California is currently home to 5602 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Study of Nivolumab and Relatlimab in Advanced Mismatch Repair Deficient Cancers Resistant to Prior PD-(L)1 Inhibitor
Recruiting
The purpose of this study is to evaluate the safety and clinical activity of nivolumab and relatlimab in patients with microsatellite instability high (MSI-H) solid tumors refractory to prior PD-(L)1 therapy.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/21/2024
Locations: Cedars Sinai Medical Center, Los Angeles, California
Conditions: Refractory MSI - H Solid Tumors Prior of PD-(L) 1 Therapy, MSI-H Tumors
An Evaluation of LASIK, SMILE and PRK Surgery in Physicians
Recruiting
The principle investigator is evaluating self-reported quality of vision and quality of life in physicians undergoing LASIK, SMILE and PRK surgery.
Gender:
ALL
Ages:
Between 21 years and 62 years
Trial Updated:
10/21/2024
Locations: Byers Eye Institute at Stanford, Palo Alto, California
Conditions: Nearsightedness, Farsightedness, Astigmatism
Early vs. Late Time-Restricted Eating in Adolescents With Obesity (EL TREA)
Recruiting
Determine the effectiveness of how limiting the time you eat within an early or late eating window and fasting for remainder of the day will impact weight loss and body mass index (BMI).
Gender:
ALL
Ages:
Between 12 years and 21 years
Trial Updated:
10/19/2024
Locations: Children's Hospital Los Angeles, Los Angeles, California
Conditions: Pediatric Obesity, Time Restricted Feeding, Time Restricted Eating
First in Human Study of TORL-3-600 in Participants With Advanced Cancer
Recruiting
This first-in-human study will evaluate the safety, tolerability, pharmacokinetics, and antitumor activity of TORL-3-600 in patients with advanced cancer
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/18/2024
Locations: Providence Medical Foundation, Fullerton, California
Conditions: Advanced Solid Tumor, Colorectal Cancer
Outcomes in Pediatric and Young Adult B-Cell Malignancies After Commercially Available Immunotherapy
Recruiting
To use a consistent and standardized platform to retrospectively and prospectively study children and young adults with B cell malignancies receiving Immunotherapy, blinatumomab and/or inotuzumab ozogamicin.
Gender:
ALL
Ages:
26 years and below
Trial Updated:
10/17/2024
Locations: Stanford University, Palo Alto, California
Conditions: Lymphoid Leukemia
Weighted Blankets for Postsurgical Pain
Recruiting
The strongest psychological predictor of persistent pain after surgery is anxiety before surgery. The weight of blanket a person uses overnight may alter both anxiety and pain levels. The proposed study will determine whether a heavier or lighter blanket alters presurgical anxiety or postsurgical pain in individuals undergoing a breast surgery. We will also study whether any blanket-induced changes in postsurgical pain are related to reductions in anxiety before surgery induced by the blanket. F... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/17/2024
Locations: Actri, Ucsd, La Jolla, California
Conditions: Pain, Postsurgical
Magnetic Apnea Prevention(MAGNAP) Device to Treat Obstructive Sleep Apnea:First-In-Human Study of Feasibility and Safety
Recruiting
The purpose of this study is to determine the safety and feasibility of the Magnap magnetic device in the treatment of obstructive sleep apnea (OSA).
Gender:
ALL
Ages:
Between 21 years and 70 years
Trial Updated:
10/17/2024
Locations: University of California San Francisco/Mount Zion Hospital, San Francisco, California
Conditions: Obstructive Sleep Apnea
Fall Risk Assessment and Speech Intelligibility Enhancement Using In-ear Device
Recruiting
The purpose of this study is to develop and validate methods to use hearing aids equipped with embedded sensors and artificial intelligence to assist in the assessment of fall risk and in the implementation of interventions aimed at reducing the risk of falling, as well as to improve speech intelligibility in quiet and in background noise, track physical activity, and social engagement. The investigators hope is that the knowledge that is generated through this study will ultimately translate to... Read More
Gender:
ALL
Ages:
55 years and above
Trial Updated:
10/16/2024
Locations: Stanford Ear Institute, Palo Alto, California
Conditions: Hearing Loss, Dizziness, Vertigo, Fall Related Injury Risk, Fall Prevention, Imbalance, Speech Intelligibility
Human Embryonic Stem Cell-Derived Cardiomyocyte Therapy for Chronic Ischemic Left Ventricular Dysfunction
Recruiting
This clinical study will utilize a new cell therapy approach (Human embryonic stem cells derived cardiomyocytes or hESC-CMs) to improve survival and cardiac function in patients with chronic left ventricular dysfunction secondary to MI (Myocardial Infarction).
Gender:
ALL
Ages:
Between 21 years and 80 years
Trial Updated:
10/16/2024
Locations: Stanford Hospital and Clinics, Palo Alto, California
Conditions: Chronic Ischemic Left Ventricular Dysfunction
A Study of the Natural History of Participants With LGMD2E/R4, LGMD2D/R3, LGMD2C/R5, and LGMD2A/R1 ≥ 4 Years of Age, Who Are Managed in Routine Clinical Practice
Recruiting
This study will follow participants who are screened and confirmed with a genetic diagnosis of Limb-girdle muscular dystrophy type 2E (LGMD2E/R4), Limb-girdle muscular dystrophy type 2D (LGMD2D/R3), Limb-girdle muscular dystrophy type 2C (LGMD2C/R5), or Limb-girdle muscular dystrophy type 2A (LGMD2A/R1). These enrolled participants will be followed to evaluate mobility and pulmonary function for up to 5 years after enrollment for participants with LGMD2C/R5, LGMD2D/R3, and LGMD2E/R4 with a Nort... Read More
Gender:
ALL
Ages:
4 years and above
Trial Updated:
10/16/2024
Locations: University of California San Diego, La Jolla, California
Conditions: Limb-girdle Muscular Dystrophy
Effects of Common Meals on Appetite and Satiety
Recruiting
The objectives of this study are to assess the impacts of meals composed of lean steak and potatoes (with a small portion of broccoli) in comparison to other common entrée/starch food combinations on metabolic and appetite responses.
Gender:
ALL
Ages:
Between 18 years and 50 years
Trial Updated:
10/15/2024
Locations: San Diego State University, San Diego, California
Conditions: Healthy
Diluted Aqueous Povidone-Iodine Compared to Saline to Decrease Surgical Site Infections
Recruiting
This is a multicenter randomized controlled trial of 1100 patients to evaluate the superiority of combined intraoperative wound irrigation with intraoperative peritoneal lavage with dilute aqueous povidone-iodine compared to normal saline in male and female patients between the ages of 18 and 80 years old undergoing emergency laparotomies with Centers for Disease Control (CDC) class 2 and 3 wounds.
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
10/15/2024
Locations: Loma Linda University Health, Loma Linda, California
Conditions: Surgical Site Infection