California is currently home to 5585 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Post Approval Study for Treatment of Drug-resistant Adult and Pediatric Primary FSGS Using the LIPOSORBER® LA-15 System
Recruiting
This multicenter, prospective, single-arm clinical study will evaluate the probable benefit and safety of the LIPOSORBER® LA-15 System for the treatment of adult patients with nephrotic syndrome associated with primary focal segmental glomerulosclerosis, when the standard treatment options, including corticosteroid and/or calcineurin inhibitors treatments, have been unsuccessful or not well tolerated, and the patient has a GFR ≥ 45 ml/min/1.73m2, or the patient has post-renal transplant recurren... Read More
Gender:
ALL
Ages:
75 years and below
Trial Updated:
10/07/2024
Locations: Loma Linda University Children's Hospital, Loma Linda, California
Conditions: Focal Segmental Glomerulosclerosis
A Center Based Early Intervention Program for Preschoolers with Developmental Disorders
Recruiting
The purpose of this study is to examine the effectiveness of a 12-week early intervention program that will include 12 weekly hours in an intensive center-based preschool environment or in the home to treat social communication deficits in children with developmental disorders. The study will include children with developmental disorders, such as Autism Spectrum Disorder, neurogenetic disorders, or intellectual disability.
Gender:
ALL
Ages:
Between 2 years and 5 years
Trial Updated:
10/07/2024
Locations: Stanford University School of Medicine, Stanford, California
Conditions: Development Disorder, Child, Developmental Disability, Development Delay, Autism Spectrum Disorder
Dabrafenib, Trametinib, and IMRT in Treating Patients With BRAF Mutated Anaplastic Thyroid Cancer
Recruiting
This trial studies how well dabrafenib, trametinib, and intensity modulated radiation therapy (IMRT) work together in treating patients with BRAF mutated anaplastic thyroid cancer. Dabrafenib and trametinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Radiation therapy uses high energy beams to kill tumor cells and shrink tumors. Giving dabrafenib, trametinib, and IMRT together may kill more tumor cells.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/07/2024
Locations: City of Hope Medical Center, Duarte, California
Conditions: BRAF NP_004324.2:p.V600E, BRAF V600K Mutation Present, Thyroid Gland Anaplastic Carcinoma
A Center Based Study of Pivotal Response Treatment for Preschoolers with Autism
Recruiting
The purpose of this study is to examine the effectiveness of pivotal response training (PRT) in an intensive center-based environment to treat social communication deficits in children with autism spectrum disorder (ASD).
Gender:
ALL
Ages:
Between 2 years and 3 years
Trial Updated:
10/07/2024
Locations: Stanford University School of Medicine, Stanford, California
Conditions: Autism Spectrum Disorder, Autism
Neuroimaging Predictors of Improvement to Pivotal Response Treatment (PRT) in Young Children with Autism
Recruiting
Autism spectrum disorder (ASD) is a very heterogeneous disorder with limited empirically validated behavioral and biological interventions. The goal of this pilot investigation is to apply a biologically-based approach to identify predictors of treatment response in children with ASD who are receiving Pivotal Response Treatment (PRT), an evidence-based behavioral intervention. Specifically, the investigators propose to identify neuroimaging biomarkers of treatment response to a PRT program (PRT-... Read More
Gender:
ALL
Ages:
Between 2 years and 4 years
Trial Updated:
10/07/2024
Locations: Stanford University, Stanford, California
Conditions: Autism Spectrum Disorder, Autism
Local Bisphosphonate Effect on Recurrence Rate in Extremity Giant Cell Tumor of Bone
Recruiting
The purpose of the clinical study is to investigate whether the local delivery of bisphosphonate as a surgical adjuvant can decrease the chance of a giant cell tumor of bone coming back to the same location. The hypothesis is that the local administration of bisphosphonate will decrease the rate of the tumor returning compared to traditional aggressive surgical removal of the tumor.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/07/2024
Locations: University of California - Los Angeles, Los Angeles, California
Conditions: Giant Cell Tumor of Bone
Hyperpolarized 13C Pyruvate MRI Scan in Predicting Tumor Aggressiveness in Patients With Renal Tumors
Recruiting
This feasibility study will evaluate how well hyperpolarized 13C pyruvate magnetic resonance imaging (MRI) scan works in predicting tumor aggressiveness in participants with renal tumors. Hyperpolarized 13C pyruvate is a non-radioactive substance with potential usage in the diagnostic imaging of tumors. Hyperpolarized 13C pyruvate MRI may help doctors determine non-invasively whether a kidney tumor is a benign tumor or cancer, and if cancer, how aggressive it is. This may help doctors and partic... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/06/2024
Locations: University of California, San Francisco, San Francisco, California
Conditions: Benign Kidney Neoplasm, Kidney Neoplasm, Renal Cell Cancer
Cognitive Control Training for Extinction in PTSD
Recruiting
The proposed study will test whether a working memory training (WMT) program improves fear extinction learning and its underlying neural circuitry in Veterans with posttraumatic stress disorder (PTSD). WMT is designed to improves the ability to maintain task-relevant information in mind. The project will further validate the relationship between working memory and fear extinction using novel computational and multivariate analyses that link to specific PTSD symptoms. If WMT can enhance fear exti... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
10/04/2024
Locations: VA San Diego Healthcare System, San Diego, CA, San Diego, California
Conditions: Post-Traumatic Stress Disorders, Stress Disorders, Traumatic, Post Traumatic Stress Disorder, PTSD, Trauma and Stressor Related Disorders
Molecular Optimization Via Exercise (MOVE)
Recruiting
This study is to investigate characteristics of muscle, blood, and urine samples from older adults (ages 65-80) who are either sedentary or athletes performing at an elite level for their age. This observational study will include bio-specimen collection, as well as physical and cognitive function testing and body composition.
Gender:
ALL
Ages:
Between 65 years and 80 years
Trial Updated:
10/04/2024
Locations: Buck Institute for Research on Aging, Novato, California
Conditions: Aging
Esophageal Temperature During PVI Using Q-DOT Micro
Recruiting
This study will assess how two different ablation strategies, using two different ablation catheters during catheter ablation for paroxysmal atrial fibrillation, affect the temperature of the esophagus during ablation, and the risk of injury to the esophagus.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/04/2024
Locations: Cedars-Sinai Smidt Heart Institute, Los Angeles, California
Conditions: Atrial Fibrillation Paroxysmal
Time-Restricted Eating for Type II Diabetes: TRE-T2D
Recruiting
This is a randomized clinical trial to assess the feasibility and efficacy of time-restricted eating (TRE) to improve glucose regulation and cardiovascular health of participants with type 2 diabetes mellitus (T2DM). Participants will be randomized into 2 groups: 1) standard of care (SOC), in which they will continue to follow their physician's treatment plan, or 2) SOC and TRE (8-10 hours eating window).
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
10/04/2024
Locations: Altman Clinical and Translational Research Institute, La Jolla, California
Conditions: Diabetes Mellitus, Type 2, Time Restricted Feeding, Diabetes type2
Smart Boot Use to Measure Offloading Adherence
Recruiting
The purpose of this study is to help people with diabetes who develop neuropathic diabetic foot ulcers (DFUs). These ulcers, or sores, if left untreated can increase the chance of amputation. Part of the treatment is to have the person wear a diabetic shoe or boot to help their foot heal. Sometimes people don't wear the boot like they are told. The investigators want to compare three different kinds of diabetic boots to see if they can help make it easier for people to wear their boots as instru... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/04/2024
Locations: Rancho Los Amigos National Rehabilitation Center, Downey, California
Conditions: Diabetic Foot Ulcer