California is currently home to 5602 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Achieving Chronic Care equiTy by leVeraging the Telehealth Ecosystem
Recruiting
This study examines the impact of a multi-level intervention aiming to improve telehealth access for low-income patients managing chronic health conditions, such as hypertension and diabetes. The multi-level intervention includes clinic-level practice facilitation and patient-level digital health coaching.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/09/2024
Locations: Zuckerberg San Francisco General Hospital (ZSFG) & SF Department of Public Health (DPH), San Francisco, California
Conditions: Diabetes
CONNECTing to LungCare
Recruiting
This study evaluates a smoking cessation intervention (CONNECTing to LungCare) for improving shared decision-making conversations about smoking cessation and lung cancer screening between patients and providers. Shared decision making is a patient care model in which providers offer information regarding risks and benefits, patients express their values and preferences, and then healthcare decisions are jointly discussed between the patient and provider. Patient education, aided by decision supp... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/09/2024
Locations: University of California, San Francisco, San Francisco, California
Conditions: Smoking Cessation, Cigarette Smoking-Related Carcinoma, Lung Carcinoma
A Study of Oral MBQ-167 in Participants With Advanced Breast Cancer
Recruiting
A Phase 1, open-label, dose-escalation clinical trial of MBQ-167 in participants with advanced Breast Cancer for whom Standard of Care (SOC) has failed or has proven intolerable.
Gender:
ALL
Ages:
21 years and above
Trial Updated:
12/09/2024
Locations: Precision Next Gen Oncology & Research Center, Beverly Hills, California
Conditions: Breast Cancer, Breast Neoplasm, Breast Cancer Stage IV
Youth Partners in Care for Suicide Prevention
Recruiting
This randomized comparative effectiveness trial will compare two evidence-based approaches to emergency care for youth ages 13-24 who present to the Emergency Department (ED) with suicidal ideation or behavior. Outcomes will be monitored at baseline and at 3, 6 \& 12 month follow-up assessments.
Gender:
ALL
Ages:
Between 13 years and 24 years
Trial Updated:
12/09/2024
Locations: Ronald Reagan Medical Center, Los Angeles, California
Conditions: Suicide and Self-harm
Biomarker and Edema Attenuation in IntraCerebral Hemorrhage (BEACH)
Recruiting
This first-in-patient phase 2a pilot study will assess the safety and tolerability of MW01-6-189WH (hereafter called MW189) in patients with Intracerebral Hemorrhage (ICH).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/09/2024
Locations: Stanford University, Palo Alto, California
Conditions: Intracerebral Hemorrhage
Phase 1 Study of INBRX-109 in Subjects with Locally Advanced or Metastatic Solid Tumors Including Sarcomas
Recruiting
This is a first-in-human, open-label, non-randomized, three-part phase 1 trial of INBRX-109, which is a recombinant humanized tetravalent antibody targeting the human death receptor 5 (DR5).
Gender:
ALL
Ages:
Between 12 years and 85 years
Trial Updated:
12/09/2024
Locations: Precision NextGen Oncology and Research, Beverly Hills, California
Conditions: Colorectal Adenocarcinoma, Ewing Sarcoma
Electroacupuncture in Symptom Management After Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy
Recruiting
The investigators are conducting this research study is to evaluate the feasibility (recruitment, compliance, safety, and acceptance) of using electroacupuncture (EA) to manage complex symptoms such as pain, nausea/vomiting, diarrhea, and insomnia in patients who have undergone Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy. Additionally, the investigators are aiming to determine the effectiveness of EA in reducing these symptoms, and to examine how EA impacts important biom... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/08/2024
Locations: UCI Health Susan Samueli Integrative Health Institute, Irvine, California
Conditions: Cancer
Multicenter Evaluation of Near Vision and Outdoor Time in Kids Study
Recruiting
Currently, optical and pharmacological interventions have been developed to prevent the progression of childhood myopia. However, no myopia control strategy has been shown to have complete efficacy in controlling myopia progression in children. One possible reason is that risk factors contributing to the development of myopia were not controlled in previous clinical studies including time outdoors and near vision behaviour. This study aims to quantify time spent outdoors and near vision behavior... Read More
Gender:
ALL
Ages:
Between 4 years and 14 years
Trial Updated:
12/08/2024
Locations: School of Optometry, University of California, Berkeley, Berkeley, California
Conditions: Myopia
Effect of Dupilumab on the Muscle Function of the Esophagus (food Pipe) in Participants with Eosinophilic Esophagitis (EoE)
Recruiting
The goal of this study is to research Dupilumab, an FDA approved medication in treating patients diagnosed with Eosinophilic esophagitis (EoE). The drug works by controlling allergic inflammation of the esophagus. The esophagus is a food pipe that transfers food from the mouth into the stomach. Participants with EoE have dysfunction of the muscle of the esophagus (impaired peristalsis) that is not favorable for the transport function. Main question this study aims to answer is: Whether Dupiluma... Read More
Gender:
ALL
Ages:
22 years and above
Trial Updated:
12/06/2024
Locations: University of California San Diego (UCSD) Health Medical center, La Jolla, California
Conditions: Eosinophilic Esophagitis (EoE)
Nivolumab and Ipilimumab With and Without Camu Camu for the Treatment of Patients With Metastatic Renal Cell Carcinoma
Recruiting
This phase I trial tests the safety, side effects, and best dose of camu camu when used in combination with nivolumab and ipilimumab in treating patients with kidney cancer that has spread to other places in the body. A monoclonal antibody is a type of protein that can bind to certain targets in the body, such as molecules that cause the body to make an immune response (antigens). Immunotherapy with monoclonal antibodies, such as nivolumab and ipilimumab, may help the body's immune system attack... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/06/2024
Locations: City of Hope Medical Center, Duarte, California
Conditions: Clear Cell Renal Cell Carcinoma, Sarcomatoid Renal Cell Carcinoma, Stage III Renal Cell Cancer AJCC v8, Stage IV Renal Cell Cancer AJCC v8
LAM-001 in Lung Transplant Recipients With Bronchiolitis Obliterans Syndrome.
Recruiting
The goal of this clinical trial is to learn about the safety and effectiveness of LAM-001 in patients who have developed bronchiolitis obliterans syndrome (BOS), a form of chronic rejection, after lung transplantation. The main questions it aims to answer are: * Is LAM-001 safe in these patients? * Is LAM-001 effective in slowing BOS progression? Participants will: * Be randomly assigned to inhale either LAM-001 or placebo (a look-alike substance that contains no active drug) daily for 48 we... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/06/2024
Locations: University of California, San Francisco, San Francisco, California
Conditions: Bronchiolitis Obliterans Syndrome, Chronic Lung Allograft Dysfunction, Lung Transplantation
Lenvatinib Plus Pembrolizumab in Well Differentiated G3 Neuroendocrine Tumors
Recruiting
This is the first study to be done in a newly described class of neuroendocrine tumors known as well-differentiated grade 3 neuroendocrine tumors (WD G3 NET). First described in the pancreas in 2017, the classification was broadened to include gastrointestinal tract tumors in 2019. Recent data suggest an equivalent subtype exists in the lungs (NEC with carcinoid morphology). WD G3 NETs can occur de novo as well as the result of grade progression over time. This is a single arm, multi-site, Phase... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/06/2024
Locations: University of California, San Francisco, San Francisco, California
Conditions: Neuroendocrine Tumors, Well-Differentiated Neuroendocrine Carcinoma, High Grade Neuroendocrine Carcinoma, Any Site