California is currently home to 5585 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
A Study to Assess Safety, Tolerability, and Pharmacokinetics of ABSK121-NX in Patients With Advanced Solid Tumors
Recruiting
This is an open-label phase 1 study with expansion. The study will start with a dose escalation of single-agent ABSK121-NX administered in repeated 28-day cycles in patients with advanced solid tumors to evaluate safety and tolerability. The expansion part will investigate oral ABSK121-NX at the recommended dose for expansion (RDE) to further evaluate safety and tolerability among selected tumor types. Preliminary antitumor activity will also be assessed.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/07/2024
Locations: UC San Diego Moores Cancer Center, La Jolla, California
Conditions: Solid Tumor
The Willow LTE Study With M5049 in Participants With SCLE, DLE and/or SLE (WILLOW LTE)
Recruiting
The purpose of the study is to evaluate the long term safety and efficacy of orally administered M5049 in participants with subacute cutaneous lupus erythematosus (SCLE), discoid lupus erythematosus (DLE) and/or systemic lupus erythematosus (SLE) who have completed the 24 week treatment period of Willow study (MS200569_0003 \[NCT05162586\]).
Gender:
ALL
Ages:
Between 18 years and 76 years
Trial Updated:
08/07/2024
Locations: The Lundquist Institute at Harbor-UCLA Medical Center, Torrance, California
Conditions: Systemic Lupus Erythematosus
Normative Database and Test-Retest Reliability for BrainCheck Assessments
Recruiting
The purpose of this study is to collect normative test values and demographic information for normative and referential data for a rapid, portable, computerized neurocognitive testing device from healthy adults 50 and older.
Gender:
ALL
Ages:
50 years and above
Trial Updated:
08/07/2024
Locations: BrainCheck, Palo Alto, California
Conditions: Cognitive Change, Cognitive Decline, Cognitive Deterioration, Neurocognitive Deficit
Building a Platform for Precision Anesthesia in the Geriatric Surgical Patient
Recruiting
The research team is creating a foundational infrastructure in order to develop a precision medicine approach for geriatric patients who require surgery with anesthesia. The team plans to build the first of its kind comprehensive database of demographic and risk factor questionnaire responses, biobanked blood specimens, intraoperative electroencephalography (EEG), and inclusive cognitive testing throughout patient interaction starting at the preop appointment until a year later. This will be use... Read More
Gender:
ALL
Ages:
65 years and above
Trial Updated:
08/07/2024
Locations: Stanford Medical Center, Stanford, California
Conditions: Cognitive Decline, Cognitive Change, Cognitive Impairment, Postoperative Delirium, Anesthesia; Reaction, Anesthesia; Adverse Effect
A Study of Intravesical BCG in Combination With ALT-803 in Patients With Non-Muscle Invasive Bladder Cancer
Recruiting
This is a Phase Ib/IIb, randomized, two-cohort, open-label, multicenter study of intravesical N-803 plus BCG versus BCG alone, in BCG naïve patients with high-grade NMIBC.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/07/2024
Locations: Hoag Cancer Center, Irvine, California
Conditions: Non-muscle Invasive Bladder Cancer
Hypofractionated External Beam Radiotherapy With Adaptive Planning for Endometrial and Cervical Cancers
Recruiting
After surgery to remove the main endometrial and/or cervical tumor, most women receive radiation therapy. This study uses hypo-fractionated radiation therapy, which is a type of radiation therapy in which the total prescribed dose of radiation is delivered in fewer but larger doses than conventional or standard radiotherapy. This research study aims to determine if hypo-fractionated radiation therapy given after surgery can improve treatment tolerability (i.e., fewer treatments) with comparable... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
08/06/2024
Locations: University of California at Los Angeles, Los Angeles, California
Conditions: Endometrial Cancer, Cervical Cancer
ABTECT - Maintenance
Recruiting
This is a multicenter, randomized, placebo-controlled study to evaluate the long-term efficacy and safety of ABX464 50mg and 25mg administered once daily (QD) as maintenance therapy in subjects with moderately to severely active ulcerative colitis who have inadequate response, no response, a loss of response, or an intolerance to either conventional therapies \[corticosteroids, immunosuppressant (i.e. azathioprine, 6-mercaptopurine, methotrexate)\] and/or advanced therapies \[biologics (TNF inhi... Read More
Gender:
ALL
Ages:
16 years and above
Trial Updated:
08/06/2024
Locations: National Institute of Clinical Research, Bakersfield, California
Conditions: Ulcerative Colitis
Mental Health Crises in Youth With IDDs
Recruiting
This study is an unmatched, case-control study of 150 youth (Ages 7-17) with a parent reported Intellectual Developmental Disability (IDD) who present to Rady Children's Hospital Emergency Department with a Mental Health Crisis (MHC). Rady Children's Institute for Genomic Medicine (RCIGM) will collect biological samples (such as blood) of these participants to study their genomes, medical and psychiatric profiles to better understand specific characteristics that may predispose them to MHC's. Th... Read More
Gender:
ALL
Ages:
Between 7 years and 17 years
Trial Updated:
08/06/2024
Locations: Rady Children's Hospital San Diego, San Diego, California
Conditions: Intellectual Disability
Neurocognition in Congenital Central Hypoventilation Syndrome (CCHS)
Recruiting
Congenital central hypoventilation syndrome (CCHS) is a rare disorder of autonomic and respiratory regulation that frequently alters oxygen delivery to the brain. In CCHS, neurocognitive function has been of great concern because of the potential for repeated hypoxemia and hypercarbia in activities of daily living in addition to hypoventilation with related hypoxemia and hypercarbia during sleep. As the world's leading referral center for CCHS, the Center for Autonomic Medicine in Pediatrics (CA... Read More
Gender:
ALL
Ages:
Between 3 years and 85 years
Trial Updated:
08/06/2024
Locations: Children's Hospital Los Angeles, Los Angeles, California
Conditions: Congenital Central Hypoventilation Syndrome, Congenital Central Hypoventilation, CCHS, CCHS With Hirschsprung Disease, CCHS With Neural Crest Tumor, CCHS With Neuroblastoma
Azithromycin Before Induction
Recruiting
This is a double blinded randomized control trial involving administration of 2 grams prophylactic azithromycin in third trimester patients undergoing induction of labor at our institution to demonstrate reduction in maternal and neonatal infection.
Gender:
FEMALE
Ages:
Between 18 years and 45 years
Trial Updated:
08/05/2024
Locations: Arrowhead Regional Medical Center, Colton, California
Conditions: Infections
Mechanisms of Semaglutide Therapy in Heart Failure Patients
Recruiting
Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist, primarily used for treatment of type-2 diabetes mellitus. GLP-1 receptors are present on pancreatic islet β-cells, δ-cells and α-cells. Their stimulation increases insulin and somatostatin secretion, and decreases glucagon secretion. In addition, GLP-1 receptor agonists appear to have multiple extrapancreatic actions, which remain poorly defined. In large clinical trials, semaglutide improved the outcomes in obese patients, patie... Read More
Gender:
ALL
Ages:
Between 20 years and 80 years
Trial Updated:
08/05/2024
Locations: Greenstone Biosciences, Palo Alto, California
Conditions: Heart Failure, Obesity
Title: A Multimodal Exercise Program With Gamification for Parkinson Disease (MEP+G)
Recruiting
In this pilot study the research will explore whether exercises and the outcome measures would be acceptable to conduct a more detailed research study. This 8 week pilot study will utilize a comprehensive exercise program that includes non-contact boxing along with computerized games for individuals with Parkinson Disease.
Gender:
ALL
Ages:
Between 40 years and 80 years
Trial Updated:
08/05/2024
Locations: Equilibrium Physical Therapy, Ventura, California
Conditions: Parkinson Disease