California is currently home to 5622 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
PARTNER 3 Trial - Aortic Valve-in-Valve
Recruiting
This study will assess the safety and effectiveness of the SAPIEN 3/SAPIEN 3 Ultra transcatheter heart valve (THV) in patients with a failing aortic bioprosthetic valve.
Gender:
ALL
Ages:
All
Trial Updated:
05/08/2024
Locations: University of California Los Angeles, Los Angeles, California
Conditions: Aortic Stenosis, Aortic Stenosis, Severe
Blunt Fascial vs. Veress Needle Peritoneal Entry in Laparoscopic Gynecologic Surgery
Recruiting
This study aims to investigate the effect of two peritoneal entry techniques on intraoperative and post-operative outcomes among patients undergoing laparoscopic surgery with a minimally invasive gynecologic surgeon. Patients will be randomized to either blunt fascial or veress needle peritoneal entry. Insufflation times, failed entries, complications and post-operative pain scores will be collected. The investigators hypothesize that the blunt entry technique will be associated with shorter in... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
05/07/2024
Locations: Cedars Sinai Medical Center, Los Angeles, California
Conditions: Laparoscopic Surgery
Optimizing Treatment of Adhesive Small Bowel Obstruction
Recruiting
Small bowel obstruction (SBO) is one of the most common causes of serious gastrointestinal disease in the US. Adhesion-related SBO (aSBO) is usually treated by the placement of a nasogastric tube (NGT) to decompress the stomach, administration of intravenous (IV) fluids and observation by a surgical team. The purpose of this feasibility study is to determine the potential for implementation of treatment protocols for aSBO and determine the feasibility of randomizing patients with aSBO to receiv... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/07/2024
Locations: University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, California
Conditions: Adhesive Small Bowel Obstruction
Engaging Diverse and Underserved Communities in Cancer Awareness Training and Education
Recruiting
The University of California Davis, Comprehensive Cancer Center's (UCDCCC) Office of Community Outreach and Engagement (OCOE) serves the 19 catchment counties which approximately consists of 5 million residents. Currently, the overall catchment population cancer screening rates fall below 80%. The aim of OCOE is to increase cancer education (prevention, screening, and vaccination) and training. Through education, and encouraging participation in routine screening for early detection, this can he... Read More
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
05/07/2024
Locations: University of California, Davis Comprehensive Cancer Center, Sacramento, California
Conditions: Cancer Awareness and Prevention Education
Effect of Anti-inflammatory (ITIS) Diet in Knee Osteoarthritis
Recruiting
To study the effect of anti-inflammatory diet on clinical and biological outcomes in patients with knee osteoarthritis
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/07/2024
Locations: UCSD, La Jolla, California
Conditions: Osteoarthritis, Knee
Micro/Nanobubbles (MNBs) for Treatment of Acute and Chronic Wounds
Recruiting
The purpose of this study is to assess the safety and efficacy of Micro/nanobubbles (MNB's) for the healing of acute and chronic wounds.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/07/2024
Locations: UCI Medical Center, Orange, California
Conditions: Open Wound, Wound Heal
Medial-prefrontal Enhancement During Schizophrenia Systems Imaging
Recruiting
This randomized controlled trial in healthy controls (HC) and patients with schizophrenia (SZ) aims to examine 1) the underlying cognitive and neural cause of self-agency deficits in SZ; 2) the responsiveness to a novel navigated repetitive transcranial magnetic stimulation (nrTMS) target in the medial/superior prefrontal cortex (mPFC); and 3) how modulation of mPFC activity impacts the larger self-agency network to mediate changes in self-agency judgments. Our overall hypothesis is that increas... Read More
Gender:
ALL
Ages:
Between 18 years and 64 years
Trial Updated:
05/07/2024
Locations: UCSF, San Francisco, California
Conditions: Schizophrenia
Effect of Anti-inflammatory Diet in Rheumatoid Arthritis
Recruiting
In a previous exploratory study, the investigators observed an effect on disease activity outcomes of anti-inflammatory diet. The investigators also observed change in microbiome and circulating metabolites. The current study will determine whether or not the addition of anti-inflammatory diet improves the clinical outcomes in participants with rheumatoid arthritis, and the role of microbiome and circulating metabolites.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/07/2024
Locations: UCSD, La Jolla, California
Conditions: Rheumatoid Arthritis
AETOS Shoulder System
Recruiting
The goal of this study is to confirm the safety and performance of the AETOS Shoulder System for USA adoption. This is a prospective, open, adaptive, non-comparative, multi-centre investigation enrolling a maximum of 220 subjects in 2 cohorts (anatomic and reverse) at up to 15 sites. No intra-study comparator group will be included, and there will be no randomization
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/06/2024
Locations: California Pacific Orthopedics, San Francisco, California
Conditions: Shoulder Osteoarthritis, Shoulder Arthritis
Assessing Comorbidities in Epilepsy Using Eye Movement Recordings
Recruiting
This study wants to make it easier to find kids with a type of epilepsy called childhood absence epilepsy (CAE) who might have problems with ongoing seizures and thinking. Right now, doctors use tests that can be expensive and take a long time. Eysz is developing a system that looks at how kids move their eyes which might help find CAE more quickly and accurately. This study will compare Eysz with the usual tests to see if it can predict seizures and thinking problems in kids with CAE. The goal... Read More
Gender:
ALL
Ages:
Between 4 years and 12 years
Trial Updated:
05/06/2024
Locations: Children's Hospital Orange County, Orange, California
Conditions: Childhood Absence Epilepsy, Absence Seizures, Epilepsy Comorbidities
Comparing Clinical Outcomes of Suture Button Versus Fibulink Fixation for Acute Ankle Syndesmosis Injuries
Recruiting
This project consists of a randomized controlled study design. Study candidates will include all patients 18 years or older, who were evaluated at UCSD and found to have an acute ankle syndesmosis injury requiring surgery. Patients who consent to study participation will be randomized to receive one of two standard of care procedures - either a suture button or Fibulink implant. Outcome measures, including the Olerud-Molander and American Orthopaedic Foot and Ankle Society scores, pain, range of... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/06/2024
Locations: University of California, San Diego, San Diego, California
Conditions: Ankle Injuries, Syndesmotic Injuries, Ankle Fractures
A Case Series: TRUMATCH Graft Cage for Segmental Long Bone Defects
Recruiting
This project consists of a prospective case design. Study candidates will include all patients ages 18 and over who were evaluated at UCSD and found to have a critical-sized humerus, femur, or tibia segmental defect that would be fixed through surgery. Patients who consent to study participation will receive the TRUMATCH Graft Cage for their long bone segmental defect repair. Data on healing rates, complication rates, re-operation rates, time to return to normal activity, and pain levels will be... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/06/2024
Locations: University of California, San Diego, San Diego, California
Conditions: Tibia Fracture, Humerus Fracture, Femoral Fracture, Long Bone Segmental Defect