California is currently home to 5618 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Comparing the Stanford Letter Project Form to Traditional Advance Directives
Recruiting
Our goal is to compare two types of advance directives forms available in English and Spanish to determine which is more easy to use for patients.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/04/2024
Locations: Stanford School of Medicine, Stanford, California
Conditions: Advance Directives, Palliative Care
Acute Plasma Abeta Responses to Stress
Recruiting
Research has shown that activation of the sympathetic nervous system for extended periods or during certain times in life can increase the risk for Alzheimer's disease. Some research in animal models show that acute activation of the sympathetic nervous system through stress exposure can increase certain Alzheimer's disease-related biomarkers, such as amyloid-beta, within hours of exposure. However, how acute sympathetic nervous system activation via stress exposure affects amyloid-beta levels i... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
04/03/2024
Locations: University of Southern California, Los Angeles, California
Conditions: Stress Reaction, Stress Physiology
Mechanisms of Dupilumab in AERD
Recruiting
Aspirin-Exacerbated Respiratory Disease (AERD), although uncommon in the general population, is an important phenotype of severe asthma and nasal polyposis where it occurs in 15% of severe asthmatics, and up to 30% of those with nasal polyposis. An important therapy for AERD is aspirin therapy after desensitization (ADAT). This is an inexpensive and proven therapy to improve the burden of sinus disease in AERD. Aspirin desensitization is the mechanism by which tolerance is induced in AERD patien... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/03/2024
Locations: Scripps Clini, San Diego, California
Conditions: Aspirin-exacerbated Respiratory Disease
ARGONAUT: Stool and Blood Sample Bank for Cancer Patients
Recruiting
ARGONAUT is a longitudinal, prospective, observational study that will enroll up to 5,000 advanced-stage cancer patients of diverse racial backgrounds to collect data used to develop precision microbiome medicines and for the identification of clinically actionable cancer-specific biomarkers to guide therapeutic decisions. Four types of solid tumor cancers will be profiled including non-small cell lung cancer (NSCLC), triple negative breast cancer (TNBC), colorectal cancer (CRC) and pancreatic c... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/03/2024
Locations: Knowledge Research Center, Orange, California
Conditions: Non-small Cell Lung Cancer, Colorectal Cancer, Triple Negative Breast Cancer, Pancreas Cancer
Development and Analysis of a Stool Bank for Cancer Patients
Recruiting
This study is aimed at understanding the impact of gut microbiota on efficacy of cancer therapies, in particular checkpoint inhibitors, and using the resulting information to design microbial immunotherapies. Although animal models are of use to determine the influences of gut and other microbiota on cancer treatment modalities, they are limited due to differences between mouse and human physiology and immunology, as well as the inherent differences in gut microbial populations between the two m... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/03/2024
Locations: Compassionate Care Research Group, Inc., Fountain Valley, California
Conditions: Carcinoma, Non-Small-Cell Lung, Carcinoma, Colorectal
Enhancing Lung Cancer Screening Through Human-Centered Intervention
Recruiting
The purpose of this study is to further understand the factors involved in increasing lung cancer screening.
Gender:
ALL
Ages:
Between 50 years and 80 years
Trial Updated:
04/01/2024
Locations: University of California, Davis, Sacramento, California
Conditions: Lung Cancer
Effect of Mediterranean Diet in Inflammatory Bowel Disease
Recruiting
The effects of diet on inflammatory bowel disease is an under-studied area of research. The investigators are interested in further investigating the role that diet contributes to inflammatory bowel disease severity. The investigators will collect blood and stool samples from patients with inflammatory bowel disease (IBD) before and after diet changes. The stool samples will be analyzed using metabolomics and microbiome analysis to determine changes after the new diet has been implemented. The i... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/01/2024
Locations: University of California, San Diego, San Diego, California
Conditions: Inflammatory Bowel Disease
Prediction of Rehospitalization Following a Sepsis Admission Using a Wearable Biopatch
Recruiting
The goal of this observational study is to learn about the utility of biopatches predicting 30-day readmissions in patients discharged from the hospital with sepsis. The main question\[s\] it aims to answer are: • Does the application of a biopatch provide data that can improve prediction of an unplanned 30-day readmission following a hospitalization for sepsis. Participants will be asked to wear a biopatch on their chest for 30-days following hospital discharge or until readmission to the ho... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/01/2024
Locations: UC San Diego Health, San Diego, California
Conditions: Sepsis
Targeting the Default Mode Network: A TMS-fMRI Study
Recruiting
In post-traumatic stress disorder (PTSD), intrusive, traumatic, autobiographical memories lead to anxiety symptoms. Recent work suggests a new repetitive pulse transcranial magnetic stimulation (rTMS) brain target that might bring relief. Since this proposed target is not well understood, the goal of the study is to use functional magnetic resonance imaging (fMRI) to identify the brain regions and networks that change with rTMS stimulation at this target area in PTSD patients. Ultimately, this w... Read More
Gender:
ALL
Ages:
Between 18 years and 55 years
Trial Updated:
04/01/2024
Locations: VA Palo Alto, Palo Alto, California
Conditions: Post Traumatic Stress Disorder, PTSD
The BENeFiTS Trial in Beta Thalassemia Intermedia
Recruiting
Beta-thalassemias and hemoglobinopathies are serious inherited blood diseases caused by abnormal or deficiency of beta A chains of hemoglobin, the protein in red blood cells which delivers oxygen throughout the body.The diseases are characterized by hemolytic anemia, organ damage, and early mortality without treatment. Increases in another type of (normal) hemoglobin, fetal globin (HbF), which is normally silenced in infancy, reduces anemia and morbidity. Even incremental augmentation of fetal g... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/01/2024
Locations: UCSF Benioff Children's Hospital at Oakland, Oakland, California
Conditions: Beta Thalassemia Intermedia, Sickle Cell Disease
Evaluating Pulse Oximetry Bias in Children With Darker Skin Pigmentation
Recruiting
In this prospective study, the investigators will enroll 154 children with arterial lines to determine the accuracy of pulse oximeters in children with darker skin pigmentation. Studies in adults suggest pulse oximeters may overestimate the true level of oxygenation in the blood as measured directly by co-oximetry. However, pediatric data are relatively limited. This study, which is funded by the FDA through the Stanford-UCSF (University of California San Francisco) Clinical Excellence in Regula... Read More
Gender:
ALL
Ages:
21 years and below
Trial Updated:
03/29/2024
Locations: Lucile Packard Children's Hospital, Palo Alto, California
Conditions: Congenital Heart Disease in Children, Cardiomyopathies
A Clinical Trial on Safety and Efficacy of CBT-001 in Patients With Pterygium
Recruiting
The objective is to evaluate the safety and efficacy of low dose and high dose CBT-001 eye drop dosed twice daily for 24 months compared to vehicle in reducing conjunctival hyperemia and preventing pterygium progression in eyes with pterygia.
Gender:
ALL
Ages:
12 years and above
Trial Updated:
03/29/2024
Locations: Bakersfield Eye Institute, Bakersfield, California
Conditions: Pterygium