California is currently home to 5602 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Post-Market Study to Assess iTind Safety in Comparison to UroLift
Recruiting
The study objective is to evaluate the safety of the iTind device comparied to UroLift.
Gender:
MALE
Ages:
50 years and above
Trial Updated:
12/05/2024
Locations: Urology Associates of Central California, Fresno, California
Conditions: Benign Prostatic Hyperplasia (BPH)
Capillary Endoscopy Aspiration Catheter
Recruiting
The small intestine is an understudied frontier of microbiome research. While aspiration during endoscopy is considered the gold standard to assess small bowel bacteria, the tools for sterile retrieval are primitive and poorly validated. Endoscopic aspiration is time-consuming and prone to contamination. Inspired by plants' ability to draw water by capillary action, a novel multi-capillary sterile system was designed which is a modified version of the conventional aspiration catheter. The purp... Read More
Gender:
ALL
Ages:
Between 18 years and 85 years
Trial Updated:
12/05/2024
Locations: Cedars-Sinai Medical Center, Los Angeles, California
Conditions: Microbiota, SIBO
Testing a Self-management Intervention in HIV+ Asian Pacific Americans
Recruiting
HIV infection rates are on a rapid rise within Asian Pacific Americans (APA) communities, with 80% of new infects being men. The purpose of this study is to adapt and evaluate the feasibility of a 4-session, 4-week family-informed self-management intervention protocol to promote health among APA men with HIV (APAMHIV). Family-informed self-management is a promising intervention to assist APAMHIV in securing family support and promoting health, and hence help address HIV epidemics in this underst... Read More
Gender:
ALL
Ages:
Between 18 years and 99 years
Trial Updated:
12/05/2024
Locations: APAIT, Los Angeles, California
Conditions: Self-management
The Active Mind Trial: An Adaptive Randomized Trial to Improve Function and Delay Dementia
Recruiting
Older adults at risk for dementia show a variety of cognitive deficits, which can be ameliorated by different cognitive training (CT) exercises. The best combination of CT exercises is unknown. The aim is to discover the most efficacious combination of CT exercises as compared to cognitive stimulation (which will serve as a stringent, active control) to modify the functional trajectories of older adults' with MCI, who are at high risk for dementia. The primary objective of the U01 phase was to d... Read More
Gender:
ALL
Ages:
Between 55 years and 89 years
Trial Updated:
12/05/2024
Locations: University of California San Francisco, San Francisco, California
Conditions: Age-related Cognitive Decline, Mild Cognitive Impairment, Dementia
Dissemination of the Donor Application: Utilizing Social Media to Identify Potential Live Organ Donors
Recruiting
This study utilizes a web-based application to help patients on the organ transplant waitlist communicate patient's need for a living donor via social media and provide interested potential donors the opportunity to engage with the evaluation process.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/05/2024
Locations: Scripps Green Hospital, San Diego, California
Conditions: End Stage Renal Disease, End Stage Liver Disease
Diagnostic and Therapeutic Applications of Microarrays in Heart Transplantation
Recruiting
Demonstrate the impact of the Molecular Microscope Diagnostic System as the standard of care for heart transplant patients.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/05/2024
Locations: UCLA Medical Centre, Los Angeles, California
Conditions: Cardiac Transplant Disorder
A Vaccine (Neoantigen-Targeted ppDC) for the Treatment of H3 G34-mutant Diffuse Hemispheric Glioma
Recruiting
This phase I trial tests the safety and side effects, and best dose of a vaccine (neoantigen-target ppDC) in treating patients with H3 G34-mutant diffuse hemispheric glioma. Vaccines made from the patient's own white blood cells and peptide-pulsed dendritic cells may help the body build an effective immune response to kill tumor cells. Giving neoantigen-targeted ppDC may be safe, tolerable and/or effective in treating patients with diffuse hemispheric glioma with a H3 G34 mutation.
Gender:
ALL
Ages:
Between 18 years and 50 years
Trial Updated:
12/04/2024
Locations: UCLA / Jonsson Comprehensive Cancer Center, Los Angeles, California
Conditions: Diffuse Hemispheric Glioma, H3 G34-Mutant
Longitudinal Assessment of Brain Structure and Function in Juvenile-onset Huntington's Disease
Recruiting
The goal of this observational study is to learn about brain development in Juvenile-onset Huntington's Disease (JoHD). The main questions it aims to answer are: * Is brain development different in JoHD than Adult-onset Huntington's Disease (AoHD)? * Can reliable biomarkers for JoHD be found in brain structure and function? Participants will be asked to complete cognitive tests, behavioral assessments, physical and neurologic evaluation, and MRI. Data collected will be compared to populations... Read More
Gender:
ALL
Ages:
Between 6 years and 30 years
Trial Updated:
12/04/2024
Locations: University of California Davis, Sacramento, California
Conditions: Juvenile Huntington Disease, Juvenile-Onset Huntington Disease
Perinatal Research on Improving Sleep and Mental Health
Recruiting
The goal of this clinical trial is to compare two sleep programs in pregnant people with insomnia. The main questions it aims to answer are: 1. What is the efficacy of digital cognitive behavioral therapy for insomnia (CBT-I) versus digital sleep hygiene education (SHE) for preventing perinatal depression? 2. Is the effect of digital CBT-I on perinatal depression mediated through prenatal insomnia symptom improvement? 3. Is the effect of digital CBT-I on perinatal depression moderated by baseli... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
12/04/2024
Locations: University of California, San Francisco, San Francisco, California
Conditions: Insomnia, Depression
A Practice-Based Intervention to Improve Care for a Diverse Population of Women with Urinary Incontinence
Recruiting
The main goal of this clinical trial is to improve the care for urinary incontinence (UI) provided to adult women by primary care providers. The main questions it aims to answer are: * Can a practice-based intervention involving primary care providers lead to improved quality of incontinence care? * Will this intervention reduce the utilization of specialist care for urinary incontinence? * What effect will this intervention have on patient outcomes, including disease-specific outcomes, symptom... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/04/2024
Locations: University of California, San Diego, La Jolla, California
Conditions: Urinary Incontinence
Volunteers to Investigate Best Results for Ablation and Novel Therapies for Atrial Fibrillation
Recruiting
VIBRANT-AF seeks to: * Identify clinically relevant predictors of effectiveness and complications of AF ablation procedures in a prospective, US-based, multi-center, real-world longitudinal study * Assess changes in modifiable lifestyle-related exposures influence the effectiveness of AF ablation * Determine incidence and predictors of complications of AF ablation procedures Participants will connect with the Eureka Research Platform and answer a series of surveys and activities over a one-yea... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/04/2024
Locations: University of California, San Francisco, San Francisco, California
Conditions: Atrial Fibrillation
Tagraxofusp in Pediatric Patients With Relapsed or Refractory CD123 Expressing Hematologic Malignancies
Recruiting
Tagraxofusp is a protein-drug conjugate consisting of a diphtheria toxin redirected to target CD123 has been approved for treatment in pediatric and adult patients with blastic plasmacytoid dendritic cell neoplasm (BPDCN). This trial aims to examine the safety of this novel agent in pediatric patients with relapsed/refractory hematologic malignancies. The mechanism by which tagraxofusp kills cells is distinct from that of conventional chemotherapy. Tagraxofusp directly targets CD123 that is pre... Read More
Gender:
ALL
Ages:
Between 1 year and 21 years
Trial Updated:
12/04/2024
Locations: Children's Hospital Los Angeles, Los Angeles, California
Conditions: Hematologic Malignancy, AML, ALL, BPDCN, MDS, Lymphoblastic Lymphoma, Lymphoma, B-Cell, Lymphoma, T-Cell, Hodgkin Lymphoma, Mixed Phenotype Acute Leukemia, Acute Undifferentiated Leukemia