California is currently home to 5595 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Enhancing Lung Cancer Screening Through Human-Centered Intervention
Recruiting
The purpose of this study is to further understand the factors involved in increasing lung cancer screening.
Gender:
ALL
Ages:
Between 50 years and 80 years
Trial Updated:
04/01/2024
Locations: University of California, Davis, Sacramento, California
Conditions: Lung Cancer
AutologousCD22 Chimeric Antigen Receptor (CAR)T Cells in w/Recurrent/Refractory B Cell Lymphomas
Recruiting
This is a non-randomized clinical trial to evaluate the safety and efficacy of CD22CART administered after lymphodepleting chemotherapy in adults with relapsed / refractory B Cell Lymphomas. All evaluable participants will be followed for overall survival (OS), progression free survival (PFS), and duration of response (DOR). An evaluable participant is one who completes leukapheresis, lymphodepleting chemotherapy and CART infusion.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/01/2024
Locations: Stanford University, Palo Alto, California
Conditions: Follicular Lymphoma, Mantle Cell Lymphoma, Hairy Cell Leukemia, Lymphoplasmacytic Lymphoma, Burkitt Lymphoma, Marginal Zone Lymphoma, Waldenstrom Macroglobulinemia
Effect of Mediterranean Diet in Inflammatory Bowel Disease
Recruiting
The effects of diet on inflammatory bowel disease is an under-studied area of research. The investigators are interested in further investigating the role that diet contributes to inflammatory bowel disease severity. The investigators will collect blood and stool samples from patients with inflammatory bowel disease (IBD) before and after diet changes. The stool samples will be analyzed using metabolomics and microbiome analysis to determine changes after the new diet has been implemented. The i... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/01/2024
Locations: University of California, San Diego, San Diego, California
Conditions: Inflammatory Bowel Disease
A Biobehavioral Intervention to Reduce Adverse Outcomes in Young Adult Testicular Cancer Survivors
Recruiting
This study is a randomized controlled biobehavioral efficacy trial designed to investigate the feasibility and acceptability of a novel intervention, Goal-focused Emotion-Regulation Therapy (GET) aimed at improving distress symptoms, emotion regulation, goal navigation skills, and stress-sensitive biomarkers in young adult testicular cancer patients. Participants will be randomized to receive six sessions of GET or Individual Supportive Listening (ISL) delivered over eight weeks. In addition to... Read More
Gender:
MALE
Ages:
Between 18 years and 39 years
Trial Updated:
04/01/2024
Locations: University of California, Irvine, Irvine, California
Conditions: Testicular Cancer
Prediction of Rehospitalization Following a Sepsis Admission Using a Wearable Biopatch
Recruiting
The goal of this observational study is to learn about the utility of biopatches predicting 30-day readmissions in patients discharged from the hospital with sepsis. The main question\[s\] it aims to answer are: • Does the application of a biopatch provide data that can improve prediction of an unplanned 30-day readmission following a hospitalization for sepsis. Participants will be asked to wear a biopatch on their chest for 30-days following hospital discharge or until readmission to the ho... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/01/2024
Locations: UC San Diego Health, San Diego, California
Conditions: Sepsis
Targeting the Default Mode Network: A TMS-fMRI Study
Recruiting
In post-traumatic stress disorder (PTSD), intrusive, traumatic, autobiographical memories lead to anxiety symptoms. Recent work suggests a new repetitive pulse transcranial magnetic stimulation (rTMS) brain target that might bring relief. Since this proposed target is not well understood, the goal of the study is to use functional magnetic resonance imaging (fMRI) to identify the brain regions and networks that change with rTMS stimulation at this target area in PTSD patients. Ultimately, this w... Read More
Gender:
ALL
Ages:
Between 18 years and 55 years
Trial Updated:
04/01/2024
Locations: VA Palo Alto, Palo Alto, California
Conditions: Post Traumatic Stress Disorder, PTSD
Pregistry International Pregnancy Exposure Registry (PIPER)
Recruiting
The aims of the Pregistry International Pregnancy Exposure Registry (PIPER) are to provide early signals of risk after prenatal exposure to medical products and to define boundaries of safety for medical products. The goal is to assist prescribers and study participants in weighing the potential risks of prenatal treatments on the wellbeing of mother and the unborn offspring. Specifically, the PIPER will estimate the risk of obstetric outcomes (spontaneous abortion, antenatal bleeding, gestatio... Read More
Gender:
FEMALE
Ages:
Between 18 years and 50 years
Trial Updated:
04/01/2024
Locations: Pregistry, Los Angeles, California
Conditions: Pregnancy Related
A Phase I Study of KB301, a Replication-Incompetent, Non-Integrating Vector Expressing Human Type III Collagen (COL3) for the Treatment of Superficial Skin Depressions
Recruiting
A Phase I Study of KB301, a Replication-Incompetent, Non-Integrating Vector Expressing Human Type III Collagen (COL3) for the Treatment of Superficial Skin Depressions
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
04/01/2024
Locations: Aesthetx, Campbell, California
Conditions: Wrinkle, Skin Roughness, Fine Lines, Skin Thickness
The BENeFiTS Trial in Beta Thalassemia Intermedia
Recruiting
Beta-thalassemias and hemoglobinopathies are serious inherited blood diseases caused by abnormal or deficiency of beta A chains of hemoglobin, the protein in red blood cells which delivers oxygen throughout the body.The diseases are characterized by hemolytic anemia, organ damage, and early mortality without treatment. Increases in another type of (normal) hemoglobin, fetal globin (HbF), which is normally silenced in infancy, reduces anemia and morbidity. Even incremental augmentation of fetal g... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/01/2024
Locations: UCSF Benioff Children's Hospital at Oakland, Oakland, California
Conditions: Beta Thalassemia Intermedia, Sickle Cell Disease
Confirmatory Clinical Evaluation of Novilase® Laser Therapy for Focal Destruction of Malignant Breast Tumors
Recruiting
Prior to this confirmatory pivotal study, the multicenter Br-002 feasibility study was completed. 98% of tumors less than or equal to 15mm were completely ablated in one procedure.This study will evaluate Novilase for the focal destruction of malignant tumors of the breast that are less than or equal to 15 mm against a performance goal for the standard of care, lumpectomy. The ASBrS' goal of less than 20% retreatment by 2020 was selected as a representative performance goal, i.e., 80.0%, and is... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
04/01/2024
Locations: City of Hope, Duarte, California
Conditions: Malignant Neoplasm of Breast
Evaluating Pulse Oximetry Bias in Children With Darker Skin Pigmentation
Recruiting
In this prospective study, the investigators will enroll 154 children with arterial lines to determine the accuracy of pulse oximeters in children with darker skin pigmentation. Studies in adults suggest pulse oximeters may overestimate the true level of oxygenation in the blood as measured directly by co-oximetry. However, pediatric data are relatively limited. This study, which is funded by the FDA through the Stanford-UCSF (University of California San Francisco) Clinical Excellence in Regula... Read More
Gender:
ALL
Ages:
21 years and below
Trial Updated:
03/29/2024
Locations: Lucile Packard Children's Hospital, Palo Alto, California
Conditions: Congenital Heart Disease in Children, Cardiomyopathies
Effect of VR on Pain and Patient Satisfaction in Adults Receiving GNRFA
Recruiting
The study team aims to investigate whether implementing virtual reality therapy (VRT) during Genicular nerve radiofrequency ablation (GNRFA) procedure will provide better alleviation of procedural pain and augmented satisfaction for patients.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/29/2024
Locations: UC Irvine Gottschalk Medical Plaza, Irvine, California
Conditions: Pain, Patient Satisfaction