California is currently home to 5602 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
A Study of Pembrolizumab+ sEphB4 in Metastatic Urothelial Carcinoma
Recruiting
sEphB-HSA may prevent tumor cells from multiplying and blocks several compounds that promote the growth of blood vessels that bring nutrients to the tumor. The purpose of this study is to evaluate the combination of Pembrolizumab + sEphB4-HSA in the population of patients with previously untreated advanced (metastatic or recurrent) urothelial carcinoma who are chemotherapy ineligible or who refuse chemotherapy.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/30/2024
Locations: Sarcoma Oncology Center, Santa Monica, California
Conditions: Metastatic Urothelial Carcinoma
A Study of sEphB4-HSA in Kaposi Sarcoma
Recruiting
sEphB-HSA may prevent tumor cells from multiplying and blocks several compounds that promote the growth of blood vessels that bring nutrients to the tumor. The purpose of this study is to learn if sEphB4-HSA will decrease the number or size of Kaposi sarcoma lesions in people.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/30/2024
Locations: AIDS Healthcare Foundation, Beverly Hills, California
Conditions: Kaposi Sarcoma
Defining the Molecular and Radiologic Phenotype of Progressive RA Interstitial Lung Disease
Recruiting
A study to identify patients with Rheumatoid Arthritis - Associated Interstitial Lung Disease (RA-ILD) that are at the highest risk for progression. The goal of the investigators is to recruit a group of patients with RA-ILD and collect information to help us understand more about disease progression. The investigators will do this using a combination of clinical, radiologic, and biologic features.
Gender:
ALL
Ages:
Between 18 years and 90 years
Trial Updated:
04/29/2024
Locations: University of California San Francisco, San Francisco, California
Conditions: Rheumatoid Arthritis, Interstitial Lung Disease
xPedite: A Study to Expedite DIPG and DMG Research
Recruiting
This study will gather data from new and existing patients with patient medical records, and patient/family/caregiver reported information to establish a clear natural history of disease suitable to serve as an external, contemporary or historical control arm for future therapeutic development programs of drugs, devices, or biologic interventions in DMG or DIPG.
Gender:
ALL
Ages:
All
Trial Updated:
04/29/2024
Locations: xCures, Inc., Los Altos, California
Conditions: Oncology, DIPG, DMG
Peripheral Heating and Glucose Tolerance
Recruiting
Effect of peripheral heating on glucose tolerance
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
04/29/2024
Locations: San Diego State University, San Diego, California
Conditions: Glucose Tolerance
A Mobile Health Intervention to Reduce Sweet Beverage Consumption in Latino Children
Recruiting
Sugar-sweetened beverage consumption is a major contributor to childhood obesity, caries, fatty liver disease, and Type 2 diabetes. Latino children are more likely to consume sugar-sweetened beverages (SSBs) and to suffer from all of the aforementioned conditions. Reading out loud to children from birth through age 5 is critical for the promotion of language and early literacy skills. Children whose parents read aloud to them are more likely to start school with the skills required for early rea... Read More
Gender:
ALL
Ages:
Between 12 months and 59 months
Trial Updated:
04/29/2024
Locations: San Francisco General Hospital Children's Health Center, San Francisco, California
Conditions: Child Obesity, Child Development
Accelerated Intermittent Theta-Burst Stimulation (aiTBS) in Treatment-Resistant Depression of Bipolar II Disorder
Recruiting
The purpose of this study is to investigate the effectiveness of accelerated intermittent theta-burst transcranial magnetic stimulation (aiTBS) in inducing anti-depressant responses in individuals with treatment-resistant depression of bipolar II disorder. This is a double-blind, randomized, sham-controlled trial that targets a single location on the left dorsolateral prefrontal cortex (LDLPFC) using the MagPro rTMS system.
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
04/26/2024
Locations: Stanford University, Palo Alto, California
Conditions: Bipolar II Disorder, Most Recent Episode Major Depressive, Current Depressive Episode, Treatment Resistant Depression
[Lu-177]Ludotadipep in Castration-resistant Prostate Cancer(CRPC): Investigation of Drug and Application
Recruiting
Phase 1: The objective of the Phase 1 part of the clinical trial is to verify safety and tolerability (dose-limiting toxicity \[DLT\], maximum tolerated dose \[MTD\]) of a single 3.7 Giga-Becquerel (GBq) dose with the potential for one dose level de-escalation to 2.775 GBq if necessary, to determine the recommended \[177Lu\]Ludotadipep dose for use in the Phase 2a part of the trial. Phase 2a: The objective of the Phase 2a part of the trial is to evaluate safety and efficacy for repeated adminis... Read More
Gender:
MALE
Ages:
18 years and above
Trial Updated:
04/25/2024
Locations: VA Greater Los Angeles Healthcare System,Cancer Center Research, Los Angeles, California
Conditions: Metastatic Castration-resistant Prostate Cancer
Patient Decision Aid for Opioid Use Disorder
Recruiting
The aim of the study is to test the effectiveness of the Patient Decision Aid for Opioid Use Disorder (PtDA-MAT) by conducting a stepped-wedge cluster-randomized trial in CA H\&SS (stratified by rural vs. non-rural areas) for adults with OUD. Patient outcomes will be tracked by (1) personal assessments (baseline, 3 months, and 6 months): drug use, overdose, healthcare utilization, and (2) clinical and administrative records (over approximately 24 months): drug treatment status and retention, phy... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/25/2024
Locations: UCLA Integrated Substance Abuse Programs, Los Angeles, California
Conditions: Opioid Use Disorder
PREDICT Therapy Selection for JAK, T-cell, or IL-6 Inhibitor Therapies Using a Molecular Signature Response Classifier (PREDICT)
Recruiting
Prospective, multi-center-observational study conducted within the US, collecting patient samples for research and development to train, test, and validate precision medicine classifiers. These molecular signature response classifiers (MSRC) aim to predict response status to JAK, T-cell, and IL-6 inhibitor therapies in patients with rheumatoid arthritis (RA).
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
04/24/2024
Locations: Medvin Clinical Research//Amicus Arthritis, Whittier, California
Conditions: Rheumatoid Arthritis
Wound Irrigation Comparative Effectiveness Study
Recruiting
The primary objective of this study is to compare the presence of C acnes in bacteriologic cultures taken from participant samples of subcutaneous and deep tissue prior to deep surgical irrigation using either Normal Saline Irrigation (Group 1) or Irrisept Irrigation (Group 2). Secondary objectives are evaluation of patient reported outcome measures and range of motion in relation to C acnes presence among subjects in the two groups.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/24/2024
Locations: Hoag Orthopedics, Orange, California
Conditions: Cutibacterium Acnes Contamination
Phase 2 Trial of HY209gel in Atopic Dermatitis Patients
Recruiting
This is a randomized, double-blind, placebo-controlled, multi-center, phase 2 study in patients with mild to moderate Atopic Dermatitis(AD), which consists of 2 parts.
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
04/24/2024
Locations: RAOOF MD Dermatology, Encino, California
Conditions: Atopic Dermatitis, Atopic Dermatitis Eczema, Atopic Dermatitis of Scalp