California is currently home to 5959 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
JAB-3312 Based Combination Therapy in Adult Patients With Advanced Solid Tumors
Recruiting
To evaluate the safety and tolerability of JAB-3312 administered in investigational regimens in adult participants with advanced solid tumors.
Gender:
All
Ages:
18 years and above
Trial Updated:
05/16/2023
Locations: Research Site, Los Angeles, California
Conditions: Solid Tumor, NSCLC
Fermented Food-Supplemented Diet in Ulcerative Colitis
Recruiting
The purpose of this study is to see how a diet that supplements fermented foods effects inflammation and quality of life in patients with mild to moderate Ulcerative Colitis (UC). There is a paucity of research and an enormous need for better understanding of diet and intestinal inflammation. Fermented food have been shown to positively influence inflammatory cytokines and intestinal microbial diversity in healthy volunteers.
Gender:
All
Ages:
18 years and above
Trial Updated:
05/16/2023
Locations: Stanford University, Palo Alto, California
Conditions: Inflammatory Bowel Diseases, Diet Modification, Ulcerative Colitis
DECAMP 1 PLUS: Prediction of Lung Cancer Using Noninvasive Biomarkers
Recruiting
DECAMP 1 PLUS aims to improve the efficiency of the diagnostic evaluation of patients with indeterminate pulmonary nodules (8-25 mm). Molecular biomarkers for lung cancer diagnosis measured in minimally invasive and non-invasive biospecimens may be able to distinguish between malignant or benign indeterminate pulmonary nodules in high-risk smokers. Ultimately, this study aims to validate molecular as well as clinical and imaging biomarkers of lung cancer in individuals with indeterminate lung no... Read More
Gender:
All
Ages:
46 years and above
Trial Updated:
05/16/2023
Locations: University of California Los Angeles, Los Angeles, California
Conditions: Pulmonary Disease
PrecISE (Precision Interventions for Severe and/or Exacerbation-Prone Asthma) Network Study
Recruiting
The primary objective of this study is to evaluate several interventions given to participants with severe asthma. Interventions are administered in a crossover manner with 16-week treatment periods followed by 8 to 16 week washout.
Gender:
All
Ages:
12 years and above
Trial Updated:
05/16/2023
Locations: University of California Davis, Sacramento, California
Conditions: Asthma
HeartShare: Combining Omics, Deep Phenotyping, and Electronic Health Records for Heart Failure Subtypes and Treatment Targets
Recruiting
HeartShare is a comprehensive study of heart failure, a common and serious medical condition which occurs when the heart is unable to keep up with the demands of the body, resulting in shortness of breath, fluid retention, and fatigue. HeartShare aims to better classify heart failure into subtypes to help develop more personalized treatments for patients, with the hope that this will improve the lives of heart failure patients. To do this, HeartShare is bringing together a large amount of data (... Read More
Gender:
All
Ages:
30 years and above
Trial Updated:
05/15/2023
Locations: University of California Davis, Sacramento, California
Conditions: Heart Failure, Heart Failure With Preserved Ejection Fraction
Patient Derived Vascularized MicroTumor Model of Gastrointestinal Peritoneal Carcinomatosis
Recruiting
This is a pilot study gathering and using samples and data from patients with gastrointestinal peritoneal carcinomatosis. Participants will be asked for permission to provide blood and ascites/peritoneal wash fluid, tumor samples during their planned surgical procedure.
Gender:
All
Ages:
18 years and above
Trial Updated:
05/15/2023
Locations: Chao Family Comprehensive Cancer Center, University of California, Irvine, Orange, California
Conditions: Peritoneal Carcinomatosis, Gastrointestinal Peritoneal Carcinomatosis
18F-F-AraG PET Imaging to Evaluate Immunological Response to CAR T Cell Therapy in Lymphoma
Recruiting
This is a pilot study in adult subjects with aggressive B-cell lymphoma who will receive commercial or research CAR T cell therapy as anticancer treatment.
Gender:
All
Ages:
18 years and above
Trial Updated:
05/15/2023
Locations: Stanford University, School of Medicine, Stanford, California
Conditions: Non-Hodgkin's Lymphoma
Leflunomide for the Treatment of High-Risk Smoldering Multiple Myeloma in African-American and European-American Patients
Recruiting
This phase II trial studies the effects of leflunomide in treating African-American and European-American patients with high-risk smoldering multiple myeloma. Leflunomide is used to decrease the body's immune response and may delay the symptoms of multiple myeloma in patients of African-American and European decent.
Gender:
All
Ages:
18 years and above
Trial Updated:
05/15/2023
Locations: City of Hope Medical Center, Duarte, California
Conditions: Smoldering Plasma Cell Myeloma
Using Nicotine to Reverse Age-related Auditory Processing Deficits
Recruiting
The present study will evaluate the effects of both aging and nicotine on psychophysical tasks and electrophysiological measures. Nicotine will be administered to study participants in the form of gum that is available as an over-the-counter medication. The hypothesis is that nicotine will reverse the detrimental effects of aging on auditory processing. The proposed experiments will characterize the effects of nicotine and may eventually lead to improved treatments of hearing loss in a variety o... Read More
Gender:
All
Ages:
Between 18 years and 85 years
Trial Updated:
05/15/2023
Locations: Hearing and Speech Lab, Irvine, California
Conditions: Auditory Perceptual Impairment, Aging
Technology-Enabled Activation of Skin Cancer Screening for Stem Cell Transplant Survivors and Their Primary Care Providers, TEACH Study
Recruiting
This trial studies the impact of a 12-month invention focused on early detection of skin cancer and timely follow up in patients who underwent stem cell transplant and their primary care providers. Some stem cell transplant survivors may develop complications related to the treatment they received. Many of these complications may not be known for years after the treatment and preventive measures can be taken to reduce the chances that a complication will occur and encourage early detection. This... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
05/15/2023
Locations: City of Hope Medical Center, Duarte, California
Conditions: Skin Carcinoma
Pancreatic Islets and Parathyroid Gland Co-transplantation for Treatment of Type 1 Diabetes
Recruiting
The primary objective is to test the hypothesis that co-transplantation of allogeneic PTG with adult pancreatic islets (derived from same deceased donor) in the IM site in people with Type 1 diabetes with functioning kidney and/or liver transplants is safe, allows islet engraftment, and leads to insulin independence.
Gender:
All
Ages:
18 years and above
Trial Updated:
05/15/2023
Locations: University of California, San Francisco, California
Conditions: Type 1 Diabetes
iKanEat: A Randomized-controlled, Multi-center Trial of Megestrol for Chronic Oral Food Refusal in Children
Recruiting
This is a multi-center, randomized, placebo-controlled, double-blind clinical trial. The primary focus of the study is the evaluation of the effectiveness of treatment with megestrol as part of a 24 week behavioral feeding protocol in transitioning from tube to oral feedings in a pediatric population. Approximately 60 pediatric subjects matching the criteria for eligibility will be enrolled in the study and randomized to receive either megestrol (n=30) or placebo (n=30).
Gender:
All
Ages:
Between 9 months and 108 months
Trial Updated:
05/15/2023
Locations: Rady Children's Hospital - San Diego, San Diego, California
Conditions: Feeding Behavior, Feeding Disorder of Infancy or Early Childhood