California is currently home to 5616 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Longitudinal Prospective Study of Neurocognition & Neuroimaging in Primary BT Patients
Recruiting
In this proposal, the investigators introduce a novel, translational study to prospectively examine primary brain tumor patients undergoing fractionated radiation therapy to the brain. Quantitative neuroimaging, radiation dose information, and directed neurocognitive testing will be acquired through this study to improve understanding of cognitive changes associated with radiation dosage to non-targeted tissue, and will provide the basis for evidence-based cognitive- sparing brain radiotherapy.
Gender:
ALL
Ages:
Between 18 years and 99 years
Trial Updated:
06/14/2024
Locations: Moores Cancer Center, San Diego, California
Conditions: Primary Brain Tumor, Glioma, Meningioma, Schwannoma
UCSD Image-Guided Cognitive-Sparing Radiosurgery for Brain Metastases
Recruiting
In this proposal, the investigators introduce advanced diffusion and volumetric imaging techniques along with innovative, automated image parcellation methods to identify critical brain regions, incorporate into cognitive-sparing SRS, and analyze biomarkers of radiation response. This work will advance the investigators' understanding of neurocognitive changes after brain SRS and help create interventions that preserve cognitive-function in brain metastases patients.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/14/2024
Locations: Moores Cancer Center, San Diego, California
Conditions: Brain Metastases, Adult, Neurocognitive Function, Cancer
Pharmacokinetics Distribution of Raltegravir by PET/MR
Recruiting
This is a single-center drug distribution and pharmacokinetic study of a single microdose of 18F-raltegravir given to 10 HIV-infected subjects who are either taking or not taking a raltegravir-containing ART regimen. After administration of IV 18F-raltegravir, subjects will undergo PET/MRI in order to determine the distribution of radiolabeled drug through the lymphoreticular system and other tissues throughout the entire body.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/14/2024
Locations: University of California, San Francisco, San Francisco, California
Conditions: HIV-1-infection
Study of Effect of Azeliragon in Patients Refractory to Prior Treatment of Metastatic Pancreatic Cancer
Recruiting
This is an open label study to determine the safety and preliminary evidence of a therapeutic effect of azeliragon in patients refractory to prior treatment of metastatic pancreatic cancer.
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
06/13/2024
Locations: Cedars-Sinai Medical Center, Samuel Oschin Comprehensive Cancer Institute, Los Angeles, California
Conditions: Metastatic Pancreatic Cancer
Multi-analyte Blood Test Clinical Trial
Recruiting
The objective of this study is the acquisition of whole blood samples and serum samples from participants with untreated Hepatocellular Carcinoma (HCC) and subjects undergoing Hepatocellular Carcinoma (HCC) surveillance. These samples will be used for research purposes to develop and validate the Helio multi-analyte blood test.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/13/2024
Locations: Providence Facey Medical Foundation, Mission Hills, California
Conditions: Liver Cirrhosis, Liver Cancer, HCC, Hepatocellular Carcinoma
Collection of Blood From Healthy Patients, Patients With Benign Disease and Patients With Cancer
Recruiting
To acquire blood samples from subjects for various purposes, including: i) determining the sensitivity and specificity of select DNA methylation markers for the detection of various types of cancer, ii) identifying benign conditions that may induce false positive or false negative results, and iii) defining the effects of potential interfering substances, such as chemotherapy drugs.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/13/2024
Locations: Torrance Memorial Physician Network - Cancer Care, Redondo Beach, California
Conditions: Cancer, Liver Cirrhosis, Chronic Hepatitis, Hepatitis B, Hepatitis C, Diabetes, COPD
NIA_Improving Function and Well-being by Improving Patient Memory: Transdiagnostic Sleep and Circadian Treatment
Recruiting
Mental illness is often chronic, severe, and difficult to treat. Though there has been significant progress towards establishing effective and efficient interventions for psychological health problems, many individuals do not gain lasting benefits from these treatments. The Memory Support Intervention (MSI) was developed utilizing existing findings from the cognitive science literature to improve treatment outcomes. In this study, the investigators aim to conduct an open trial that includes indi... Read More
Gender:
ALL
Ages:
50 years and above
Trial Updated:
06/12/2024
Locations: University of California, Berkeley, Berkeley, California
Conditions: Sleep Disorder, Circadian Dysregulation, Memory Impairment
Telehealth Treatment for Alcohol Use Disorder
Recruiting
Participants with alcohol use disorder will be randomly assigned to either the Ria Treatment Platform or a waitlist control. The Ria Treatment Platform is a telehealth approach that incorporates medical assessment, medications for alcohol use disorder, individual and group coaching, educational video modules, and a Bluetooth-enabled breathalyzer. Patients are followed for three months during which data are collected, including measures of alcohol consumption and its consequences.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/12/2024
Locations: Stanford University, Stanford, California
Conditions: Alcohol Use Disorder, Alcohol Dependence, Alcoholism
A Phase 1, Open-label Trial of Belzupacap Sarotalocan (AU-011) in Bladder Cancer
Recruiting
The main objectives of this study are to determine the feasibility and safety of AU-011 treatment of bladder cancer utilizing intratumoral injection with or without intramural injection and with or without laser application.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/11/2024
Locations: Saint John's Cancer Institute, Santa Monica, California
Conditions: Non-muscle-invasive Bladder Cancer, Muscle-Invasive Bladder Carcinoma
Use of Continuous Glucose Monitoring in Non-Diabetic Population to Compliment Signos Mobile Health Platform
Recruiting
Metabolic syndrome and resulting downstream health effects remains a growing health concern. In published trials, the use of continuous glucose monitoring (CGM) assists behavioral changes efforts, leading to improved adherence and results from diet and exercise changes in individuals with obesity, pre-diabetes and diabetes. Mobile health (mHealth) platforms provide satisfactory, easy-to-use tools that help participants in the pursuit of weight change goals. We hypothesize that the use of CGM dat... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/11/2024
Locations: Signos, Palo Alto, California
Conditions: Weight Loss, Metabolic Syndrome, Pre-diabetes, Central Obesity, Glucose Intolerance, Metabolic Glucose Disorders
Development of Effective, Opioid Sparing Techniques for Peri-operative Pain Management of Transgender Patients Undergoing Gender Affirming Surgeries
Recruiting
This study will compare the current standard-of-care pain treatment regimen options that are available to patients who undergo gender-affirming surgery. The purpose of this research is to determine if any of these options are more (versus less) effective than the others to manage surgery related pain, after surgery.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/11/2024
Locations: Cedars-Sinai Medical Center - North and South Towers, Los Angeles, California
Conditions: Gender Dysphoria
Accuracy of the EvieMED Ring Pulse Oximeter in Profound Hypoxia
Recruiting
The goal of this study was to evaluate the accuracy of pulse oximeters over the range of 70-100% per the International Organization for Standardization (ISO) 80601-2-61:2019. Four test devices were placed on each subject on the left or right hand with two at the finger base and two at the fingertip. Motion equipment was used to control motion of the test devices. In addition, two test devices were placed on the contralateral hand on the base of a finger and also on the fingertip. Finally, a test... Read More
Gender:
ALL
Ages:
Between 18 years and 49 years
Trial Updated:
06/10/2024
Locations: Hypoxia Research Laboratory, San Francisco, California
Conditions: Hypoxia