California is currently home to 5592 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Comparing Clinical Outcomes of Suture Button Versus Fibulink Fixation for Acute Ankle Syndesmosis Injuries
Recruiting
This project consists of a randomized controlled study design. Study candidates will include all patients 18 years or older, who were evaluated at UCSD and found to have an acute ankle syndesmosis injury requiring surgery. Patients who consent to study participation will be randomized to receive one of two standard of care procedures - either a suture button or Fibulink implant. Outcome measures, including the Olerud-Molander and American Orthopaedic Foot and Ankle Society scores, pain, range of... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/06/2024
Locations: University of California, San Diego, San Diego, California
Conditions: Ankle Injuries, Syndesmotic Injuries, Ankle Fractures
A Case Series: TRUMATCH Graft Cage for Segmental Long Bone Defects
Recruiting
This project consists of a prospective case design. Study candidates will include all patients ages 18 and over who were evaluated at UCSD and found to have a critical-sized humerus, femur, or tibia segmental defect that would be fixed through surgery. Patients who consent to study participation will receive the TRUMATCH Graft Cage for their long bone segmental defect repair. Data on healing rates, complication rates, re-operation rates, time to return to normal activity, and pain levels will be... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/06/2024
Locations: University of California, San Diego, San Diego, California
Conditions: Tibia Fracture, Humerus Fracture, Femoral Fracture, Long Bone Segmental Defect
Expression of Stress Markers During Meth Treatment (EXPRESS+)
Recruiting
This is a non-randomized behavioral trial that aims to investigate whether changes in inflammatory and type I IFN expression coincide with changes in methamphetamine use and viral load over the course of 12 weeks in HIV-positive people assigned male at birth with and without methamphetamine use disorder.
Gender:
MALE
Ages:
Between 18 years and 45 years
Trial Updated:
05/06/2024
Locations: UCLA Vine Street Clinic, Los Angeles, California
Conditions: Substance-Related Disorders, HIV
Writing About Experiences and Health in Older Adults II
Recruiting
UCLA researchers looking for healthy older adults (aged 65+) to participate in a study investigating how writing about experiences can affect your brain and body. Once a week for 6 weeks, participants will write about their experiences and fill out online questionnaires. Participants will also come to the UCLA campus to complete a neuroimaging session (fMRI), provide a blood spot sample, and fill out questionnaires 2 times: once prior to the 6-week writing period and once immediately after the... Read More
Gender:
ALL
Ages:
65 years and above
Trial Updated:
05/06/2024
Locations: Center for Cognitive Neuroscience, Los Angeles, California
Conditions: Social Psychology
Levonorgestrel 52 mg IUD for Emergency Contraception and Same-Day Start
Recruiting
This is a prospective clinical research study to test the effectiveness of the Levonorgestrel (LNG) 52 mg Intrauterine Device (IUD) for emergency contraception (EC) and same-day start use that will enroll people receiving care at Planned Parenthood affiliates across the U.S. Our prior work demonstrated efficacy (shows that it works in an ideal setting) for the LNG 52 mg IUD for these uses and this study will test effectiveness (how well it works in the real world) in a larger, heterogenous popul... Read More
Gender:
FEMALE
Ages:
Between 16 years and 35 years
Trial Updated:
05/06/2024
Locations: Planned Parenthood Mar Monte, San Jose, California
Conditions: Contraception
Trazodone vs. Quetiapine for the Treatment of ICU Delirium
Recruiting
This is a single-center, prospective observational pilot study. The objective of this study is to evaluate the effectiveness of trazodone as compared to quetiapine, in the management of ICU delirium in adult (\>=18 years old) surgical and medical ICU patients. The investigators will compare outcomes such as delirium duration, delirium-free days, coma-free days, in-hospital mortality, 28-day mortality, hospital length of stay (LOS), ICU LOS, mechanical ventilator days, complications, adverse effe... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/06/2024
Locations: Keck Hospital of the University of Southern California, Los Angeles, California
Conditions: Delirium, Delirium of Mixed Origin, Delirium, Sepsis Associated, Delirium in Old Age, Delirium Confusional State, Psych, Morality, Treatment Side Effects
Warfarin Patient Self-management Implementation in the US Healthcare System
Recruiting
In the US, patients receiving warfarin therapy are rarely allowed to engage in patient self-management (PSM) which is less burdensome, less expensive, and safer than standard clinic-directed warfarin management. The long-term objective of our application is to improve the safety of ambulatory warfarin therapy through increasing the implementation of PSM.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/06/2024
Locations: VA Loma Linda Healthcare System, Loma Linda, California
Conditions: Atrial Fibrillation, Venous Thromboembolism, Heart Valve Diseases
A Prospective, Randomized, Open Label Trial of Two Doses of Oral Betaine
Recruiting
Betaine (trimethyglycine) is a food supplement that is approved for sale in the United States without a prescription. In this study, betaine will be provided to patients as a powder that can be mixed with aqueous solutions and consumed orally.
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
05/06/2024
Locations: VA Long Beach Healthcare System, Long Beach, California
Conditions: Non-Alcoholic Fatty Liver Disease, Non Insulin Dependent Diabetes, ALT
Studying Tumor Tissue Samples and Blood Samples to Learn More About DNA Changes in Patients With Lung Cancer
Recruiting
RATIONALE: Studying samples of tumor tissue and blood from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. PURPOSE: This laboratory study is looking at tumor tissue samples and blood samples to learn more about DNA changes in patients with lung cancer.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/06/2024
Locations: University of California Davis Cancer Center, Sacramento, California
Conditions: Lung Cancer
Dosimetry of Tc-99m-Tilmanocept
Recruiting
This proposal will use kidney SPECT/CT of Tc-99m-tilmanocept to evaluate the mesangial changes seen in diabetics across the spectrum of kidney disease as well as persons with hypertensive kidney disease, the next most common cause of kidney disease in patients with diabetes. We aim to demonstrate that these different disease types and stages can be differentiated with Tc-99m-tilmanocept SPECT/CT and can thus be used for future trials evaluating early diagnosis and treatment of diabetic nephropat... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/04/2024
Locations: UC San Diego Medical Center, San Diego, California
Conditions: Diabetic Kidney Disease
Bioresorbable Glass Fiber Matrix in the Treatment of Diabetic Foot Ulcers
Recruiting
This study is a prospective, multi-center, randomized controlled trial designed to collect patient outcome data on 2 commercially available SOC treatments for Diabetic Foot Wounds.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/03/2024
Locations: LA Foot and Ankle, Los Angeles, California
Conditions: Diabetic Foot Ulcer, Ulcer Foot, Diabetic Foot
Effect of LEQEMBI on Cerebral and Retinal Amyloid in Mild Cognitive Impairment Due to Alzheimer's Disease
Recruiting
This is a proof of concept observational study is to determine if there is correlation between Aβ plaques and vascular findings in the Retina versus brain ARIA.
Gender:
ALL
Ages:
All
Trial Updated:
05/03/2024
Locations: Sutter Health, Sacramento, California
Conditions: Mild Cognitive Impairment, Alzheimer Disease