California is currently home to 5610 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Phase 2 Trial of HY209gel in Atopic Dermatitis Patients
Recruiting
This is a randomized, double-blind, placebo-controlled, multi-center, phase 2 study in patients with mild to moderate Atopic Dermatitis(AD), which consists of 2 parts.
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
04/24/2024
Locations: RAOOF MD Dermatology, Encino, California
Conditions: Atopic Dermatitis, Atopic Dermatitis Eczema, Atopic Dermatitis of Scalp
A Study of SNP-ACTH (1-39) Gel in Patients With Primary Membranous Nephropathy
Recruiting
The goal of the Phase 3a part of this clinical trial is to determine the optimal dose that will be used in the Phase 3b part of this clinical trial. The goal of the Phase 3b part is to assess the efficacy of SNP-ACTH (1-39) Gel relative to rituximab in patients with primary membranous nephropathy (PMN) at month 24.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/24/2024
Locations: Academic Medical Research Institute, Los Angeles, California
Conditions: Primary Membranous Nephropathy
Study of Dextromethorphan in OCD and Related Disorders
Recruiting
The purpose of the study is to assess the tolerability and efficacy of dextromethorphan in combination with fluoxetine for symptom relief in OCD and related disorders.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
04/24/2024
Locations: Stanford University, Stanford, California
Conditions: Obsessive-Compulsive Disorder, Illness Anxiety Disorder, Body Dysmorphic Disorders, Somatic Symptom Disorder
The Effect of Adipose-Derived Stem Cells for Knee Osteoarthritis
Recruiting
The purpose of this study is to compare the clinical and functional outcomes of patients with mild to moderate arthroscopically confirmed osteoarthritis between the following two groups: 1. Partial fat pad harvest with Adipose-Derived Stem Cell (ADSC) transplantation with standard arthroscopic treatment consisting of: partial meniscectomy, cartilage stabilization, loose body removal and selective synovectomy. 2. Standard arthroscopic treatment (above) without cell transplant.
Gender:
ALL
Ages:
Between 35 years and 70 years
Trial Updated:
04/24/2024
Locations: Kerlan Jobe Orthopedic Institute, Santa Monica, California
Conditions: Knee Osteoarthritis
Microfracture Versus Adipose Derived Stem Cells for the Treatment of Articular Cartilage Defects
Recruiting
The purpose of this study is to compare two biologic methods for the treatment of articular cartilage defects in the knee. The first method, microfracture, is the standard of care and is routinely used to recruit cells from the subchondral bone marrow to the site of cartilage loss. The second method is the application of adipose-derived stem cells (ADSCs) to the defect site. In theory, ADSCs on a collagen scaffold should enable the delivery of more specific progenitor cells to the site of injury... Read More
Gender:
ALL
Ages:
Between 18 years and 50 years
Trial Updated:
04/24/2024
Locations: Stanford Medical Outpatient Center, Redwood City, California
Conditions: Degenerative Lesion of Articular Cartilage of Knee
Treating Genital Herpes Infection to Reduce Racial Disparities in the Risk of Severe Maternal Morbidity
Recruiting
Severe Maternal Morbidity (SMM) has been associated with maternal mortality, fetal risk, and long-term maternal risk. African American (AA) women are at consistently higher risk than White women. However, factors contributing to these racial disparities are largely unknown and commonly known factors have not been able to explain them, so strategies to reduce them are absent. CDC reports that the rate of GHSV infection is 4 times higher in AA than White women. Studies have shown that pregnant wom... Read More
Gender:
FEMALE
Ages:
Between 18 years and 55 years
Trial Updated:
04/23/2024
Locations: Division of Research, Kaiser Permanente Northern California, Oakland, California
Conditions: Genital Herpes Simplex, Maternal Morbidity, Racial Disparities
Performance of SGM-101 for the Delineation of Primary and Recurrent Tumor and Metastases in Patients Undergoing Surgery for Colorectal Cancer
Recruiting
The performance of SGM-101, an intraoperative imaging agent, will be compared to that of standard "white light" visualization during surgical resections of colorectal cancer.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/23/2024
Locations: City of Hope National Medical Center, Duarte, California
Conditions: Colorectal Neoplasms
Wide-Area Transepithelial Sampling in Endoscopic Eradication Therapy for Barrett's Esophagus
Recruiting
Esophageal cancer is a deadly disease that is becoming increasingly common in the United States. Barrett's esophagus (BE) is a pre-cancerous state that can develop into esophageal cancer, but is highly treatable. Progression of BE to esophageal cancer is still common due to missed diagnosis of Barrett's esophagus recurrence following treatment. Wide-Area Trans-Epithelial Sampling (WATS-3D) is a new technology that uses brush sampling to examine larger areas of the esophagus as compared to conven... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/22/2024
Locations: University of California, LA, Los Angeles, California
Conditions: Barrett Esophagus, Esophageal Cancer
Can Nitrous Oxide (Laughing Gas) be Used as a Sedative for GI Endoscopy Procedures?
Recruiting
Nitrous oxide (commonly known as 'laughing gas') is often used during dental and other outpatient procedures, because it is easy to administer, is short-acting and rapidly clears from the body following the procedure. The investigators hypothesize that use of Nitrous oxide during GI endoscopy may enhance patient comfort during the procedure and speed-up post-procedure recovery, while minimizing the fatigue and mental fogginess some patients report the day after receiving standard sedative and n... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/19/2024
Locations: Stanford University Hospital, Stanford, California
Conditions: Endoscopy, Colonoscopy
Ancora-SB Overtube Complete Positioning and Optical Visualization During Endoscopic Procedures
Recruiting
Demonstrate superiority of the Aspero Medical Ancora-SB balloon Overtube compared to the Olympus ST-SB1 Balloon Overtube.
Gender:
ALL
Ages:
Between 18 years and 90 years
Trial Updated:
04/18/2024
Locations: Cedars Sinai, Los Angeles, California
Conditions: Small Bowel Disease
Bedside Ultrasonic Assessment for Gastric Content in Patients With Upper GI Bleeding Undergoing Endoscopy: a Pilot Study
Recruiting
Emerging studies have evaluated POCUS (Point of Care Ultrasound) for assessing of gastric content prior to anesthesia to reduce the risk of aspiration and demonstrated that POCUS can accurately identify presence of gastric food or fluid. Despite accumulating studies evaluating POCUS as a diagnostic modality to evaluate for gastric food content prior to anesthesia, there is no study to date that has evaluated the role of POCUS prior to endoscopy among patients with upper GI bleeding. Therefore, t... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/18/2024
Locations: Loma Linda University Medical Center, Loma Linda, California
Conditions: Upper GI Bleeding, Point of Care Ultrasound, Upper Endoscopy, Gastric Content, GI Bleed
A Study to Evaluate TROP2 ADC LCB84 Single Agent and in Combination With an Anti-PD-1 Ab in Advanced Solid Tumors
Recruiting
This is a first-in-human, Phase 1/2 study to evaluate LCB84, a TROP2-directed antibody-drug conjugate, alone and in combination with an anti-PD-1 Ab, in dose escalation (Phase 1) followed by dose expansion (Phase 2). The study population in dose escalation (Phase 1) consists of patients with advanced solid tumors refractory to standard of care, or for whom no standard of care exists. After the MTD and/or RP2D for single agent LCB84 is determined, dose escalation cohorts with select tumor types... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/17/2024
Locations: Cedars Sinai Medical Center, Los Angeles, California
Conditions: Advanced Solid Tumors