California is currently home to 5595 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Descartes-08 CAR-T Cells in Generalized Myasthenia Gravis (MG)
Recruiting
This is a Phase IIb study to evaluate the safety and preliminary efficacy of Descartes-08 CAR T-cells in patients with Generalized Myasthenia Gravis
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/22/2024
Locations: Profound Research, Carlsbad, California
Conditions: Myasthenia Gravis, Generalized
Collection of Immunology Specimens From Patients With Cancer or Blood Disorders, and Healthy Volunteers
Recruiting
This research trial collects and stores blood, tissue, and bone marrow specimens from patients with cancer or blood disorders, and healthy volunteers to study the immune system in a variety of different types of experiments, as well as associated clinical data as appropriate, focused on understanding mechanisms of immunotherapy.
Gender:
ALL
Ages:
19 years and above
Trial Updated:
05/22/2024
Locations: USC / Norris Comprehensive Cancer Center, Los Angeles, California
Conditions: Healthy Subject, Hematologic and Lymphocytic Disorder, Hematopoietic and Lymphoid Cell Neoplasm, Immune System Disorder, Malignant Neoplasm
HF2 Registry - Hemodynamic Frontiers in Heart Failure Registry
Recruiting
The purpose of the HF2 (Hemodynamic Frontiers in Heart Failure) registry is to collect relevant patient-level demographic, clinical, laboratory, and hemodynamic data from patients implanted with pulmonary artery pressure sensor at participating centers to advance scientific knowledge about ambulatory hemodynamics monitoring and HF (Heart Failure) therapies. The data collected will be used for retrospective studies, quality improvement, identifying research cohorts, and member-initiated research.
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
05/21/2024
Locations: Scripps Health, La Jolla, California
Conditions: Heart Failure
The da Vinci Single Port Robotic System for Use in Abdominal and Pelvic Surgical Procedures
Recruiting
This phase II trial test the effectiveness and safety of a single-port robotic device (the da Vinci single port \[SP\]1098) for use in abdominal and pelvic surgeries. The da Vinci SP1098 robotic device can be used to perform less invasive surgeries that allow entry into the body through a single, small incision. The use of this device during surgery may allow surgeons to perform complex procedures that result in less pain, fewer complications and side effects, and improved recovery.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/21/2024
Locations: City of Hope Comprehensive Cancer Center, Duarte, California
Conditions: Disease or Disorder
Dynamic Critical Congenital Heart Screening With Addition of Perfusion Measurements
Recruiting
The purpose of this study is to implement and externally validate an inpatient ML algorithm that combines pulse oximetry features for critical congenital heart disease (CCHD) screening.
Gender:
ALL
Ages:
Between 0 minutes and 21 days
Trial Updated:
05/21/2024
Locations: UC Davis Medical Center, Davis, California
Conditions: Congenital Heart Disease
Motor Cortical Neuromodulation in Women With Interstitial Cystitis/Bladder Pain Syndrome
Recruiting
Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS) is a common, chronic, and debilitating condition in women. Preliminary evidence suggests that IC/BPS pain can be reduced applying non-invasive repetitive transcranial magnetic stimulation (rTMS) to areas of the brain that regulate pelvic floor muscle activity. However, prior studies have examined rTMS in a very limited sample and have not examined changes in brain or pelvic floor muscle activity to determine the mechanism of rTMS for IC/BPS. T... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
05/21/2024
Locations: University of Southern California, Los Angeles, California
Conditions: Interstitial Cystitis, Bladder Pain Syndrome
Slow Heart Registry of Fetal Immune-mediated High Degree Heart Block
Recruiting
Few studies are specifically designed to address health concerns that are already relevant during pregnancy. The consequence is a lack of evidence on best clinical practice. This includes mothers and their babies when pregnancy is complicated by an abnormally slow heart rate due to maternal antibody-mediated heart disease in the unborn baby (fetus). Since the late seventies, it has been possible to detect and monitor fetal disease by ultrasound images and to treat selected conditions with pharma... Read More
Gender:
FEMALE
Ages:
Between 16 years and 50 years
Trial Updated:
05/21/2024
Locations: University of California San Francisco, San Francisco, California
Conditions: Heart Block Complete, Heart Block Second Degree
Prospective Observational Cohort Study of Fetal Atrial Flutter & Supraventricular Tachycardia
Recruiting
The FAST Trial Registry is a prospective observational cohort study of fetuses with a new diagnosis of atrial flutter (AF) or supraventricular tachycardia (SVT) that is severe enough to consider prenatal treatment (see eligibility criteria below). Aims of the Registry include to establish a large clinical database to determine and compare the efficacy and safety of different prenatal treatment strategies including observation without immediate treatment, transplacental antiarrhythmic fetal treat... Read More
Gender:
FEMALE
Ages:
Between 16 years and 50 years
Trial Updated:
05/21/2024
Locations: University of California, San Francisco, San Francisco, California
Conditions: Atrial Flutter, Tachycardia, Supraventricular, Tachycardia, Atrial Ectopic, Tachycardia, Reciprocating, Tachycardia Atrial, Tachycardia, Atrioventricular Nodal Reentry, Tachycardia, Paroxysmal, Fetal Hydrops
Clinical Data Registry of Amblyopia Patients on Luminopia Treatment
Recruiting
Amblyopia is the most prevalent cause of reduced monocular visual acuity in children and young adults, with estimates of prevalence ranging from 1% to 5%. The most common associated amblyogenic risk factors are uncorrected anisometropia, strabismus, or a combination of these. In addition to reduced visual acuity, amblyopic patients may also have measurable dysfunction of accommodation, fixation, binocularity, vergence, reading fluency, depth perception, and contrast sensitivity. For the first t... Read More
Gender:
ALL
Ages:
All
Trial Updated:
05/20/2024
Locations: UCSF Benioff Children's Physicians, San Ramon, California
Conditions: Amblyopia
An Integrative Multi-Omic Characterization of Head and Neck Carcinogenesis, Progression and Recurrence
Recruiting
This study evaluates the cell and biomarkers associated with the aggressive behavior of cancer.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/20/2024
Locations: USC / Norris Comprehensive Cancer Center, Los Angeles, California
Conditions: Head and Neck Carcinoma
Autologous CD22 CAR T Cells Following Commercial CD19 CAR T Cells in B Cell Malignancies
Recruiting
The primary purpose of this study is to determine safety, feasibility, and the Maximum Tolerated Dose (MTD)/Recommended Phase 2 Dose (RP2D) of CD22 Chimeric Antigen Receptor T-Cell Therapy (CART) cells when administered 28 to 42 days after an infusion of a commercial CAR called Tisagenlecleucel, to children and young adults with relapsed or refractory B-cell leukemia.
Gender:
ALL
Ages:
Between 1 year and 25 years
Trial Updated:
05/20/2024
Locations: Stanford University, Palo Alto, California
Conditions: Leukemia, Acute Lymphoblastic Leukemia
Improving Social Communication in Individuals With ASD Using AI
Recruiting
The purpose of this study is to identify whether researched and commonly used face-to-face interventions can be effectively implemented through artificial intelligence (AI) using an application on the phone or computer. The investigators plan to recruit verbal individuals diagnosed with autism spectrum disorder who demonstrate challenges with socialization. Modules focusing on various difficulties experienced by autistic individuals will provide practice and feedback using voice recognition and... Read More
Gender:
ALL
Ages:
Between 11 years and 35 years
Trial Updated:
05/20/2024
Locations: Stanford University School of Medicine, Stanford, California
Conditions: Autism Spectrum Disorder