California is currently home to 5619 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Oral Axl/Mer/CSF1R Selective Tyrosine Kinase Inhibitor Q702 in Combination With Pembrolizumab in Patients With Selected Advanced Solid Tumors
Recruiting
This study is a phase 1B/2 open-label, study to determine safety and preliminary efficacy of Q702 in combination with pembrolizumab in study subjects with advanced esophageal, gastric/GEJ, hepatocellular, and cervical cancers.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/08/2024
Locations: University of Southern California, Los Angeles, California
Conditions: Esophageal Cancer, Gastric Cancer, Hepatocellular Cancer, Cervical Cancer
Highly Selective CDK7 Inhibitor Q901 in Selected Advanced Solid Tumors
Recruiting
Multicenter, open-label, dose-escalation, safety, tolerability, PK and pharmacodynamic study with a dose expansion at the RP2D to evaluate safety and potential antitumor activity of Q901 as a monotherapy and in combination with pembrolizumab
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/08/2024
Locations: University of Southern California, Los Angeles, California
Conditions: Advanced Cancer, Metastatic Cancer
Remote Assessment and Intervention for Behavior Problems in Kids With TSC
Recruiting
The RAINBOW study is a fully remote study focused on understanding and treating behavior problems in young children with tuberous sclerosis complex (TSC). The first goal is to enroll a group of 100 children with TSC between the ages of 3 and 6 years old, with and without problem behaviors, to learn about how best to measure behavioral challenges in TSC and how common these behaviors are during this age period. All families will get feedback from the clinical assessments collected. Eligible child... Read More
Gender:
ALL
Ages:
Between 3 years and 6 years
Trial Updated:
03/07/2024
Locations: University of California, Los Angeles, Los Angeles, California
Conditions: Tuberous Sclerosis
Understanding Ozanimod's MOA Via Mass Cytometry in Ulcerative Colitis
Recruiting
The goal of this observational study is to learn about the mechanism of action of ozanimod in patients with ulcerative colitis (UC). The main questions it aims to answer are: 1. Prospectively assess the effects of ozanimod on the cellular composition of intestinal lamina propria and blood by deep immunophenotyping (CyTOF) of immune cell subsets prior and after the drug's administration. 2. Determine whether changes in cell subsets observed via mass cytometry correlate with with clinical or hist... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/07/2024
Locations: University of California San Diego, San Diego, California
Conditions: Ulcerative Colitis, Ulcerative Colitis Chronic Moderate
Secretin in Refeeding
Recruiting
Patients with restrictive-type anorexia nervosa who are admitted to the hospital for feeding often urinate excessive amounts. Others have changes in the way that they handle acid and base. These issues prolong hospitalizations. Current data suggest that one hormone--named secretin--may control both urine output and how the body handles acid and base. This study will evaluate whether secretin levels are different in anorexic patients who urinate an excessive amount compared to those who urinate n... Read More
Gender:
ALL
Ages:
Between 13 years and 24 years
Trial Updated:
03/06/2024
Locations: University of California, Los Angeles (UCLA), Los Angeles, California
Conditions: Anorexia in Adolescence
Guselkumab Immunogenetics
Recruiting
This is a two-arm open-label study to evaluate the clinical and immunogenetic responses of patients with plaque or guttate psoriasis to treatment with guselkumab.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/06/2024
Locations: UCSF Psoriasis and Skin Treatment Center, San Francisco, California
Conditions: Psoriasis Guttate, Plaque Psoriasis
Kebele Elimination of Trachoma for Ocular Health
Recruiting
The investigators propose a cluster-randomized clinical trial to determine whether an intensive, targeted azithromycin distribution strategy is effective for elimination of trachoma at the kebele level compared to the World Health Organization (WHO) recommendation of annual azithromycin distribution.
Gender:
ALL
Ages:
All
Trial Updated:
03/06/2024
Locations: UCSF Proctor Foundation, San Francisco, California
Conditions: Trachoma
An Adaptive Clinical Trial of BeginNGS Newborn Screening for Hundreds of Genetic Diseases by Genome Sequencing
Recruiting
The goal of this clinical trial is to test a new method for newborn screening using whole genome sequencing, called BeginNGS. Parents will be approached to provide informed consent to enroll their newborns in prenatal, postnatal, and outpatient settings. The main questions this study aims to answer are: What is the utility of BeginNGS as compared to state newborn screening? What is the acceptability and feasibility of BeginNGS as compared to state newborn screening? What is the cost effectivene... Read More
Gender:
ALL
Ages:
Between 1 day and 28 days
Trial Updated:
03/05/2024
Locations: Rady Children's Hospital San Diego, San Diego, California
Conditions: Genetic Disease
A Study of Vedolizumab in Children With Ulcerative Colitis (UC) or Crohn's Disease (CD)
Recruiting
The study is an extension of two parent studies (MLN0002-3024 \[NCT04779307\] and MLN0002-3025 \[NCT04779320\]). Participants must have participated in one of the previous studies. The purpose of this study is to collect the long-term safety of vedolizumab in children with UC or CD.
Gender:
ALL
Ages:
2 years and above
Trial Updated:
03/05/2024
Locations: Rady Childrens Hospital San Diego - PIN, San Diego, California
Conditions: Ulcerative Colitis, Crohn's Disease
ET140203 T Cells in Pediatric Subjects With Hepatoblastoma, HCN-NOS, or Hepatocellular Carcinoma
Recruiting
Open-label, dose escalation, multi-center, Phase I/II clinical trial to assess the safety/tolerability and determine the recommended Phase II Dose (RP2D) of ET140203 T-cells in pediatric subjects who are AFP-positive/HLA-A2-positive and have relapsed/refractory HB, HCN-NOS, or HCC.
Gender:
ALL
Ages:
Between 1 year and 21 years
Trial Updated:
03/05/2024
Locations: UCSF Benioff Children's Hospitals, San Francisco, California
Conditions: Hepatoblastoma, Hepatocellular Carcinoma (HCC), Liver Neoplasms, Metastatic Liver Cancer, Liver Cancer, HEMNOS
Evaluation of Symphony™ Posterior Cervical System for Surgical Treatment of Adult Cervical Deformity
Recruiting
Multi-center, prospective, non-randomized study to evaluate Symphony™ Posterior Cervical System in the setting of surgical treatment of adult cervical deformity.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/04/2024
Locations: University of California Davis, Sacramento, California
Conditions: Cervical Deformity
Prospective Evaluation of Complex Adult Spinal Deformity (CAD) Treated With Minimally Invasive Surgery
Recruiting
Evaluate surgical treatment outcomes and identify best practice guidelines for complex adult spinal deformity (ASD) patients treated with minimally invasive approach, including radiographic and clinical outcomes, surgical and postoperative complications, risk factors for and revision surgery rates, and the role of standard work to improve patient outcomes and reduce surgical and postoperative complications.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/04/2024
Locations: Shiley Center for Orthopaedic Research and Education at Scripps Clinic, La Jolla, California
Conditions: Adult Spinal Deformity, Scoliosis, Kyphosis, Sagittal Imbalance