California is currently home to 5602 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Treating Genital Herpes Infection to Reduce Racial Disparities in the Risk of Severe Maternal Morbidity
Recruiting
Severe Maternal Morbidity (SMM) has been associated with maternal mortality, fetal risk, and long-term maternal risk. African American (AA) women are at consistently higher risk than White women. However, factors contributing to these racial disparities are largely unknown and commonly known factors have not been able to explain them, so strategies to reduce them are absent. CDC reports that the rate of GHSV infection is 4 times higher in AA than White women. Studies have shown that pregnant wom... Read More
Gender:
FEMALE
Ages:
Between 18 years and 55 years
Trial Updated:
04/23/2024
Locations: Division of Research, Kaiser Permanente Northern California, Oakland, California
Conditions: Genital Herpes Simplex, Maternal Morbidity, Racial Disparities
Performance of SGM-101 for the Delineation of Primary and Recurrent Tumor and Metastases in Patients Undergoing Surgery for Colorectal Cancer
Recruiting
The performance of SGM-101, an intraoperative imaging agent, will be compared to that of standard "white light" visualization during surgical resections of colorectal cancer.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/23/2024
Locations: City of Hope National Medical Center, Duarte, California
Conditions: Colorectal Neoplasms
Wide-Area Transepithelial Sampling in Endoscopic Eradication Therapy for Barrett's Esophagus
Recruiting
Esophageal cancer is a deadly disease that is becoming increasingly common in the United States. Barrett's esophagus (BE) is a pre-cancerous state that can develop into esophageal cancer, but is highly treatable. Progression of BE to esophageal cancer is still common due to missed diagnosis of Barrett's esophagus recurrence following treatment. Wide-Area Trans-Epithelial Sampling (WATS-3D) is a new technology that uses brush sampling to examine larger areas of the esophagus as compared to conven... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/22/2024
Locations: University of California, LA, Los Angeles, California
Conditions: Barrett Esophagus, Esophageal Cancer
Can Nitrous Oxide (Laughing Gas) be Used as a Sedative for GI Endoscopy Procedures?
Recruiting
Nitrous oxide (commonly known as 'laughing gas') is often used during dental and other outpatient procedures, because it is easy to administer, is short-acting and rapidly clears from the body following the procedure. The investigators hypothesize that use of Nitrous oxide during GI endoscopy may enhance patient comfort during the procedure and speed-up post-procedure recovery, while minimizing the fatigue and mental fogginess some patients report the day after receiving standard sedative and n... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/19/2024
Locations: Stanford University Hospital, Stanford, California
Conditions: Endoscopy, Colonoscopy
Ancora-SB Overtube Complete Positioning and Optical Visualization During Endoscopic Procedures
Recruiting
Demonstrate superiority of the Aspero Medical Ancora-SB balloon Overtube compared to the Olympus ST-SB1 Balloon Overtube.
Gender:
ALL
Ages:
Between 18 years and 90 years
Trial Updated:
04/18/2024
Locations: Cedars Sinai, Los Angeles, California
Conditions: Small Bowel Disease
Bedside Ultrasonic Assessment for Gastric Content in Patients With Upper GI Bleeding Undergoing Endoscopy: a Pilot Study
Recruiting
Emerging studies have evaluated POCUS (Point of Care Ultrasound) for assessing of gastric content prior to anesthesia to reduce the risk of aspiration and demonstrated that POCUS can accurately identify presence of gastric food or fluid. Despite accumulating studies evaluating POCUS as a diagnostic modality to evaluate for gastric food content prior to anesthesia, there is no study to date that has evaluated the role of POCUS prior to endoscopy among patients with upper GI bleeding. Therefore, t... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/18/2024
Locations: Loma Linda University Medical Center, Loma Linda, California
Conditions: Upper GI Bleeding, Point of Care Ultrasound, Upper Endoscopy, Gastric Content, GI Bleed
A Study to Evaluate TROP2 ADC LCB84 Single Agent and in Combination With an Anti-PD-1 Ab in Advanced Solid Tumors
Recruiting
This is a first-in-human, Phase 1/2 study to evaluate LCB84, a TROP2-directed antibody-drug conjugate, alone and in combination with an anti-PD-1 Ab, in dose escalation (Phase 1) followed by dose expansion (Phase 2). The study population in dose escalation (Phase 1) consists of patients with advanced solid tumors refractory to standard of care, or for whom no standard of care exists. After the MTD and/or RP2D for single agent LCB84 is determined, dose escalation cohorts with select tumor types... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/17/2024
Locations: Cedars Sinai Medical Center, Los Angeles, California
Conditions: Advanced Solid Tumors
Zona Pellucida Bound Sperm vs. Embryologist Selected Sperm for Intracytoplasmic Sperm Injection
Recruiting
This study aims to assess the clinical significance of the intracytoplasmic sperm injection (ICSI) with zona-pellucida (ZP) bound sperm compared to ICSI with embryologist selected sperm for patients undergoing in vitro fertilization treatment of their infertility.
Gender:
ALL
Ages:
Between 18 years and 41 years
Trial Updated:
04/17/2024
Locations: Reproductive Medicine Associates of Northern California, San Francisco, California
Conditions: Infertility
Assessment of the Safety and Efficacy of 0.1% RGN-259 Ophthalmic Solution for the Treatment of NK: SEER-2
Recruiting
The objective of this study is to compare the safety and efficacy of RGN-259 to placebo for the treatment of Neurotrophic Keratopathy (NK)
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/17/2024
Locations: Harvard Eye Associates, Laguna Hills, California
Conditions: Neurotrophic Keratopathy
Diet in the Management of Acromegaly
Recruiting
Impact of low carbohydrate and low gluten diet on acromegaly progression, symptoms, complications, and treatment outcomes.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/17/2024
Locations: Cedars-Sinai Medical Center, Los Angeles, California
Conditions: Acromegaly
The Use of Butyrate Therapy in Pediatric Ulcerative Colitis
Recruiting
Butyrate is an important metabolite produced by the gut microbiome and has been shown as a helpful therapy in ulcerative colitis. This is a feasibility study to determine the efficacy of butryate enemas in pediatric ulcerative colitis.
Gender:
ALL
Ages:
Between 7 years and 21 years
Trial Updated:
04/17/2024
Locations: Children's Hospital Los Angeles, Los Angeles, California
Conditions: Ulcerative Colitis
Safety Study of Unlicensed IND Cord Blood Units Manufactured by the National Cord Blood Program for Unrelated Transplantation
Recruiting
This study will evaluate the safety of infusion of the investigational cord blood units by carefully documenting all infusion-related problems.
Gender:
ALL
Ages:
All
Trial Updated:
04/17/2024
Locations: City of Hope, Duarte, California
Conditions: Infusion Reactions