California is currently home to 5600 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Safety and Efficacy Study of reSept ASD Occluder for Treating Secundum ASD
Recruiting
Evaluation of the safety and efficacy of the reSept ASD Occluder to treat patients with clinically significant secundum atrial septal defect
Gender:
ALL
Ages:
84 years and below
Trial Updated:
12/21/2023
Locations: Children's Hospital of Los Angeles, Los Angeles, California
Conditions: Heart Septal Defect, Heart Septal Defects, Atrial, Heart Defects, Congenital, Cardiovascular Abnormalities, Cardiovascular Diseases, Heart Diseases, Congenital Abnormalities
Angiotensin II in Liver Transplantation
Recruiting
The purpose of this study is to determine the efficacy and safety of Angiotensin II as a second-line vasopressor (drug that raises the blood pressure) during liver transplantation.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/20/2023
Locations: University of California, San Francisco, San Francisco, California
Conditions: Liver Transplant; Complications, Vasoplegia
A Registry of Subjects With Primary Indeterminate Lesions or Choroidal Melanoma
Recruiting
The purpose of this observational research study is to follow participants who have been treated with either bel-sar or received alternate treatment (sham, standard of care therapy, etc.) while participating in a previous Aura Biosciences clinical research study to assess the long-term safety and effectiveness in these subjects. This study will collect information from procedures conducted as part of routine follow-up eye care and cancer care. Additionally, the registry will collect all adverse... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/20/2023
Locations: UCLA Jules Stein Eye Institute, Los Angeles, California
Conditions: Choroidal Melanoma, Indeterminate Lesions of Eye
7 Tesla MRI Neuroimaging in Testicular Cancer Patients With Hypogonadism and on Androgen Replacement Therapy
Recruiting
This study evaluates 7 Tesla (T) magnetic resonance imaging (MRI) in observing changes in the brain (neuroimaging) in testicular cancer patients who have decreased testosterone (hypogonadism) and are on testosterone (androgen) replacement therapy. Symptoms of hypogonadism can include fatigue, weakness, loss of libido, depression, poor concentration and erectile dysfunction. Some patients experience mental changes after diagnosis and treatment. There is some evidence that hypogonadism produces st... Read More
Gender:
MALE
Ages:
18 years and above
Trial Updated:
12/19/2023
Locations: Los Angeles County-USC Medical Center, Los Angeles, California
Conditions: Hypogonadism, Malignant Testicular Germ Cell Tumor
Financial Incentives and Recruitment to the APT Webstudy
Recruiting
This single-blind, three-arm, randomized, controlled trial will assess the impact of messages and financial incentives on the enrollment of demographically diverse individuals to the Alzheimer Prevention Trials (APT) Webstudy. The APT Webstudy is a novel, online registry that employs quarterly cognitive testing using validated platforms. The APT Webstudy implements fully remote assessments, coordinated by the Alzheimer's Therapeutic Research Institute (ATRI) under USC IRB #HS-17-00746. The purpo... Read More
Gender:
ALL
Ages:
50 years and above
Trial Updated:
12/19/2023
Locations: Contra Costa Health Plan, Martinez, California
Conditions: Alzheimer Disease, Dementia, Preclinical Alzheimer's Disease, Prodromal Alzheimer's Disease
Modifiers of Disease Severity in Cerebral Cavernous Malformations
Recruiting
Cerebral cavernous malformations (CCMs) are clusters of abnormal blood vessels in the brain and spine. CCMs can bleed and cause strokes, seizures, and headaches. CCMs are often caused by an inherited gene mutation (alteration) in one of three CCM genes (CCM1, CCM2, or CCM3). There is a wide range of disease severity even among family members with this disease, though the natural history has not been clearly described for this particular population. This study will continue to enroll and follow... Read More
Gender:
ALL
Ages:
All
Trial Updated:
12/19/2023
Locations: University of California, San Francisco, San Francisco, California
Conditions: Cavernous Angioma, Familial, Cerebral Cavernous Malformations, Cerebral Cavernous Hemangioma
Endovascular Repair of Descending ThoracoAbdominal Aortic Pathologies Using Physician Modified Endovascular Prosthesis
Recruiting
This is an early feasibility study that investigates the outcome of selected patients with complex thoracoabdominal aortic lesions who are suitable for endovascular (within the vessel) repair with a physician-modified Medtronic Thoracic Valiant stent graft. The Medtronic Valiant System includes a Valiant Thoracic Stent Graft, a self-expanding, tubular end prosthesis which is modified/customized by the Investigators to fit the patient's anatomy. The device is constructed by making a taper in the... Read More
Gender:
ALL
Ages:
Between 21 years and 90 years
Trial Updated:
12/16/2023
Locations: Long Beach Memorial Medical Center, Memorial Heart & Vascular Institute, Long Beach, California
Conditions: Aortic Disease
Feasibility of Endovascular Repair Of Ascending Aortic Pathologies
Recruiting
The purpose of this study is to investigate the outcome of patients with pathologies of the ascending thoracic aorta (diseases in the great blood vessel or artery that leads away from the heart) including type A aortic dissection, retrograde type A aortic dissection, intramural hematoma, penetrating ulcer or pseudoaneurysm who are suitable for endovascular (within the vessel) repair with the Medtronic Valiant PS-IDE (Physician Sponsored-Investigational Device Exemption) Stent Graft. Type A aorti... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/16/2023
Locations: Long Beach Memorial Medical Center, Long Beach, California
Conditions: Aortic Dissection, Intramural Hematoma, Penetrating Ulcer, Pseudoaneurysm
Self-Administered Intralesional Injections for Acne
Recruiting
The goal of this clinical trial is to test the safety of intralesional injections of triamcinolone self-administered into acne lesions via an injection assistance device. The main question\[s\] it aims to answer are: * is use of the injection assistance device safe? * is delivery of triamcinolone to acne lesions via the injection assistance device efficacious? Participants will self-inject low dose triamcinolone into acne lesions and track lesion response via photos and survey for 14 days foll... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/15/2023
Locations: Center For Dermatology Clinical Research, Inc, Fremont, California
Conditions: Acne Vulgaris
DMT310-009 Topical in the Treatment of Acne Vulgaris
Recruiting
The objective is to evaluate the tolerability, safety, and efficacy of DMT310 topical powder mixed with diluent in male and female patients with moderate to severe facial acne vulgaris
Gender:
ALL
Ages:
9 years and above
Trial Updated:
12/15/2023
Locations: Center for Dermatology Clinical Research, Inc., Fremont, California
Conditions: Acne Vulgaris
Aspirin for Postpartum Patients With Preeclampsia
Recruiting
The purpose of this research study is to evaluate the effect of low-dose aspirin on recovery from severe preeclampsia (a high blood pressure disorder of pregnancy) among women who have given birth. We hypothesize that taking aspirin for the first week after giving birth will enhance recovery from preeclampsia by decreasing the levels of a protein called soluble fms-like tyrosine kinase (sFlt-1), which is thought to be a main contributor to the development of preeclampsia, and speeding up return... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
12/15/2023
Locations: Miller Children's and Women's Hospital, Long Beach/MemorialCare Long Beach, Long Beach, California
Conditions: Preeclampsia Postpartum
TPIV100 and Sargramostim for the Treatment of HER2 Positive, Stage II-III Breast Cancer in Patients With Residual Disease After Chemotherapy and Surgery
Recruiting
This phase II trial studies how well TPIV100 and sargramostim work in treating patients with HER2 positive, stage II-III breast cancer that has residual disease after chemotherapy prior to surgery. It also studies why some HER2 positive breast cancer patients respond better to chemotherapy in combination with trastuzumab and pertuzumab. TPIV100 is a type of vaccine made from HER2 peptide that may help the body build an effective immune response to kill tumor cells that express HER2. Sargramostim... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
12/15/2023
Locations: City of Hope Comprehensive Cancer Center, Duarte, California
Conditions: Breast Adenocarcinoma, Stage II Breast Cancer AJCC v6 and v7, Stage IIA Breast Cancer AJCC v6 and v7, Stage IIB Breast Cancer AJCC v6 and v7, Stage III Breast Cancer AJCC v7, Stage IIIA Breast Cancer AJCC v7, Stage IIIB Breast Cancer AJCC v7, Stage IIIC Breast Cancer AJCC v7