California is currently home to 5930 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Prepare for Your Diabetes Care
Recruiting
As adults with type 2 diabetes age, they are increasingly vulnerable to treatment-related hypoglycemia and its related complications (including hospitalization and death). This study proposes to evaluate, in a randomized clinical trial, a strategy of expanded advance care planning to support older adults in value-aligned re-assessment of diabetes treatment regimens with their primary care team. If the aims of this project are achieved and incidence of clinically-significant hypoglycemia is reduc... Read More
Gender:
All
Ages:
75 years and above
Trial Updated:
07/14/2023
Locations: Kaiser Permanente - Oakland Medical Center, Oakland, California
Conditions: Type 2 Diabetes Mellitus With Hypoglycemia, Aging, Patient Activation
WARRIOR Ancillary Study for CCTA Analysis
Recruiting
In this study, quantitative characterization of plaque using coronary computed tomographic angiography (CTA) will be used to determine if women who were treated with intensive medical therapy have a greater reduction in the amount and type of cholesterol plaque compared to women receiving usual care and if this results in beneficial changes in clinical symptoms. The study will provide an understanding of how intensive medical therapy works in providing clinical benefit in women with nonobstructi... Read More
Gender:
Female
Ages:
18 years and above
Trial Updated:
07/14/2023
Locations: Cedars-Sinai Medical Center, Los Angeles, California
Conditions: Coronary Artery Disease, Non-Obstructive Coronary Atherosclerosis, Ischemia
Changing Health Through Food Support for Diabetes
Recruiting
This is a pragmatic randomized controlled trial (RCT) of Changing Health through Food Support for Diabetes (CHEFS-DM). This pragmatic RCT will leverage Project Open Hand's (POH) real-world programs to test the impact of a six month medically tailored food support and nutrition intervention ("CHEFS-DM") on glycemic control and other cardiometabolic outcomes, investigate the paths through which CHEFS-DM may durably improve health, and assess the economic value of the intervention to society.
Gender:
All
Ages:
18 years and above
Trial Updated:
07/14/2023
Locations: Project Open Hand, San Francisco, California
Conditions: Type 2 Diabetes, Food Insecurity
NAD+ Augmentation in Cardiac Surgery Associated Myocardial Injury Trial
Recruiting
A Randomized, Double-blind, placebo-controlled Trial to Evaluate the Efficacy of Oral Nam for the Prevention of Acute Kidney Injury in Patients Undergoing On-Pump Cardiac Surgery
Gender:
All
Ages:
18 years and above
Trial Updated:
07/14/2023
Locations: Kaiser Permanente San Francisco Medical Center, San Francisco, California
Conditions: Ischemia Reperfusion Injury, Myocardial Injury, Acute Kidney Injury
Study BT5528-100 in Patients With Advanced Solid Tumors Associated With EphA2 Expression
Recruiting
This clinical trial is evaluating a drug called BT5528 alone and in combination with nivolumab in participants with advanced solid tumors historically known for expression of EphA2. The main goals of this study are to: Find the recommended dose(s) of BT5528 that can be given safely to participants alone and in combination with nivolumab Learn more about the side effects of BT5528 Learn about how effective BT5528 is for the treatment of ovarian cancer, urothelial/bladder cancer, lung cancer (NSC... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
07/14/2023
Locations: California Cancer Associates for Research and Excellence, Inc., Encinitas, California
Conditions: Advanced Solid Tumor Historically Known for High EphA2 Expression, Urothelial Cancer, Ovarian Cancer, Non-small Cell Lung Cancer, Head and Neck Cancer, Triple Negative Breast Cancer, Gastric/Upper Gastrointestinal Cancer
Non-Inferiority Trial of TrIGR for PTSD
Recruiting
Trauma-related guilt is common and impairing among trauma survivors, particularly among Veterans with posttraumatic stress disorder (PTSD). The investigators' work shows that a brief treatment targeting trauma-related guilt, Trauma Informed Guilt Reduction Therapy (TrIGR), can reduce guilt and PTSD and depression symptoms. Whether TrIGR is no less effective than longer, more resource heavy PTSD treatments disseminated by by VA, like cognitive processing therapy (CPT), is the next critical questi... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
07/13/2023
Locations: VA San Diego Healthcare System, San Diego, CA, San Diego, California
Conditions: PTSD
Early Trial of Allogeneic Hematopoietic Stem Cell Transplantation for Patients Who Will Receive a Kidney Transplant From the Same Donor
Recruiting
This is a single center, non-randomized, non-controlled open-label phase 1b/2a trial of performing sequential αβdepleted-HSCT and KT in patients requiring KT to prevent kidney rejection post-KT, in the absence of any post-KT immunosuppression, to abrogate the need for lifelong immunosuppression, the risk of chronic rejection and, ultimately, the need for repeated transplantation.
Gender:
All
Ages:
Between 1 year and 30 years
Trial Updated:
07/13/2023
Locations: Lucile Packard Children's Hospital, Palo Alto, California
Conditions: SIOD, Cystinosis, FSGS, SLE Nephritis, CKD Stage 4
A Multilevel Intervention to Improve Adherence to Childhood Cancer Survivorship
Recruiting
More than 80% of childhood cancer survivors develop serious or life-threatening late effects after cancer therapy, but <20% receive recommended survivorship care offered at cancer center survivorship clinics. In a shared care model, the investigators propose to investigate an innovative multi-level intervention consisting of: 1) patient survivorship education via telehealth with the cancer center, 2) ongoing patient-tailored education program within the electronic health record patient portal, 3... Read More
Gender:
All
Ages:
2 years and above
Trial Updated:
07/13/2023
Locations: MemorialCare Miller Children's & Women's Hospital Long Beach, Long Beach, California
Conditions: Childhood Cancer, Survivorship, Health Care Utilization, Health Knowledge, Attitudes, Practice, Adherence, Patient
Comparative Effectiveness of MRgFUS Versus CTgRFA for Osteoid Osteomas
Recruiting
Osteoid osteomas are painful, benign bone tumors that occur most frequently in young males between ages 10 and 20 years. The goal of the proposed study is based on the premise that MRgFUS is noninferior to CT-guided radiofrequency ablation (CTgRFA), in terms of pain reduction following treatment of osteoid osteomas, and offers possible improvements with regards to 1) post-procedural pain, 2) clinical resource utilization, 3) patient experience, and/or 4) adverse events. The data from the current... Read More
Gender:
All
Ages:
8 years and above
Trial Updated:
07/13/2023
Locations: Stanford Medical Center, Palo Alto, California
Conditions: Osteoid Osteoma
Hydrus Microstent as a Quality of Life Consideration
Recruiting
The study aims to identify if Hydrus microstent implantation in patients with open angle glaucoma (OAG) at the time of cataract surgery improves quality of life for patients and explore what quality of life factors motivate patients.
Gender:
All
Ages:
18 years and above
Trial Updated:
07/12/2023
Locations: Terri Smith, Fresno, California
Conditions: Open Angle Glaucoma
Study Comparing Ultrasound-guided FICNB Block to Systemic Analgesia in Treatment of Pediatric Femur Fracture
Recruiting
The goal of this prospective observational study is to compare pain control strategies in children with femur fractures. Researchers will compare ultrasound-guided fascia iliaca compartment nerve block to IV pain control alone. The main questions it aims to answer are: Are ultrasound-guided fascia iliaca compartment nerve blocks as effective as IV pain control in controlling pain? Do patients who receive an ultrasound-guided fascia iliaca compartment nerve block require less opioid pain medicat... Read More
Gender:
All
Ages:
Between 4 years and 17 years
Trial Updated:
07/12/2023
Locations: University of California, San Diego, San Diego, California
Conditions: Femur Fracture
Gastric Sleeve-Induced Weight Loss on Shortness of Breath in Obesity
Recruiting
Most research to date on bariatric surgery outcomes has been about metabolic syndrome, a disorder very effectively treated by bariatric surgery. However, obesity is also associated with many other problems that have received much less attention. Amongst the most troubling of these for patients is dyspnea. Dyspnea results in substantial patient distress that can greatly reduce health-related quality of life. Little is known about the relationship between dyspnea, weight loss, and bariatric surger... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
07/12/2023
Locations: Surgery Departement, UCLA, Los Angeles, California
Conditions: Dyspnea, Quality of Life