California is currently home to 5605 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
A 52-Week Study of the Efficacy and Safety of BLU-5937 in Adults With Refractory Chronic Cough
Recruiting
This is a randomized, double-blind, placebo-controlled, parallel-arm, Phase 3 study of BLU-5937 in participants with Refractory Chronic Cough (RCC).
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
02/14/2024
Locations: Warren W. Pleskow, MD, 1071572, Encinitas, California
Conditions: Refractory Chronic Cough
Feasibility of Telehealth Palliative Care and Digital Symptom Monitoring for Patients With Acute Myeloid Leukemia
Recruiting
AML is the most common leukemia diagnosed in adults. In spite of recent low-intensity therapies that have improved outcomes for older AML patients, AML remains associated with poor prognosis as well as high symptom burden. While the benefits of early palliative care as well as electronic PROs have been well-described in the oncology population, neither have been well-studied in the AML population, and have never been studied in combination. We propose a prospective, single-center, single-arm tri... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/14/2024
Locations: Stanford University, Palo Alto, California
Conditions: Acute Myeloid Leukemia
Norris ORIEN Total Cancer Care
Recruiting
This research trial collects biological samples and clinical information to create a repository of data from patients with cancer or a predisposition for cancer. Combining genetic information from biological samples and clinical data may lead to more knowledge about why certain cancers respond to treatment and help create more personalized medicine.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/14/2024
Locations: USC / Norris Comprehensive Cancer Center, Los Angeles, California
Conditions: Cancer Risk, Malignant Neoplasm
Multicohort Phase II Trial of sEphB4-HSA+Pembrolizumab in Solid Tumors
Recruiting
This is a multi-cohort single arm phase II/screening trial of the combination of a fusion protein that binds EphrinB2 and blocks interaction with cell surface EphB receptors (sEphB4-HSA) in combination with an anti-PD1 antibody (MK-7435 / Pembrolizumab) for treatment of patients with specific solid tumors. There will be four cohorts in this trial: 1. Cohort A, phase II 2nd line trial of sEphB4-HSA and pembrolizumab for platinum refractory metastatic urothelial carcinoma. 2. Cohort B, phase II 3... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/14/2024
Locations: City of Hope, Duarte, California
Conditions: Stage IV Bladder Urothelial Carcinoma, Prostate Cancer, Urothelial Carcinoma
Confirming the Effectiveness of Online Guided Self-Help Family-Based Treatment for Adolescent Anorexia Nervosa
Recruiting
With an incidence rate of about 1%, Anorexia Nervosa (AN) is a serious mental disorder associated with high mortality, morbidity, and cost. AN in youth is more responsive to early treatment but becomes highly resistant once it has taken an enduring course. The first-line treatment for adolescents with AN is Family Based Treatment (FBT). While FBT can be delivered using videoconferencing (FBT-V), therapists' limited availability hampers scalability. Guided self-help (GSH) versions of efficacious... Read More
Gender:
ALL
Ages:
Between 12 years and 18 years
Trial Updated:
02/13/2024
Locations: Stanford University, Stanford, California
Conditions: Anorexia Nervosa
Mechanical Coring to Achieve Directional Skin Tightening
Recruiting
The objective of this clinical study is to evaluate the safety and efficacy of mechanical coring for directional skin tightening. This study is a prospective, up to 3 center, multiple skin treatment area study of the safety and efficacy of mechanical coring with directional closure to achieve directional skin tightening.
Gender:
ALL
Ages:
Between 30 years and 70 years
Trial Updated:
02/13/2024
Locations: Berman Skin Institute, Los Altos, California
Conditions: Skin Tightening, Healthy Volunteers
A Study of HMPL-306 in Advanced Hematological Malignancies With mIDH
Recruiting
An open label single-arm clinical trial to evaluate the safety, tolerability, PK, PD, and preliminary efficacy of HMPL-306 in subjects with advanced relapsed, refractory, or resistant hematological malignancies that harbor IDH mutations.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/13/2024
Locations: University of California Irvine Medical Center (UCIMC) - Chao Family Comprehensive Cancer Center, Orange, California
Conditions: Isocitrate Dehydrogenase Gene Mutation
The OPAL Study: AVM0703 for Treatment of Lymphoid Malignancies
Recruiting
This is an open-label, Phase 1/2 study designed to characterize the safety, tolerability, Pharmacokinetics(PK), and preliminary antitumor activity of AVM0703 administered as a single intravenous (IV) infusion to patients with lymphoid malignancies.
Gender:
ALL
Ages:
Between 12 years and 95 years
Trial Updated:
02/13/2024
Locations: City of Hope, Duarte, California
Conditions: Lymphoid Malignancies
Computational Drug Repurposing for All EBS Cases
Recruiting
The study will compare gene expression differences between blistered and non-blistered skin from individuals with all subtypes of EB, as well as normal skin from non-EB subjects. State of the art computational analysis will be performed to help identify new drugs that might help all EB wound healing and reduce pain. Researchers will focus on drugs that have already been approved for treatment of other dermatologic or non-dermatologic diseases, and therefore be repurposed for treatment of EB. Dru... Read More
Gender:
ALL
Ages:
0 years and above
Trial Updated:
02/11/2024
Locations: Pediatric Dermatology Clinic at Stanford Children's Hospital, Palo Alto, California
Conditions: Epidermolysis Bullosa Simplex, Healthy, Genetic Skin Disease, Epidermolysis Bullosa, Epidermolysis Bullosa, Junctional, Epidermolysis Bullosa Dystrophica
Longitudinal Study of Urea Cycle Disorders
Recruiting
Urea cycle disorders (UCD) are a group of rare inherited metabolism disorders. Infants and children with UCD commonly experience episodes of vomiting, lethargy, and coma. The purpose of this study is to perform a long-term analysis of a large group of individuals with various UCDs. The study will focus on the natural history, disease progression, treatment, and outcome of individuals with UCD.
Gender:
ALL
Ages:
All
Trial Updated:
02/10/2024
Locations: University of California, Los Angeles, Los Angeles, California
Conditions: Brain Diseases, Metabolic, Inborn, Amino Acid Metabolism, Inborn Errors, Urea Cycle Disorders
The Sequencing for Detection in Congenital Heart Disease (SD-CHD) Study
Recruiting
This study is enrolling pregnant persons treated at Rady Children's Hospital fetal cardiology program with a prenatal diagnosis of congenital heart disease to look for genetic disorders in the fetus or unborn baby. Congenital heart disease (CHD) is a group of structural differences to the heart that represent the most common birth defect among liveborn infants world-wide. CHD is the leading cause of birth-defect associated infant death. Prenatal detection allows for delivery planning, postnatal... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
02/09/2024
Locations: Rady Children's Institute for Genomic Medicine, San Diego, California
Conditions: Congenital Heart Disease
Subcutaneous Atezolizumab for the Treatment of Non-small Cell Lung Cancer
Recruiting
This phase II trial tests whether subcutaneous atezolizumab can be effectively given at home with medical care provided primarily using telemedicine in patients with non-small cell lung cancer. Immunotherapy with monoclonal antibodies, such as atezolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. This study may help determine if a telemedicine based approach that gives atezolizumab at home using a version of the d... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/09/2024
Locations: USC / Norris Comprehensive Cancer Center, Los Angeles, California
Conditions: Lung Non-Small Cell Carcinoma, Stage II Lung Cancer AJCC v8, Stage IIA Lung Cancer AJCC v8, Stage IIB Lung Cancer AJCC v8, Stage III Lung Cancer AJCC v8, Stage IIIA Lung Cancer AJCC v8, Stage IIIB Lung Cancer AJCC v8, Stage IIIC Lung Cancer AJCC v8, Stage IV Lung Cancer AJCC v8, Stage IVA Lung Cancer AJCC v8, Stage IVB Lung Cancer AJCC v8