California is currently home to 5617 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
HIV/STD Risk and PrEP Implementation Messaging Among Gay, Bisexual, and Other Men Who Have Sex with Men
NCT06183502
Recruiting
The goal of this observational study is to learn about awareness around PrEP use and adherence, condom use, sexual risk-taking behavior, and substance-using behaviors in men having sex with men. The main objective is to study a prospective cohort of MSM in Atlanta, Chicago, and San Diego to understand men's strategies to prevent HIV/Sexually Transmissible Infections (STIs), including PrEP use and adherence, condom use, sexual risk-taking behavior, and substance-using behaviors Participants will... Read More
Gender:
MALE
Ages:
18 years and above
Trial Updated:
11/25/2024
Locations: San Diego State University, San Diego, California
Conditions: Sexually Transmitted Infections, Gay, Pre Exposure Prophylaxis
Register for Updates
Determinants of Incident Stroke Cognitive Outcomes and Vascular Effects on RecoverY
NCT04916210
Recruiting
The overall goal of the DISCOVERY study is to better understand what factors contribute to changes in cognitive (i.e., thinking and memory) abilities in patients who experienced a stroke. The purpose of the study is to help doctors identify patients at risk for dementia (decline in memory, thinking and other mental abilities that significantly affects daily functioning) after their stroke so that future treatments may be developed to improve outcomes in stroke patients. For this study, a "stroke... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/25/2024
Locations: Kaiser Permanente Los Angeles Medical Center, Los Angeles, California
Conditions: Ischemic Stroke, Intracerebral Hemorrhage, Subarachnoid Hemorrhage, Dementia, Vascular, Mild Cognitive Impairment, Vascular Cognitive Impairment
Register for Updates
Fermented Food-Supplemented Diet in Ulcerative Colitis
NCT04401605
Recruiting
The purpose of this study is to see how a diet that supplements fermented foods effects inflammation and quality of life in patients with mild to moderate Ulcerative Colitis (UC). There is a paucity of research and an enormous need for better understanding of diet and intestinal inflammation. Fermented food have been shown to positively influence inflammatory cytokines and intestinal microbial diversity in healthy volunteers.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/25/2024
Locations: Stanford University, Palo Alto, California
Conditions: Inflammatory Bowel Diseases, Diet Modification, Ulcerative Colitis
Register for Updates
Melanoma Margins Trial-II: 1cm v 2cm Wide Surgical Excision Margins for AJCC Stage II Primary Cutaneous Melanoma
NCT03860883
Recruiting
Patients with a primary invasive melanoma are recommended to undergo excision of the primary lesion with a wide margin. There is evidence that less radical margins of excision may be just as safe. This is a randomised controlled trial of 1 cm versus 2 cm margin of excision of the primary lesion for adult patients with stage II primary invasive cutaneous melanomas (AJCC 8th edition) to determine differences in disease-free survival. A reduction in margins is expected to improve patient quality of... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/25/2024
Locations: UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care, Irvine, California
Conditions: Cutaneous Melanoma, Stage II
Register for Updates
The Role of Secondary Bile Acids in Intestinal Inflammation
NCT03724175
Recruiting
The cause of Inflammatory bowel disease (IBD) is unknown, but intestinal bacteria-involved in the production of molecules that impact health-are widely accepted to play a key role. A significant proportion of IBD patients with pouches (surgically created rectums after the diseased colon is removed) continue to have inflammation similar to their previous disease. Only a few microbes are known to have the capability to modify primary bile acids (PBAs) made by the liver to secondary bile acids (SB... Read More
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
11/25/2024
Locations: Stanford University, Stanford, California
Conditions: Ulcerative Colitis, Pouchitis
Register for Updates
Flavored, Oral Irinotecan VAL-413 (Orotecan®) Given With Temozolomide for Treatment of Recurrent Pediatric Solid Tumors
NCT04337177
Recruiting
A pilot pharmacokinetic trial to determine the safety and efficacy of a flavored, orally administered irinotecan VAL-413 (Orotecan®) given with temozolomide for treatment of recurrent pediatric solid tumors including but not limited to neuroblastoma, rhabdomyosarcoma, Ewing sarcoma, hepatoblastoma and medulloblastoma
Gender:
ALL
Ages:
Between 1 year and 30 years
Trial Updated:
11/24/2024
Locations: UCSF, Mission Bay - Benioff Children's Hospital, San Francisco, California
Conditions: Solid Tumors, Neuroblastoma, Rhabdomyosarcoma, Ewing Sarcoma, Hepatoblastoma, Medulloblastoma
Register for Updates
Quantitative Ultrasound to Assess Steatotic Liver Disease in Children
NCT06706856
Recruiting
This research study is being conducted to find out more about advanced ultrasound techniques to non-invasively evaluate liver disease in children. The investigators are developing advanced techniques for analyzing ultrasound data and images of the liver, and they will compare it to other established methods used to evaluate the liver, including liver MRI. The investigators plan to develop and test the advanced analysis techniques using conventional full-size ultrasound machines and, if possible... Read More
Gender:
ALL
Ages:
Between 9 years and 18 years
Trial Updated:
11/22/2024
Locations: University of California San Diego, La Jolla, California
Conditions: MASLD, MASLD - Metabolic Dysfunction-Associated Steatotic Liver Disease
Register for Updates
Examining the Effects of Cytisinicline on Neural Substrates of Cigarette Cue-reactivity
NCT06617312
Recruiting
This study will randomize 64 non-treatment seeking individuals who smoke cigarettes daily in a double-blind, placebo-controlled laboratory study testing the effects of cytisinicline on the neural substrates of cigarette cue reactivity.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
11/22/2024
Locations: University of California Los Angeles, Los Angeles, California
Conditions: Smoking Cessation, Tobacco Use Disorder
Register for Updates
Healthy Lifestyles in Bipolar Disorder: Bay Area Study
NCT06555406
Recruiting
The goal of this clinical trial is to understand how level of adherence with time-restricted eating (TRE) predicts change in diurnal rhythms (as measured using the amplitude of diurnal peripheral clock gene expression), and how those changes predict lower mania and depressive symptoms, and downstream improvements in quality of life. The effects of diurnal amplitude of clock gene expression is expected to remain significant when controlling for change in glucose tolerance and inflammation. Partic... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
11/22/2024
Locations: University of California Berkeley, Berkeley, California
Conditions: Bipolar Disorder, Time Restricted Eating
Register for Updates
Neurobehavioral Affective Control Training
NCT06226467
Recruiting
The goal of this clinical trial is to test a new cognitive training program to improve emotion regulation in adults. The investigators' primary aim is to determine whether participating in this program addresses two key features of emotion dysregulation associated with psychiatric disorders: (1) emotion-related impulsivity and (2) rumination. The investigators will further evaluate participants' perceived acceptability and feasibility of treatment procedures. Secondarily, the investigators will... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
11/22/2024
Locations: University of California, Berkeley, California
Conditions: Emotional Distress, Impulsive Behavior, Mood Lability, Mood Instability, Rumination, Psychopathology, Affective Symptoms
Register for Updates
Food FARMacia: Reducing Childhood Obesity in Households With Food Insecurity
NCT06051591
Recruiting
The goal of this clinical trial is to test whether the Food FARMacia intervention to reduce food insecurity is feasible and accepted among families with an infant age 6 to less than 18 months receiving pediatric primary care. All participants will receive nutrition education and anticipatory guidance to support healthy meal preparation in addition to usual care.
Gender:
ALL
Ages:
6 months and above
Trial Updated:
11/22/2024
Locations: Stanford University School of Medicine, Stanford, California
Conditions: Nutrition, Healthy
Register for Updates
Terazosin and Parkinson's Disease Extension Study
NCT05109364
Recruiting
The purpose of this study is to investigate the long-term effects of treatment with the selective post-synaptic a1-adrenergic blocker terazosin on serial in a population of subjects with defined pre-motor Parkinson's disease (PD) risks and abnormal imaging exams. Imaging changes will be correlated to the presence and severity of motor and non-motor symptoms of PD, measured by validated clinical scales and cardiac autonomic function tests.
Gender:
ALL
Ages:
Between 50 years and 85 years
Trial Updated:
11/22/2024
Locations: Cedars Sinai Medical Center, Los Angeles, California
Conditions: Symptomatic Parkinson Disease, REM Sleep Behavior Disorder, Pre-motor Parkinson's Disease
Register for Updates