California is currently home to 5616 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
The Effect of Zolpidem on Outcomes Following Lumbar Spine Fusion
Recruiting
The purpose of this study is to evaluate if peri-operative zolpidem for posterior lumbar spinal fusion improves patient reported outcomes following surgery.
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
06/20/2024
Locations: Keck Medical Center of USC, Los Angeles, California
Conditions: Spine Fusion, Lumbar Spine Degeneration, Pain, Postoperative, Lumbar Spine Spondylosis
A Phase 2a Study of IV BCV in Subjects With Adenovirus Infection
Recruiting
The purpose of this study is to determine the safety and tolerability of intravenous (IV) brincidofovir (BCV; SyB V-1901) 0.2 mg/kg, 0.3 mg/kg or 0.4 mg/kg dosed twice weekly (BIW) or 0.4 mg/kg dosed once weekly (QW) for 4 weeks in subjects with AdV, and IV BCV in subjects with CMV
Gender:
ALL
Ages:
2 months and above
Trial Updated:
06/20/2024
Locations: Research Site, Los Angeles, California
Conditions: Adenovirus Infections, Cytomegalovirus Infection
Phase 3 Study of Toripalimab Alone or in Combination With Tifcemalimab as Consolidation Therapy in Patients With Limited-stage Small Cell Lung Cancer (LS-SCLC)
Recruiting
The Study is a Phase 3, randomized, three-arm, double-blind, placebo-controlled, multi-regional clinical research study to evaluate the safety and efficacy use of toripalimab alone or in combination with tifcemalimab as consolidation therapy in patients with limited-stage small cell lung cancer without disease progression following chemoradiotherapy. Tifcemalimab is a monoclonal antibody against B and T lymphocyte attenuator (BTLA). Toripalimab is a monoclonal antibody against programmed death... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/19/2024
Locations: SCRI Nashville, Davis, California
Conditions: Limited-stage Small Cell Lung Cancer (LS-SCLC)
Multiple Sclerosis Falls Insight Track
Recruiting
The purpose of this study is to develop an application: MS Falls Insight Track (MS FIT) which allows patients to log their falls and near falls, view their MS relevant data and responses to the clinic intake survey as well as communicate with their care team about falls and receive educational material on falls prevention.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/18/2024
Locations: University of California, San Francisco, San Francisco, California
Conditions: Multiple Sclerosis
Selective Early Medical Treatment of Patent Ductus Arteriosus in Extremely Low Gestational Age Infants: A Pilot RCT
Recruiting
Background: Among preterm infants, those born at a gestational age less than 26 weeks are considered the most vulnerable with a high risk of short- and long-term health problems that include chronic lung disease, brain bleeds, gut injury, kidney failure and death. Patent ductus arteriosus (PDA) is the most common heart condition with almost 70% preterm infants in this gestational age group being diagnosed with a PDA. Though many PDAs spontaneously resolve on their own, research suggests that if... Read More
Gender:
ALL
Ages:
72 hours and below
Trial Updated:
06/18/2024
Locations: Children's Hospital of Orange County, Orange, California
Conditions: Patent Ductus Arteriosus After Premature Birth
Virtual 1-Session Spanish "Empowered Relief" Group Intervention for Chronic Pain
Recruiting
Empowered Relief (ER) is a 1-session pain relief skills intervention that is delivered in-person or online by certified clinicians to groups of patients with acute or chronic pain. Prior work in has shown ER efficacy for reducing chronic pain, pain-related distress, and other symptoms 6 months post-treatment. The purpose of this randomized trial is to conduct the first feasibility and early efficacy test of online Spanish ER delivered to Spanish-speaking adult patients with chronic pain. Partici... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/18/2024
Locations: 1070 Arastradero Rd, Palo Alto, California
Conditions: Chronic Pain
A Study of TSR-022 in Participants With Advanced Solid Tumors (AMBER)
Recruiting
This is a first-in-human study evaluating the anti-T cell immunoglobulin and mucin containing protein-3 (TIM-3) antibody TSR-022. The study will be conducted in 2 parts with Part 1 consisting of dose escalation and Part 2 dose expansion. Part 1 will determine the recommended Phase 2 dose (RP2D) of TSR-022 and Part 2 will evaluate the antitumor activity of TSR-022 in combination with TSR-042 or docetaxel and as monotherapy.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/18/2024
Locations: GSK Investigational Site, Encinitas, California
Conditions: Neoplasms
Restoring Metabolic and Reproductive Health With Sleep in PCOS Study, CPAP Trial
Recruiting
In this study, the researchers are trying to learn more about the relationship between Polycystic Ovary Syndrome and Obstructive Sleep Apnea (OSA). Obstructive Sleep Apnea is a sleep-related breathing disorder that involves a decrease or complete stop in airflow. The purpose of this study is to find out why some people with obstructive sleep apnea have higher levels of insulin resistance, and the investigators will study the role of hypoxia (low levels of oxygen in the blood at night) in insulin... Read More
Gender:
FEMALE
Ages:
Between 18 years and 40 years
Trial Updated:
06/17/2024
Locations: University of California, San Francisco, San Francisco, California
Conditions: Polycystic Ovary Syndrome, Obstructive Sleep Apnea
Social Influences on Sensorimotor Integration of Speech Production and Perception During Early Vocal Learning
Recruiting
The goal of this study is to investigate the role of social factors on speech learning, including production and perception, in infants ranging in age from \~7-18 months. Infants have either typical hearing or sensorineural hearing loss. The main prediction of the study is that social reinforcement will engender improvements in vocal learning above and beyond gains in hearing in infants with hearing loss. As part of this study: * The parent and infant engage in a free play session in the playro... Read More
Gender:
ALL
Ages:
Between 7 months and 24 months
Trial Updated:
06/17/2024
Locations: University of Southern California, Los Angeles, California
Conditions: Sensorineural Hearing Loss, Speech
SCOPE Analytic Treatment Interruption Protocol
Recruiting
The goal of this study is to understand the interaction between HIV and the host at the earliest stages when HIV medications are paused. Volunteers with HIV will interrupt antiretroviral therapy (ART) and then have intensive studies preformed two to three times per week. Most will resume therapy within three weeks, even if the virus does not rebound during this time.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/17/2024
Locations: University of California San Francisco, San Francisco, California
Conditions: HIV/AIDS
The Use of Lymph Node Biopsies to Support HIV Pathogenesis Studies
Recruiting
HIV medicines have led to dramatic improvements in health. However, there remains a concern for potential drug toxicities, cost of drugs, and need for life-long treatment. In addition, research has found that health is not completely restored in HIV-infected patients, even if they have been taking effective HIV medicines for a long time. This may be due to direct drug-toxicity, continued replication of the virus, and/or inflammation of the body in response to the virus. Therefore, a more complet... Read More
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
06/17/2024
Locations: San Francisco General Hospital, San Francisco, California
Conditions: HIV
The Effects of Almond on Facial Skin Collagen and Wrinkles
Recruiting
Investigate the effects of almond consumption on collagen production, elastin levels, wrinkles, and pigmentation among premenopausal women and postmenopausal women belonging to all Fitzpatrick skin types.
Gender:
FEMALE
Ages:
Between 35 years and 70 years
Trial Updated:
06/15/2024
Locations: Integrative Skin Science and Research, Sacramento, California
Conditions: Collagen Degeneration, Wrinkle, Pigmentation, Elastic Skin