California is currently home to 5591 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Pembrolizumab in Treating Participants with Leukoplakia
Recruiting
This phase II pilot trial studies how well pembrolizumab works in treating leukoplakia. Monoclonal antibodies, such as pembrolizumab, may interfere with the ability of tumor cells to grow and spread.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/15/2024
Locations: UC San Diego Moores Cancer Center, La Jolla, California
Conditions: Erythroleukoplakia, Leukoplakia, Verrucous Oral Leukoplakia
Performance and Safety of a Digital Tool for Unsupervised Self-assessment of NMOSD
Recruiting
NMOSDCopilot is a digital tool developed for the self-assessment of Neuromyelitis Optica Spectrum Disorder symptoms that impact patients' functioning and quality of life. It has been co-designed with the help of patient advocacy groups, NMOSD patients and medical experts. It includes a smartphone-based application for patients, connected to a web portal developed for healthcare professionals (HCSPs). The patient application is composed of vision, walking, cognition, and dexterity e-active tests... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/14/2024
Locations: University of Southern California, Los Angeles, California
Conditions: Neuromyelitis Optica
Phase I Single Ascending Dose and Multiple Ascending Doses of Oral AFA-281 in Healthy Volunteers
Recruiting
Phase I Part 1 (single ascending dose): Double-blind dosing will occur in healthy volunteers in 4 cohorts of 8 subjects each. Six subjects in each cohort will be randomized to receive AFA-281 and 2 subjects will be randomized to receive the matching placebo. At the end of the Part 1 study is to evaluate the safety and tolerability of AFA-281. Following completion of each cohort, bioanalytical analyses will be conducted to evaluate the pharmacokinetic profile. Phase I Part 2 (multiple dose for... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
10/13/2024
Locations: CenExcel CNS, Los Alamitos, California
Conditions: Pain, Neuropathic, Pain, Inflammatory
More Fresh Fruit and Vegetable Prescription Program for Families with Type 2 Diabetes Mellitus
Recruiting
Rady Children's Hospital San Diego (RCHSD), UCSD Division of Child and Community Health and the Center for Community Health, and Northgate Gonzalez (NG) Markets will collaborate to create a Produce Prescription Program (Fruit and Vegetable Prescription Program) to be implemented in the RCHSD Diabetes Clinic. We will provide families on Medi-Cal who have a child with T2DM with a fruit and vegetable prescription (FVRx) which will enhance their ability to purchase GusNIP-eligible fresh fruits and v... Read More
Gender:
ALL
Ages:
18 years and below
Trial Updated:
10/13/2024
Locations: Rady Children's Hospital San Diego, San Diego, California
Conditions: Type 2 Diabetes
Sacramento Clinical High Risk for Psychosis Stepped-Care Program
Recruiting
This is a dissemination and implementation study that is evaluating a stepped-care intervention for identifying and treating youths at clinical high-risk for psychosis within multiple community mental health centers.
Gender:
ALL
Ages:
Between 12 years and 25 years
Trial Updated:
10/11/2024
Locations: River Oak Center for Children, Elk Grove, California
Conditions: Clinical High Risk for Psychosis, Ultra High Risk for Psychosis
Safety and Efficacy of NEO212 in Patients with Astrocytoma IDH-mutant, Glioblastoma IDH-wildtype or Brain Metastasis
Recruiting
This multi-site, Phase 1/2 clinical trial is an open-label study to identify the safety, pharmacokinetics, and efficacy of a repeated dose regimen of NEO212 alone for the treatment of patients with radiographically-confirmed progression of Astrocytoma IDH- mutant, Glioblastoma IDH-wildtype, and the safety, pharmacokinetics and efficacy of a repeated dose regimen of NEO212 when given with select SOC for the treatment of solid tumor patients with radiographically confirmed uncontrolled metastases... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/11/2024
Locations: Precision NextGen Oncology, Beverly Hills, California
Conditions: Diffuse Astrocytoma, IDH-Mutant, Glioblastoma, IDH-wildtype, Brain Metastases, Adult, Cervical Cancer, Colorectal Cancer, Esophageal Cancer, Esophageal Squamous Cell Carcinoma, Gastric Cancer, Gastroesophageal Junction Adenocarcinoma, Head and Neck Squamous Cell Carcinoma, Melanoma, Merkel Cell Carcinoma, Microsatellite Instability-High Solid Malignant Tumor, Mismatch Repair Deficient Solid Malignant Tumor, Microsatellite Instability-High Colorectal Cancer, Mismatch Repair Deficient Colorectal Cancer, Non-small Cell Lung Cancer, Renal Cell Carcinoma, Small Cell Lung Cancer, Squamous Cell Carcinoma, Urothelial Carcinoma
Abdominal Scar Improvement in Microsurgical Breast Reconstruction
Recruiting
Microsurgical breast reconstruction is most commonly performed with free abdominal flaps, which leave a long transverse lower abdominal scar. Due to tension across the incision, these scars frequently widen and hypertrophy. Hence, modalities that can reduce this tendency, thus, improving scar appearance are desirable. Here, we wish to investigate the impact of the Neodyne embrace device on postoperative abdominal scar appearance. The proposed study is novel in that it is the first RCT investigat... Read More
Gender:
FEMALE
Ages:
Between 18 years and 89 years
Trial Updated:
10/11/2024
Locations: Stanford University Medical Center, Stanford, California
Conditions: Cicatrix, Breast Reconstruction
GWICTIC: NAC Mechanistic Study in Gulf War Veterans
Recruiting
This mechanistic study will test if NAC affects chronic oxidative stress and depletion of antioxidants in GWI participants. Blood specimen collection and neuroimaging will be used to determine whether NAC affects serum glutathione (GSH) concentration and oxidative stress in the CNS when compared to placebo.
Gender:
ALL
Ages:
Between 47 years and 70 years
Trial Updated:
10/11/2024
Locations: VA Palo Alto Health Care System War Related Illness and Injury Study Center, Palo Alto, California
Conditions: Gulf War Syndrome
Protonix Treatment of Maintenance of Healing in Pediatric Participants Aged 1-11 Years and 12-17 Years
Recruiting
The purpose of this study is to explore the outcomes, tolerability and safety of 2 different doses of oral pantoprazole (full healing dose, half healing dose), assigned based upon weight, for the maintenance of healing of erosive esophagitis in pediatric participants aged 1 to 17 years with endoscopically-confirmed, healed erosive esophagitis.
Gender:
ALL
Ages:
Between 1 year and 17 years
Trial Updated:
10/11/2024
Locations: Childrens Hospital of Orange County, Orange, California
Conditions: Esophagitis
Compliant Analysis of Patient Samples and Data
Recruiting
Patients of scientific interest who have provided a commercial sample to LabCorp or one of its' affiliates will have their de-identified remnant samples and/or data used for research and development. Other commercial patients will be followed up on after informed consent is obtained.
Gender:
ALL
Ages:
All
Trial Updated:
10/11/2024
Locations: Sequenom, Inc, San Diego, California
Conditions: Pregnancy Related, Cancer, Infectious Disease
Hidradenitis Suppurativa Prospective Observational Registry and Biospecimen Repository
Recruiting
Hidradenitis suppurativa (HS) is a common and debilitating skin disease that is poorly understood and understudied. As a result, little is known about disease prognosis and few effective treatments exist for this condition. This prospective observational cohort study aims to comprehensively characterize the clinical and biological features of HS. The results of this research will provide a basis for the development of an HS clinical classification system and identification of potential treatment... Read More
Gender:
ALL
Ages:
10 years and above
Trial Updated:
10/11/2024
Locations: University of California San Francisco, San Francisco, California
Conditions: Hidradenitis Suppurativa
Clinical and Biological Characteristics of Hidradenitis Suppurativa
Recruiting
Hidradenitis suppurativa (HS) is a common and debilitating skin disease that is poorly understood and understudied. As a result, little is known about disease prognosis and few effective treatments exist for this condition. This prospective observational cohort study aims to comprehensively characterize the clinical and biological features of HS. The results of this research will provide a basis for the development of an HS clinical classification system and identification of potential treatment... Read More
Gender:
ALL
Ages:
13 years and above
Trial Updated:
10/11/2024
Locations: University of California, San Francisco, San Francisco, California
Conditions: Hidradenitis Suppurativa