California is currently home to 5602 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Valve Hemodynamic Optimization Based on Doppler-Echocardiography vs Catheterization Measurements Following ViV TAVR
Recruiting
Data on valve performance following ViV-TAVR has usually been obtained with the use of Doppler-echocardiography. However, some reports have shown significant discordances in the evaluation of mean transvalvular gradient between echocardiography and catheterization, with an overestimation of the real gradient with echo (vs. cath) in most cases. Thus, the incidence of procedural-device failure may be lower than that reported in the ViV-TAVR literature,
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/10/2024
Locations: University of California, San Francisco, California
Conditions: Aortic Valve Stenosis, Aortic Valve Regurgitation, Prosthesis Failure
Regional Blood Flow During Peripheral Heating
Recruiting
Blood flow through the popliteal, brachial, and carotid arteries during peripheral heating of the feet
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
07/09/2024
Locations: Jeff Moore, San Diego, California
Conditions: Blood Flow
Early Intervention to Promote Cardiovascular Health of Mothers and Children
Recruiting
Early Intervention to Promote Cardiovascular Health of Mothers and Children (ENRICH) is a cluster randomized clinical trial, funded by the National Heart Lung \& Blood Institute. The study is designed to test the effectiveness of home visiting intervention to promote cardiovascular health and reduce disparities in maternal and early childhood cardiovascular health. Sites, in partnership with evidence-based home visiting programs, are recruiting 6400 participants in total (i.e., 3200 parent-dyads... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
07/08/2024
Locations: California Polytechnic State University, San Luis Obispo, California
Conditions: Cardiovascular Health
IMProving Adherence to Colonoscopy Through Teams and Technology
Recruiting
Complete and timely colonoscopy after an abnormal stool-based colorectal cancer screening test results in early detection, cancer prevention, and reduction in mortality, but follow-up in safety-net health systems occurs in less than 50% at 6 months. The proposal will implement multi-level approach consisting of a stepped-wedge clinic-level intervention of team-based best practices co-developed with primary and specialty care, a patient-level technology intervention to provide enhanced instructio... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/08/2024
Locations: Zuckerberg San Francisco General Hospital, San Francisco, California
Conditions: Colon Cancer, Cancer Colorectal, Colorectal Cancer
Brain Health Virtual Reality Study
Recruiting
The Interventions for Brain Health Virtual Reality Study is a NIH-funded clinical research trial at the University of California San Diego (UCSD) Health under the supervision of the study principal investigator Dr. Judy Pa. The overarching goal of this trial is to use a novel virtual reality (VR) based intervention that simultaneously engages physical and cognitive activity aimed at improving brain health and cognition in older adults. The investigators will compare 3 types of interventions: phy... Read More
Gender:
ALL
Ages:
Between 50 years and 85 years
Trial Updated:
07/08/2024
Locations: University of California, San Diego, San Diego, California
Conditions: Aging, Aging Problems, Memory Loss, Memory Impairment, Memory Disorders in Old Age, Memory Disorder, Spatial, Memory Disorders, Mild Cognitive Impairment, Cognitive Decline, Cognitive Change, Cognition Disorders in Old Age
FOOD PRESCRIPTION APP
Recruiting
This study will develop and test and app that will create meal plans to improve diet quality and support weight loss. This app will allow participants to customize their meal plans and substitute recipes for nutritionally equivalent options that they find more appealing, thus potentially increasing adherence.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/08/2024
Locations: Kaiser Permanente, Pasadena, California
Conditions: Diet, Healthy
Centralized Virtual SBIRT for Pediatric Primary Care
Recruiting
Adolescent alcohol and other drug (AOD) use is a significant public health problem which contributes to high levels of mortality, morbidity and healthcare costs in young people, and identification and early intervention for these problems is critical to improving outcomes. Screening, Brief Intervention and Referral to Treatment (SBIRT) in pediatric primary care is an evidence-based strategy for addressing these problems, but has not been widely and systematically implemented, for a variety of re... Read More
Gender:
ALL
Ages:
Between 12 years and 17 years
Trial Updated:
07/04/2024
Locations: Kaiser Permanente Division of Research, Pleasanton, California
Conditions: Adolescent Alcohol Use, Mental Health Issue, Alcohol Related Disorders, Adolescents
Creatine Supplementation At Simulated Altitude
Recruiting
Creatine supplementation has been shown to increase exercise performance at sea level. The goal of this study is to determine the effects of creatine supplementation on exercise performance at simulated altitude.
Gender:
ALL
Ages:
Between 18 years and 40 years
Trial Updated:
07/03/2024
Locations: California Polytechnic State University, San Luis Obispo, California
Conditions: Exercise Performance
LINNOVATE: Lurbinectedin, Ipilimumab and Nivolumab for Soft Tissue Sarcoma
Recruiting
This is an open label, dose-seeking phase 1/2 study using escalating doses of LURBINECTEDIN administered intravenously with fixed doses of IPILIMUMAB and NIVOLUMAB administered intravenously.
Gender:
ALL
Ages:
Between 18 years and 90 years
Trial Updated:
07/02/2024
Locations: Sarcoma Oncology Research Center, Santa Monica, California
Conditions: Advanced Soft-tissue Sarcoma
A Study of Vibegron in Pediatric Participants 2 Years to Less Than (<) 18 Years of Age With NDO and on CIC
Recruiting
The purpose of this study is to evaluate the safety, efficacy, and PK of vibegron in pediatric participants with NDO who are regularly using CIC
Gender:
ALL
Ages:
Between 2 years and 17 years
Trial Updated:
07/02/2024
Locations: Children's Hospital of Orange County, Orange, California
Conditions: Neurogenic Detrusor Overactivity
Cannabis Use, Cognition, and the Endocannabinoid System in HIV
Recruiting
Understanding how co-morbidities in persons with HIV (PWH) such as substance use affect risk-taking, decision-making, and other cognitive behaviors is important given implications for everyday functioning and transmission risk. The high prevalence of cannabis use in PWH, medicinally and recreationally, may indicate disease severity, impart therapeutic benefits, or adverse consequences. In fact, cannabis is recommended to those with HIV to alleviate nausea, improve appetite, relieve pain, and lif... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
07/02/2024
Locations: UC San Diego Medical Center-Hillcrest, San Diego, California
Conditions: HIV-1-infection
GALLANT: Metronomic Gemcitabine, Doxorubicin, Docetaxel and Nivolumab for Advanced Sarcoma
Recruiting
This is an open label phase 2 study for advanced sarcoma using metronomic doses of gemcitabine, doxorubicin and docetaxel, and nivolumab immunotherapy given intravenously.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/02/2024
Locations: Sant P Chawla, Santa Monica, California
Conditions: Sarcoma