California is currently home to 5602 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Los Angeles, San Francisco, San Diego and Sacramento. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Expanding Fertility Care to Poor and Low Resourced Settings Study
Recruiting
The investigators currently lack an understanding of barriers to completing the male factor infertility evaluation. Furthermore, as the investigators continue to expand access to fertility treatment particularly within low-resourced settings, it is important that all aspects of infertility within a couple are equally explored. The COVID-19 pandemic has disproportionately affected low-income communities and communities of color at greater rates in terms of not only disease morbidity/mortality but... Read More
Gender:
MALE
Ages:
Between 18 years and 64 years
Trial Updated:
02/15/2024
Locations: University of California San Francisco, San Francisco, California
Conditions: Healthy, Male Infertility, Infertility, Male, Fertility Disorders
A Non-randomized, Open-Label Study to Evaluate the Safety and Effectiveness of Insight® Pro Device for Evaluating Lymphatic and Venous Disorders (VOLGA)
Recruiting
To demonstrate that the Insight Pro Device is safe and effective for use in detecting lymphatic and venous disorders.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/14/2024
Locations: Koya Medical, Inc., Oakland, California
Conditions: Lymphedema, Chronic Venous Insufficiency, Edema, Venous Insufficiency of Leg
Mechanical Coring to Achieve Directional Skin Tightening
Recruiting
The objective of this clinical study is to evaluate the safety and efficacy of mechanical coring for directional skin tightening. This study is a prospective, up to 3 center, multiple skin treatment area study of the safety and efficacy of mechanical coring with directional closure to achieve directional skin tightening.
Gender:
ALL
Ages:
Between 30 years and 70 years
Trial Updated:
02/13/2024
Locations: Berman Skin Institute, Los Altos, California
Conditions: Skin Tightening, Healthy Volunteers
A Study of HMPL-306 in Advanced Hematological Malignancies With mIDH
Recruiting
An open label single-arm clinical trial to evaluate the safety, tolerability, PK, PD, and preliminary efficacy of HMPL-306 in subjects with advanced relapsed, refractory, or resistant hematological malignancies that harbor IDH mutations.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/13/2024
Locations: University of California Irvine Medical Center (UCIMC) - Chao Family Comprehensive Cancer Center, Orange, California
Conditions: Isocitrate Dehydrogenase Gene Mutation
The OPAL Study: AVM0703 for Treatment of Lymphoid Malignancies
Recruiting
This is an open-label, Phase 1/2 study designed to characterize the safety, tolerability, Pharmacokinetics(PK), and preliminary antitumor activity of AVM0703 administered as a single intravenous (IV) infusion to patients with lymphoid malignancies.
Gender:
ALL
Ages:
Between 12 years and 95 years
Trial Updated:
02/13/2024
Locations: City of Hope, Duarte, California
Conditions: Lymphoid Malignancies
Computational Drug Repurposing for All EBS Cases
Recruiting
The study will compare gene expression differences between blistered and non-blistered skin from individuals with all subtypes of EB, as well as normal skin from non-EB subjects. State of the art computational analysis will be performed to help identify new drugs that might help all EB wound healing and reduce pain. Researchers will focus on drugs that have already been approved for treatment of other dermatologic or non-dermatologic diseases, and therefore be repurposed for treatment of EB. Dru... Read More
Gender:
ALL
Ages:
0 years and above
Trial Updated:
02/11/2024
Locations: Pediatric Dermatology Clinic at Stanford Children's Hospital, Palo Alto, California
Conditions: Epidermolysis Bullosa Simplex, Healthy, Genetic Skin Disease, Epidermolysis Bullosa, Epidermolysis Bullosa, Junctional, Epidermolysis Bullosa Dystrophica
Longitudinal Study of Urea Cycle Disorders
Recruiting
Urea cycle disorders (UCD) are a group of rare inherited metabolism disorders. Infants and children with UCD commonly experience episodes of vomiting, lethargy, and coma. The purpose of this study is to perform a long-term analysis of a large group of individuals with various UCDs. The study will focus on the natural history, disease progression, treatment, and outcome of individuals with UCD.
Gender:
ALL
Ages:
All
Trial Updated:
02/10/2024
Locations: University of California, Los Angeles, Los Angeles, California
Conditions: Brain Diseases, Metabolic, Inborn, Amino Acid Metabolism, Inborn Errors, Urea Cycle Disorders
The Sequencing for Detection in Congenital Heart Disease (SD-CHD) Study
Recruiting
This study is enrolling pregnant persons treated at Rady Children's Hospital fetal cardiology program with a prenatal diagnosis of congenital heart disease to look for genetic disorders in the fetus or unborn baby. Congenital heart disease (CHD) is a group of structural differences to the heart that represent the most common birth defect among liveborn infants world-wide. CHD is the leading cause of birth-defect associated infant death. Prenatal detection allows for delivery planning, postnatal... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
02/09/2024
Locations: Rady Children's Institute for Genomic Medicine, San Diego, California
Conditions: Congenital Heart Disease
Use of Continuous Glucose Monitors in Children and Adolescents With Obesity
Recruiting
To study if continuous glucose monitors are feasible for use in children and adolescents with obesity.
Gender:
ALL
Ages:
Between 10 years and 21 years
Trial Updated:
02/08/2024
Locations: Pediatric Endocrinology Division, University of California, Los Angeles, California
Conditions: Pediatric Obesity
Safety of Ashwagandha (Withania Somnifera) Root Extract
Recruiting
The primary objective is to evaluate the laboratory safety of Ashwagandha standardized root extract 500 mg capsules in healthy adults over 12-week therapy based on Complete Blood Count, Renal Function Test, Liver Function Test, Lipid Profile and Thyroid Function Test, Fasting blood sugar and HbA1c Test. The secondary objectives are to evaluate the clinical safety of Ashwagandha standardized root extract 500 mg capsules in healthy adults over 12-week therapy and to evaluate the effect of the Ashw... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
02/07/2024
Locations: SF Research Institute, San Francisco, California
Conditions: Healthy
Enhancing PAP Adherence Among Spanish-speaking Hispanic Adults With OSA
Recruiting
This study seeks to enhance long-term positive airway pressure (PAP) adherence among Spanish-speaking Hispanics, a group with known PAP outcomes disparities. This study will assess the feasibility of a linguistically and culturally adapted tele-management intervention (Automated Management, AM) for Spanish-speaking Hispanic adults with OSA.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/07/2024
Locations: Kaiser Permanent Southern California, Fontana, California
Conditions: Obstructive Sleep Apnea
Feasibility of Acquiring Hyperpolarized Imaging in Patients With Primary CNS Lymphoma
Recruiting
This phase I trial evaluates the feasibility of using hyperpolarized carbon C 13 pyruvate magnetic resonance imaging (MRI) in diagnosing patients with primary central nervous system lymphoma. This trial aims to see whether MRI using hyperpolarized carbon-13 pyruvate is safe and useful for detecting central nervous system lymphoma and evaluating response to treatment.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/07/2024
Locations: University of California, San Francisco, San Francisco, California
Conditions: Primary CNS Lymphoma