California is currently home to 5955 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
PE Audit and Feedback Pilot Study
Recruiting
School physical education (PE) is one of the most valuable tools for increasing physical activity and fitness among youth of all backgrounds; however, compliance with existing PE laws is low (and differential by school race/ethnic and family-income composition, contributing to health disparities), and best practices for increasing compliance remain unknown. This study proposes to examine a novel approach for increasing PE law compliance by testing a PE audit and feedback tool (adapted from a too... Read More
Gender:
All
Ages:
All
Trial Updated:
05/08/2023
Locations: UC Berkeley, Berkeley, California
Conditions: Physical Inactivity, Cardiovascular Diseases
Aging and Reward System Response to Inflammation and Anxiety Study
Recruiting
The purpose of this study is to use an experimental inflammatory challenge to examine whether older adults with symptoms of anxiety experience loss of pleasure or loss of motivation when they are exposed to inflammation. Loss of pleasure or loss of motivation will be evaluated using self-report questionnaires, computer tasks, and during a brain scan.
Gender:
All
Ages:
Between 60 years and 80 years
Trial Updated:
05/08/2023
Locations: Norman Cousins Center for Psychoneuroimmunology, University of California, Los Angeles, Los Angeles, California
Conditions: Anhedonia, Inflammation, Anxiety, Aging, Depression
Physician Modified Endograft For Complex Aortic Aneurysm Repair
Recruiting
The physician modified endograft is intended for treating complex, pararenal, juxtarenal and thoracoabdominal aortic aneurysms requiring coverage of renal arteries, the superior mesenteric artery or the celiac trunk in high-risk patients who do not have an option for endovascular repair with an FDA approved endograft and have an appropriate anatomy. There will be one investigational site with a total of 40 subjects to be enrolled. Time to complete enrollment will be 24 months and the subject fol... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
05/08/2023
Locations: University of California San Diego, San Diego, California
Conditions: Complex Abdominal Aortic Aneurysm, Juxtarenal Aortic Aneurysm, Pararenal Aortic Aneurysm, Thoracoabdominal Aortic Aneurysm
Food Prescriptions to Promote Affordable Diets
Recruiting
This is an Randomized controlled trial (RCT) to assess the impact of meal planning and affordable grocery delivery on weight loss, dietary quality and health on members of multigenerational Latino households.
Gender:
All
Ages:
2 years and above
Trial Updated:
05/08/2023
Locations: Kaiser Permanente, Pasadena, California
Conditions: Diet, Healthy, Overweight and Obesity
Affect Treatment for Depression and Anxiety
Recruiting
The purpose of this study is to evaluate the efficacy and mediators of change in Positive Affect Treatment, a psychotherapy specifically aimed at enhancing reward sensitivity in individuals with low positive affect (a core feature of anhedonia) in the context of depression or anxiety. Target enrollment is 100 male and female participants with low positive affect and depression or anxiety and impaired functioning, between the ages of 18 and 65 years, who will be randomized to either Positive Aff... Read More
Gender:
All
Ages:
Between 18 years and 65 years
Trial Updated:
05/08/2023
Locations: University of California, Los Angeles, Los Angeles, California
Conditions: Depression, Anxiety
Evaluation of Smoked THC and CBD in Men and Women
Recruiting
The purpose of this study is to determine the pharmacokinetics and pharmacodynamics of inhaled cannabis with varying amounts of delta-9-tetrahydrocannabinol (THC), and cannabidiol (CBD) and to evaluate detection of recently smoked THC in oral fluid.
Gender:
All
Ages:
Between 21 years and 55 years
Trial Updated:
05/08/2023
Locations: University of California, Los Angeles, Los Angeles, California
Conditions: Drug Abuse, Intoxication by Drug, Impairment
Neural Correlates of Real World Spatial Navigation in Humans
Recruiting
The purpose of this study is to understand the neural mechanisms that support real world spatial navigation in humans using deep brain recordings and stimulation during virtual reality (VR), augmented reality, and real world memory tasks. We will determine the cognitive (i.e., memory) and behavioral (i.e., body, head, eye position and movement) factors that modulate deep brain activity and the consequent effects of memory-enhancing deep brain stimulation.
Gender:
All
Ages:
Between 18 years and 90 years
Trial Updated:
05/08/2023
Locations: University of California Los Angeles, Los Angeles, California
Conditions: Memory, Delayed
Prevalence and Predictors of Hepatic Steatosis in Persons Living With HIV
Recruiting
Nonalcoholic fatty liver disease (NAFLD) is a spectrum of liver conditions associated with fat accumulation that ranges from benign, non-progressive liver fat accumulation to severe liver injury, cirrhosis, and liver failure. NAFLD is the most common liver disease in US adults and the second leading cause for liver transplantation in the US. The natural history of NAFLD in the general population has been well described, with those with non-alcoholic fatty liver (NAFL, or simple steatosis) destin... Read More
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
05/08/2023
Locations: University of California, San Diego, La Jolla, California
Conditions: NAFLD, NAFLD-HIV, Hiv
Frailty and Physician Modified Fenestrated Endograft for Thoracoabdominal Aortic Pathologies
Recruiting
The primary objective of this single arm, prospective feasibility study, Impact of Frailty on Clinical Outcomes of Patients Treated for Thoracoabdominal and Complex Abdominal Aortic Aneurysms with Physician-Modified Fenestrated and Branched Stent Grafts, is to assess the use of the physician-modified fenestrated/branched endografts to repair thoracoabdominal and complex aortic aneurysms in subjects having appropriate anatomy, at high risks for open repairs. The primary intent of the study is to... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
05/08/2023
Locations: Keck Hospital of University of Southern California, Los Angeles, California
Conditions: Thoracoabdominal Aortic Aneurysm, Thoracoabdominal; Aortic, Aneurysm, Dissecting, Pararenal Aneurysm, Frailty Syndrome
SCOPE Analytic Treatment Interruption Protocol
Recruiting
The goal of this study is to understand the interaction between HIV and the host at the earliest stages when HIV medications are paused. Volunteers with HIV will interrupt antiretroviral therapy (ART) and then have intensive studies preformed two to three times per week. Most will resume therapy within three weeks, even if the virus does not rebound during this time.
Gender:
All
Ages:
18 years and above
Trial Updated:
05/08/2023
Locations: University of California San Francisco, San Francisco, California
Conditions: HIV/AIDS
Applying Best Clinical Practices to Patients at High Risk of Respiratory Complications
Recruiting
The purpose of this study is to: Perform a retrospective analysis on data contained in the UCLA Perioperative Data Warehouse on the incidence of respiratory dysfunction in the post-operative care unit (PACU) before and after the introduction of sugammadex into clinical practice. Develop and implement a clinical best practice pathway designed to prevent postoperative respiratory complications in higher risk patients (such as those with OSA or preexisting respiratory disease) using education and... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
05/08/2023
Locations: Ronald Reagan UCLA Medical Center, Los Angeles, California
Conditions: Respiratory Complication, Obstructive Sleep Apnea
Effects of Cannabis on Cognition and Endocannabinoid Levels in Bipolar Disorder Patients and Healthy Volunteers
Recruiting
Cannabis use is associated with younger age at onset of bipolar disorder, poor outcome, and more frequent manic episodes, but the effects of cannabis on cognition are less clear. Contrary to reports among non-psychiatric patients, cannabis may improve cognition among people with bipolar disorder. Nevertheless, no study to date has systematically tested the acute effects of cannabis on cognition in bipolar disorder. Therefore, the investigators propose to determine the effects of oral cannabinoid... Read More
Gender:
All
Ages:
Between 18 years and 50 years
Trial Updated:
05/08/2023
Locations: UC San Diego Medical Center, San Diego, California
Conditions: Bipolar Disorder