California is currently home to 5592 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Quantifying Radiation Induced Vaginal Stenosis
Recruiting
Radiation (RT) affects the vagina by narrowing, tightening and scarring, termed vaginal stenosis (VS). VS occurs in up to 88% of patients treated with radiation for cervical cancer. VS is not well characterized in measurements. There is a lack of understanding of how short and tight the vagina becomes after RT. This study will use specific measurements of the vagina during the routine physician physical exam after RT in the follow up periods: after RT, 3 months, 6 months, and 12 months using a p... Read More
Gender:
FEMALE
Ages:
Between 18 years and 99 years
Trial Updated:
04/04/2024
Locations: UCSD Moores Cancer Center, La Jolla, California
Conditions: Vaginal Stricture, Vaginal Stenosis
Comparing the Stanford Letter Project Form to Traditional Advance Directives
Recruiting
Our goal is to compare two types of advance directives forms available in English and Spanish to determine which is more easy to use for patients.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/04/2024
Locations: Stanford School of Medicine, Stanford, California
Conditions: Advance Directives, Palliative Care
Acute Plasma Abeta Responses to Stress
Recruiting
Research has shown that activation of the sympathetic nervous system for extended periods or during certain times in life can increase the risk for Alzheimer's disease. Some research in animal models show that acute activation of the sympathetic nervous system through stress exposure can increase certain Alzheimer's disease-related biomarkers, such as amyloid-beta, within hours of exposure. However, how acute sympathetic nervous system activation via stress exposure affects amyloid-beta levels i... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
04/03/2024
Locations: University of Southern California, Los Angeles, California
Conditions: Stress Reaction, Stress Physiology
Mechanisms of Dupilumab in AERD
Recruiting
Aspirin-Exacerbated Respiratory Disease (AERD), although uncommon in the general population, is an important phenotype of severe asthma and nasal polyposis where it occurs in 15% of severe asthmatics, and up to 30% of those with nasal polyposis. An important therapy for AERD is aspirin therapy after desensitization (ADAT). This is an inexpensive and proven therapy to improve the burden of sinus disease in AERD. Aspirin desensitization is the mechanism by which tolerance is induced in AERD patien... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/03/2024
Locations: Scripps Clini, San Diego, California
Conditions: Aspirin-exacerbated Respiratory Disease
ARGONAUT: Stool and Blood Sample Bank for Cancer Patients
Recruiting
ARGONAUT is a longitudinal, prospective, observational study that will enroll up to 5,000 advanced-stage cancer patients of diverse racial backgrounds to collect data used to develop precision microbiome medicines and for the identification of clinically actionable cancer-specific biomarkers to guide therapeutic decisions. Four types of solid tumor cancers will be profiled including non-small cell lung cancer (NSCLC), triple negative breast cancer (TNBC), colorectal cancer (CRC) and pancreatic c... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/03/2024
Locations: Knowledge Research Center, Orange, California
Conditions: Non-small Cell Lung Cancer, Colorectal Cancer, Triple Negative Breast Cancer, Pancreas Cancer
Development and Analysis of a Stool Bank for Cancer Patients
Recruiting
This study is aimed at understanding the impact of gut microbiota on efficacy of cancer therapies, in particular checkpoint inhibitors, and using the resulting information to design microbial immunotherapies. Although animal models are of use to determine the influences of gut and other microbiota on cancer treatment modalities, they are limited due to differences between mouse and human physiology and immunology, as well as the inherent differences in gut microbial populations between the two m... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/03/2024
Locations: Compassionate Care Research Group, Inc., Fountain Valley, California
Conditions: Carcinoma, Non-Small-Cell Lung, Carcinoma, Colorectal
Can Overall Adenoma Detection Rate Replace Screening Adenoma Detection Rate ? Multicenter Study
Recruiting
This is a prospective equivalence colonoscopy study evaluating whether overall adenoma detection rate (ADR) is a reliable alternate for screening ADR. Overall indication includes screening, surveillance, and diagnostic indications.
Gender:
ALL
Ages:
Between 50 years and 80 years
Trial Updated:
04/02/2024
Locations: Sepulveda Ambulatory Care Center, VAGLAHS, North Hills, California
Conditions: Adenoma Detection Rate, Colonoscopy
Enhancing Lung Cancer Screening Through Human-Centered Intervention
Recruiting
The purpose of this study is to further understand the factors involved in increasing lung cancer screening.
Gender:
ALL
Ages:
Between 50 years and 80 years
Trial Updated:
04/01/2024
Locations: University of California, Davis, Sacramento, California
Conditions: Lung Cancer
Effect of Mediterranean Diet in Inflammatory Bowel Disease
Recruiting
The effects of diet on inflammatory bowel disease is an under-studied area of research. The investigators are interested in further investigating the role that diet contributes to inflammatory bowel disease severity. The investigators will collect blood and stool samples from patients with inflammatory bowel disease (IBD) before and after diet changes. The stool samples will be analyzed using metabolomics and microbiome analysis to determine changes after the new diet has been implemented. The i... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/01/2024
Locations: University of California, San Diego, San Diego, California
Conditions: Inflammatory Bowel Disease
Prediction of Rehospitalization Following a Sepsis Admission Using a Wearable Biopatch
Recruiting
The goal of this observational study is to learn about the utility of biopatches predicting 30-day readmissions in patients discharged from the hospital with sepsis. The main question\[s\] it aims to answer are: • Does the application of a biopatch provide data that can improve prediction of an unplanned 30-day readmission following a hospitalization for sepsis. Participants will be asked to wear a biopatch on their chest for 30-days following hospital discharge or until readmission to the ho... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/01/2024
Locations: UC San Diego Health, San Diego, California
Conditions: Sepsis
Targeting the Default Mode Network: A TMS-fMRI Study
Recruiting
In post-traumatic stress disorder (PTSD), intrusive, traumatic, autobiographical memories lead to anxiety symptoms. Recent work suggests a new repetitive pulse transcranial magnetic stimulation (rTMS) brain target that might bring relief. Since this proposed target is not well understood, the goal of the study is to use functional magnetic resonance imaging (fMRI) to identify the brain regions and networks that change with rTMS stimulation at this target area in PTSD patients. Ultimately, this w... Read More
Gender:
ALL
Ages:
Between 18 years and 55 years
Trial Updated:
04/01/2024
Locations: VA Palo Alto, Palo Alto, California
Conditions: Post Traumatic Stress Disorder, PTSD
Pregistry International Pregnancy Exposure Registry (PIPER)
Recruiting
The aims of the Pregistry International Pregnancy Exposure Registry (PIPER) are to provide early signals of risk after prenatal exposure to medical products and to define boundaries of safety for medical products. The goal is to assist prescribers and study participants in weighing the potential risks of prenatal treatments on the wellbeing of mother and the unborn offspring. Specifically, the PIPER will estimate the risk of obstetric outcomes (spontaneous abortion, antenatal bleeding, gestatio... Read More
Gender:
FEMALE
Ages:
Between 18 years and 50 years
Trial Updated:
04/01/2024
Locations: Pregistry, Los Angeles, California
Conditions: Pregnancy Related