California is currently home to 5602 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Registry for Intra-Operative Radiotherapy During Breast Conserving Surgery in Patients With Early Stage Breast Cancer
Recruiting
This is a prospective, registry study that will enroll all women with early stage breast cancer who will be treated with intraoperative radiotherapy (IORT) during breast-conserving surgery. The purpose of this study is to further validate the long-term effectiveness and safety of this treatment method. We aim to assess short and long-term patient outcomes associated with IORT, including perioperative complications, local and distance disease recurrences, as well as disease-free survival and over... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/15/2024
Locations: John Wayne Cancer Institute, Providence Saint John's Health Center, Santa Monica, California
Conditions: Early-stage Breast Cancer, Breast Carcinoma in Situ, Breast Neoplasms
Phase 0 Master Protocol for CIVO Intratumoral Microdosing of Anti-Cancer Therapies
Recruiting
This is a multi-center, open-label Phase 0 Master Protocol designed to study the localized pharmacodynamics (PD) of anti-cancer therapies within the tumor microenvironment (TME) when administered intratumorally in microdose quantities via the CIVO device in patients with surface accessible solid tumors for which there is a scheduled surgical intervention. CIVO stands for Comparative In Vivo Oncology. Multiple substudies will include specified investigational agents and combinations to be evaluat... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/15/2024
Locations: UC Davis, Sacramento, California
Conditions: Solid Tumor
The DETECT(Digital Engagement & Tracking for Early Control, & Treatment) Study
Recruiting
Develop an app-based nationwide study of individuals who routinely use a smartwatch or other wearable activity tracker to determine if individualized tracking of changes in heart rate, activity and sleep can provide an early indication of influenza-like illnesses (ILI) and possibly other viral infections.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/15/2024
Locations: Scripps Research Translational Institute, San Diego, California
Conditions: Influenza, Virus
MyGeneRank: A Digital Platform for Next-Generation Genetic Studies
Recruiting
Many conditions affecting health are caused by a combination of environment, behaviors, and genes. While individuals can alter some factors in their lives to reduce the chances of developing different diseases (e.g., not smoking cigarettes), the contribution from genetic risk encoded by DNA remains with people throughout their lives. Scientists are still trying to determine the entirety of genetic factors that influence disease, but for some conditions it has been shown that the factors identifi... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/15/2024
Locations: Scripps Translational Science Institute, La Jolla, California
Conditions: Heart Diseases
POWERMOM, A Healthy Pregnancy Research Community
Recruiting
This study will take advantage of the open source framework of ResearchKit developed by Apple to bring research directly to participants. Using the ResearchKit platform as well as a stand alone app available for Android and HTML, it makes it easier to enroll large numbers of participants and carry out real-world health research to answer questions important to a broad population.
Gender:
FEMALE
Ages:
16 years and above
Trial Updated:
04/15/2024
Locations: Scripps Research Translational Institute, La Jolla, California
Conditions: Pregnancy Related, Weight Change, Body, Health Problems in Pregnancy, Behavior
Mental Health in Veterans and Families After Group Therapies
Recruiting
PTSD (posttraumatic stress disorder) and associated mental health conditions affect both veterans and their family members. This study investigates whether group therapy using EFT (Emotional Freedom Techniques) and CBT (Cognitive Behavior Therapy) produce reductions in PTSD and comorbid symptoms.
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
04/15/2024
Locations: Soul Medicine Institute, Santa Rosa, California
Conditions: Post-Traumatic Stress Disorders
Treat-to-Target of Endoscopic Remission in Patients With IBD in Symptomatic Remission
Recruiting
The purpose of this study is to compare the effectiveness and safety of a strategy of switching to an alternative targeted immunomodulator (TIM) therapy to treat to a target of endoscopic remission, versus continuing index TIM in patients with inflammatory bowel disease (IBD) (Crohn's disease or ulcerative colitis \[UC\]) in symptomatic remission with moderate to severe endoscopic inflammation despite optimization of index TIM in a real-world setting.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/12/2024
Locations: Hoag Hospital, Irvine, California
Conditions: Ulcerative Colitis, Crohn Disease
Quality of Pediatric Resuscitation in a Multicenter Collaborative
Recruiting
This is a prospective, observational, multi-center cohort study of pediatric cardiac arrests. The purpose of the study is to determine the association between chest compression mechanics (rate, depth, flow fraction, compression release) and patient outcomes. In addition, the investigators will determine the association of post cardiac arrest care with patient outcomes.
Gender:
ALL
Ages:
Between 0 years and 17 years
Trial Updated:
04/12/2024
Locations: Kaiser Permanente, Los Angeles, California
Conditions: Cardiac Arrest, Cardiopulmonary Arrest
Enhancing Team Effectiveness for a Collaborative School-based Intervention for ADHD
Recruiting
The proposed project aims to integrate team-based implementation strategies with an established school-based intervention for children with ADHD, the Collaborative Life Skills Program (CLS), to enhance its implementation and optimize its effectiveness. The investigators will tailor three empirically-supported team development interventions, Team Charters, Team Communication Training (Student Handoff Protocols), and Team Performance Monitoring, and integrate them into a team-enhanced CLS implemen... Read More
Gender:
ALL
Ages:
Between 7 years and 11 years
Trial Updated:
04/11/2024
Locations: IN STEP Children's Mental Health Center, San Diego, California
Conditions: Team-effectiveness Research, School-based Interventions, Attention Deficit/ Hyperactivity Disorder, Implementation Science
Phase 1 Study of SON-1010 in Adult Patients With Advanced Solid Tumors
Recruiting
This is a Phase 1, first-in-human, open-label, adaptive-design outpatient study to assess the safety, tolerability, and PK/PD of SON-1010 administered to patients with advanced solid tumors.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/11/2024
Locations: Sarcoma Oncology Center, Santa Monica, California
Conditions: Advanced Solid Tumor
Effects of Nicotine and Attention on Frequency Tuning in Auditory Cortex
Recruiting
Nicotine enhances auditory-cognitive function because it mimics the brain's system for "paying attention" to important sounds amid distractions (for example, understanding speech in a noisy environment). In part, nicotine does this by activating inhibitory neurons in the auditory cortex. Since age-related hearing deficits result, in part, from the loss of inhibitory neurons in auditory cortex, this project will determine whether nicotine's effects can compensate for reduced inhibition in the agi... Read More
Gender:
ALL
Ages:
Between 18 years and 85 years
Trial Updated:
04/11/2024
Locations: University of California, Berkeley, Berkeley, California
Conditions: Aging
Intravenous Iron Versus Oral Iron for the Treatment of Iron Deficiency Anemia
Recruiting
This study aims to assess whether administering intravenous iron early in pregnancy, compared to standard oral iron treatment, can enhance hemoglobin levels before delivery and reduce the need for blood transfusions in patients with iron deficiency anemia. Patients diagnosed with iron deficiency anemia were randomly assigned to receive either oral or intravenous iron. Before treatment initiation, patients completed a symptom questionnaire baseline hemoglobin, and ferritin levels were measured. F... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
04/10/2024
Locations: Arrowhead Regional Medical Center, Colton, California
Conditions: Iron Deficiency Anemia of Pregnancy