trial of Pembrolizumab in Metastatic or Locally Advanced Anaplastic/Undifferentiated Thyroid Cancer
Recruiting
This is a single-arm, open-label trial designed to evaluate the activity of pembrolizumab therapy in anaplastic thyroid cancer in patients with no curative alternative therapy. Pembrolizumab (Keytruda-Merck) 200 mg, given IV every 3 weeks, until evidence of progression, intolerance of treatment, withdrawal of consent or death
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/17/2024
Locations: Stanford University, Palo Alto, California
Conditions: Thyroid Cancer
STABILITY 2: Anterior Cruciate Ligament Reconstruction +/- Lateral Tenodesis With Patellar vs Quad Tendon
Recruiting
Anterior cruciate ligament (ACL) rupture is one of the most common musculoskeletal injuries in young individuals, particularly those that are active in sports. Up to 30% of individuals under the age of 20 years suffer a re-injury to the reconstructed ACL. Revision ACLR has been associated with degeneration of the articular cartilage and increased rates of meniscal tears, increasing the risk of post-traumatic osteoarthritis (PTOA), additional surgical procedures, reduced physical function and qua... Read More
Gender:
ALL
Ages:
Between 14 years and 25 years
Trial Updated:
12/17/2024
Locations: Stanford University, Redwood City, California
Conditions: Anterior Cruciate Ligament Injury, Anterior Cruciate Ligament Reconstruction, Joint Instability
Ruxolitinib in Treating Patients with Hypereosinophilic Syndrome or Primary Eosinophilic Disorders
Recruiting
This phase II trial studies how well ruxolitinib works in treating patients with hypereosinophilic syndrome or primary eosinophilic disorders.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/17/2024
Locations: Stanford Cancer Institute Palo Alto, Palo Alto, California
Conditions: BCR-JAK2 Fusion Protein Expression, Blasts 20 Percent or Less of Peripheral Blood White Cells, Blasts More Than 5 Percent of Bone Marrow Nucleated Cells, Blasts More Than 5 Percent of Peripheral Blood White Cells, Blasts Under 20 Percent of Bone Marrow Nucleated Cells, Chronic Eosinophilic Leukemia, Not Otherwise Specified, Eosinophilia, Hepatomegaly, Hypereosinophilic Syndrome, JAK2 Gene Mutation, Splenomegaly, TEL-JAK2 Fusion Protein Expression
Genomic Profiling in Recommending Treatment for Patients With Metastatic Solid Tumors
Recruiting
This research trial studies using genomic profiling to recommend anticancer treatment to patients with cancer that has spread beyond the original site of the tumor (metastatic cancer). Genomic profiling studies the deoxyribonucleic acid (DNA) of a tumor to detect genetic changes or abnormalities. This information can then be used to recommend treatments that may be more likely to result in a beneficial response. It is not yet known whether genomic profiling will detect abnormalities that can be... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/17/2024
Locations: Stanford University, Palo Alto, California
Conditions: Unspecified Adult Solid Tumor, Protocol Specific
Long Term Effects On Recipients of Hematopoietic Stem Cell Transplantation
Recruiting
This project allows for the systematic collection and analysis of long-term follow-up clinical parameters in children who have received a stem cell transplant. The data collected will assist in determining appropriate intervention and treatment plans for patients enrolled on this study. In addition, future patients may benefit by having the ability to anticipate problems and develop methods of prevention or early intervention.
Gender:
ALL
Ages:
18 years and below
Trial Updated:
12/17/2024
Locations: Stanford University School of Medicine, Stanford, California
Conditions: Blood and Marrow Transplant (BMT)
Clinical & Pathological Studies of Upper Gastrointestinal Carcinoma
Recruiting
Our research of the biology of upper gastrointestinal cancers involves the study of tissue samples and cells from biopsies of persons with gastric or esophageal cancer or blood samples from upper gastrointestinal cancer patients and persons at high inherited risk for these cancers. We hope to learn the role genes and proteins play in the development of gastric and esophageal cancer.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/17/2024
Locations: Stanford University School of Medicine, Stanford, California
Conditions: Stomach Cancer, Gastro-Esophageal(GE) Junction Cancer, Gastric (Stomach) Cancer, Esophageal Cancer, Gastrointestinal Stromal Tumor (GIST)
Clinical and Pathologic Studies in Non-Hodgkin's Lymphoma and Hodgkin's Disease
Recruiting
The purpose of this study is to characterize the molecular and cell biology of the tumor cells in lymphoma.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/17/2024
Locations: Stanford University School of Medicine, Stanford, California
Conditions: Lymphoma, Non-Hodgkin, Hodgkin's Disease
Identification and Characterization of Novel Proteins and Genes in Head and Neck Cancer
Recruiting
Through this study, we hope to learn more about the mechanisms, which may contribute to development and progression of head and neck cancer. The long-term goal of this study will be to develop new strategies and drugs for the diagnosis and treatment of head and neck cancer.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/17/2024
Locations: Stanford University School of Medicine, Stanford, California
Conditions: Head and Neck Cancer
Patient-Centered Approach for Treatment Decisions in Mitral Valve Prolapse
Recruiting
This is a qualitative and quantitative study that seeks to obtain information from patients with degenerative mitral valve prolapse and providers regarding factors important in deciding between surgical mitral valve repair (MVR) and transcatheter edge-to-edge repair (TEER). Findings from this study will provide data that can be used to develop decision aids that can assist patients in decision making between these two therapies and assist providers in integrating shared decision making the withi... Read More
Gender:
ALL
Ages:
21 years and above
Trial Updated:
12/16/2024
Locations: Cedars-Sinai Medical Center, Los Angeles, California
Conditions: Mitral Valve Prolapse