California is currently home to 5605 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
The K-Map Study, Global Prevalence of KC
Recruiting
Keratoconus is a ocular disease classified under ectatic diseases which often results in bilateral and asymmetrical corneal distortion. It usually affects patients at young age and can cause severe visual loss. The overall goal of this study is to assess the prevalence of keratoconus (KC) in children and adolescents in various regions of the world based on modern tomographic imaging methods, and to verify whether the occurrence rates reported from literature should be corrected. Our hypothesis... Read More
Gender:
ALL
Ages:
Between 6 years and 23 years
Trial Updated:
12/04/2023
Locations: USC Roski Eye Institute, Los Angeles, California
Conditions: Keratoconus
Normative Radiographic Parameters and Growth Curve of Hips Less Than Six Weeks of Gestational Age Using Ultrasound
Recruiting
This study aims to collect normative population data on the ultrasound radiographic parameters used to evaluate hip dysplasia in infants between 32 and 46 weeks of gestational age. This data would be utilized to develop a growth chart with standard deviations for this cohort that would be beneficial in the appropriate treatment of suspected hip dysplasia.
Gender:
ALL
Ages:
6 weeks and below
Trial Updated:
12/04/2023
Locations: Community Regional Medical Center, Fresno, California
Conditions: Newborn, Hip Dysplasia
Biomarker Verification in Pediatric Chronic GvHD: ABLE 2.0 / PTCTC GVH 1901 Study
Recruiting
This study will validate a previously developed pediatric prognostic biomarker algorithm aimed at improving prediction of risk for the later development of chronic graft-versus-host disease (cGvHD) in children and young adults undergoing allogeneic hematopoietic stem cell transplant. By developing an early risk stratification of patients into low-, intermediate-, and high-risk for future cGvHD development (based upon their biomarker profile, before the onset of cGvHD), pre-emptive therapies aim... Read More
Gender:
ALL
Ages:
Between 0 years and 24 years
Trial Updated:
12/02/2023
Locations: University of California San Francisco, San Francisco, California
Conditions: Chronic Graft-versus-Host-Disease, Leukemia, Allogeneic Hematopoietic Stem Cell Transplantation, Blood Cancer, Non-Malignant Hematologic and Lymphocytic Disorder
Travoprost Ophthalmic Topical Cream for Open-angle Glaucoma or Ocular Hypertension
Recruiting
The goal of this clinical trial is to learn about the safety of Travoprost Ophthalmic Topical Cream and how well it works in lowering high intraocular pressure (IOP) in patients with open-angle glaucoma (OAG) or ocular hypertension (OHT). A low dose, medium dose and high dose of Travoprost Ophthalmic Topical Cream will be compared to timolol maleate ophthalmic solution, 0.5% and to travoprost ophthalmic solution, 0.004%.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/30/2023
Locations: Glaukos Clinical Study Site, Newport Beach, California
Conditions: Open Angle Glaucoma, Ocular Hypertension
Eyelid Androgen Treatment in Dry Eye
Recruiting
The purpose of this research study is to evaluate the effectiveness and safety of applying androgen sex hormone (i.e., testosterone) gel on the eyelids in the treatment of dry eye patients. Several studies have demonstrated positive treatment effects in dry eye, but few have applied testosterone gels to the eyelids.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/29/2023
Locations: Southern California College of Optometry at Marshall B. Ketchum University, Fullerton, California
Conditions: Aqueous Tear Deficiency, Meibomian Gland Dysfunction of Bilateral Eyes (Disorder)
Adolescent Acts of Kindness Intervention With Reflection
Recruiting
Adolescents will complete a 4-week intervention, during which they will either complete a kind act for others, complete a kind act for others with a reflection component, or report their daily activities three days per week. Psychological measures will be indexed before and after the intervention.
Gender:
ALL
Ages:
Between 14 years and 17 years
Trial Updated:
11/29/2023
Locations: Adolescent Development Lab, Los Angeles, California
Conditions: Mental Health Wellness 1
Efficacy of Daromun Neoadjuvant Intratumoral Treatment in Clinical Stage IIIB/C Melanoma Patients
Recruiting
The trial aims to evaluate the efficacy of Daromun neoadjuvant treatment followed by surgery and adjuvant therapy to improve in a statistically significant manner the recurrence-free survival (RFS) of Stage IIIB/C melanoma patients with respect to the standard of care (surgery and adjuvant therapy).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/29/2023
Locations: UC San Diego Moores Cancer Center, La Jolla, California
Conditions: Melanoma Stage IIIB/C
A Phase 3 Study to Evaluate Safety and Biomarkers of Resmetirom (MGL-3196) in Patients With Non-alcoholic Fatty Liver Disease (NAFLD), MAESTRO-NAFLD-Open-Label-Extension (MAESTRO-NAFLD-OLE)
Recruiting
A 52-Week, Multi-center, Open-label, Active Treatment Extension Study to Evaluate Safety and Tolerability of Once Daily, Oral Administration of Resmetirom (MGL-3196)
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/28/2023
Locations: Fresno Clinical Research Center, Fresno, California
Conditions: Non-Alcoholic Fatty Liver Disease
Enzalutamide and Indomethacin in Treating Patients With Recurrent or Metastatic Hormone-Resistant Prostate Cancer
Recruiting
This phase I/II trial studies the side effects of enzalutamide and indomethacin and to see how well they work in treating patients with prostate cancer that does not respond to treatment with hormones, has come back, or has spread from where it started to other places in the body. Androgens can cause the growth of prostate cancer cells. Hormone therapy using enzalutamide and indomethacin may fight prostate cancer by lowering the amount of androgen the body makes and/or blocking the use of androg... Read More
Gender:
MALE
Ages:
19 years and above
Trial Updated:
11/28/2023
Locations: University of California Davis Comprehensive Cancer Center, Sacramento, California
Conditions: Metastatic Prostate Carcinoma, Recurrent Prostate Carcinoma, Stage IV Prostate Cancer
A Pilot Trial to Test the Feasibility of Utilizing Home Blood Pressure Monitoring to Optimize the Administration of Midodrine Among Decompensated Cirrhosis Patients
Recruiting
This is a randomized single-blind feasibility trial to test the utilization of home blood pressure devices to improve the clinical management of decompensated cirrhosis patients.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/27/2023
Locations: University of California San Francisco, San Francisco, California
Conditions: Cirrhosis, Liver, Portal Hypertension, Ascites Hepatic
Treatment With Endovascular Intervention for STroke Patients With Existing Disability
Recruiting
TESTED will compare the risks and benefits of endovascular thrombectomy (EVT) to medical management (no EVT) in ischemic stroke patients who have a blockage in one of the large blood vessels in the brain and have a moderate-to-severe disability prior to their stroke.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/27/2023
Locations: University of California at Los Angeles, Los Angeles, California
Conditions: Stroke, Stroke, Acute, Stroke, Ischemic
Study of HQP1351 in Subjects With Refractory CML and Ph+ ALL
Recruiting
A multi-center, open-label, randomized, phase Ib study to evaluate the pharmacokinetics (PK) of HQP1351 and to determine the recommended phase 2 dose (RP2D) of HQP1351 in subjects with CML chronic phase (CP), accelerated phase (AP), or blast phase (BP) or with Ph+ ALL, who have experienced resistance or intolerance to at least two tyrosine kinase inhibitors (TKIs) or in subjects with Ph+ B-cell precursor (BCP) ALL or lymphoid blast phase CML (CML LBP), who have experienced resistance or intolera... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/27/2023
Locations: City of Hope, Duarte, California
Conditions: Leukemia, Myeloid, Chronic, Myeloid Leukemia, Chronic Myeloid Leukemia, Philadelphia Positive Acute Lymphoblastic Leukemia, B Cell Precursor Type Acute Leukemia