California is currently home to 5930 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
A Study of Prucalopride in Breastfeeding Women With Constipation
Recruiting
Prucalopride is a medicine used to treat constipation. The main aim of the study is to measure prucalopride concentrations in breast milk. Other aims are to check the growth and development of babies breastfed by their mothers who took prucalopride and to check if the babies had any side effects. During the study, participants will provide one set of milk samples over 24 hours using an electric breast pump. Breast milk samples will be collected at home and will be shipped to the laboratory. Al... Read More
Gender:
Female
Ages:
18 years and above
Trial Updated:
06/16/2023
Locations: University of California San Diego, La Jolla, California
Conditions: Chronic Constipation
Racial/Ethnic in Calcium and Sodium Metabolism
Recruiting
The increased interest in personalized nutrition has arisen because scientists are beginning to understand subgroup differences in response to the environment including diet. Some suggest that dietary guidance which promotes milk is racially and ethnically insensitive because of higher prevalence of lactose intolerance/maldigestion in non-white groups. Preliminary evidence in Black and White adolescent girls shows that Blacks retain more calcium and excrete more sodium than white girls on a high... Read More
Gender:
All
Ages:
Between 18 years and 50 years
Trial Updated:
06/15/2023
Locations: San Diego State University, San Diego, California
Conditions: Healthy
Acupuncture Therapy and Hypertension
Recruiting
Acupuncture therapy will be provided to reduce blood pressure in hypertensive patients. The mild to moderate hypertensive patients will not be on hypertensive medications. The course last for 8 weeks and the frequency is once a week.
Gender:
All
Ages:
Between 50 years and 75 years
Trial Updated:
06/15/2023
Locations: Susan Samueli Integrative Health Institute, Irvine, California
Conditions: Mild to Moderate Hypertension
Tianeptine for Treatment Resistant Depression
Recruiting
The studies will be conducted in parallel at two sites: the the Mood and Anxiety Disorders Program at the Icahn School of Medicine at Mount Sinai (MSSM), and Stanford Depression Research Clinic at Stanford University School of Medicine (SUSM). In addition, MRI studies for the MSSM patients will be carried out at the New York State Psychaitric Institute (NYSPI). The following procedures will be approved by the local Institutional Review Boards (IRBs) at each site, where the site PIs (Alla Landa,... Read More
Gender:
All
Ages:
Between 21 years and 60 years
Trial Updated:
06/15/2023
Locations: Stanford Depression Research Clinic at Stanford University School of Medicine, Stanford, California
Conditions: Treatment Resistant Depression
Autologous huMNC2-CAR44 or huMNC2-CAR22 T Cells for Breast Cancer Targeting Cleaved Form of MUC1 (MUC1*)
Recruiting
Phase I/II study of adoptive immunotherapy for advanced MUC1* positive breast cancer with autologous T cells engineered to express either a chimeric antigen receptor, huMNC2-CAR44 or huMNC2-CAR22, which are specific for a cleaved form of MUC1 (MUC1*).
Gender:
All
Ages:
18 years and above
Trial Updated:
06/15/2023
Locations: City of Hope Medical Center, Duarte, California
Conditions: Metastatic Breast Cancer
First-in-human Study of DS-1062a for Advanced Solid Tumors (TROPION-PanTumor01)
Recruiting
This study is one single group of participants with non-small cell lung cancer (NSCLC) who have not been cured by other treatments. It is the first time the drug has been used in humans. There will be two parts and a sub-study. The primary purpose of the parts are: Dose Escalation: To investigate the safety and tolerability and to determine the maximum tolerated dose (MTD) and the recommended dose for expansion (RDE) of DS-1062a Dose Expansion: To investigate the safety and tolerability of DS-... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
06/15/2023
Locations: University of California, Los Angeles, Los Angeles, California
Conditions: Triple Negative Breast Cancer, Hormone Receptor Positive Breast Cancer, Non-small Cell Lung Cancer
Immunologic Response to Pneumococcal Polysaccharide Vaccine in Splenic Injury Patients
Recruiting
Persons without a spleen are susceptible to potentially lethal infections from certain bacteria, with pneumococcus being the most prevalent. Vaccines are provided to help protect against these infections, though they do not so with certainty. Trauma patients who sustain an injury to their spleen currently have three treatment options available for the treating surgeon - nonoperative management, embolization, or removal of the spleen. The purpose of this study is to investigate the antibody respo... Read More
Gender:
All
Ages:
Between 18 years and 65 years
Trial Updated:
06/15/2023
Locations: University of California, Davis Medical Center, Sacramento, California
Conditions: Asplenia
Effect of Electro-Acupuncture on Blood Pressure
Recruiting
Based on previous published research in animals and human, the investigators hypothesize that electroacupuncture (EA) will have a positive effect on hypertension.
Gender:
All
Ages:
Between 39 years and 85 years
Trial Updated:
06/15/2023
Locations: Susan Samueli Integrative Health Institute, Costa Mesa, California
Conditions: Hypertension
The Actuate-CBC Study
Recruiting
The study team will use implementation science to accelerate the uptake of teleconsultationfor burn patients by 1) examining the relationships between clinician perceptions of acceptability, feasibility, intention to use, and actual use of burn teleconsultation 2) identifying the optimal process for burn teleconsultation and the barriers and facilitators for its use during a crisis or prolonged care situation, and 3) designing and testing the effectiveness of a specific, tailored burn teleconsul... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
06/14/2023
Locations: UCI Health Regional Burn Center, Orange, California
Conditions: Telemedicine
A Study of Avapritinib in Pediatric Patients With Solid Tumors Dependent on KIT or PDGFRA Signaling
Recruiting
This is a Phase 1/2, multicenter, open-label trial of avapritinib in participants 2 to < 18 years of age with advanced relapsed/refractory (R/R) solid tumors, including central nervous system (CNS) tumors, that harbor a PDGFRA and/or KIT mutation (including non-synonymous point mutations, insertions, and deletions) or amplification, or DMG-H3K27a who have no available curative treatment options. This is a single-arm trial in which all participants will receive avapritinib. The study consists of... Read More
Gender:
All
Ages:
Between 2 years and 17 years
Trial Updated:
06/14/2023
Locations: University of California San Francisco, Benioff Children's Hospital, San Francisco, California
Conditions: Solid Tumor, Unspecified, Child, Relapsed Solid Neoplasm, CNS Tumor
TRIAD Appendicitis Decision-making Surveys
Recruiting
While appendectomy has been the main treatment of appendicitis for over 100 years, recent European studies found that, at least among highly selected patients, antibiotics alone can be an effective alternative. Surgeons and patients alike have a difficult time deciding if surgery or antibiotics are the best choice to treat appendicitis. The goal of the TRIAD is to evaluate the patients who are a part of the TRIAD implementation program and assess satisfaction and decisional regret for patients w... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
06/13/2023
Locations: Kaiser Permanente Baldwin Park, Baldwin Park, California
Conditions: Appendicitis
Impact of Metabolic Dysfunction and Mucus Plugging on Asthma Physiology
Recruiting
This is a single-center study of 80 subjects with asthma including those with obesity and metabolic dysfunction (MD), those with obesity and without metabolic dysfunction, those with severe asthma and mucus plugging and those with severe asthma and without mucus plugging. Screening data will be reviewed to determine participant eligibility. Participants who meet all inclusion criteria will participate in a cardiopulmonary exercise testing (CPET) visit to compare lung function markers and change... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
06/13/2023
Locations: UCSF Airway Clinical Research Center, San Francisco, California
Conditions: Asthma