California is currently home to 5930 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Brain Changes in Pediatric OSA
Recruiting
Obstructive sleep apnea (OSA) is highly prevalent in children and is often caused by overgrowth of the child's adenoids and/or tonsils. Consequently, adenotonsillectomy (removal of the tonsils and adenoids) is the most common treatment of OSA in children, although just the tonsils or adenoids may be removed depending on the case. As well, OSA in children is often associated with cognitive dysfunction and mood issues, suggesting brain changes due to the condition. However, the link between brain... Read More
Gender:
All
Ages:
Between 7 years and 12 years
Trial Updated:
07/20/2023
Locations: UCLA, Los Angeles, California
Conditions: Pediatric Obstructive Sleep Apnea
Asymptomatic Renal Calculi in Recurrent Urinary Tract Infections
Recruiting
This study will assess patients who have recurrent urinary tract infections and kidney stones which are not blocking the kidney or causing other problems. Currently, we don't know if taking out these stones will improve recurrent urinary tract infections or not. Patients will make a decision with their surgeon about removing or monitoring their stone(s). Whether or not their infections continue with surgery or monitoring will be noted, and this information may help to inform future treatment dec... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
07/20/2023
Locations: University of California San Diego, San Diego, California
Conditions: Urinary Tract Infections, Kidney Stone
Ureteral Stent Placement After Ureteroscopy for Renal Stones: A Randomized Controlled Trial
Recruiting
The rationale for this study is to determine if there is a difference in complications among patients undergoing ureteroscopy for renal stones who receive a stent compared to not receiving a stent postoperatively.
Gender:
All
Ages:
18 years and above
Trial Updated:
07/20/2023
Locations: University of California Los Angeles, Los Angeles, California
Conditions: Kidney Calculi
Lysosomal Acid Lipase (LAL) Deficiency Registry
Recruiting
This is an observational, multi-center, international disease registry designed to collect longitudinal data and create a knowledge base that will be utilized to improve the care and treatment of patients with LAL Deficiency. Participation in the Registry by both physicians and patients is voluntary.
Gender:
All
Ages:
All
Trial Updated:
07/20/2023
Locations: Not set, Los Angeles, California
Conditions: Lysosomal Acid Lipase Deficiency, Cholesterol Ester Storage Disease, Wolman Disease, Acid Cholesteryl Ester Hydrolase Deficiency, Type 2, Acid Lipase Deficiency, LIPA Deficiency, LAL-Deficiency
Study of Avutometinib (VS-6766) + Adagrasib in KRAS G12C NSCLC Patients
Recruiting
This study will assess the safety and efficacy of avutometinib (VS-6766) in combination with adagrasib in patients with G12C Non-Small Cell Lung Cancer (NSCLC) who have been exposed to prior G12C inhibitor and experienced progressive disease.
Gender:
All
Ages:
18 years and above
Trial Updated:
07/19/2023
Locations: UCSF Thoracic Oncology, San Francisco, California
Conditions: Non Small Cell Lung Cancer, KRAS Activating Mutation, Advanced Cancer, Metastatic Cancer, Malignant Neoplasm of Lung, Malignant Neoplastic Disease
A Study to Determine Eligibility for CAH-301 (A Study of Gene Therapy for Classic Congenital Adrenal Hyperplasia (CAH) [NCT04783181])
Recruiting
This pre-screening study is designed to determine potential eligibility of adults with classic CAH due to 21-hydroxylase deficiency (21-OHD) for participation in the CAH-301 [NCT04783181] gene therapy trial with BBP-631.
Gender:
All
Ages:
18 years and above
Trial Updated:
07/19/2023
Locations: Science37, Los Angeles, California
Conditions: Congenital Adrenal Hyperplasia
The ExTINGUISH Trial of Inebilizumab in NMDAR Encephalitis
Recruiting
Determine the difference in the modified Rankin score at 16 weeks in participants with anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis treated with "first-line" immunomodulatory therapies provided as standard-of-care, and either inebilizumab (investigational agent) or placebo.
Gender:
All
Ages:
18 years and above
Trial Updated:
07/19/2023
Locations: UC Irvine, Orange, California
Conditions: Autoimmune Encephalitis, Encephalitis
Phase III DAS181 Lower Tract PIV Infection in Immunocompromised Subjects (Substudy: DAS181 for COVID-19): RCT Study
Recruiting
This study will seek to enroll immunocompromised patients with Lower Tract parainfluenza infection. It also contains a sub-study to enroll patients with severe COVID-19.
Gender:
All
Ages:
All
Trial Updated:
07/19/2023
Locations: City of Hope cancer Center, Duarte, California
Conditions: Lower Respiratory Tract Infection, Parainfluenza, Immunocompromised, COVID-19
Blood Flow Monitoring to Prevent Post-Polypectomy Induced Ulcer Bleeding
Recruiting
The primary specific aim is to perform a randomized controlled trial (RCT) to compare rates of delayed hemorrhage after DEP detection of arterial blood flow and focal treatment in PPIU's (treatment arm) with standard treatment using medical guidelines alone (controls) for prevention of delayed bleeding in high risk patients (on anti-coagulants or anti-platelet drugs or with large ulcers) after snare resection of benign colon polyps.
Gender:
All
Ages:
35 years and above
Trial Updated:
07/19/2023
Locations: Kaiser Permanente-Downey Medical Center, Downey, California
Conditions: Delayed Post-Polypectomy Induced Ulcer Hemorrhage
Post-operative Adjuvant Treatment for HPV-positive Tumours (PATHOS)
Recruiting
The main objectives of the PATHOS study are: To assess whether swallowing function can be improved following transoral resection of HPV-positive OPSCC, by reducing the intensity of adjuvant treatment protocols. The aim is to personalise treatment, based on disease biology (HPV status and pathology findings), to optimise patient outcomes. To demonstrate the non-inferiority of reducing the intensity of adjuvant treatment protocols in terms of overall survival in the reduced intensity treatment a... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
07/19/2023
Locations: Board of Trustees of the Leland Stanford Junior University, Redwood City, California
Conditions: Human Papillomavirus (HPV)-Positive Oropharyngeal Cancer
Personalized Need-focused Single Session Intervention
Recruiting
This is a two-site randomized controlled trial, with two goals. First, the investigators aim to demonstrate that single-session interventions for mild-to-moderate anxiety and depression can generate statistically significant symptom change as a main effect across control and experimental (i.e. personalized) conditions. Second, the investigators hope to establish the additional incremental efficacy of personalization via person-specific intensive longitudinal data collection and analysis.
Gender:
All
Ages:
18 years and above
Trial Updated:
07/18/2023
Locations: University of California, Berkeley, Berkeley, California
Conditions: Depression and/or Anxiety in the Mild-to-moderate Range
Targeted Nutrition for Moderate to Late Preterm Infants
Recruiting
This study will be comparing the postnatal growth of moderate to late preterm infants in the Neonatal Intensive Care Unit (NICU) born between gestational ages of 30 weeks 0 days to 35 weeks and 6 days who are receiving enteral feeds of mother's own breast milk using the NICU's standard nutritional fortification protocol versus a targeted nutritional fortification protocol.
Gender:
All
Ages:
All
Trial Updated:
07/18/2023
Locations: Loma Linda University, Loma Linda, California
Conditions: Premature Birth, Breastmilk Collection, Postnatal Growth Restriction