California is currently home to 5602 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
ARDS in Children and ECMO Initiation Strategies Impact on Neurodevelopment (ASCEND)
Recruiting
ASCEND researchers are partnering with families of children who receive extracorporeal membrane oxygenation (ECMO) after a sudden failure of breathing named pediatric acute respiratory distress syndrome (PARDS). ECMO is a life support technology that uses an artificial lung outside of the body to do the lung's work. ASCEND has two objectives. The first objective is to learn more about children's abilities and quality of life among ECMO-supported children in the year after they leave the pediatr... Read More
Gender:
ALL
Ages:
Between 14 days and 20 years
Trial Updated:
12/11/2024
Locations: Loma Linda University Children's Hospital, Loma Linda, California
Conditions: Acute Respiratory Distress Syndrome, Extracorporeal Membrane Oxygenation
Genomic Biomarker-Selected Umbrella Neoadjuvant Study for High Risk Localized Prostate Cancer
Recruiting
The objective of this study is to see if providing an appropriate therapy based on the genomic testing of prostate tumour tissue will result in an improved clinical response. Each participant will be treated with 8 weeks of a luteinizing hormone-releasing hormone agonist (LHRHa) plus apalutamide (APA) while genome sequence characterization is being done. Participants with biopsy specimens deemed unevaluable for genomic testing will remain on LHRHa plus APA for an additional 16 weeks. Participa... Read More
Gender:
MALE
Ages:
18 years and above
Trial Updated:
12/11/2024
Locations: University of California Davis, Sacramento, California
Conditions: Prostate Cancer
Imaging Synapses With [11C] UCB-J in the Human Brain
Recruiting
The purpose of this study is to utilize the radioactive positron emission tomography (PET) tracer \[11C\]UCB-J to test the neural synaptic pruning hypothesis of schizophrenia. This imaging method allows for the quantification of synaptic density in the living human brain and has the unprecedented ability to directly examine the synaptic pathology underlying neuropsychiatric disease. The neural synaptic pruning hypothesis posits that a key pathogenic process of schizophrenia is the over-exuberant... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
12/11/2024
Locations: VA Palo Alto Health Care System, Palo Alto, California
Conditions: Schizophrenia
Observational PIC Destination Cohort
Recruiting
This study is being done to see if people who control HIV without antiretroviral therapy (ART) after receiving an intervention can remain off ART safely. The information collected in this study is also being used to try to understand how people control HIV without ART after receiving an intervention.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/10/2024
Locations: University of California, San Francisco HIV/AIDS CRS (801), San Francisco, California
Conditions: HIV-1-infection
Dextromethorphan for Treatment of Postoperative Pain
Recruiting
A Randomized, Placebo-Controlled Study to Evaluate the Efficacy of Perioperative Dextromethorphan compared to Placebo for the Treatment of Postoperative Pain
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/10/2024
Locations: Keck School of Medicine of USC, Los Angeles, California
Conditions: Post-operative Pain
CYP2C19 Variants and Limonene Metabolism
Recruiting
The investigators will examine whether a non-invasive screening tool for CYP2C19 genetic variants can be developed by measuring limonene metabolism.
Gender:
ALL
Ages:
Between 18 years and 45 years
Trial Updated:
12/10/2024
Locations: Stanford School of Medicine, Stanford, California
Conditions: CYP2C19 Genetic Variants
Study Assessing MTD, Safety, Tolerability, PK and Anti-tumor Effects of LNS8801alone and with Pembrolizumab
Recruiting
This Phase 1/2, first-in-human, open-label, multicenter study follows a 3+3 ascending dose escalation design to determine the MTD/RP2D and to characterize the safety, tolerability, PK, and antitumor effects of LNS8801 alone and in combination with pembrolizumab. The study will include a dose escalation phase, a dose expansion phase, and phase 2A cohorts. Up to 200 patients will be accrued for this study. Up to 15 study sites in the United States will participate in the study.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/10/2024
Locations: Cedars-Sinai Medical Center, Los Angeles, California
Conditions: Solid Tumor, Adult
A Clinical Trial to Assess the Efficacy and Tolerance of a Berberine-based Nutraceutical Formula to Aid Blood Sugar Regulation and Metabolism
Recruiting
This randomized, triple-blind, placebo-controlled study will evaluate the efficacy of Diaberine, a berberine-based nutraceutical, in aiding blood sugar regulation and metabolism in 80 participants over 24 weeks.
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
12/09/2024
Locations: Citruslabs, Santa Monica, California
Conditions: Metabolism Disorder, Nutraceutical
Achieving Chronic Care equiTy by leVeraging the Telehealth Ecosystem
Recruiting
This study examines the impact of a multi-level intervention aiming to improve telehealth access for low-income patients managing chronic health conditions, such as hypertension and diabetes. The multi-level intervention includes clinic-level practice facilitation and patient-level digital health coaching.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/09/2024
Locations: Zuckerberg San Francisco General Hospital (ZSFG) & SF Department of Public Health (DPH), San Francisco, California
Conditions: Diabetes
CONNECTing to LungCare
Recruiting
This study evaluates a smoking cessation intervention (CONNECTing to LungCare) for improving shared decision-making conversations about smoking cessation and lung cancer screening between patients and providers. Shared decision making is a patient care model in which providers offer information regarding risks and benefits, patients express their values and preferences, and then healthcare decisions are jointly discussed between the patient and provider. Patient education, aided by decision supp... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/09/2024
Locations: University of California, San Francisco, San Francisco, California
Conditions: Smoking Cessation, Cigarette Smoking-Related Carcinoma, Lung Carcinoma
A Study of Oral MBQ-167 in Participants With Advanced Breast Cancer
Recruiting
A Phase 1, open-label, dose-escalation clinical trial of MBQ-167 in participants with advanced Breast Cancer for whom Standard of Care (SOC) has failed or has proven intolerable.
Gender:
ALL
Ages:
21 years and above
Trial Updated:
12/09/2024
Locations: Precision Next Gen Oncology & Research Center, Beverly Hills, California
Conditions: Breast Cancer, Breast Neoplasm, Breast Cancer Stage IV
Youth Partners in Care for Suicide Prevention
Recruiting
This randomized comparative effectiveness trial will compare two evidence-based approaches to emergency care for youth ages 13-24 who present to the Emergency Department (ED) with suicidal ideation or behavior. Outcomes will be monitored at baseline and at 3, 6 \& 12 month follow-up assessments.
Gender:
ALL
Ages:
Between 13 years and 24 years
Trial Updated:
12/09/2024
Locations: Ronald Reagan Medical Center, Los Angeles, California
Conditions: Suicide and Self-harm