California is currently home to 5605 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
iMmune SignAtures and Clinical outComes in AP
Recruiting
The MoSAIC study is a prospective, observational study designed to develop an early prediction tool for severe acute pancreatitis (SAP) and define a distinct immunologic profile compared to moderate acute pancreatitis (MAP). The aims are to validate a new multi-cytokine panel for early prediction of SAP and to identify the specific immune cells that correspond with cytokine signatures in early acute pancreatitis to characterize the immune pathways driving the development of SAP. Participants wil... Read More
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
12/07/2023
Locations: University of Southern California, Los Angeles, California
Conditions: Acute Pancreatitis
Evaluation of the Effectiveness of Nail Genesis DLSO Product for Onychomycosis
Recruiting
This is a Pre-IDE, prospective, multicenter, randomized, parallel-group, double-blind, vehicle- controlled study to evaluate safety and effectiveness of Nail Genesis DLSO Product for the treatment of DLSO compared with vehicle in infected great toenails in a total of 338 males and non-pregnant, non-lactating, females between 18 and 65 years of age (inclusive). Subjects will be randomized in a 2:1 ratio to receive either Nail Genesis DLSO Product or vehicle. Subject eligibility will be determine... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
12/06/2023
Locations: Catalina Research Institute, LLC, Montclair, California
Conditions: Distal Lateral Subungual Onychomycosis, Onychomycosis
Contrast Enhanced Ultrasound Medical Imaging for Identifying Breast Masses
Recruiting
This clinical trial investigates the role of contrast enhanced ultrasound (CEUS) in identifying cystic breast masses as benign or malignant. Ultrasound is a diagnostic imaging test that uses sound waves to make pictures of the body without using radiation (x-rays). Ultrasounds are widely used to diagnose many diseases in the body. This trial may help researchers learn if using CEUS will help in determining whether or not an ultrasound guided biopsy is necessary.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
12/05/2023
Locations: Los Angeles County-USC Medical Center, Los Angeles, California
Conditions: Breast Carcinoma
Autologous Fat Grafting to the Face With Use of the Viality™ System
Recruiting
The purpose of this research is to collect data on the short and long-term effects of facial fat grafting by injectable tissue replacement and regeneration in the midfacial zone, with the use of the VialityTM system. The Viality system is a US Food and Drug Administration (FDA) cleared device.
Gender:
FEMALE
Ages:
Between 18 years and 65 years
Trial Updated:
12/05/2023
Locations: Faces Plus, San Diego, California
Conditions: Adipose Tissue
Prostate Resection After Microwave Ablation (PRAMA)
Recruiting
This phase I trial tests the safety of magnetic resonance imaging (MRI)/ ultrasound (US) fusion guided transperineal targeted microwave ablation (TMA) before a radical prostatectomy (RP) and how well it works in treating patients with prostate cancer. Prostate cancer is the second most common cancer in men and most will never become aggressive. Despite this, most men choose to undergo treatment which may include surgery. Removing the prostate gland and sometimes the lymph nodes (radical prostate... Read More
Gender:
MALE
Ages:
18 years and above
Trial Updated:
12/05/2023
Locations: USC / Norris Comprehensive Cancer Center, Los Angeles, California
Conditions: Prostate Carcinoma
International CDKL5 Clinical Research Network
Recruiting
Pathogenic variants in the Cyclin-dependent kinase like 5 (CDKL5) gene cause CDKL5 deficiency disorder (CDD, MIM 300672, 105830), a severe developmental and epileptic encephalopathy associated with cognitive and motor impairments and cortical visual impairment. While capability for disease modifying therapies is accelerating, there is a critical barrier for clinical trial readiness that may result in failure of these therapies, not due to lack of efficacy but due to lack of validated outcome mea... Read More
Gender:
ALL
Ages:
Between 1 month and 100 years
Trial Updated:
12/05/2023
Locations: University of California Los Angeles/UCLA Mattel Children's Hospital, Los Angeles, California
Conditions: CDKL5, CDKL5 Deficiency Disorder, CDD
Probing the Dorsolateral Prefrontal Cortex and Central Executive Network for Improving Neuromodulation in Depression
Recruiting
Depression is a highly prevalent condition characterized by persistent low mood, energy, and activity that can affect one's thoughts, mood, behavior, and sense of well-being. Repetitive transcranial magnetic stimulation (rTMS), a non-invasive neuromodulatory technique, is an effective treatment for depression when targeting the dorsolateral prefrontal cortex (dlPFC) of the central executive network (CEN). However, remission rates are suboptimal and individual methods to target the dlPFC are lack... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
12/05/2023
Locations: Stanford University, Stanford, California
Conditions: Major Depressive Disorder
Exercise for Brain Regeneration in Epilepsy
Recruiting
Nearly 100 million Americans are affected by neurological disorders with an overall cost above $765 billion for the more prevalent conditions. Given this significant burden, effective treatments to prevent dementia and new disease modifying therapies are urgently needed. Regeneration of lost neurons with new ones (i.e., neurogenesis) is compromised at early stages of dementia and in part correlates with cognitive impairment in Alzheimer's disease. Boosting the neurogenesis delays the cognitive... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
12/05/2023
Locations: University of Southern California Department of Neurosurgery, Los Angeles, California
Conditions: Temporal Lobe Epilepsy
Brain Imaging Biomarkers for Response to Spinal Cord Stimulation in Patients With Chronic Low Back Pain
Recruiting
In this protocol, "Brain imaging biomarkers for response to Spinal Cord Stimulation in patients with chronic low back pain," the investigators plan to perform brain mapping studies in 42 patients who are undergoing spinal cord stimulation (SCS) for chronic low back pain (CLBP) as part of the participants normal clinical care during a 2-year period. This imagining study is completed for research purposes. There is no standard of care imaging for the participants. This study requires two visits in... Read More
Gender:
ALL
Ages:
21 years and above
Trial Updated:
12/05/2023
Locations: University of California Los Angeles, Los Angeles, California
Conditions: Chronic Low-back Pain
Closed-loop Optimized rTMS for Depression
Recruiting
Targeted and individualized treatments for mental health disorders are critically needed. Repetitive transcranial magnetic stimulation (rTMS) represents the front-line of new and innovative approaches to normalizing dysfunctional brain networks in those with mental illness. rTMS is FDA-approved for depression and obsessive-compulsive disorder with clinical trials underway for PTSD and addiction, among others. However, remission rates are suboptimal and ideal stimulation parameters are unknown. W... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
12/05/2023
Locations: Stanford University, Stanford, California
Conditions: Major Depressive Disorder
Peer Support for Patients With Diabetic Foot Ulcers
Recruiting
The objective of the study is to develop a peer support program that helps improve ulcer care in patients with a diabetic foot ulcer (DFU).Diabetes, peripheral arterial disease (PAD), foot ulceration, and subsequent amputation are unevenly patterned in terms of racial/ethnicity, socioeconomic status, health insurance, and geographic area. The project will identify opportunities to reduce health disparities among economically marginalized patients regarding DFU outcomes.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/04/2023
Locations: Rancho Los Amigos National Rehabilitation Center, Downey, California
Conditions: Diabetic Foot Ulcer, Diabetic Wound, Diabetes Mellitus, Type 2, Diabetic Foot, Diabetes Complications, Peripheral Neuropathy
Simplified IMmunosuppressive Protocol Utilizing Low Dose EnvarsusXR
Recruiting
The purpose of this study is to determine if the combination of once-daily tacrolimus extended-release (EnvarsusXR) and Azathioprine is non inferior with respect to the composite outcome of acute rejection, graft and patient survival as compared to a combination of twice-daily immediate release tacrolimus and mycophenolate mofetil/mycophenolic acid.
Gender:
ALL
Ages:
Between 18 years and 85 years
Trial Updated:
12/04/2023
Locations: University of Southern California, Los Angeles, California
Conditions: Kidney Transplantation, Kidney Transplant Rejection