California is currently home to 5600 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
A Study of NTX-1088, a Monoclonal Antibody Targeting the Poliovirus Receptor (PVR, CD155), as Monotherapy and Combined With Pembrolizumab
Recruiting
This is a Phase 1,open-label, multi-center, first-in-human, 2-part (Part 1: dose escalation and Part 2: expansion) study, evaluating multiple doses and schedules of intravenously (IV) administered NTX-1088, with or without pembrolizumab, in patients with advanced solid malignancies (i.e., locally advanced or metastatic).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/25/2024
Locations: City of Hope, Duarte, California
Conditions: Cancer, Tumor, Solid, Advanced Solid Tumor, Metastatic Cancer, Locally Advanced Solid Tumor
Safety and Efficacy Study of CBT-004 in Patients With Vascularized Pinguecula
Recruiting
STUDY DESIGN: Structure: Multicenter, randomized, double-masked, vehicle-controlled, parallel-group study. Duration of Treatment: 4 weeks of study treatment with 4 weeks follow-up observations. Control: Vehicle for CBT-004 (hereafter referred to as Vehicle). Masking: Subjects, Investigators, Study Monitors and the Independent Image Reading Center are all masked to the study medications. Dosage/Dose regimen: One drop of the assigned study medication will be administered in the study eye... Read More
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
01/25/2024
Locations: Global Research Management, Glendale, California
Conditions: Pinguecula
Validation of Early Prognostic Data for Recovery Outcome After Stroke for Future, Higher Yield Trials
Recruiting
VERIFY will validate biomarkers of upper extremity (UE) motor outcome in the acute ischemic stroke window for immediate use in clinical trials, and explore these biomarkers in acute intracerebral hemorrhage. VERIFY will create the first multicenter, large-scale, prospective dataset of clinical, transmagnetic stimulation (TMS), and MRI measures in the acute stroke time window.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/24/2024
Locations: Ronald Reagan UCLA Medical Center, Los Angeles, California
Conditions: Stroke, Stroke, Acute, Stroke, Ischemic, Stroke Hemorrhagic
A Study to Investigate Fadraciclib (CYC065), in Subjects With Advanced Solid Tumors and Lymphoma
Recruiting
This is a 2-part, phase 1/2, open-label, multicenter study designed to evaluate the safety, tolerability, PK, pharmacodynamics, PGx, and efficacy of fadraciclib administered orally BID. This study consists of Phase 1 and Phase 2 components in subjects with advanced solid tumors and lymphoma who have progressed despite having standard therapy or for which no standard therapy exists.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/24/2024
Locations: City of Hope, Duarte, California
Conditions: Solid Tumor, Adult, Lymphoma
A Phase 3 Study Evaluating Efficacy and Safety of Lanifibranor Followed by an Active Treatment Extension in Adult Patients With (NASH) and Fibrosis Stages F2 and F3 ( NATiV3 )
Recruiting
This Phase 3 study is conducted to evaluate lanifibranor in adults with NASH and liver fibrosis histological stage F2 or F3
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/24/2024
Locations: Office of Franco Felizarta, MD, Bakersfield, California
Conditions: NASH - Nonalcoholic Steatohepatitis
Biomarker Monitoring of Prostate Cancer Patients With RSI MRI (ProsRSI)
Recruiting
Adult male patients with high-risk, localized prostate cancer and planning to undergo radiation therapy (RT) with androgen deprivation therapy (ADT) will undergo an advanced Magnetic Resonance Imaging (MRI) examination called Restriction Spectrum Imaging (RSI-MRI) to evaluate whether RSI-MRI can predict treatment response.
Gender:
MALE
Ages:
18 years and above
Trial Updated:
01/24/2024
Locations: UCSD Moores Cancer Center, La Jolla, California
Conditions: Prostate Cancer
Role of CBD in Improving Alexithymia
Recruiting
Given the treatments that are available today for HIV disease, people living with HIV (PLWH) can generally expect good medical outcomes. However, HIV is still a chronic disease and there are remaining barriers to achieving ideal health status and quality of life. One barrier may be a condition that is common among PLWH, called alexithymia, which can make it difficult for a person to name and describe the emotions that they are feeling. As a result, it is difficult to resolve negative emotional s... Read More
Gender:
ALL
Ages:
21 years and above
Trial Updated:
01/23/2024
Locations: HIV Neurobehavioral Research Center/Center for Medicinal Cannabis Research, San Diego, California
Conditions: Alexithymia, HIV
Sleepless at Scripps: An Inpatient White Noise Study
Recruiting
Sleep is an important part of the healing process, and patients admitted to the hospital often report poor sleep. Patients have difficulty not only falling sleep, but also staying asleep. Prior studies show that hospital noise may be a contributing factor, and in particular, sound level changes (which refers to an increase in sound above the background/baseline noise level) may cause arousals from sleep. Based on preliminary data, this study aims to use white noise to reduce the number of releva... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/22/2024
Locations: Scripps Health, La Jolla, California
Conditions: White Noise, Sleep, Sleep Fragmentation, Sleep Duration
The Family Perspectives Project Pilot Trial
Recruiting
The purpose of the study is to conduct a pilot randomized trial of a program designed to enhance equitable communication and emotional support for families of critically ill patients in order to determine feasibility, acceptability, and participant experience with the program. The primary study procedures include: chart abstraction, questionnaires, meetings with ICU support counselors, meetings with ICU physicians and care team, audio recordings of these meetings (optional), and interviews with... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/19/2024
Locations: Cedars-Sinai Medical Center, Los Angeles, California
Conditions: Respiratory Failure, Family Support, Physician-Patient Relations, Critical Illness
Characterization of the Melanoma-Specific Immune Response
Recruiting
The aim of this study is to study T-cells. Blood will be collected and the samples will be used to generate T cell clones. Two separate blood draws will be required at the maximum.
Gender:
ALL
Ages:
Between 18 years and 85 years
Trial Updated:
01/19/2024
Locations: University of California, Davis Department of Dermatology, Sacramento, California
Conditions: Melanoma
The Rapid Diagnosis of MCI and Depression in Patients Ages 60 and Over
Recruiting
Mild cognitive impairment (MCI) leading to Alzheimer's disease and related disorders (ADRD) represents a significant health and economic burden of the rapidly expanding senior population. The accurate detection and diagnosis of MCI and its common comorbidity, late-life depression (LLD), is essential for prolonging patient quality of life and developing advancements in research and treatment options. The purpose of the proposed program is to refine Miro Health's A.I. to accurately detect, differe... Read More
Gender:
ALL
Ages:
60 years and above
Trial Updated:
01/18/2024
Locations: Miro Health, Sacramento, California
Conditions: Depression, Mild Cognitive Impairment
Solve Together: A Data Collection Platform for the Collection of Patient and Control Health Information to Support Future Research That Will Accelerate Understanding of the Causes of and Possible Treatments for ME/CFS and Other Chronic Diseases, Including Post-viral Illnesses
Recruiting
Solve Together is a platform designed to collect clinical data about post-infectious diseases, including ME/CFS and Long Covid. This data is made available to researchers and will be used to identify participants eligible for clinical studies. The platform also empowers patients to make reports for their doctors, connect medical records and/or a health-tracking wearable device, and identify their unique symptoms and health patterns.
Gender:
ALL
Ages:
All
Trial Updated:
01/18/2024
Locations: Solve ME/CFS Initiative, Los Angeles, California
Conditions: ME/CFS, Post-Acute COVID-19 Syndrome