California is currently home to 5600 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Trajectories of Recovery After Intravenous Propofol Versus Inhaled VolatilE Anesthesia Trial
Recruiting
The investigators will conduct a 12,500-patient randomized multi-center trial to determine (i) which general anesthesia technique yields superior patient recovery experiences in any of three surgical categories ((a) major inpatient surgery, (b) minor inpatient surgery, (c) outpatient surgery) and (ii) whether TIVA confers no more than a small (0.2 %) increased risk of intraoperative awareness than INVA in patients undergoing both outpatient and inpatient surgeries
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/15/2024
Locations: University of California San Francisco, San Francisco, California
Conditions: Surgery-Complications, Anesthesia Complication, Anesthesia Awareness, Anesthesia, Surgery, Quality of Life, Pain, Postoperative, Anesthesia Morbidity
Aveir VR Real-World Evidence Post-Approval Study
Recruiting
The purpose of this post-approval study is to evaluate the long-term safety of the single-chamber Aveir VR leadless pacemaker using real-world evidence methods.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/15/2024
Locations: Abbott, Sylmar, California
Conditions: Cardiac Pacemaker, Arrythmia, Bradycardia
WARRIOR Ancillary Study for CCTA Analysis
Recruiting
In this study, quantitative characterization of plaque using coronary computed tomographic angiography (CTA) will be used to determine if women who were treated with intensive medical therapy have a greater reduction in the amount and type of cholesterol plaque compared to women receiving usual care and if this results in beneficial changes in clinical symptoms. The study will provide an understanding of how intensive medical therapy works in providing clinical benefit in women with nonobstructi... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
08/15/2024
Locations: Cedars-Sinai Medical Center, Los Angeles, California
Conditions: Coronary Artery Disease, Non-Obstructive Coronary Atherosclerosis, Ischemia
Study to Evaluate Safety and Tolerability of CC-91633 (BMS-986397) in Participants With Relapsed or Refractory Acute Myeloid Leukemia or Relapsed or Refractory Higher-Risk Myelodysplastic Syndromes
Recruiting
Study CC-91633-AML-001 is a Phase 1, open-label, dose escalation and expansion, first-in-human (FIH) clinical study of CC-91633 (BMS-986397) in participants with relapsed or refractory acute myeloid leukemia (R/R AML) or in participants with relapsed or refractory higher-risk myelodysplastic syndromes (R/R HR-MDS). The Dose Escalation part (Part A) of the study will enroll participants with R/R AML and R/R HR-MDS and will evaluate the safety and tolerability of escalating doses of CC-91633 (BMS-... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/15/2024
Locations: Local Institution - 103, La Jolla, California
Conditions: Leukemia, Myeloid, Acute, Myelodysplastic Syndromes
Local Cerebral Oxygenation in Chronic Pain Patients Utilizing Spinal Cord Stimulation
Recruiting
The primary objective of the study is to determine changes in cerebral nociceptive hemodynamic response (blood oxygenation/flow) before, during and following spinal cord stimulation (SCS). Objective measurements of cerebral nociceptive hemodynamic responses will be obtained with the CereVu sensor and ROPA system and will be analyzed offline and compared against subjective measures of pain. Proprietary analysis algorithms will be incorporated and developed to understand how the objective measurem... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/14/2024
Locations: Boomerang Healthcare, Walnut Creek, California
Conditions: Chronic Pain
DFC 004 Biomarkers for Active Diabetic Foot Ulcers
Recruiting
This study is a platform study designed to efficiently test multiple biomarkers to identify diabetic foot ulcers (DFUs) with a higher potential for healing versus not healing that ultimately could be applied at the point of care to drive personalized management decisions, and to better inform clinical trials of wound healing interventions
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/14/2024
Locations: University of Southern California, Los Angeles, California
Conditions: Diabetic Foot Ulcer, Diabetic Foot, Diabetes
A Natural History Study in Participants With DOK7 Congenital Myasthenic Syndromes (CMS)
Recruiting
Participants will attend up to 3 study visits to collect clinical assessments. The assessments will evaluate participants' symptoms and quality of life to understand disease activity in patients with DOK7-CMS better and may inform future study design.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/14/2024
Locations: UC Davis Health - UC Davis Health Midtown Ambulatory Care Center, Sacramento, California
Conditions: Congenital Myasthenic Syndrome
A Study to Evaluate the Efficacy and Safety of TL118 in Solid Tumors Patients
Recruiting
The main objective of the study will be to evaluate the efficacy of TL118 in participants with solid tumors harboring NTRK gene fusions
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/14/2024
Locations: Adventist Health Glendale, Glendale, California
Conditions: Solid Tumor
Phase II Study to Evaluate Efficacy and Safety of D-0120 in Combination With Allopurinol in Subjects With Gout
Recruiting
D-0120 is being tested in combination with Allopurinol in adult subjects with Gout.
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
08/14/2024
Locations: Study Center, Panorama City, California
Conditions: Gout
Pain Relief After Trapeziectomy: Ibuprofen & Acetaminophen Versus Oxycodone
Recruiting
In the US, pain management after surgery for surgical treatment of osteoarthritis at the base of the thumb typically consists of prescription opioids during the early recovery phase. Given the highly addictive nature of prescription opioids, guidelines are being evaluated by hand surgeons to reduce opioid use while still maintaining pain control after surgery. A promising approach is to use non-narcotic medication as the first line of treatment. The purpose of this study is to demonstrate the ef... Read More
Gender:
ALL
Ages:
45 years and above
Trial Updated:
08/14/2024
Locations: Stanford Health Care, Redwood City, California
Conditions: Pain, Postoperative, Osteoarthritis Thumb
Pivotal Study of the CapsoCam Colon (CV-3) in Detecting Colonic Polyps, Using Colonoscopy as the Reference
Recruiting
This study will evaluate the safety and effectiveness of the CapsoCam Colon (CV-3) endoscope system for the detection of colonic polyps.
Gender:
ALL
Ages:
Between 45 years and 75 years
Trial Updated:
08/14/2024
Locations: Gastro Care Institute, Lancaster, California
Conditions: Colonic Polyp
A Study to Compare the Administration of Encorafenib + Binimetinib + Nivolumab Versus Ipilimumab + Nivolumab in BRAF-V600 Mutant Melanoma With Brain Metastases
Recruiting
This phase II trial compares the effect of encorafenib, binimetinib, and nivolumab versus ipilimumab and nivolumab in treating patients with BRAF- V600 mutant melanoma that has spread to the brain (brain metastases). Encorafenib and binimetinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Ipilimumab and nivolumab are monoclonal antibodies that may interfere with the ability of tumor cells to grow and spread. This trial aims to find out which approach... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/14/2024
Locations: Providence Saint Joseph Medical Center/Disney Family Cancer Center, Burbank, California
Conditions: Acral Lentiginous Melanoma, Clinical Stage IV Cutaneous Melanoma AJCC v8, Metastatic Cutaneous Melanoma, Metastatic Malignant Neoplasm in the Brain, Metastatic Melanoma, Metastatic Mucosal Melanoma, Pathologic Stage IV Cutaneous Melanoma AJCC v8