California is currently home to 5930 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Crisis Response Planning for Military Personnel
Recruiting
The study is a randomized trial comparing outcomes of active duty service members who present to the emergency department at risk for suicide and receive care from providers trained in crisis response planning versus those providing treatment as usual.
Gender:
All
Ages:
18 years and above
Trial Updated:
06/30/2023
Locations: Naval Medical Center San Diego, San Diego, California
Conditions: Suicidal, Suicide Threat, Suicidal Ideation
Selinexor and Pembrolizumab for the Treatment of Cisplatin-Ineligible or Cisplatin-Refractory Locally Advanced or Metastatic Urothelial Carcinoma
Recruiting
This phase Ib/II trial finds the best dose of selinexor and its effect with pembrolizumab in treating patients with urothelial carcinoma that are not eligible to receive the chemotherapy drug cisplatin, or have been given cisplatin and the cancer has gotten worse. Patients must also have urothelial carcinoma that has spread locally, near where it started (locally advanced), or has spread to other parts of the body (metastatic). Selinexor may stop the growth of tumor cells by blocking a protein,... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
06/30/2023
Locations: University of California Davis Comprehensive Cancer Center, Sacramento, California
Conditions: Advanced Urothelial Carcinoma, Locally Advanced Urothelial Carcinoma, Metastatic Urothelial Carcinoma, Refractory Urothelial Carcinoma
Canadian-American Spinal Cord Perfusion Pressure and Biomarker Study
Recruiting
This multicenter study will enroll 100 patients with acute traumatic cervical and thoracic SCI who have a lumbar intrathecal catheter inserted within 24 hours of their injury. The lumbar intrathecal catheter will be inserted pre-operatively for the measurement of ITP and the collection of cerebrospinal fluid (CSF) samples. SCPP will be calculated as the difference between MAP and the ITP. There are two important distinct yet related objectives in this prospective interventional study. Determin... Read More
Gender:
All
Ages:
17 years and above
Trial Updated:
06/30/2023
Locations: Zuckerberg San Francisco General Hospital and Trauma Center, San Francisco, California
Conditions: Acute Spinal Cord Injury, Acute Spinal Paralysis, Spinal Cord Injuries, SPINAL Fracture
Acoustic and Electrical Stimulation for the Treatment of Tinnitus
Recruiting
Tinnitus, or ringing in the ears, affects 10% to 30% of the population. Of those, 20% have tinnitus bothersome enough to seek medical attention. In many people, tinnitus can significantly affect the quality of life. At this point in time, there is no effective treatment or cure available for tinnitus. It has been found that electrical stimulation of the inner ear can reduce and in some cases eliminate tinnitus. The purpose of this research is to investigate both acoustic and electrical stimulat... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
06/30/2023
Locations: Hamid R. Djalilian, Irvine, California
Conditions: Tinnitus
Skin Imaging With Technologies in Development
Recruiting
The purpose of this research is to develop non-invasive imaging modalities for assessment of skin. This is a pilot study which will use multiple imaging modalities to collect information on normal and lesional skin. The researchers understand that the purpose of this study is not to evaluate any particular treatment and an investigation of a new therapeutic intervention would require an additional protocol. Skin conditions to be studied include vascular lesions, pigmentary disorders, inflammator... Read More
Gender:
All
Ages:
7 years and above
Trial Updated:
06/30/2023
Locations: Beckman Laser Institute Medical clinic, Irvine, California
Conditions: Pigmented Skin Lesion of Uncertain Nature
Cellular Aging and Neurobiology of Depression Study
Recruiting
We are conducting an eight week longitudinal study to learn if blood levels of certain naturally occurring compounds and genetic markers differ between patients with depression and healthy adults who are not depressed, and if any such differences relate to memory performance, mood, and neurobiology. We are also interested in how the gut microbiome is affected by antidepressant treatment. We will do this by comparing the unmedicated depressed patients with matched healthy controls at baseline an... Read More
Gender:
All
Ages:
Between 21 years and 60 years
Trial Updated:
06/30/2023
Locations: University of California San Francisco, San Francisco, California
Conditions: Major Depressive Disorder
Evaluate the Safety and Efficacy of Dura Sealant Patch in Reducing CSF Leakage Following Elective Cranial Surgery
Recruiting
The objective of the study is to clinically assess the safety and effectiveness of LIQOSEAL® as a means of reducing intra- as well as post-operative CSF leakage in patients undergoing elective cranial intradural surgery with a dural closure procedure to show noninferiority compared to a control group.
Gender:
All
Ages:
18 years and above
Trial Updated:
06/29/2023
Locations: Stanford University, Palo Alto, California
Conditions: Cerebrospinal Fluid Leak
A Study of MACI in Patients Aged 10 to 17 Years With Symptomatic Chondral or Osteochondral Defects of the Knee
Recruiting
The objective of this study is to compare the efficacy and safety of MACI® vs arthroscopic microfracture in the treatment of patients aged 10 to 17 years with symptomatic articular chondral or osteochondral defects of the knee.
Gender:
All
Ages:
Between 10 years and 17 years
Trial Updated:
06/29/2023
Locations: Stanford University, Palo Alto, California
Conditions: Chondral Defect, Articular Cartilage Defect, Articular Cartilage Disorder of Knee, Osteochondritis Dissecans (OCD)
Cholesterol and Inflammation Lowering Via Bempedoic Acid, an ACL-inhibiting Regimen in HIV Trial (CLEAR HIV Trial)
Recruiting
This is a randomized placebo-controlled study in treated and suppressed HIV-infected individuals aged ≥40 years with either known CVD or 1 CVD risk factor to study the effect of Bempedoic acid (BA) on safety, arterial inflammation as assessed by FDG-PET/CT, lipids, inflammation, immune activation, cardiometabolic indices, and non-calcified plaque (NCP) in the coronary arteries (assessed by coronary CT angiography, CCTA). This trial will be enrolled at UCSF and UCLA. Collaborators at Massachusett... Read More
Gender:
All
Ages:
40 years and above
Trial Updated:
06/28/2023
Locations: San Francisco General Hospital, San Francisco, California
Conditions: Dyslipidemias, Cardiovascular Diseases, HIV Infections, Atherosclerosis
Platform Trial of Novel Regimens Versus Standard of Care (SoC) in Participants With Non-small Cell Lung Cancer (NSCLC)
Recruiting
This study will compare the clinical activity of novel regimens (in combination or as single agents) to SoC in participants with relapsed/refractory advanced NSCLC. The study will be conducted in two parts. Part 1 is an open-label, optional, non-randomized part based on safety and pharmacokinetics/pharmacodynamics (PK/PD) evaluation intended to generate additional data to qualify novel regimens for the randomized study. Part 2 is a randomized, Phase II open-label part comparing the efficacy and... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
06/28/2023
Locations: GSK Investigational Site, Los Angeles, California
Conditions: Neoplasms
Effect of PCSK9 Inhibition on Cardiovascular Risk in Treated HIV Infection (EPIC-HIV Study)
Recruiting
Atherosclerosis in the setting of HIV infection is distinct and includes increased vascular inflammation, worsened endothelial function, and a predominance of non-calcified plaque. These outcomes can be assessed using specialized noninvasive imaging which strongly predict future CV events in the general population. PCSK9 has emerged as an important pharmacologic target for cholesterol lowering in the general population and recent studies among individuals without HIV have shown that PCSK9 inhib... Read More
Gender:
All
Ages:
40 years and above
Trial Updated:
06/28/2023
Locations: San Francisco General Hospital, San Francisco, California
Conditions: Dyslipidemias, Cardiovascular Diseases, HIV Infections
Dental Block for Pain Relief in ED Dental Pain Patients
Recruiting
This will be a prospective, observational cohort study assessing immediate pain relief from dental block in ED patients presenting with dental pain. The study will be conducted in the Community Regional Medical Center ED. The aim of this study, then, is to prospectively determine if dental block provides minimal clinically important difference in pain relief to these patients.
Gender:
All
Ages:
18 years and above
Trial Updated:
06/27/2023
Locations: Community Regional Trauma and Burn Center, Fresno, California
Conditions: Dental Pain