California is currently home to 5602 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Micro/Nanobubbles (MNBs) for Treatment of Acute and Chronic Wounds
NCT05169814
Recruiting
The purpose of this study is to assess the safety and efficacy of Micro/nanobubbles (MNB's) for the healing of acute and chronic wounds.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/07/2024
Locations: UCI Medical Center, Orange, California
Conditions: Open Wound, Wound Heal
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Medial-prefrontal Enhancement During Schizophrenia Systems Imaging
NCT04807530
Recruiting
This randomized controlled trial in healthy controls (HC) and patients with schizophrenia (SZ) aims to examine 1) the underlying cognitive and neural cause of self-agency deficits in SZ; 2) the responsiveness to a novel navigated repetitive transcranial magnetic stimulation (nrTMS) target in the medial/superior prefrontal cortex (mPFC); and 3) how modulation of mPFC activity impacts the larger self-agency network to mediate changes in self-agency judgments. Our overall hypothesis is that increas... Read More
Gender:
ALL
Ages:
Between 18 years and 64 years
Trial Updated:
05/07/2024
Locations: UCSF, San Francisco, California
Conditions: Schizophrenia
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Effect of Anti-inflammatory Diet in Rheumatoid Arthritis
NCT04748809
Recruiting
In a previous exploratory study, the investigators observed an effect on disease activity outcomes of anti-inflammatory diet. The investigators also observed change in microbiome and circulating metabolites. The current study will determine whether or not the addition of anti-inflammatory diet improves the clinical outcomes in participants with rheumatoid arthritis, and the role of microbiome and circulating metabolites.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/07/2024
Locations: UCSD, La Jolla, California
Conditions: Rheumatoid Arthritis
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AETOS Shoulder System
NCT06319911
Recruiting
The goal of this study is to confirm the safety and performance of the AETOS Shoulder System for USA adoption. This is a prospective, open, adaptive, non-comparative, multi-centre investigation enrolling a maximum of 220 subjects in 2 cohorts (anatomic and reverse) at up to 15 sites. No intra-study comparator group will be included, and there will be no randomization
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/06/2024
Locations: California Pacific Orthopedics, San Francisco, California
Conditions: Shoulder Osteoarthritis, Shoulder Arthritis
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Assessing Comorbidities in Epilepsy Using Eye Movement Recordings
NCT06310772
Recruiting
This study wants to make it easier to find kids with a type of epilepsy called childhood absence epilepsy (CAE) who might have problems with ongoing seizures and thinking. Right now, doctors use tests that can be expensive and take a long time. Eysz is developing a system that looks at how kids move their eyes which might help find CAE more quickly and accurately. This study will compare Eysz with the usual tests to see if it can predict seizures and thinking problems in kids with CAE. The goal... Read More
Gender:
ALL
Ages:
Between 4 years and 12 years
Trial Updated:
05/06/2024
Locations: Children's Hospital Orange County, Orange, California
Conditions: Childhood Absence Epilepsy, Absence Seizures, Epilepsy Comorbidities
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Comparing Clinical Outcomes of Suture Button Versus Fibulink Fixation for Acute Ankle Syndesmosis Injuries
NCT05729542
Recruiting
This project consists of a randomized controlled study design. Study candidates will include all patients 18 years or older, who were evaluated at UCSD and found to have an acute ankle syndesmosis injury requiring surgery. Patients who consent to study participation will be randomized to receive one of two standard of care procedures - either a suture button or Fibulink implant. Outcome measures, including the Olerud-Molander and American Orthopaedic Foot and Ankle Society scores, pain, range of... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/06/2024
Locations: University of California, San Diego, San Diego, California
Conditions: Ankle Injuries, Syndesmotic Injuries, Ankle Fractures
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A Case Series: TRUMATCH Graft Cage for Segmental Long Bone Defects
NCT05668182
Recruiting
This project consists of a prospective case design. Study candidates will include all patients ages 18 and over who were evaluated at UCSD and found to have a critical-sized humerus, femur, or tibia segmental defect that would be fixed through surgery. Patients who consent to study participation will receive the TRUMATCH Graft Cage for their long bone segmental defect repair. Data on healing rates, complication rates, re-operation rates, time to return to normal activity, and pain levels will be... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/06/2024
Locations: University of California, San Diego, San Diego, California
Conditions: Tibia Fracture, Humerus Fracture, Femoral Fracture, Long Bone Segmental Defect
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Expression of Stress Markers During Meth Treatment (EXPRESS+)
NCT05558345
Recruiting
This is a non-randomized behavioral trial that aims to investigate whether changes in inflammatory and type I IFN expression coincide with changes in methamphetamine use and viral load over the course of 12 weeks in HIV-positive people assigned male at birth with and without methamphetamine use disorder.
Gender:
MALE
Ages:
Between 18 years and 45 years
Trial Updated:
05/06/2024
Locations: UCLA Vine Street Clinic, Los Angeles, California
Conditions: Substance-Related Disorders, HIV
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Levonorgestrel 52 mg IUD for Emergency Contraception and Same-Day Start
NCT05444582
Recruiting
This is a prospective clinical research study to test the effectiveness of the Levonorgestrel (LNG) 52 mg Intrauterine Device (IUD) for emergency contraception (EC) and same-day start use that will enroll people receiving care at Planned Parenthood affiliates across the U.S. Our prior work demonstrated efficacy (shows that it works in an ideal setting) for the LNG 52 mg IUD for these uses and this study will test effectiveness (how well it works in the real world) in a larger, heterogenous popul... Read More
Gender:
FEMALE
Ages:
Between 16 years and 35 years
Trial Updated:
05/06/2024
Locations: Planned Parenthood Mar Monte, San Jose, California
Conditions: Contraception
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Trazodone vs. Quetiapine for the Treatment of ICU Delirium
NCT05307003
Recruiting
This is a single-center, prospective observational pilot study. The objective of this study is to evaluate the effectiveness of trazodone as compared to quetiapine, in the management of ICU delirium in adult (\>=18 years old) surgical and medical ICU patients. The investigators will compare outcomes such as delirium duration, delirium-free days, coma-free days, in-hospital mortality, 28-day mortality, hospital length of stay (LOS), ICU LOS, mechanical ventilator days, complications, adverse effe... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/06/2024
Locations: Keck Hospital of the University of Southern California, Los Angeles, California
Conditions: Delirium, Delirium of Mixed Origin, Delirium, Sepsis Associated, Delirium in Old Age, Delirium Confusional State, Psych, Morality, Treatment Side Effects
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Warfarin Patient Self-management Implementation in the US Healthcare System
NCT04766216
Recruiting
In the US, patients receiving warfarin therapy are rarely allowed to engage in patient self-management (PSM) which is less burdensome, less expensive, and safer than standard clinic-directed warfarin management. The long-term objective of our application is to improve the safety of ambulatory warfarin therapy through increasing the implementation of PSM.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/06/2024
Locations: VA Loma Linda Healthcare System, Loma Linda, California
Conditions: Atrial Fibrillation, Venous Thromboembolism, Heart Valve Diseases
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A Prospective, Randomized, Open Label Trial of Two Doses of Oral Betaine
NCT03073343
Recruiting
Betaine (trimethyglycine) is a food supplement that is approved for sale in the United States without a prescription. In this study, betaine will be provided to patients as a powder that can be mixed with aqueous solutions and consumed orally.
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
05/06/2024
Locations: VA Long Beach Healthcare System, Long Beach, California
Conditions: Non-Alcoholic Fatty Liver Disease, Non Insulin Dependent Diabetes, ALT
Register for Updates